Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01615:Vmn2r75'

92339

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r75

Ensembl Gene

ENSMUSG00000090436

Gene Name

vomeronasal 2, receptor 75

Synonyms

EG546981

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.079) question?

Stock #

IGL01615

Quality Score

Status

Chromosome

Chromosomal Location

86148042-86171724 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 86148473 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 711 (I711V)

Ref Sequence

ENSEMBL: ENSMUSP00000126973 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167830]

AlphaFold

G5E8Z7

Predicted Effect

probably benign
Transcript: ENSMUST00000167830
AA Change: I711V

PolyPhen 2 Score 0.030 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000126973
Gene: ENSMUSG00000090436
AA Change: I711V

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	80	466	2.8e-31	PFAM
Pfam:NCD3G	510	562	4.6e-20	PFAM
Pfam:7tm_3	593	829	7.7e-51	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adnp2	T	C	18: 80,128,477	T906A	probably damaging	Het
Akap13	A	G	7: 75,697,393	S1731G	probably damaging	Het
Apbb2	A	G	5: 66,307,701	V650A	probably benign	Het
Appl1	A	G	14: 26,959,470		probably benign	Het
Avpr1b	T	G	1: 131,600,147	V136G	probably damaging	Het
B020004J07Rik	T	A	4: 101,837,004	R227S	possibly damaging	Het
C6	T	C	15: 4,781,896	F409L	probably benign	Het
Cdk20	A	G	13: 64,436,310		probably benign	Het
Cenpf	T	C	1: 189,653,184	K2300E	possibly damaging	Het
Cfap57	C	T	4: 118,600,796	R399Q	probably damaging	Het
Cnnm1	A	T	19: 43,471,936	S706C	probably benign	Het
Cr1l	T	C	1: 195,129,881	I45V	possibly damaging	Het
D130043K22Rik	A	T	13: 24,899,796	R1081S	probably damaging	Het
Ddx60	A	T	8: 61,963,740	H573L	probably null	Het
Eif5b	T	C	1: 38,045,706	L878S	probably damaging	Het
Ets1	T	C	9: 32,732,939		probably benign	Het
Evi5	A	G	5: 107,764,707	L696P	probably damaging	Het
Fbxo18	C	A	2: 11,757,523	E12*	probably null	Het
Gabpb1	C	A	2: 126,653,600	M77I	possibly damaging	Het
Glul	T	A	1: 153,906,476	N152K	probably benign	Het
Gm45234	T	C	6: 124,746,431	Y613C	probably damaging	Het
Gm5611	A	G	9: 17,030,351		noncoding transcript	Het
Gm6583	A	G	5: 112,355,830	S3P	possibly damaging	Het
Gpr156	T	A	16: 37,988,591	I225K	probably damaging	Het
Herc4	T	C	10: 63,290,682		probably benign	Het
Iqsec3	C	T	6: 121,410,621	V720M	probably damaging	Het
Itgam	A	T	7: 128,116,767	H1104L	possibly damaging	Het
Itgb3	T	A	11: 104,643,965	D549E	probably damaging	Het
Kctd7	A	T	5: 130,148,135	M76L	probably damaging	Het
Kdm3b	T	G	18: 34,829,231	N1523K	probably damaging	Het
Map3k12	T	A	15: 102,503,751	E318D	probably damaging	Het
Mc1r	T	C	8: 123,408,050	Y181H	probably damaging	Het
Mex3c	G	A	18: 73,573,632	A197T	unknown	Het
Mvk	A	G	5: 114,446,292	D71G	probably benign	Het
Ndufb3	T	A	1: 58,595,753	L88*	probably null	Het
Olfr476	A	G	7: 107,967,937	D180G	probably damaging	Het
Olfr684	A	G	7: 105,157,460	V74A	probably benign	Het
Pifo	G	T	3: 105,997,207		probably null	Het
Psmg2	G	A	18: 67,653,223	V218I	probably benign	Het
Slc5a3	C	T	16: 92,079,112	Q686*	probably null	Het
Vps13c	T	A	9: 67,955,781	H3026Q	probably benign	Het
Zfp354c	A	G	11: 50,817,905	S22P	possibly damaging	Het

