Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01619:Vmn2r18'

92523

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r18

Ensembl Gene

ENSMUSG00000091794

Gene Name

vomeronasal 2, receptor 18

Synonyms

EG632671

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.082) question?

Stock #

IGL01619

Quality Score

Status

Chromosome

Chromosomal Location

151485126-151529232 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 151510229 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Isoleucine at position 48 (N48I)

Ref Sequence

ENSEMBL: ENSMUSP00000127506 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165928]

AlphaFold

A0A3B2WB67

Predicted Effect

probably benign
Transcript: ENSMUST00000165928
AA Change: N48I

PolyPhen 2 Score 0.248 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000127506
Gene: ENSMUSG00000091794
AA Change: N48I

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	1	403	5.7e-39	PFAM
Pfam:NCD3G	446	499	5.5e-20	PFAM
Pfam:7tm_3	531	767	5e-53	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ankrd46	T	C	15: 36,486,113 (GRCm39)	T47A	possibly damaging	Het
Asxl3	T	G	18: 22,656,385 (GRCm39)	V1465G	probably damaging	Het
Celsr3	A	T	9: 108,711,756 (GRCm39)	D1657V	probably damaging	Het
Celsr3	A	G	9: 108,714,603 (GRCm39)	H1995R	probably benign	Het
Cimip2b	G	A	4: 43,427,814 (GRCm39)	T170I	possibly damaging	Het
Cntn6	G	A	6: 104,705,335 (GRCm39)		probably benign	Het
Def6	C	T	17: 28,426,838 (GRCm39)	L8F	probably damaging	Het
Dnah9	T	A	11: 65,722,441 (GRCm39)	K1940*	probably null	Het
Dock10	A	G	1: 80,612,015 (GRCm39)		probably benign	Het
Fam72a	A	G	1: 131,461,650 (GRCm39)	I112V	probably benign	Het
Fgl1	A	T	8: 41,650,008 (GRCm39)	W258R	probably damaging	Het
Ints6l	G	T	X: 55,542,104 (GRCm39)		probably benign	Het
Lifr	A	T	15: 7,220,643 (GRCm39)	N1091I	probably damaging	Het
Mga	T	C	2: 119,762,309 (GRCm39)	I1100T	possibly damaging	Het
Mrpl40	T	A	16: 18,691,294 (GRCm39)	M139L	probably benign	Het
Myom1	T	C	17: 71,351,471 (GRCm39)		probably benign	Het
Or2m12	T	A	16: 19,104,909 (GRCm39)	T195S	probably damaging	Het
Pcdhb5	T	C	18: 37,455,992 (GRCm39)	F791L	probably damaging	Het
Prss29	T	C	17: 25,540,113 (GRCm39)		probably null	Het
Ranbp2	A	G	10: 58,299,900 (GRCm39)		probably null	Het
Serpinb9e	A	G	13: 33,439,108 (GRCm39)	K178R	probably damaging	Het
Shtn1	A	G	19: 59,016,601 (GRCm39)	S233P	probably damaging	Het
Smpd1	G	A	7: 105,204,549 (GRCm39)	V143M	possibly damaging	Het
Terb1	G	A	8: 105,199,646 (GRCm39)	H433Y	probably benign	Het
Traf6	C	T	2: 101,520,443 (GRCm39)	Q164*	probably null	Het
Trip12	C	A	1: 84,792,631 (GRCm39)	R4L	probably damaging	Het
Ttn	G	A	2: 76,693,879 (GRCm39)	P208S	possibly damaging	Het
Ube2c	T	C	2: 164,613,232 (GRCm39)	I50T	probably damaging	Het
Uggt1	T	C	1: 36,200,775 (GRCm39)	D1174G	probably damaging	Het
Vmn2r121	T	G	X: 123,041,997 (GRCm39)	M387L	probably benign	Het
Zc3h15	T	C	2: 83,490,517 (GRCm39)	L217P	probably damaging	Het
Zyg11a	T	A	4: 108,062,414 (GRCm39)	E129V	probably damaging	Het

