Incidental Mutation 'IGL01614:Mettl14'
ID92336
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mettl14
Ensembl Gene ENSMUSG00000028114
Gene Namemethyltransferase like 14
SynonymsG430022H21Rik
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock #IGL01614
Quality Score
Status
Chromosome3
Chromosomal Location123368297-123386108 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to T at 123373960 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000134198 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029759] [ENSMUST00000090371] [ENSMUST00000174006] [ENSMUST00000174323]
Predicted Effect probably benign
Transcript: ENSMUST00000029759
SMART Domains Protein: ENSMUSP00000029759
Gene: ENSMUSG00000028114

DomainStartEndE-ValueType
low complexity region 4 23 N/A INTRINSIC
coiled coil region 65 90 N/A INTRINSIC
Pfam:MT-A70 186 363 2.7e-66 PFAM
low complexity region 397 406 N/A INTRINSIC
low complexity region 408 452 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000090371
SMART Domains Protein: ENSMUSP00000087848
Gene: ENSMUSG00000028114

DomainStartEndE-ValueType
low complexity region 4 23 N/A INTRINSIC
coiled coil region 65 90 N/A INTRINSIC
Pfam:MT-A70 186 289 3e-33 PFAM
low complexity region 310 319 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000174006
SMART Domains Protein: ENSMUSP00000133741
Gene: ENSMUSG00000028114

DomainStartEndE-ValueType
low complexity region 4 13 N/A INTRINSIC
Pfam:MT-A70 28 146 6e-45 PFAM
low complexity region 180 189 N/A INTRINSIC
low complexity region 191 202 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000174323
SMART Domains Protein: ENSMUSP00000134198
Gene: ENSMUSG00000028114

DomainStartEndE-ValueType
low complexity region 4 23 N/A INTRINSIC
coiled coil region 65 90 N/A INTRINSIC
Pfam:MT-A70 186 360 7.3e-63 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrf5 T A 17: 43,424,471 S143T possibly damaging Het
Arhgap32 G T 9: 32,260,505 S1527I probably damaging Het
Atp8a2 A G 14: 60,044,988 V128A probably damaging Het
Bpi T C 2: 158,271,946 F255L probably damaging Het
Clptm1 A T 7: 19,637,700 D269E probably benign Het
E2f7 T C 10: 110,759,978 V63A probably damaging Het
Eif4e1b T A 13: 54,786,916 I184N probably damaging Het
Fam49a T C 12: 12,361,573 probably null Het
Gal3st1 T A 11: 3,998,996 L401Q probably damaging Het
Gm7808 G A 9: 19,928,146 probably benign Het
Hdac5 G A 11: 102,200,028 T741I probably benign Het
Ipo5 A G 14: 120,935,095 T522A probably benign Het
Lama5 A C 2: 180,180,864 F2832V probably damaging Het
Ltk A C 2: 119,753,487 L230R probably damaging Het
Myom1 T C 17: 71,126,178 F1507L possibly damaging Het
Nsd3 T A 8: 25,666,079 I554K possibly damaging Het
Olfr1044 A T 2: 86,171,397 I140N possibly damaging Het
Olfr107 G A 17: 37,405,638 C30Y probably benign Het
Olfr340 T G 2: 36,452,624 I13S probably benign Het
Olfr644 C T 7: 104,068,369 V221I probably benign Het
Prr14 T A 7: 127,475,133 L279H probably damaging Het
Rbm25 G T 12: 83,659,567 D229Y probably damaging Het
Sdk2 T C 11: 113,793,858 K1926E probably damaging Het
Slc25a23 C T 17: 57,045,579 R435Q probably null Het
Srebf2 A G 15: 82,178,853 N457S probably benign Het
Stac2 T C 11: 98,052,948 D12G probably benign Het
Tal1 A C 4: 115,063,128 probably null Het
Usp25 G A 16: 77,077,117 R527Q probably damaging Het
Other mutations in Mettl14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00718:Mettl14 APN 3 123371339 missense probably damaging 1.00
IGL00846:Mettl14 APN 3 123371363 missense probably damaging 1.00
IGL02219:Mettl14 APN 3 123374891 splice site probably benign
IGL02960:Mettl14 APN 3 123374885 missense probably damaging 1.00
R0147:Mettl14 UTSW 3 123371394 missense probably damaging 1.00
R0148:Mettl14 UTSW 3 123371394 missense probably damaging 1.00
R0266:Mettl14 UTSW 3 123382826 missense probably benign 0.05
R0468:Mettl14 UTSW 3 123371412 missense probably damaging 1.00
R0543:Mettl14 UTSW 3 123374762 missense possibly damaging 0.65
R1181:Mettl14 UTSW 3 123374002 missense probably damaging 1.00
R1463:Mettl14 UTSW 3 123374073 splice site probably benign
R4256:Mettl14 UTSW 3 123383605 missense probably damaging 1.00
R4679:Mettl14 UTSW 3 123369414 utr 3 prime probably benign
R4845:Mettl14 UTSW 3 123371355 missense probably damaging 1.00
R5163:Mettl14 UTSW 3 123374825 missense possibly damaging 0.90
R6476:Mettl14 UTSW 3 123374037 missense probably damaging 1.00
R7499:Mettl14 UTSW 3 123374854 missense probably benign 0.30
R7682:Mettl14 UTSW 3 123383604 missense possibly damaging 0.86
R7808:Mettl14 UTSW 3 123372585 missense possibly damaging 0.46
R8044:Mettl14 UTSW 3 123369660 missense probably benign 0.14
R8381:Mettl14 UTSW 3 123374798 missense probably damaging 1.00
Posted On2013-12-09