Other mutations in Vmn2r75

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01133:Vmn2r75	APN	7	86148032	unclassified	probably benign
IGL01287:Vmn2r75	APN	7	86148593	missense	probably damaging	0.97
IGL01318:Vmn2r75	APN	7	86165566	missense	probably benign	0.06
IGL01331:Vmn2r75	APN	7	86171662	nonsense	probably null
IGL01406:Vmn2r75	APN	7	86163292	splice site	probably benign
IGL01657:Vmn2r75	APN	7	86164247	missense	probably damaging	1.00
IGL02237:Vmn2r75	APN	7	86165578	missense	possibly damaging	0.88
IGL02275:Vmn2r75	APN	7	86165140	missense	probably benign	0.04
IGL02307:Vmn2r75	APN	7	86165766	missense	probably benign	0.00
IGL03136:Vmn2r75	APN	7	86148703	missense	possibly damaging	0.89
IGL03160:Vmn2r75	APN	7	86148436	missense	probably damaging	1.00
IGL03244:Vmn2r75	APN	7	86171725	unclassified	probably benign
PIT4449001:Vmn2r75	UTSW	7	86165583	missense	probably damaging	1.00
R0049:Vmn2r75	UTSW	7	86148101	nonsense	probably null
R0049:Vmn2r75	UTSW	7	86148101	nonsense	probably null
R0083:Vmn2r75	UTSW	7	86165658	missense	probably benign	0.00
R0108:Vmn2r75	UTSW	7	86165658	missense	probably benign	0.00
R0276:Vmn2r75	UTSW	7	86148307	missense	probably benign	0.01
R0320:Vmn2r75	UTSW	7	86165080	missense	probably benign	0.36
R0471:Vmn2r75	UTSW	7	86165513	missense	probably benign	0.01
R0562:Vmn2r75	UTSW	7	86148241	nonsense	probably null
R0631:Vmn2r75	UTSW	7	86163270	missense	probably null	1.00
R0661:Vmn2r75	UTSW	7	86165658	missense	probably benign	0.00
R0811:Vmn2r75	UTSW	7	86165367	missense	probably benign	0.38
R0812:Vmn2r75	UTSW	7	86165367	missense	probably benign	0.38
R0891:Vmn2r75	UTSW	7	86164268	missense	possibly damaging	0.81
R1340:Vmn2r75	UTSW	7	86148590	missense	probably damaging	0.98
R1501:Vmn2r75	UTSW	7	86165642	missense	possibly damaging	0.85
R1760:Vmn2r75	UTSW	7	86148811	missense	probably damaging	1.00
R1970:Vmn2r75	UTSW	7	86148262	missense	probably damaging	1.00
R2060:Vmn2r75	UTSW	7	86165164	missense	probably benign	0.00
R2292:Vmn2r75	UTSW	7	86148936	missense	probably damaging	1.00
R3688:Vmn2r75	UTSW	7	86148421	missense	probably damaging	0.99
R3892:Vmn2r75	UTSW	7	86164286	missense	probably null	1.00
R4532:Vmn2r75	UTSW	7	86148141	nonsense	probably null
R4583:Vmn2r75	UTSW	7	86164082	missense	possibly damaging	0.81
R4592:Vmn2r75	UTSW	7	86166286	missense	probably benign	0.00
R4792:Vmn2r75	UTSW	7	86163170	missense	possibly damaging	0.46
R4859:Vmn2r75	UTSW	7	86148403	missense	probably benign	0.35
R4896:Vmn2r75	UTSW	7	86171579	missense	probably benign	0.01
R4943:Vmn2r75	UTSW	7	86165497	missense	probably damaging	1.00
R4992:Vmn2r75	UTSW	7	86166167	critical splice donor site	probably null
R5048:Vmn2r75	UTSW	7	86165527	missense	possibly damaging	0.66
R5063:Vmn2r75	UTSW	7	86164164	missense	probably benign
R5156:Vmn2r75	UTSW	7	86164228	missense	possibly damaging	0.51
R5243:Vmn2r75	UTSW	7	86164239	missense	probably damaging	1.00
R5277:Vmn2r75	UTSW	7	86166292	missense	probably benign
R5574:Vmn2r75	UTSW	7	86166302	missense	probably benign	0.22
R5622:Vmn2r75	UTSW	7	86148494	missense	probably benign	0.15
R5680:Vmn2r75	UTSW	7	86171571	missense	probably benign	0.10
R5884:Vmn2r75	UTSW	7	86165370	missense	probably benign
R6021:Vmn2r75	UTSW	7	86171612	missense	probably benign	0.01
R6217:Vmn2r75	UTSW	7	86166167	critical splice donor site	probably benign
R6242:Vmn2r75	UTSW	7	86165384	missense	probably damaging	1.00
R6299:Vmn2r75	UTSW	7	86165274	missense	probably benign	0.12
R6441:Vmn2r75	UTSW	7	86171576	missense	probably damaging	0.99
R6495:Vmn2r75	UTSW	7	86164079	missense	probably benign	0.00
R6553:Vmn2r75	UTSW	7	86164245	missense	probably benign	0.28
R6670:Vmn2r75	UTSW	7	86148436	missense	probably damaging	1.00
R7078:Vmn2r75	UTSW	7	86166360	missense	probably damaging	1.00
R7164:Vmn2r75	UTSW	7	86165384	missense	probably damaging	1.00
R8411:Vmn2r75	UTSW	7	86148514	missense	probably damaging	1.00
R8507:Vmn2r75	UTSW	7	86148477	nonsense	probably null
R8559:Vmn2r75	UTSW	7	86166272	missense	possibly damaging	0.65
R8677:Vmn2r75	UTSW	7	86165202	missense	possibly damaging	0.86
R8708:Vmn2r75	UTSW	7	86163268	missense	probably damaging	0.99
R8778:Vmn2r75	UTSW	7	86164289	missense	probably benign	0.40
R8968:Vmn2r75	UTSW	7	86171557	nonsense	probably null
R9145:Vmn2r75	UTSW	7	86164239	missense	probably damaging	1.00
R9316:Vmn2r75	UTSW	7	86148105	missense	possibly damaging	0.63
R9363:Vmn2r75	UTSW	7	86166215	missense	probably benign	0.03

Posted On

2013-12-09