Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01615:Gpr156'

92354

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gpr156

Ensembl Gene

ENSMUSG00000046961

Gene Name

G protein-coupled receptor 156

Synonyms

Gababl

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01615

Quality Score

Status

Chromosome

Chromosomal Location

37916496-38007530 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 37988591 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Lysine at position 225 (I225K)

Ref Sequence

ENSEMBL: ENSMUSP00000055958 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000061274]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000061274
AA Change: I225K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000055958
Gene: ENSMUSG00000046961
AA Change: I225K

Domain	Start	End	E-Value	Type
low complexity region	38	50	N/A	INTRINSIC
Pfam:7tm_3	61	313	2.6e-37	PFAM
coiled coil region	353	390	N/A	INTRINSIC
low complexity region	584	593	N/A	INTRINSIC
low complexity region	635	648	N/A	INTRINSIC
low complexity region	681	716	N/A	INTRINSIC
low complexity region	729	739	N/A	INTRINSIC
low complexity region	753	766	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] G protein-coupled receptors (GPCRs) are a large superfamily of cell surface receptors characterized by 7 helical transmembrane domains, together with N-terminal extracellular and C-terminal intracellular domains.[supplied by OMIM, Mar 2008]

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adnp2	T	C	18: 80,128,477	T906A	probably damaging	Het
Akap13	A	G	7: 75,697,393	S1731G	probably damaging	Het
Apbb2	A	G	5: 66,307,701	V650A	probably benign	Het
Appl1	A	G	14: 26,959,470		probably benign	Het
Avpr1b	T	G	1: 131,600,147	V136G	probably damaging	Het
B020004J07Rik	T	A	4: 101,837,004	R227S	possibly damaging	Het
C6	T	C	15: 4,781,896	F409L	probably benign	Het
Cdk20	A	G	13: 64,436,310		probably benign	Het
Cenpf	T	C	1: 189,653,184	K2300E	possibly damaging	Het
Cfap57	C	T	4: 118,600,796	R399Q	probably damaging	Het
Cnnm1	A	T	19: 43,471,936	S706C	probably benign	Het
Cr1l	T	C	1: 195,129,881	I45V	possibly damaging	Het
D130043K22Rik	A	T	13: 24,899,796	R1081S	probably damaging	Het
Ddx60	A	T	8: 61,963,740	H573L	probably null	Het
Eif5b	T	C	1: 38,045,706	L878S	probably damaging	Het
Ets1	T	C	9: 32,732,939		probably benign	Het
Evi5	A	G	5: 107,764,707	L696P	probably damaging	Het
Fbxo18	C	A	2: 11,757,523	E12*	probably null	Het
Gabpb1	C	A	2: 126,653,600	M77I	possibly damaging	Het
Glul	T	A	1: 153,906,476	N152K	probably benign	Het
Gm45234	T	C	6: 124,746,431	Y613C	probably damaging	Het
Gm5611	A	G	9: 17,030,351		noncoding transcript	Het
Gm6583	A	G	5: 112,355,830	S3P	possibly damaging	Het
Herc4	T	C	10: 63,290,682		probably benign	Het
Iqsec3	C	T	6: 121,410,621	V720M	probably damaging	Het
Itgam	A	T	7: 128,116,767	H1104L	possibly damaging	Het
Itgb3	T	A	11: 104,643,965	D549E	probably damaging	Het
Kctd7	A	T	5: 130,148,135	M76L	probably damaging	Het
Kdm3b	T	G	18: 34,829,231	N1523K	probably damaging	Het
Map3k12	T	A	15: 102,503,751	E318D	probably damaging	Het
Mc1r	T	C	8: 123,408,050	Y181H	probably damaging	Het
Mex3c	G	A	18: 73,573,632	A197T	unknown	Het
Mvk	A	G	5: 114,446,292	D71G	probably benign	Het
Ndufb3	T	A	1: 58,595,753	L88*	probably null	Het
Olfr476	A	G	7: 107,967,937	D180G	probably damaging	Het
Olfr684	A	G	7: 105,157,460	V74A	probably benign	Het
Pifo	G	T	3: 105,997,207		probably null	Het
Psmg2	G	A	18: 67,653,223	V218I	probably benign	Het
Slc5a3	C	T	16: 92,079,112	Q686*	probably null	Het
Vmn2r75	T	C	7: 86,148,473	I711V	probably benign	Het
Vps13c	T	A	9: 67,955,781	H3026Q	probably benign	Het
Zfp354c	A	G	11: 50,817,905	S22P	possibly damaging	Het

