Incidental Mutation 'IGL01619:Ints6l'
ID92543
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ints6l
Ensembl Gene ENSMUSG00000035967
Gene Nameintegrator complex subunit 6 like
Synonyms6330505F04Rik, 4930535D10Rik, Ddx26b
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.170) question?
Stock #IGL01619
Quality Score
Status
ChromosomeX
Chromosomal Location56454857-56507843 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) G to T at 56496744 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000139507 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039374] [ENSMUST00000101553] [ENSMUST00000132428] [ENSMUST00000186445]
Predicted Effect probably benign
Transcript: ENSMUST00000039374
SMART Domains Protein: ENSMUSP00000035379
Gene: ENSMUSG00000035967

DomainStartEndE-ValueType
VWA 1 275 1.29e-1 SMART
Blast:VWA 311 335 1e-6 BLAST
low complexity region 617 633 N/A INTRINSIC
Pfam:INT_SG_DDX_CT_C 776 838 3.8e-34 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000101553
SMART Domains Protein: ENSMUSP00000099089
Gene: ENSMUSG00000035967

DomainStartEndE-ValueType
VWA 1 275 1.29e-1 SMART
Blast:VWA 298 335 7e-7 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000132428
SMART Domains Protein: ENSMUSP00000138630
Gene: ENSMUSG00000035967

DomainStartEndE-ValueType
VWA 1 275 1.29e-1 SMART
Blast:VWA 311 335 1e-6 BLAST
low complexity region 617 633 N/A INTRINSIC
Pfam:INT_SG_DDX_CT_C 775 839 2.1e-34 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134138
Predicted Effect probably benign
Transcript: ENSMUST00000143142
SMART Domains Protein: ENSMUSP00000118865
Gene: ENSMUSG00000035967

DomainStartEndE-ValueType
Blast:VWA 2 223 1e-148 BLAST
low complexity region 394 410 N/A INTRINSIC
Pfam:INT_SG_DDX_CT_C 553 615 1.1e-34 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000186445
SMART Domains Protein: ENSMUSP00000139507
Gene: ENSMUSG00000035967

DomainStartEndE-ValueType
VWA 1 275 1.29e-1 SMART
Blast:VWA 311 335 1e-6 BLAST
low complexity region 617 633 N/A INTRINSIC
Pfam:INT_SG_DDX_CT_C 775 839 2.1e-34 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd46 T C 15: 36,485,967 T47A possibly damaging Het
Asxl3 T G 18: 22,523,328 V1465G probably damaging Het
Celsr3 A G 9: 108,837,404 H1995R probably benign Het
Celsr3 A T 9: 108,834,557 D1657V probably damaging Het
Cntn6 G A 6: 104,728,374 probably benign Het
Def6 C T 17: 28,207,864 L8F probably damaging Het
Dnah9 T A 11: 65,831,615 K1940* probably null Het
Dock10 A G 1: 80,634,298 probably benign Het
Fam166b G A 4: 43,427,814 T170I possibly damaging Het
Fam72a A G 1: 131,533,912 I112V probably benign Het
Fgl1 A T 8: 41,196,971 W258R probably damaging Het
Lifr A T 15: 7,191,162 N1091I probably damaging Het
Mga T C 2: 119,931,828 I1100T possibly damaging Het
Mrpl40 T A 16: 18,872,544 M139L probably benign Het
Myom1 T C 17: 71,044,476 probably benign Het
Olfr164 T A 16: 19,286,159 T195S probably damaging Het
Pcdhb5 T C 18: 37,322,939 F791L probably damaging Het
Prss29 T C 17: 25,321,139 probably null Het
Ranbp2 A G 10: 58,464,078 probably null Het
Serpinb9e A G 13: 33,255,125 K178R probably damaging Het
Shtn1 A G 19: 59,028,169 S233P probably damaging Het
Smpd1 G A 7: 105,555,342 V143M possibly damaging Het
Terb1 G A 8: 104,473,014 H433Y probably benign Het
Traf6 C T 2: 101,690,098 Q164* probably null Het
Trip12 C A 1: 84,814,910 R4L probably damaging Het
Ttn G A 2: 76,863,535 P208S possibly damaging Het
Ube2c T C 2: 164,771,312 I50T probably damaging Het
Uggt1 T C 1: 36,161,694 D1174G probably damaging Het
Vmn2r121 T G X: 124,132,300 M387L probably benign Het
Vmn2r18 T A 5: 151,586,764 N48I probably benign Het
Zc3h15 T C 2: 83,660,173 L217P probably damaging Het
Zyg11a T A 4: 108,205,217 E129V probably damaging Het
Other mutations in Ints6l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02552:Ints6l APN X 56455197 utr 5 prime probably benign
IGL02974:Ints6l APN X 56506936 missense probably benign 0.00
IGL03224:Ints6l APN X 56497927 missense probably damaging 1.00
R0308:Ints6l UTSW X 56481355 missense possibly damaging 0.93
R0733:Ints6l UTSW X 56501748 missense probably benign 0.03
R0733:Ints6l UTSW X 56504812 missense probably benign 0.01
R2121:Ints6l UTSW X 56504868 missense probably benign
R2124:Ints6l UTSW X 56504868 missense probably benign
R2191:Ints6l UTSW X 56504750 missense probably benign 0.03
R2192:Ints6l UTSW X 56504750 missense probably benign 0.03
R2924:Ints6l UTSW X 56504836 missense probably benign 0.01
R3775:Ints6l UTSW X 56481371 missense probably damaging 1.00
Z1176:Ints6l UTSW X 56497935 missense probably damaging 0.97
Posted On2013-12-09