Incidental Mutation 'IGL01621:Pramel25'
ID 92558
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pramel25
Ensembl Gene ENSMUSG00000066031
Gene Name PRAME like 25
Synonyms MGC:91194, Gm13023
Accession Numbers
Essential gene? Probably non essential (E-score: 0.078) question?
Stock # IGL01621
Quality Score
Status
Chromosome 4
Chromosomal Location 143515922-143522145 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 143520502 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 85 (F85L)
Ref Sequence ENSEMBL: ENSMUSP00000115387 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000085144] [ENSMUST00000105770] [ENSMUST00000149739]
AlphaFold A2A8N2
Predicted Effect probably benign
Transcript: ENSMUST00000085144
AA Change: F249L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000082232
Gene: ENSMUSG00000066031
AA Change: F249L

DomainStartEndE-ValueType
SCOP:d1a4ya_ 222 420 3e-9 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000105770
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139978
Predicted Effect probably benign
Transcript: ENSMUST00000149739
AA Change: F85L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik C T 5: 64,055,726 (GRCm39) T154I possibly damaging Het
4933434E20Rik T A 3: 89,971,809 (GRCm39) M56K possibly damaging Het
Abca6 A G 11: 110,075,534 (GRCm39) L1319S probably damaging Het
Adh4 C T 3: 138,134,788 (GRCm39) probably benign Het
Aloxe3 A G 11: 69,020,839 (GRCm39) N188S probably benign Het
Ap1s1 G A 5: 137,070,658 (GRCm39) R119* probably null Het
Apc2 T G 10: 80,142,035 (GRCm39) L318R probably damaging Het
Atg101 A G 15: 101,184,976 (GRCm39) S33G possibly damaging Het
Atp8a2 A T 14: 60,253,317 (GRCm39) probably benign Het
Bpifb9b C A 2: 154,158,871 (GRCm39) probably null Het
Braf A T 6: 39,623,787 (GRCm39) probably benign Het
Cabp5 A G 7: 13,135,189 (GRCm39) D43G probably damaging Het
Cfap46 T C 7: 139,186,523 (GRCm39) N2462S unknown Het
Cit C T 5: 116,130,662 (GRCm39) probably benign Het
Cpa4 T C 6: 30,574,415 (GRCm39) V68A probably damaging Het
Cyp2j5 T C 4: 96,517,791 (GRCm39) I474V probably benign Het
Dennd1a C A 2: 37,734,821 (GRCm39) D49Y probably damaging Het
Dlg5 T C 14: 24,198,289 (GRCm39) D1525G probably damaging Het
Dnajc18 C T 18: 35,813,893 (GRCm39) R292H probably benign Het
Dync2h1 A G 9: 7,140,897 (GRCm39) probably null Het
E2f6 A G 12: 16,875,369 (GRCm39) D268G probably benign Het
Evi2b T A 11: 79,407,126 (GRCm39) T150S probably damaging Het
F13b A G 1: 139,431,589 (GRCm39) D53G probably benign Het
Fbxo38 G A 18: 62,655,595 (GRCm39) probably benign Het
Flnb C T 14: 7,950,470 (GRCm38) P2596L probably damaging Het
Fyco1 A G 9: 123,656,247 (GRCm39) probably benign Het
Gm21759 A G 5: 8,229,775 (GRCm39) probably benign Het
Gtse1 A G 15: 85,759,283 (GRCm39) N597S probably benign Het
Hcn3 G T 3: 89,055,030 (GRCm39) S739Y probably damaging Het
