Incidental Mutation 'IGL01619:Fgl1'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fgl1
Ensembl Gene ENSMUSG00000031594
Gene Namefibrinogen-like protein 1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.091) question?
Stock #IGL01619
Quality Score
Chromosomal Location41191434-41215156 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 41196971 bp
Amino Acid Change Tryptophan to Arginine at position 258 (W258R)
Ref Sequence ENSEMBL: ENSMUSP00000034003 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034003]
Predicted Effect probably damaging
Transcript: ENSMUST00000034003
AA Change: W258R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000034003
Gene: ENSMUSG00000031594
AA Change: W258R

signal peptide 1 22 N/A INTRINSIC
FBG 80 307 1.4e-131 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134510
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased body weight, decreased circulating cholesterol and free fatty acid, hyperglycemia, impaired glucose tolerance, increased gluconeogenesis, increased white adipose tissue and decreased respiratory quotient. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd46 T C 15: 36,485,967 T47A possibly damaging Het
Asxl3 T G 18: 22,523,328 V1465G probably damaging Het
Celsr3 A G 9: 108,837,404 H1995R probably benign Het
Celsr3 A T 9: 108,834,557 D1657V probably damaging Het
Cntn6 G A 6: 104,728,374 probably benign Het
Def6 C T 17: 28,207,864 L8F probably damaging Het
Dnah9 T A 11: 65,831,615 K1940* probably null Het
Dock10 A G 1: 80,634,298 probably benign Het
Fam166b G A 4: 43,427,814 T170I possibly damaging Het
Fam72a A G 1: 131,533,912 I112V probably benign Het
Ints6l G T X: 56,496,744 probably benign Het
Lifr A T 15: 7,191,162 N1091I probably damaging Het
Mga T C 2: 119,931,828 I1100T possibly damaging Het
Mrpl40 T A 16: 18,872,544 M139L probably benign Het
Myom1 T C 17: 71,044,476 probably benign Het
Olfr164 T A 16: 19,286,159 T195S probably damaging Het
Pcdhb5 T C 18: 37,322,939 F791L probably damaging Het
Prss29 T C 17: 25,321,139 probably null Het
Ranbp2 A G 10: 58,464,078 probably null Het
Serpinb9e A G 13: 33,255,125 K178R probably damaging Het
Shtn1 A G 19: 59,028,169 S233P probably damaging Het
Smpd1 G A 7: 105,555,342 V143M possibly damaging Het
Terb1 G A 8: 104,473,014 H433Y probably benign Het
Traf6 C T 2: 101,690,098 Q164* probably null Het
Trip12 C A 1: 84,814,910 R4L probably damaging Het
Ttn G A 2: 76,863,535 P208S possibly damaging Het
Ube2c T C 2: 164,771,312 I50T probably damaging Het
Uggt1 T C 1: 36,161,694 D1174G probably damaging Het
Vmn2r121 T G X: 124,132,300 M387L probably benign Het
Vmn2r18 T A 5: 151,586,764 N48I probably benign Het
Zc3h15 T C 2: 83,660,173 L217P probably damaging Het
Zyg11a T A 4: 108,205,217 E129V probably damaging Het
Other mutations in Fgl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03158:Fgl1 APN 8 41209773 missense probably benign 0.00
IGL02796:Fgl1 UTSW 8 41197058 missense probably benign 0.01
R0639:Fgl1 UTSW 8 41191624 missense probably benign 0.27
R0673:Fgl1 UTSW 8 41191624 missense probably benign 0.27
R1413:Fgl1 UTSW 8 41191601 missense possibly damaging 0.82
R1458:Fgl1 UTSW 8 41210459 missense possibly damaging 0.54
R1603:Fgl1 UTSW 8 41197018 missense probably damaging 1.00
R1951:Fgl1 UTSW 8 41197350 missense probably benign 0.02
R5686:Fgl1 UTSW 8 41200557 nonsense probably null
R5796:Fgl1 UTSW 8 41199759 splice site probably benign
R6052:Fgl1 UTSW 8 41200511 missense probably damaging 1.00
R7391:Fgl1 UTSW 8 41210446 missense probably benign 0.04
R7492:Fgl1 UTSW 8 41191587 nonsense probably null
R8114:Fgl1 UTSW 8 41191583 missense probably damaging 0.99
Posted On2013-12-09