Incidental Mutation 'IGL01614:Rbm25'
ID 92323
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rbm25
Ensembl Gene ENSMUSG00000010608
Gene Name RNA binding motif protein 25
Synonyms 2610015J01Rik, A130095G20Rik, 2600011C06Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL01614
Quality Score
Status
Chromosome 12
Chromosomal Location 83678990-83729901 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 83706341 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Tyrosine at position 229 (D229Y)
Ref Sequence ENSEMBL: ENSMUSP00000138572 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048155] [ENSMUST00000181983] [ENSMUST00000182036] [ENSMUST00000182450] [ENSMUST00000182633]
AlphaFold B2RY56
Predicted Effect unknown
Transcript: ENSMUST00000048155
AA Change: D229Y
SMART Domains Protein: ENSMUSP00000048470
Gene: ENSMUSG00000010608
AA Change: D229Y

DomainStartEndE-ValueType
low complexity region 10 44 N/A INTRINSIC
RRM 88 160 2.52e-11 SMART
low complexity region 234 241 N/A INTRINSIC
coiled coil region 270 351 N/A INTRINSIC
coiled coil region 382 549 N/A INTRINSIC
low complexity region 556 606 N/A INTRINSIC
low complexity region 616 625 N/A INTRINSIC
PWI 758 831 2.79e-38 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000181983
AA Change: D229Y

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000138572
Gene: ENSMUSG00000010608
AA Change: D229Y

DomainStartEndE-ValueType
low complexity region 10 44 N/A INTRINSIC
RRM 88 160 2.52e-11 SMART
internal_repeat_1 187 203 3e-5 PROSPERO
low complexity region 234 241 N/A INTRINSIC
internal_repeat_1 258 274 3e-5 PROSPERO
coiled coil region 382 549 N/A INTRINSIC
low complexity region 556 571 N/A INTRINSIC
low complexity region 575 584 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000182036
SMART Domains Protein: ENSMUSP00000138565
Gene: ENSMUSG00000010608

DomainStartEndE-ValueType
low complexity region 10 44 N/A INTRINSIC
RRM 88 160 2.52e-11 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000182255
Predicted Effect probably benign
Transcript: ENSMUST00000182450
SMART Domains Protein: ENSMUSP00000138416
Gene: ENSMUSG00000010608

DomainStartEndE-ValueType
low complexity region 10 44 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000182633
SMART Domains Protein: ENSMUSP00000138625
Gene: ENSMUSG00000010608

