Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01619:Vmn2r121'

92492

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r121

Ensembl Gene

ENSMUSG00000072049

Gene Name

vomeronasal 2, receptor 121

Synonyms

EG625699

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.082) question?

Stock #

IGL01619

Quality Score

Status

Chromosome

Chromosomal Location

124127339-124135910 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 124132300 bp

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 387 (M387L)

Ref Sequence

ENSEMBL: ENSMUSP00000092067 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094491]

Predicted Effect

probably benign
Transcript: ENSMUST00000094491
AA Change: M387L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000092067
Gene: ENSMUSG00000072049
AA Change: M387L

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:ANF_receptor	75	448	3.2e-26	PFAM
Pfam:NCD3G	506	560	2.1e-19	PFAM
Pfam:7tm_3	593	828	3.8e-56	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ankrd46	T	C	15: 36,485,967	T47A	possibly damaging	Het
Asxl3	T	G	18: 22,523,328	V1465G	probably damaging	Het
Celsr3	A	G	9: 108,837,404	H1995R	probably benign	Het
Celsr3	A	T	9: 108,834,557	D1657V	probably damaging	Het
Cntn6	G	A	6: 104,728,374		probably benign	Het
Def6	C	T	17: 28,207,864	L8F	probably damaging	Het
Dnah9	T	A	11: 65,831,615	K1940*	probably null	Het
Dock10	A	G	1: 80,634,298		probably benign	Het
Fam166b	G	A	4: 43,427,814	T170I	possibly damaging	Het
Fam72a	A	G	1: 131,533,912	I112V	probably benign	Het
Fgl1	A	T	8: 41,196,971	W258R	probably damaging	Het
Ints6l	G	T	X: 56,496,744		probably benign	Het
Lifr	A	T	15: 7,191,162	N1091I	probably damaging	Het
Mga	T	C	2: 119,931,828	I1100T	possibly damaging	Het
Mrpl40	T	A	16: 18,872,544	M139L	probably benign	Het
Myom1	T	C	17: 71,044,476		probably benign	Het
Olfr164	T	A	16: 19,286,159	T195S	probably damaging	Het
Pcdhb5	T	C	18: 37,322,939	F791L	probably damaging	Het
Prss29	T	C	17: 25,321,139		probably null	Het
Ranbp2	A	G	10: 58,464,078		probably null	Het
Serpinb9e	A	G	13: 33,255,125	K178R	probably damaging	Het
Shtn1	A	G	19: 59,028,169	S233P	probably damaging	Het
Smpd1	G	A	7: 105,555,342	V143M	possibly damaging	Het
Terb1	G	A	8: 104,473,014	H433Y	probably benign	Het
Traf6	C	T	2: 101,690,098	Q164*	probably null	Het
Trip12	C	A	1: 84,814,910	R4L	probably damaging	Het
Ttn	G	A	2: 76,863,535	P208S	possibly damaging	Het
Ube2c	T	C	2: 164,771,312	I50T	probably damaging	Het
Uggt1	T	C	1: 36,161,694	D1174G	probably damaging	Het
Vmn2r18	T	A	5: 151,586,764	N48I	probably benign	Het
Zc3h15	T	C	2: 83,660,173	L217P	probably damaging	Het
Zyg11a	T	A	4: 108,205,217	E129V	probably damaging	Het

Other mutations in Vmn2r121

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Vmn2r121	APN	X	124127802	missense	probably benign	0.04
IGL00990:Vmn2r121	APN	X	124127783	missense	possibly damaging	0.95
IGL00990:Vmn2r121	APN	X	124133716	missense	probably benign	0.00
IGL01125:Vmn2r121	APN	X	124132807	missense	probably damaging	0.99
IGL01450:Vmn2r121	APN	X	124131191	missense	possibly damaging	0.57
IGL01797:Vmn2r121	APN	X	124131351	splice site	probably benign
IGL02227:Vmn2r121	APN	X	124132681	missense	probably benign	0.44
IGL02971:Vmn2r121	APN	X	124127894	missense	probably damaging	1.00
IGL03058:Vmn2r121	APN	X	124132921	missense	probably benign	0.00
IGL03142:Vmn2r121	APN	X	124132938	missense	possibly damaging	0.94
IGL03183:Vmn2r121	APN	X	124132326	missense	probably benign	0.03
E0370:Vmn2r121	UTSW	X	124127920	missense	probably benign	0.01
R0196:Vmn2r121	UTSW	X	124132182	missense	probably benign	0.03
R1381:Vmn2r121	UTSW	X	124128140	missense	probably damaging	1.00
R1399:Vmn2r121	UTSW	X	124129848	missense	possibly damaging	0.94
R1423:Vmn2r121	UTSW	X	124129905	missense	possibly damaging	0.52
R1687:Vmn2r121	UTSW	X	124132791	missense	probably benign	0.39
R2121:Vmn2r121	UTSW	X	124133742	splice site	probably null
R2124:Vmn2r121	UTSW	X	124133742	splice site	probably null
R3151:Vmn2r121	UTSW	X	124131152	missense	probably benign	0.20
R4460:Vmn2r121	UTSW	X	124128584	missense	probably benign	0.01
R4735:Vmn2r121	UTSW	X	124128638	missense	probably benign
R5332:Vmn2r121	UTSW	X	124133575	missense	probably benign
R6102:Vmn2r121	UTSW	X	124133575	missense	probably benign
X0023:Vmn2r121	UTSW	X	124135657	missense	possibly damaging	0.64

Posted On

2013-12-09