Incidental Mutation 'IGL00754:Bcas3'
ID9248
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Bcas3
Ensembl Gene ENSMUSG00000059439
Gene Namebreast carcinoma amplified sequence 3
Synonyms2610028P08Rik, 1500019F07Rik, rudhira, K20D4
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.712) question?
Stock #IGL00754
Quality Score
Status
Chromosome11
Chromosomal Location85353167-85826058 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) T to A at 85495823 bp
ZygosityHeterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000074875] [ENSMUST00000092821] [ENSMUST00000108056] [ENSMUST00000108061] [ENSMUST00000108062] [ENSMUST00000144276]
Predicted Effect probably benign
Transcript: ENSMUST00000074875
SMART Domains Protein: ENSMUSP00000074416
Gene: ENSMUSG00000059439

DomainStartEndE-ValueType
Blast:WD40 56 104 3e-17 BLAST
WD40 340 380 7.7e-1 SMART
WD40 390 433 2.47e1 SMART
low complexity region 480 494 N/A INTRINSIC
low complexity region 505 514 N/A INTRINSIC
Pfam:BCAS3 521 792 2.3e-33 PFAM
low complexity region 885 901 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000092821
SMART Domains Protein: ENSMUSP00000090496
Gene: ENSMUSG00000059439

DomainStartEndE-ValueType
Blast:WD40 56 104 3e-17 BLAST
WD40 340 380 7.7e-1 SMART
WD40 390 433 2.47e1 SMART
low complexity region 480 494 N/A INTRINSIC
low complexity region 505 514 N/A INTRINSIC
Pfam:BCAS3 521 776 3.8e-35 PFAM
low complexity region 870 886 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108056
SMART Domains Protein: ENSMUSP00000103691
Gene: ENSMUSG00000059439

DomainStartEndE-ValueType
Blast:WD40 56 104 7e-18 BLAST
WD40 340 380 7.7e-1 SMART
WD40 390 433 2.47e1 SMART
low complexity region 480 494 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108061
SMART Domains Protein: ENSMUSP00000103696
Gene: ENSMUSG00000059439

DomainStartEndE-ValueType
Blast:WD40 56 104 2e-17 BLAST
WD40 340 380 7.7e-1 SMART
WD40 390 433 2.47e1 SMART
low complexity region 480 494 N/A INTRINSIC
low complexity region 505 514 N/A INTRINSIC
Pfam:BCAS3 521 789 1e-33 PFAM
low complexity region 899 913 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108062
SMART Domains Protein: ENSMUSP00000103697
Gene: ENSMUSG00000059439

DomainStartEndE-ValueType
Blast:WD40 56 104 2e-17 BLAST
WD40 340 380 7.7e-1 SMART
WD40 390 433 2.47e1 SMART
low complexity region 480 494 N/A INTRINSIC
low complexity region 505 514 N/A INTRINSIC
Pfam:BCAS3 521 796 1.3e-28 PFAM
low complexity region 899 913 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140215
Predicted Effect probably benign
Transcript: ENSMUST00000144276
SMART Domains Protein: ENSMUSP00000114415
Gene: ENSMUSG00000059439

DomainStartEndE-ValueType
WD40 94 134 7.7e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000154396
SMART Domains Protein: ENSMUSP00000122154
Gene: ENSMUSG00000059439

