Incidental Mutation 'IGL01616:Ivns1abp'
ID92393
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ivns1abp
Ensembl Gene ENSMUSG00000023150
Gene Nameinfluenza virus NS1A binding protein
SynonymsNS-1, Nd1-L, Nd1-S, 1700126I16Rik, 1190004M08Rik, ND1, HSPC068, NS1-BP
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.419) question?
Stock #IGL01616
Quality Score
Status
Chromosome1
Chromosomal Location151344477-151364422 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 151361543 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Lysine at position 486 (T486K)
Ref Sequence ENSEMBL: ENSMUSP00000095150 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023918] [ENSMUST00000097543] [ENSMUST00000111887] [ENSMUST00000186745] [ENSMUST00000190872]
Predicted Effect possibly damaging
Transcript: ENSMUST00000023918
AA Change: T528K

PolyPhen 2 Score 0.469 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000023918
Gene: ENSMUSG00000023150
AA Change: T528K

DomainStartEndE-ValueType
BTB 32 129 1.89e-25 SMART
BACK 134 233 3.39e-8 SMART
low complexity region 325 338 N/A INTRINSIC
Kelch 369 415 4.78e-15 SMART
Kelch 416 463 2.16e-13 SMART
Kelch 464 512 2.15e-8 SMART
Kelch 513 559 1.58e-15 SMART
Kelch 560 606 1.61e-12 SMART
Kelch 607 641 1.85e-1 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000097543
AA Change: T486K

PolyPhen 2 Score 0.688 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000095150
Gene: ENSMUSG00000023150
AA Change: T486K

DomainStartEndE-ValueType
BTB 32 129 1.89e-25 SMART
Pfam:BACK 134 189 3.3e-8 PFAM
low complexity region 283 296 N/A INTRINSIC
Kelch 327 373 4.78e-15 SMART
Kelch 374 421 2.16e-13 SMART
Kelch 422 470 2.15e-8 SMART
Kelch 471 517 1.58e-15 SMART
Kelch 518 564 1.61e-12 SMART
Kelch 565 599 1.85e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000111887
SMART Domains Protein: ENSMUSP00000107518
Gene: ENSMUSG00000023150

DomainStartEndE-ValueType
BTB 32 129 1.89e-25 SMART
BACK 134 219 7.04e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000186745
SMART Domains Protein: ENSMUSP00000140708
Gene: ENSMUSG00000023150

DomainStartEndE-ValueType
BTB 32 129 1.89e-25 SMART
BACK 134 219 7.04e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000190872
AA Change: T37K

PolyPhen 2 Score 0.247 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000140332
Gene: ENSMUSG00000023150
AA Change: T37K

DomainStartEndE-ValueType
Kelch 22 68 5.3e-18 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit some early lethality, increased cellular sensitivity to cytochalasin and doxorubicin, and doxorubicin-induced cardiotoxicity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts5 T A 16: 85,887,814 probably null Het
Afg3l1 T A 8: 123,502,007 W771R probably damaging Het
Braf A G 6: 39,651,652 S348P probably damaging Het
Cd200 T C 16: 45,397,056 T112A possibly damaging Het
Cep350 T C 1: 155,953,247 I304V probably benign Het
Fry A G 5: 150,399,599 T1072A probably damaging Het
Fry A T 5: 150,438,811 probably null Het
Fuk G T 8: 110,890,476 H388N possibly damaging Het
Gcdh C T 8: 84,893,659 G8D probably damaging Het
Mat1a G A 14: 41,109,479 V55M probably damaging Het
Olfr656 T C 7: 104,617,721 F22S probably damaging Het
Pcnx3 C T 19: 5,667,259 probably benign Het
Psrc1 C A 3: 108,386,692 S275Y possibly damaging Het
Ptpn21 A G 12: 98,680,013 L1062P probably damaging Het
Slc22a13b-ps A C 9: 119,220,928 probably benign Het
Slc35b1 T A 11: 95,389,084 M178K probably benign Het
Slc6a11 A T 6: 114,134,868 Q132L possibly damaging Het
Slc9a8 C T 2: 167,424,166 T21I possibly damaging Het
Tox T C 4: 6,688,430 T526A probably damaging Het
Ubr3 C T 2: 70,020,484 P1749S probably benign Het
Wdfy3 C A 5: 101,913,260 A1363S probably damaging Het
Zdhhc23 T A 16: 43,973,480 H277L probably damaging Het
Other mutations in Ivns1abp
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00225:Ivns1abp APN 1 151351112 splice site probably null
IGL02061:Ivns1abp APN 1 151351573 missense probably damaging 0.97
IGL02630:Ivns1abp APN 1 151359635 missense probably damaging 1.00
H8562:Ivns1abp UTSW 1 151354695 missense probably damaging 0.98
PIT1430001:Ivns1abp UTSW 1 151361605 missense probably damaging 1.00
R0107:Ivns1abp UTSW 1 151361570 missense probably damaging 0.99
R0609:Ivns1abp UTSW 1 151360145 missense probably benign 0.02
R1104:Ivns1abp UTSW 1 151360109 missense probably benign 0.42
R1463:Ivns1abp UTSW 1 151361540 missense probably benign 0.05
R1512:Ivns1abp UTSW 1 151360936 missense possibly damaging 0.87
R1512:Ivns1abp UTSW 1 151360937 missense probably benign 0.02
R1521:Ivns1abp UTSW 1 151351558 missense probably damaging 1.00
R1550:Ivns1abp UTSW 1 151361491 missense probably damaging 1.00
R2047:Ivns1abp UTSW 1 151351631 missense possibly damaging 0.83
R2435:Ivns1abp UTSW 1 151363310 missense probably benign 0.04
R4471:Ivns1abp UTSW 1 151361239 missense probably benign 0.29
R5011:Ivns1abp UTSW 1 151363202 missense possibly damaging 0.76
R5667:Ivns1abp UTSW 1 151354009 missense probably benign 0.01
R5671:Ivns1abp UTSW 1 151354009 missense probably benign 0.01
R6505:Ivns1abp UTSW 1 151360993 missense probably benign 0.00
R8357:Ivns1abp UTSW 1 151354010 missense probably damaging 1.00
R8457:Ivns1abp UTSW 1 151354010 missense probably damaging 1.00
Z1176:Ivns1abp UTSW 1 151351033 missense probably damaging 0.99
Posted On2013-12-09