Incidental Mutation 'IGL01618:Or5w19'
ID 92434
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or5w19
Ensembl Gene ENSMUSG00000045225
Gene Name olfactory receptor family 5 subfamily W member 19
Synonyms Olfr1152, MOR177-12, GA_x6K02T2Q125-49372426-49373358
Accession Numbers
Essential gene? Probably non essential (E-score: 0.110) question?
Stock # IGL01618
Quality Score
Chromosome 2
Chromosomal Location 87698337-87699269 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 87698488 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Alanine at position 51 (D51A)
Ref Sequence ENSEMBL: ENSMUSP00000151045 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051058] [ENSMUST00000213308]
AlphaFold Q7TR34
Predicted Effect probably damaging
Transcript: ENSMUST00000051058
AA Change: D51A

PolyPhen 2 Score 0.958 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000054645
Gene: ENSMUSG00000045225
AA Change: D51A

Pfam:7tm_4 30 307 4e-46 PFAM
Pfam:7tm_1 40 290 1e-13 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000121994
Predicted Effect probably damaging
Transcript: ENSMUST00000213308
AA Change: D51A

PolyPhen 2 Score 0.958 (Sensitivity: 0.78; Specificity: 0.95)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsl5 C T 19: 55,261,265 (GRCm39) A74V probably benign Het
Adh4 C T 3: 138,134,788 (GRCm39) probably benign Het
Aldh1a3 G A 7: 66,058,978 (GRCm39) T239I probably damaging Het
Anxa9 A G 3: 95,207,847 (GRCm39) probably null Het
Atp5me C A 5: 108,581,899 (GRCm39) K28N probably damaging Het
C9 T G 15: 6,489,149 (GRCm39) Y169D probably benign Het
Chat T A 14: 32,168,849 (GRCm39) probably null Het
Csmd3 C T 15: 47,874,479 (GRCm39) E706K probably benign Het
Ctbs A G 3: 146,160,867 (GRCm39) K145E probably benign Het
Dennd5a A G 7: 109,533,302 (GRCm39) M156T probably damaging Het
Dhx29 A G 13: 113,101,756 (GRCm39) Y1275C probably damaging Het
Dpp10 A T 1: 123,295,596 (GRCm39) F517Y probably benign Het
Dst G A 1: 34,227,990 (GRCm39) W1536* probably null Het
Galc T C 12: 98,218,340 (GRCm39) T171A possibly damaging Het
Gsap T C 5: 21,431,246 (GRCm39) I190T probably damaging Het
Hars2 A T 18: 36,922,630 (GRCm39) R388* probably null Het
Igsf21 C T 4: 139,834,675 (GRCm39) G66S possibly damaging Het
Itgbl1 T A 14: 124,065,211 (GRCm39) S122T possibly damaging Het
Jhy G T 9: 40,872,260 (GRCm39) T83K possibly damaging Het
Kcne4 A T 1: 78,795,525 (GRCm39) M58L possibly damaging Het
Lamc3 T A 2: 31,802,119 (GRCm39) I509N probably damaging Het
Lpar6 T C 14: 73,476,506 (GRCm39) S156P probably damaging Het
Man2c1 T C 9: 57,048,840 (GRCm39) probably benign Het
Marchf11 T C 15: 26,409,285 (GRCm39) I328T possibly damaging Het
Mc3r T A 2: 172,091,290 (GRCm39) C171S probably benign Het
Muc4 A T 16: 32,577,001 (GRCm39) Q2167L unknown Het
Myom1 T C 17: 71,406,988 (GRCm39) V1135A possibly damaging Het
Nectin1 C T 9: 43,702,555 (GRCm39) R101* probably null Het
Nxpe4 T C 9: 48,305,440 (GRCm39) S277P possibly damaging Het