DomainStartEndE-ValueType
low complexity region 29 63 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183242
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183282
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrf5 T A 17: 43,735,362 (GRCm39) S143T possibly damaging Het
Arhgap32 G T 9: 32,171,801 (GRCm39) S1527I probably damaging Het
Atp8a2 A G 14: 60,282,437 (GRCm39) V128A probably damaging Het
Bpi T C 2: 158,113,866 (GRCm39) F255L probably damaging Het
Clptm1 A T 7: 19,371,625 (GRCm39) D269E probably benign Het
Cyria T C 12: 12,411,574 (GRCm39) probably null Het
E2f7 T C 10: 110,595,839 (GRCm39) V63A probably damaging Het
Eif4e1b T A 13: 54,934,729 (GRCm39) I184N probably damaging Het
Gal3st1 T A 11: 3,948,996 (GRCm39) L401Q probably damaging Het
Gm7808 G A 9: 19,839,442 (GRCm39) probably benign Het
Hdac5 G A 11: 102,090,854 (GRCm39) T741I probably benign Het
Ipo5 A G 14: 121,172,507 (GRCm39) T522A probably benign Het
Lama5 A C 2: 179,822,657 (GRCm39) F2832V probably damaging Het
Ltk A C 2: 119,583,968 (GRCm39) L230R probably damaging Het
Mettl14 A T 3: 123,167,609 (GRCm39) probably benign Het
Myom1 T C 17: 71,433,173 (GRCm39) F1507L possibly damaging Het
Nsd3 T A 8: 26,156,095 (GRCm39) I554K possibly damaging Het
Or1j12 T G 2: 36,342,636 (GRCm39) I13S probably benign Het
Or1o1 G A 17: 37,716,529 (GRCm39) C30Y probably benign Het
Or51a43 C T 7: 103,717,576 (GRCm39) V221I probably benign Het
Or8u9 A T 2: 86,001,741 (GRCm39) I140N possibly damaging Het
Prr14 T A 7: 127,074,305 (GRCm39) L279H probably damaging Het
Sdk2 T C 11: 113,684,684 (GRCm39) K1926E probably damaging Het
Slc25a23 C T 17: 57,352,579 (GRCm39) R435Q probably null Het
Srebf2 A G 15: 82,063,054 (GRCm39) N457S probably benign Het
Stac2 T C 11: 97,943,774 (GRCm39) D12G probably benign Het
Tal1 A C 4: 114,920,325 (GRCm39) probably null Het
Usp25 G A 16: 76,874,005 (GRCm39) R527Q probably damaging Het
Other mutations in Rbm25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02095:Rbm25 APN 12 83,718,748 (GRCm39) missense probably damaging 1.00
IGL02227:Rbm25 APN 12 83,719,527 (GRCm39) missense probably damaging 1.00
IGL02454:Rbm25 APN 12 83,707,096 (GRCm39) missense probably benign 0.02
IGL02704:Rbm25 APN 12 83,689,500 (GRCm39) missense probably damaging 1.00
IGL02726:Rbm25 APN 12 83,719,626 (GRCm39) missense probably damaging 1.00
IGL03384:Rbm25 APN 12 83,706,297 (GRCm39) missense probably benign 0.28
Complexities UTSW 12 83,724,630 (GRCm39) missense probably damaging 1.00
R0380:Rbm25 UTSW 12 83,707,130 (GRCm39) missense probably benign 0.02
R0829:Rbm25 UTSW 12 83,707,150 (GRCm39) splice site probably benign
R1330:Rbm25 UTSW 12 83,724,666 (GRCm39) missense probably damaging 1.00
R1346:Rbm25 UTSW 12 83,691,167 (GRCm39) splice site probably benign
R1518:Rbm25 UTSW 12 83,715,219 (GRCm39) missense possibly damaging 0.91
R1566:Rbm25 UTSW 12 83,721,828 (GRCm39) missense probably damaging 0.98
R1660:Rbm25 UTSW 12 83,714,924 (GRCm39) unclassified probably benign
R1809:Rbm25 UTSW 12 83,719,501 (GRCm39) splice site probably benign
R2213:Rbm25 UTSW 12 83,722,856 (GRCm39) missense probably benign 0.00
R2336:Rbm25 UTSW 12 83,698,192 (GRCm39) missense probably damaging 1.00
R2943:Rbm25 UTSW 12 83,707,415 (GRCm39) missense probably damaging 1.00
R3971:Rbm25 UTSW 12 83,721,982 (GRCm39) missense probably benign 0.03
R4349:Rbm25 UTSW 12 83,721,947 (GRCm39) missense probably damaging 0.99
R4740:Rbm25 UTSW 12 83,691,181 (GRCm39) missense possibly damaging 0.61
R4987:Rbm25 UTSW 12 83,724,630 (GRCm39) missense probably damaging 1.00
R5205:Rbm25 UTSW 12 83,719,643 (GRCm39) missense probably benign 0.03
R5579:Rbm25 UTSW 12 83,715,281 (GRCm39) missense probably benign 0.41
R5603:Rbm25 UTSW 12 83,710,990 (GRCm39) nonsense probably null
R5909:Rbm25 UTSW 12 83,728,362 (GRCm39) missense probably damaging 0.97
R5930:Rbm25 UTSW 12 83,724,640 (GRCm39) missense possibly damaging 0.46
R5982:Rbm25 UTSW 12 83,718,725 (GRCm39) missense probably damaging 0.99
R6233:Rbm25 UTSW 12 83,706,200 (GRCm39) missense probably benign 0.24
R6275:Rbm25 UTSW 12 83,691,206 (GRCm39) missense probably damaging 0.98
R6282:Rbm25 UTSW 12 83,722,863 (GRCm39) missense probably damaging 0.98
R7156:Rbm25 UTSW 12 83,710,965 (GRCm39) missense unknown
R7188:Rbm25 UTSW 12 83,710,772 (GRCm39) missense unknown
R7217:Rbm25 UTSW 12 83,710,991 (GRCm39) missense unknown
R7403:Rbm25 UTSW 12 83,722,908 (GRCm39) missense probably damaging 1.00
R7508:Rbm25 UTSW 12 83,719,651 (GRCm39) missense probably damaging 0.99
R7703:Rbm25 UTSW 12 83,721,864 (GRCm39) missense possibly damaging 0.69
R8004:Rbm25 UTSW 12 83,721,166 (GRCm39) missense possibly damaging 0.61
R8154:Rbm25 UTSW 12 83,691,205 (GRCm39) missense unknown
R8444:Rbm25 UTSW 12 83,711,025 (GRCm39) missense unknown
Z1176:Rbm25 UTSW 12 83,719,658 (GRCm39) missense possibly damaging 0.92
Posted On 2013-12-09