Incidental Mutation 'IGL01618:Trim9'
ID 92461
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trim9
Ensembl Gene ENSMUSG00000021071
Gene Name tripartite motif-containing 9
Synonyms C030048G07Rik
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.406) question?
Stock # IGL01618
Quality Score
Status
Chromosome 12
Chromosomal Location 70291307-70394388 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 70295125 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 662 (V662I)
Ref Sequence ENSEMBL: ENSMUSP00000152887 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000110520] [ENSMUST00000110522] [ENSMUST00000222316] [ENSMUST00000223160]
AlphaFold Q8C7M3
Predicted Effect probably benign
Transcript: ENSMUST00000110520
AA Change: V666I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000106149
Gene: ENSMUSG00000021071
AA Change: V666I

DomainStartEndE-ValueType
RING 10 131 1.23e-4 SMART
BBOX 163 212 2.84e-9 SMART
BBOX 224 266 9.89e-9 SMART
BBC 273 399 1.29e-38 SMART
FN3 439 522 4.09e-7 SMART
Pfam:SPRY 598 702 2.4e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000110522
AA Change: V740I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000106151
Gene: ENSMUSG00000021071
AA Change: V740I

DomainStartEndE-ValueType
RING 10 131 1.23e-4 SMART
BBOX 163 212 2.84e-9 SMART
BBOX 224 266 9.89e-9 SMART
BBC 273 399 1.29e-38 SMART
FN3 439 522 4.09e-7 SMART
low complexity region 591 605 N/A INTRINSIC
Pfam:SPRY 674 776 1.5e-9 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000221294
AA Change: V712I
Predicted Effect noncoding transcript
Transcript: ENSMUST00000222173
Predicted Effect probably benign
Transcript: ENSMUST00000222316
AA Change: V758I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000223160
AA Change: V662I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223518
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternate splicing of this gene generates two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null mutation display increased axonal branching and increased corpus callosum thickness. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsl5 C T 19: 55,261,265 (GRCm39) A74V probably benign Het
Adh4 C T 3: 138,134,788 (GRCm39) probably benign Het
Aldh1a3 G A 7: 66,058,978 (GRCm39) T239I probably damaging Het
Anxa9 A G 3: 95,207,847 (GRCm39) probably null Het
Atp5me C A 5: 108,581,899 (GRCm39) K28N probably damaging Het
C9 T G 15: 6,489,149 (GRCm39) Y169D probably benign Het
Chat T A 14: 32,168,849 (GRCm39) probably null Het
Csmd3 C T 15: 47,874,479 (GRCm39) E706K probably benign Het
Ctbs A G 3: 146,160,867 (GRCm39) K145E probably benign Het
Dennd5a A G 7: 109,533,302 (GRCm39) M156T probably damaging Het
Dhx29 A G 13: 113,101,756 (GRCm39) Y1275C probably damaging Het
Dpp10 A T 1: 123,295,596 (GRCm39) F517Y probably benign Het
Dst G A 1: 34,227,990 (GRCm39) W1536* probably null Het
Galc T C 12: 98,218,340 (GRCm39) T171A possibly damaging Het
Gsap T C 5: 21,431,246 (GRCm39) I190T probably damaging Het
Hars2 A T 18: 36,922,630 (GRCm39) R388* probably null Het
Igsf21 C T 4: 139,834,675 (GRCm39) G66S possibly damaging Het
Itgbl1 T A 14: 124,065,211 (GRCm39) S122T possibly damaging Het
Jhy G T 9: 40,872,260 (GRCm39) T83K possibly damaging Het
Kcne4 A T 1: 78,795,525 (GRCm39) M58L possibly damaging Het
Lamc3 T A 2: 31,802,119 (GRCm39) I509N probably damaging Het
Lpar6 T C 14: 73,476,506 (GRCm39) S156P probably damaging Het
Man2c1 T C 9: 57,048,840 (GRCm39) probably benign Het
Marchf11 T C 15: 26,409,285 (GRCm39) I328T possibly damaging Het
Mc3r T A 2: 172,091,290 (GRCm39) C171S probably benign Het
Muc4 A T 16: 32,577,001 (GRCm39) Q2167L unknown Het
Myom1 T C 17: 71,406,988 (GRCm39) V1135A possibly damaging Het
Nectin1 C T 9: 43,702,555 (GRCm39) R101* probably null Het
Nxpe4 T C 9: 48,305,440 (GRCm39) S277P possibly damaging Het
Or1e35 T C 11: 73,798,303 (GRCm39) N5S probably damaging Het
Or2a52 T A 6: 43,144,637 (GRCm39) V215E probably damaging Het
Or52r1c G A 7: 102,735,582 (GRCm39) V281I probably benign Het
Or5b106 T A 19: 13,123,614 (GRCm39) K136N probably benign Het
Or5w19 A C 2: 87,698,488 (GRCm39) D51A probably damaging Het