DomainStartEndE-ValueType
WD40 120 160 7.7e-1 SMART
WD40 170 213 2.47e1 SMART
low complexity region 260 274 N/A INTRINSIC
low complexity region 285 294 N/A INTRINSIC
Pfam:BCAS3 301 561 1e-30 PFAM
low complexity region 650 666 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157154
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahi1 G A 10: 20,972,141 G483R probably damaging Het
Ano1 T C 7: 144,597,231 I816V probably damaging Het
Aprt T C 8: 122,575,493 Q77R probably benign Het
Casp8ap2 A G 4: 32,641,036 M697V probably benign Het
Chrnd A C 1: 87,195,784 E348A probably benign Het
Ctnnbl1 A T 2: 157,819,541 S324C possibly damaging Het
Dgkb C A 12: 38,438,568 N644K probably benign Het
Diexf G T 1: 193,115,001 N514K probably damaging Het
Dnajc13 A T 9: 104,174,498 L1720* probably null Het
Ehbp1 A G 11: 22,247,967 probably benign Het
Eif1b G T 9: 120,494,620 C94F probably benign Het
Fmnl3 G A 15: 99,322,670 T577I probably damaging Het
Gm28042 G A 2: 120,030,356 G96R probably damaging Het
Hcrtr1 A G 4: 130,137,233 V86A probably damaging Het
Klrc3 A T 6: 129,641,426 S131R probably damaging Het
Mb21d1 G A 9: 78,435,488 P344L probably damaging Het
Mboat4 A G 8: 34,124,554 T382A probably benign Het
Oosp1 A T 19: 11,667,705 H198Q possibly damaging Het
Parp14 T C 16: 35,839,371 D1627G probably benign Het
Pdcd11 T A 19: 47,103,782 F406I possibly damaging Het
Ppara T C 15: 85,777,642 L28S probably damaging Het
Samd3 A G 10: 26,244,527 T140A probably benign Het
Sf3b1 A G 1: 54,987,486 F1255L probably damaging Het
Stard6 T A 18: 70,483,488 S73T probably benign Het
Tnip2 T C 5: 34,499,299 I221V probably benign Het
Ttn A G 2: 76,782,085 I8859T possibly damaging Het
Ube3b T C 5: 114,415,287 S907P possibly damaging Het
Utrn A G 10: 12,663,492 V1927A probably benign Het
Zfp945 T C 17: 22,851,957 probably benign Het
Other mutations in Bcas3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00340:Bcas3 APN 11 85365591 missense probably damaging 0.98
IGL01712:Bcas3 APN 11 85581048 missense probably damaging 0.99
IGL02073:Bcas3 APN 11 85557437 missense probably damaging 1.00
IGL02261:Bcas3 APN 11 85531930 missense probably damaging 1.00
IGL02323:Bcas3 APN 11 85495845 missense probably damaging 0.97
IGL02493:Bcas3 APN 11 85495882 missense probably damaging 0.99
IGL02609:Bcas3 APN 11 85457894 missense probably damaging 1.00
IGL02808:Bcas3 APN 11 85495851 missense probably benign 0.02
IGL03085:Bcas3 APN 11 85476783 missense probably damaging 1.00
IGL03263:Bcas3 APN 11 85822122 intron probably benign
FR4340:Bcas3 UTSW 11 85509497 missense probably benign 0.12
FR4342:Bcas3 UTSW 11 85509497 missense probably benign 0.12
FR4589:Bcas3 UTSW 11 85509497 missense probably benign 0.12
IGL02991:Bcas3 UTSW 11 85457887 nonsense probably null
PIT4377001:Bcas3 UTSW 11 85495842 missense probably damaging 0.98
PIT4472001:Bcas3 UTSW 11 85531900 missense probably damaging 0.99
R0145:Bcas3 UTSW 11 85359610 splice site probably benign
R0257:Bcas3 UTSW 11 85822039 missense probably benign 0.00
R0276:Bcas3 UTSW 11 85470837 critical splice donor site probably null
R0485:Bcas3 UTSW 11 85495850 missense probably damaging 0.99
R1053:Bcas3 UTSW 11 85557410 missense probably benign 0.10
R1833:Bcas3 UTSW 11 85583949 missense probably benign 0.00
R2107:Bcas3 UTSW 11 85457878 missense probably damaging 0.97
R2108:Bcas3 UTSW 11 85457878 missense probably damaging 0.97
R2215:Bcas3 UTSW 11 85801943 missense probably damaging 0.99
R2404:Bcas3 UTSW 11 85354889 splice site probably benign
R2413:Bcas3 UTSW 11 85531855 missense probably damaging 1.00
R3694:Bcas3 UTSW 11 85801802 missense probably benign 0.00
R3880:Bcas3 UTSW 11 85371122 missense probably benign 0.02
R4241:Bcas3 UTSW 11 85470826 missense probably damaging 0.99
R4794:Bcas3 UTSW 11 85509468 missense probably damaging 1.00
R5035:Bcas3 UTSW 11 85543945 missense probably damaging 1.00
R5073:Bcas3 UTSW 11 85371132 missense probably damaging 1.00
R5245:Bcas3 UTSW 11 85559086 missense probably damaging 1.00
R5358:Bcas3 UTSW 11 85451755 missense probably benign 0.02
R5395:Bcas3 UTSW 11 85825249 missense probably damaging 0.99
R5615:Bcas3 UTSW 11 85470761 missense probably damaging 1.00
R5753:Bcas3 UTSW 11 85822084 intron probably benign
R6198:Bcas3 UTSW 11 85509435 missense probably damaging 0.99
R6668:Bcas3 UTSW 11 85801851 missense probably damaging 0.98
R7170:Bcas3 UTSW 11 85495918 missense probably damaging 0.96
R7171:Bcas3 UTSW 11 85583937 missense probably damaging 1.00
R7672:Bcas3 UTSW 11 85395387 nonsense probably null
R7689:Bcas3 UTSW 11 85495887 missense probably benign 0.10
R7912:Bcas3 UTSW 11 85371128 missense probably damaging 1.00
R7993:Bcas3 UTSW 11 85371128 missense probably damaging 1.00
V3553:Bcas3 UTSW 11 85822100 intron probably benign
X0020:Bcas3 UTSW 11 85531808 missense possibly damaging 0.95
Posted On2012-12-06