Ighv9-4 T A 12: 114,263,612 (GRCm39) N107I probably damaging Het
Inava C A 1: 136,147,513 (GRCm39) A402S probably damaging Het
Iqub T C 6: 24,446,211 (GRCm39) K738E probably benign Het
Itga6 A T 2: 71,656,000 (GRCm39) D308V probably benign Het
Klf12 T C 14: 100,260,585 (GRCm39) Y48C probably damaging Het
Klhdc9 A G 1: 171,186,384 (GRCm39) *351Q probably null Het
Krt40 A T 11: 99,433,694 (GRCm39) N97K probably damaging Het
Lrit1 A C 14: 36,782,112 (GRCm39) T262P probably damaging Het
Mcoln1 T C 8: 3,560,910 (GRCm39) Y411H probably damaging Het
Mfsd4a A G 1: 131,981,881 (GRCm39) S149P probably benign Het
Minar2 A G 18: 59,195,458 (GRCm39) M1V probably null Het
Mipep A G 14: 61,033,614 (GRCm39) probably benign Het
Mslnl A G 17: 25,962,641 (GRCm39) probably benign Het
N4bp2 A T 5: 65,948,267 (GRCm39) H299L probably damaging Het
Nbn C T 4: 15,965,221 (GRCm39) P190S probably benign Het
Nos1 T A 5: 118,083,949 (GRCm39) I1253N probably damaging Het
Nup210 G T 6: 91,007,099 (GRCm39) F572L probably damaging Het
Or10k2 T C 8: 84,268,247 (GRCm39) V158A probably benign Het
Or1e30 T C 11: 73,678,103 (GRCm39) F113S probably damaging Het
Or2y11 T C 11: 49,442,964 (GRCm39) L130P probably damaging Het
P4htm T A 9: 108,460,935 (GRCm39) E106V probably damaging Het
Pcdhb20 C T 18: 37,637,860 (GRCm39) H129Y possibly damaging Het
Pdcd6ip T C 9: 113,514,490 (GRCm39) E240G probably benign Het
Pex5l T C 3: 33,069,110 (GRCm39) probably null Het
Plcd1 T C 9: 118,905,246 (GRCm39) N181S probably damaging Het
Plekhg6 G T 6: 125,349,062 (GRCm39) L412M probably damaging Het
Ppp1r13b T A 12: 111,801,526 (GRCm39) Q386L possibly damaging Het
Prpf40b A G 15: 99,207,926 (GRCm39) probably benign Het
Rdh11 C T 12: 79,233,187 (GRCm39) probably null Het
Ripor3 A T 2: 167,839,172 (GRCm39) S110T probably damaging Het
Sec24d G A 3: 123,087,807 (GRCm39) probably null Het
Secisbp2l T C 2: 125,615,131 (GRCm39) S165G probably benign Het
Shank1 C T 7: 43,991,889 (GRCm39) A698V unknown Het
Shank1 T C 7: 44,001,023 (GRCm39) M914T unknown Het
Slc22a3 T C 17: 12,677,379 (GRCm39) Q263R probably benign Het
Smc1a C A X: 150,819,125 (GRCm39) Q647K probably damaging Het
Sohlh1 A G 2: 25,736,873 (GRCm39) probably benign Het
Tacc2 C A 7: 130,331,498 (GRCm39) T484K probably damaging Het
Ubr4 G T 4: 139,168,094 (GRCm39) E2825* probably null Het
Wbp2nl G A 15: 82,192,806 (GRCm39) M163I probably benign Het
Zfp69 T A 4: 120,788,697 (GRCm39) K206M probably damaging Het
Zswim3 G A 2: 164,663,440 (GRCm39) R640H probably damaging Het
Other mutations in Pramel25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00905:Pramel25 APN 4 143,521,844 (GRCm39) missense probably benign 0.43
IGL01777:Pramel25 APN 4 143,521,688 (GRCm39) missense possibly damaging 0.87
IGL02075:Pramel25 APN 4 143,521,602 (GRCm39) missense probably benign 0.05
IGL02098:Pramel25 APN 4 143,520,248 (GRCm39) critical splice donor site probably null