Pappa2 G T 1: 158,684,948 (GRCm39) N730K probably damaging Het
Prepl A G 17: 85,373,709 (GRCm39) V586A probably damaging Het
Prrc2a T C 17: 35,368,529 (GRCm39) Y2098C probably damaging Het
Rdh16 G A 10: 127,637,176 (GRCm39) C37Y probably damaging Het
Rnd1 A T 15: 98,571,746 (GRCm39) M100K probably benign Het
Sema3c A G 5: 17,877,504 (GRCm39) N204D probably damaging Het
Susd4 A G 1: 182,686,026 (GRCm39) probably null Het
Taar7f G T 10: 23,926,239 (GRCm39) A278S possibly damaging Het
Tle4 T A 19: 14,522,178 (GRCm39) M122L probably benign Het
Vmn2r10 C A 5: 109,150,345 (GRCm39) C233F probably damaging Het
Vmn2r98 A C 17: 19,285,521 (GRCm39) T114P possibly damaging Het
Zfyve21 C T 12: 111,794,247 (GRCm39) probably benign Het
Zng1 T C 19: 24,918,140 (GRCm39) E210G possibly damaging Het
Other mutations in Trim9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00910:Trim9 APN 12 70,393,887 (GRCm39) missense probably damaging 0.98
IGL01794:Trim9 APN 12 70,328,654 (GRCm39) missense probably damaging 1.00
IGL03101:Trim9 APN 12 70,393,428 (GRCm39) missense probably damaging 1.00
IGL03184:Trim9 APN 12 70,297,995 (GRCm39) missense probably damaging 0.99
E0354:Trim9 UTSW 12 70,319,233 (GRCm39) missense probably benign 0.01
IGL03098:Trim9 UTSW 12 70,327,467 (GRCm39) missense possibly damaging 0.95
R0518:Trim9 UTSW 12 70,393,359 (GRCm39) missense probably damaging 0.99
R0622:Trim9 UTSW 12 70,393,378 (GRCm39) missense probably damaging 1.00
R0941:Trim9 UTSW 12 70,295,037 (GRCm39) missense probably damaging 0.97
R1022:Trim9 UTSW 12 70,298,791 (GRCm39) splice site probably null
R1024:Trim9 UTSW 12 70,298,791 (GRCm39) splice site probably null
R1204:Trim9 UTSW 12 70,393,501 (GRCm39) missense probably damaging 1.00
R1439:Trim9 UTSW 12 70,297,867 (GRCm39) missense probably damaging 1.00
R1530:Trim9 UTSW 12 70,319,202 (GRCm39) missense probably damaging 0.98
R1613:Trim9 UTSW 12 70,295,169 (GRCm39) missense probably damaging 1.00
R1661:Trim9 UTSW 12 70,301,887 (GRCm39) missense probably damaging 0.99
R1665:Trim9 UTSW 12 70,301,887 (GRCm39) missense probably damaging 0.99
R1722:Trim9 UTSW 12 70,295,148 (GRCm39) missense probably benign 0.33
R2097:Trim9 UTSW 12 70,393,933 (GRCm39) missense probably damaging 1.00
R3082:Trim9 UTSW 12 70,301,887 (GRCm39) missense possibly damaging 0.93
R3123:Trim9 UTSW 12 70,295,167 (GRCm39) missense probably damaging 1.00
R3124:Trim9 UTSW 12 70,295,167 (GRCm39) missense probably damaging 1.00
R3125:Trim9 UTSW 12 70,295,167 (GRCm39) missense probably damaging 1.00
R3738:Trim9 UTSW 12 70,297,969 (GRCm39) missense probably damaging 1.00
R4013:Trim9 UTSW 12 70,393,126 (GRCm39) missense probably damaging 1.00
R4017:Trim9 UTSW 12 70,393,126 (GRCm39) missense probably damaging 1.00
R4560:Trim9 UTSW 12 70,393,892 (GRCm39) nonsense probably null
R4734:Trim9 UTSW 12 70,295,047 (GRCm39) missense probably damaging 1.00
R4748:Trim9 UTSW 12 70,295,047 (GRCm39) missense probably damaging 1.00
R4749:Trim9 UTSW 12 70,295,047 (GRCm39) missense probably damaging 1.00
R4777:Trim9 UTSW 12 70,393,845 (GRCm39) missense probably damaging 1.00
R5027:Trim9 UTSW 12 70,393,482 (GRCm39) missense probably damaging 0.96
R5451:Trim9 UTSW 12 70,393,603 (GRCm39) missense probably benign 0.17
R5471:Trim9 UTSW 12 70,393,566 (GRCm39) missense possibly damaging 0.93
R6394:Trim9 UTSW 12 70,301,987 (GRCm39) missense possibly damaging 0.91
R6901:Trim9 UTSW 12 70,393,413 (GRCm39) missense probably damaging 0.96
R7549:Trim9 UTSW 12 70,393,715 (GRCm39) missense probably damaging 1.00
R7690:Trim9 UTSW 12 70,295,117 (GRCm39) missense probably benign
R7895:Trim9 UTSW 12 70,301,961 (GRCm39) missense probably benign 0.03
R8003:Trim9 UTSW 12 70,393,608 (GRCm39) missense probably benign 0.39
R8026:Trim9 UTSW 12 70,337,161 (GRCm39) missense probably benign 0.00
R8223:Trim9 UTSW 12 70,297,789 (GRCm39) missense probably damaging 0.99
R8956:Trim9 UTSW 12 70,393,665 (GRCm39) missense probably damaging 0.97
R9017:Trim9 UTSW 12 70,314,013 (GRCm39) missense probably benign
R9475:Trim9 UTSW 12 70,393,228 (GRCm39) missense probably benign 0.28
Posted On 2013-12-09