Other mutations in Gpr156

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00943:Gpr156	APN	16	37988576	missense	probably damaging	1.00
IGL01976:Gpr156	APN	16	37979033	missense	probably damaging	0.97
IGL02217:Gpr156	APN	16	38005311	missense	probably benign	0.19
IGL02515:Gpr156	APN	16	38005679	missense	probably damaging	0.97
IGL02596:Gpr156	APN	16	37978724	missense	probably benign	0.00
IGL03068:Gpr156	APN	16	37992129	missense	probably damaging	0.99
R0690:Gpr156	UTSW	16	37992141	missense	probably damaging	1.00
R1034:Gpr156	UTSW	16	38004726	missense	probably benign
R1133:Gpr156	UTSW	16	38005321	missense	probably benign	0.10
R1317:Gpr156	UTSW	16	37987567	missense	probably damaging	1.00
R1437:Gpr156	UTSW	16	37988542	missense	probably damaging	0.99
R1484:Gpr156	UTSW	16	37992196	missense	probably damaging	0.99
R1759:Gpr156	UTSW	16	37948221	missense	probably damaging	0.96
R1761:Gpr156	UTSW	16	37987567	missense	probably damaging	1.00
R1998:Gpr156	UTSW	16	37997908	missense	possibly damaging	0.57
R2067:Gpr156	UTSW	16	37978751	missense	probably benign	0.02
R2111:Gpr156	UTSW	16	37978751	missense	probably benign	0.02
R2509:Gpr156	UTSW	16	37947787	missense	probably benign	0.04
R2872:Gpr156	UTSW	16	37992223	missense	probably damaging	0.99
R2872:Gpr156	UTSW	16	37992223	missense	probably damaging	0.99
R3839:Gpr156	UTSW	16	37988600	missense	probably damaging	0.99
R4492:Gpr156	UTSW	16	37992106	missense	probably damaging	0.99
R4988:Gpr156	UTSW	16	37948215	missense	possibly damaging	0.71
R5329:Gpr156	UTSW	16	38005448	missense	probably benign	0.00
R5361:Gpr156	UTSW	16	38005725	missense	probably damaging	0.99
R5386:Gpr156	UTSW	16	37948309	missense	possibly damaging	0.93
R5531:Gpr156	UTSW	16	38005257	missense	probably benign	0.01
R5886:Gpr156	UTSW	16	37979013	missense	probably damaging	1.00
R5942:Gpr156	UTSW	16	38004902	missense	probably benign	0.04
R6345:Gpr156	UTSW	16	37987519	missense	probably damaging	1.00
R7247:Gpr156	UTSW	16	37947741	missense	probably damaging	1.00
R7353:Gpr156	UTSW	16	37992161	missense	probably damaging	1.00
R7954:Gpr156	UTSW	16	37987558	missense	probably damaging	0.97
R8316:Gpr156	UTSW	16	37997974	missense	probably null	0.00
R8333:Gpr156	UTSW	16	37992054	missense	probably damaging	1.00
R8507:Gpr156	UTSW	16	37948236	missense	probably benign
R8770:Gpr156	UTSW	16	38004612	missense	possibly damaging	0.94
R9237:Gpr156	UTSW	16	38005286	nonsense	probably null
R9491:Gpr156	UTSW	16	38005342	missense	probably benign	0.03
R9767:Gpr156	UTSW	16	37997935	missense	probably damaging	1.00
Z1177:Gpr156	UTSW	16	38004863	missense	probably benign	0.22

Posted On

2013-12-09