IGL02148:Pramel25 APN 4 143,519,304 (GRCm39) missense probably benign 0.25
IGL02355:Pramel25 APN 4 143,519,580 (GRCm39) missense probably damaging 1.00
IGL02362:Pramel25 APN 4 143,519,580 (GRCm39) missense probably damaging 1.00
IGL02828:Pramel25 APN 4 143,521,695 (GRCm39) missense possibly damaging 0.95
IGL03102:Pramel25 APN 4 143,520,116 (GRCm39) missense possibly damaging 0.84
IGL03234:Pramel25 APN 4 143,521,506 (GRCm39) missense probably benign 0.33
BB004:Pramel25 UTSW 4 143,519,536 (GRCm39) missense probably benign 0.29
BB014:Pramel25 UTSW 4 143,519,536 (GRCm39) missense probably benign 0.29
K3955:Pramel25 UTSW 4 143,521,710 (GRCm39) missense possibly damaging 0.79
R0054:Pramel25 UTSW 4 143,521,572 (GRCm39) missense probably damaging 1.00
R0637:Pramel25 UTSW 4 143,520,479 (GRCm39) missense probably benign 0.35
R1227:Pramel25 UTSW 4 143,520,134 (GRCm39) missense probably benign 0.00
R1370:Pramel25 UTSW 4 143,521,874 (GRCm39) missense possibly damaging 0.94
R1709:Pramel25 UTSW 4 143,520,116 (GRCm39) missense possibly damaging 0.84
R1982:Pramel25 UTSW 4 143,521,720 (GRCm39) missense probably benign 0.02
R2292:Pramel25 UTSW 4 143,520,446 (GRCm39) missense probably benign 0.08
R3087:Pramel25 UTSW 4 143,520,416 (GRCm39) missense probably benign 0.25
R4235:Pramel25 UTSW 4 143,521,344 (GRCm39) missense probably damaging 0.97
R4454:Pramel25 UTSW 4 143,519,394 (GRCm39) missense probably benign 0.00
R4504:Pramel25 UTSW 4 143,520,553 (GRCm39) missense probably benign 0.08
R4937:Pramel25 UTSW 4 143,520,407 (GRCm39) missense possibly damaging 0.46
R5041:Pramel25 UTSW 4 143,520,260 (GRCm39) missense probably benign 0.01
R5379:Pramel25 UTSW 4 143,521,493 (GRCm39) missense probably benign 0.00
R5399:Pramel25 UTSW 4 143,521,602 (GRCm39) missense probably benign 0.00
R5445:Pramel25 UTSW 4 143,521,707 (GRCm39) missense possibly damaging 0.50
R6059:Pramel25 UTSW 4 143,520,550 (GRCm39) missense possibly damaging 0.80
R6885:Pramel25 UTSW 4 143,520,103 (GRCm39) missense probably damaging 1.00
R7846:Pramel25 UTSW 4 143,520,563 (GRCm39) missense probably benign 0.02
R7927:Pramel25 UTSW 4 143,519,536 (GRCm39) missense probably benign 0.29
R8285:Pramel25 UTSW 4 143,520,636 (GRCm39) missense probably benign 0.02
R8840:Pramel25 UTSW 4 143,521,638 (GRCm39) missense probably damaging 1.00
R8849:Pramel25 UTSW 4 143,521,596 (GRCm39) missense probably damaging 0.99
R8921:Pramel25 UTSW 4 143,519,322 (GRCm39) nonsense probably null
R9128:Pramel25 UTSW 4 143,520,178 (GRCm39) missense probably benign 0.00
R9232:Pramel25 UTSW 4 143,520,263 (GRCm39) missense probably benign 0.01
R9643:Pramel25 UTSW 4 143,521,855 (GRCm39) nonsense probably null
R9674:Pramel25 UTSW 4 143,520,162 (GRCm39) missense probably benign 0.02
Z1177:Pramel25 UTSW 4 143,521,551 (GRCm39) missense probably damaging 1.00
Posted On 2013-12-09