Other mutations in Vmn2r18

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01098:Vmn2r18	APN	5	151,496,296 (GRCm39)	missense	probably damaging	0.99
IGL01564:Vmn2r18	APN	5	151,508,633 (GRCm39)	missense	possibly damaging	0.69
IGL01602:Vmn2r18	APN	5	151,510,106 (GRCm39)	missense	possibly damaging	0.64
IGL01605:Vmn2r18	APN	5	151,510,106 (GRCm39)	missense	possibly damaging	0.64
IGL02177:Vmn2r18	APN	5	151,510,274 (GRCm39)	missense	possibly damaging	0.76
IGL02682:Vmn2r18	APN	5	151,508,102 (GRCm39)	missense	probably damaging	0.99
IGL02751:Vmn2r18	APN	5	151,508,072 (GRCm39)	missense	probably benign	0.09
IGL02977:Vmn2r18	APN	5	151,510,149 (GRCm39)	missense	probably damaging	1.00
R0089:Vmn2r18	UTSW	5	151,508,269 (GRCm39)	missense	probably benign	0.00
R0282:Vmn2r18	UTSW	5	151,508,668 (GRCm39)	missense	probably benign	0.02
R0529:Vmn2r18	UTSW	5	151,485,988 (GRCm39)	missense	probably damaging	0.99
R0812:Vmn2r18	UTSW	5	151,496,395 (GRCm39)	splice site	probably benign
R1467:Vmn2r18	UTSW	5	151,510,301 (GRCm39)	missense	possibly damaging	0.48
R1467:Vmn2r18	UTSW	5	151,510,301 (GRCm39)	missense	possibly damaging	0.48
R1506:Vmn2r18	UTSW	5	151,499,099 (GRCm39)	splice site	probably null
R1562:Vmn2r18	UTSW	5	151,510,301 (GRCm39)	missense	probably benign	0.12
R1637:Vmn2r18	UTSW	5	151,508,222 (GRCm39)	missense	probably damaging	1.00
R1651:Vmn2r18	UTSW	5	151,485,464 (GRCm39)	missense	probably damaging	1.00
R1883:Vmn2r18	UTSW	5	151,499,190 (GRCm39)	missense	probably benign	0.37
R1884:Vmn2r18	UTSW	5	151,499,190 (GRCm39)	missense	probably benign	0.37
R1914:Vmn2r18	UTSW	5	151,499,286 (GRCm39)	missense	probably benign	0.02
R2051:Vmn2r18	UTSW	5	151,486,016 (GRCm39)	missense	possibly damaging	0.90
R2056:Vmn2r18	UTSW	5	151,508,160 (GRCm39)	missense	probably damaging	0.98
R2252:Vmn2r18	UTSW	5	151,508,441 (GRCm39)	missense	possibly damaging	0.59
R2265:Vmn2r18	UTSW	5	151,510,127 (GRCm39)	missense	probably damaging	1.00
R2266:Vmn2r18	UTSW	5	151,510,127 (GRCm39)	missense	probably damaging	1.00
R2267:Vmn2r18	UTSW	5	151,510,127 (GRCm39)	missense	probably damaging	1.00
R2843:Vmn2r18	UTSW	5	151,485,749 (GRCm39)	missense	probably damaging	1.00
R3023:Vmn2r18	UTSW	5	151,485,148 (GRCm39)	missense	probably benign	0.13
R3694:Vmn2r18	UTSW	5	151,508,033 (GRCm39)	missense	probably benign	0.00
R3763:Vmn2r18	UTSW	5	151,508,644 (GRCm39)	missense	probably damaging	1.00
R3816:Vmn2r18	UTSW	5	151,485,148 (GRCm39)	missense	probably benign	0.13
R4007:Vmn2r18	UTSW	5	151,508,711 (GRCm39)	missense	probably damaging	0.99
R4152:Vmn2r18	UTSW	5	151,485,730 (GRCm39)	missense	probably damaging	1.00
R4308:Vmn2r18	UTSW	5	151,508,268 (GRCm39)	nonsense	probably null
R4362:Vmn2r18	UTSW	5	151,496,368 (GRCm39)	missense	probably damaging	1.00
R4618:Vmn2r18	UTSW	5	151,508,424 (GRCm39)	missense	possibly damaging	0.64
R4716:Vmn2r18	UTSW	5	151,485,602 (GRCm39)	missense	possibly damaging	0.87
R4817:Vmn2r18	UTSW	5	151,508,897 (GRCm39)	splice site	probably null
R5111:Vmn2r18	UTSW	5	151,485,913 (GRCm39)	missense	possibly damaging	0.85
R5692:Vmn2r18	UTSW	5	151,485,724 (GRCm39)	missense	possibly damaging	0.65
R6115:Vmn2r18	UTSW	5	151,508,462 (GRCm39)	missense	possibly damaging	0.81
R6244:Vmn2r18	UTSW	5	151,508,116 (GRCm39)	missense	probably damaging	1.00
R6595:Vmn2r18	UTSW	5	151,485,889 (GRCm39)	missense	probably damaging	1.00
R6997:Vmn2r18	UTSW	5	151,485,338 (GRCm39)	missense	possibly damaging	0.95
R7227:Vmn2r18	UTSW	5	151,496,264 (GRCm39)	missense	probably damaging	1.00
R7349:Vmn2r18	UTSW	5	151,485,682 (GRCm39)	nonsense	probably null
R7506:Vmn2r18	UTSW	5	151,508,485 (GRCm39)	missense	possibly damaging	0.51
R7590:Vmn2r18	UTSW	5	151,485,194 (GRCm39)	missense	probably damaging	1.00
R7721:Vmn2r18	UTSW	5	151,510,158 (GRCm39)	missense	possibly damaging	0.53
R7877:Vmn2r18	UTSW	5	151,508,437 (GRCm39)	missense	probably damaging	1.00
R7882:Vmn2r18	UTSW	5	151,485,329 (GRCm39)	missense	probably damaging	1.00
R7984:Vmn2r18	UTSW	5	151,485,526 (GRCm39)	missense	probably damaging	1.00
R8295:Vmn2r18	UTSW	5	151,508,621 (GRCm39)	missense	probably damaging	0.97
R8353:Vmn2r18	UTSW	5	151,485,373 (GRCm39)	missense	probably damaging	1.00
R8453:Vmn2r18	UTSW	5	151,485,373 (GRCm39)	missense	probably damaging	1.00
R8670:Vmn2r18	UTSW	5	151,485,854 (GRCm39)	missense	probably damaging	1.00
R8725:Vmn2r18	UTSW	5	151,508,462 (GRCm39)	missense	probably damaging	0.99
R8727:Vmn2r18	UTSW	5	151,508,462 (GRCm39)	missense	probably damaging	0.99
R8895:Vmn2r18	UTSW	5	151,485,140 (GRCm39)	missense	possibly damaging	0.46
R9286:Vmn2r18	UTSW	5	151,499,175 (GRCm39)	missense	probably benign	0.00
R9339:Vmn2r18	UTSW	5	151,485,132 (GRCm39)	missense	probably damaging	0.99
Z1176:Vmn2r18	UTSW	5	151,508,498 (GRCm39)	missense	probably damaging	0.99
Z1187:Vmn2r18	UTSW	5	151,508,497 (GRCm39)	missense	probably benign	0.00

Posted On

2013-12-09