Or1e35 T C 11: 73,798,303 (GRCm39) N5S probably damaging Het
Or2a52 T A 6: 43,144,637 (GRCm39) V215E probably damaging Het
Or52r1c G A 7: 102,735,582 (GRCm39) V281I probably benign Het
Or5b106 T A 19: 13,123,614 (GRCm39) K136N probably benign Het
Pappa2 G T 1: 158,684,948 (GRCm39) N730K probably damaging Het
Prepl A G 17: 85,373,709 (GRCm39) V586A probably damaging Het
Prrc2a T C 17: 35,368,529 (GRCm39) Y2098C probably damaging Het
Rdh16 G A 10: 127,637,176 (GRCm39) C37Y probably damaging Het
Rnd1 A T 15: 98,571,746 (GRCm39) M100K probably benign Het
Sema3c A G 5: 17,877,504 (GRCm39) N204D probably damaging Het
Susd4 A G 1: 182,686,026 (GRCm39) probably null Het
Taar7f G T 10: 23,926,239 (GRCm39) A278S possibly damaging Het
Tle4 T A 19: 14,522,178 (GRCm39) M122L probably benign Het
Trim9 C T 12: 70,295,125 (GRCm39) V662I probably benign Het
Vmn2r10 C A 5: 109,150,345 (GRCm39) C233F probably damaging Het
Vmn2r98 A C 17: 19,285,521 (GRCm39) T114P possibly damaging Het
Zfyve21 C T 12: 111,794,247 (GRCm39) probably benign Het
Zng1 T C 19: 24,918,140 (GRCm39) E210G possibly damaging Het
Other mutations in Or5w19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01418:Or5w19 APN 2 87,698,809 (GRCm39) missense probably benign 0.00
IGL02326:Or5w19 APN 2 87,699,019 (GRCm39) missense probably damaging 1.00
IGL03162:Or5w19 APN 2 87,698,484 (GRCm39) missense probably benign 0.00
IGL03189:Or5w19 APN 2 87,698,559 (GRCm39) missense possibly damaging 0.76
I2288:Or5w19 UTSW 2 87,698,479 (GRCm39) missense probably damaging 1.00
R0761:Or5w19 UTSW 2 87,698,880 (GRCm39) missense possibly damaging 0.88
R1558:Or5w19 UTSW 2 87,698,459 (GRCm39) missense probably damaging 1.00
R1938:Or5w19 UTSW 2 87,698,805 (GRCm39) missense probably benign 0.01
R3810:Or5w19 UTSW 2 87,698,745 (GRCm39) missense probably damaging 1.00
R3812:Or5w19 UTSW 2 87,698,745 (GRCm39) missense probably damaging 1.00
R4728:Or5w19 UTSW 2 87,698,779 (GRCm39) missense probably benign 0.13
R4928:Or5w19 UTSW 2 87,698,574 (GRCm39) missense probably benign 0.32
R5172:Or5w19 UTSW 2 87,699,171 (GRCm39) missense probably benign 0.20
R5174:Or5w19 UTSW 2 87,698,755 (GRCm39) missense possibly damaging 0.79
R6147:Or5w19 UTSW 2 87,699,061 (GRCm39) missense probably benign 0.03
R6195:Or5w19 UTSW 2 87,698,904 (GRCm39) missense possibly damaging 0.63
R6233:Or5w19 UTSW 2 87,698,904 (GRCm39) missense possibly damaging 0.63
R6541:Or5w19 UTSW 2 87,698,638 (GRCm39) missense probably benign 0.11
R7507:Or5w19 UTSW 2 87,698,713 (GRCm39) missense probably damaging 1.00
R8068:Or5w19 UTSW 2 87,698,995 (GRCm39) missense probably benign 0.20
R8407:Or5w19 UTSW 2 87,698,437 (GRCm39) missense probably damaging 1.00
R9110:Or5w19 UTSW 2 87,698,543 (GRCm39) missense probably damaging 1.00
R9408:Or5w19 UTSW 2 87,698,379 (GRCm39) missense probably damaging 1.00
R9797:Or5w19 UTSW 2 87,698,478 (GRCm39) missense possibly damaging 0.63
Posted On 2013-12-09