Incidental Mutation 'IGL01621:Iqub'
ID 92599
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Iqub
Ensembl Gene ENSMUSG00000046192
Gene Name IQ motif and ubiquitin domain containing
Synonyms 4932408B21Rik, Trs4
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01621
Quality Score
Status
Chromosome 6
Chromosomal Location 24444864-24515066 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 24446211 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 738 (K738E)
Ref Sequence ENSEMBL: ENSMUSP00000051177 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052277]
AlphaFold Q8CDK3
Predicted Effect probably benign
Transcript: ENSMUST00000052277
AA Change: K738E

PolyPhen 2 Score 0.451 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000051177
Gene: ENSMUSG00000046192
AA Change: K738E

DomainStartEndE-ValueType
PDB:2DAF|A 119 216 1e-38 PDB
Blast:UBQ 129 199 3e-26 BLAST
low complexity region 218 229 N/A INTRINSIC
low complexity region 289 306 N/A INTRINSIC
IQ 333 355 1.74e-1 SMART
low complexity region 357 383 N/A INTRINSIC
low complexity region 735 742 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(2) : Targeted, knock-out(2)

Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik C T 5: 64,055,726 (GRCm39) T154I possibly damaging Het
4933434E20Rik T A 3: 89,971,809 (GRCm39) M56K possibly damaging Het
Abca6 A G 11: 110,075,534 (GRCm39) L1319S probably damaging Het
Adh4 C T 3: 138,134,788 (GRCm39) probably benign Het
Aloxe3 A G 11: 69,020,839 (GRCm39) N188S probably benign Het
Ap1s1 G A 5: 137,070,658 (GRCm39) R119* probably null Het
Apc2 T G 10: 80,142,035 (GRCm39) L318R probably damaging Het
Atg101 A G 15: 101,184,976 (GRCm39) S33G possibly damaging Het
Atp8a2 A T 14: 60,253,317 (GRCm39) probably benign Het
Bpifb9b C A 2: 154,158,871 (GRCm39) probably null Het
Braf A T 6: 39,623,787 (GRCm39) probably benign Het
Cabp5 A G 7: 13,135,189 (GRCm39) D43G probably damaging Het
Cfap46 T C 7: 139,186,523 (GRCm39) N2462S unknown Het
Cit C T 5: 116,130,662 (GRCm39) probably benign Het
Cpa4 T C 6: 30,574,415 (GRCm39) V68A probably damaging Het
Cyp2j5 T C 4: 96,517,791 (GRCm39) I474V probably benign Het
Dennd1a C A 2: 37,734,821 (GRCm39) D49Y probably damaging Het
Dlg5 T C 14: 24,198,289 (GRCm39) D1525G probably damaging Het
Dnajc18 C T 18: 35,813,893 (GRCm39) R292H probably benign Het
Dync2h1 A G 9: 7,140,897 (GRCm39) probably null Het
E2f6 A G 12: 16,875,369 (GRCm39) D268G probably benign Het
Evi2b T A 11: 79,407,126 (GRCm39) T150S probably damaging Het
F13b A G 1: 139,431,589 (GRCm39) D53G probably benign Het
Fbxo38 G A 18: 62,655,595 (GRCm39) probably benign Het
Flnb C T 14: 7,950,470 (GRCm38) P2596L probably damaging Het
Fyco1 A G 9: 123,656,247 (GRCm39) probably benign Het
Gm21759 A G 5: 8,229,775 (GRCm39) probably benign Het
Gtse1 A G 15: 85,759,283 (GRCm39) N597S probably benign Het
Hcn3 G T 3: 89,055,030 (GRCm39) S739Y probably damaging Het
Ighv9-4 T A 12: 114,263,612 (GRCm39) N107I probably damaging Het
Inava C A 1: 136,147,513 (GRCm39) A402S probably damaging Het
Itga6 A T 2: 71,656,000 (GRCm39) D308V probably benign Het
Klf12 T C 14: 100,260,585 (GRCm39) Y48C probably damaging Het
Klhdc9 A G 1: 171,186,384 (GRCm39) *351Q probably null Het
Krt40 A T 11: 99,433,694 (GRCm39) N97K probably damaging Het
Lrit1 A C 14: 36,782,112 (GRCm39) T262P probably damaging Het
Mcoln1 T C 8: 3,560,910 (GRCm39) Y411H probably damaging Het
Mfsd4a A G 1: 131,981,881 (GRCm39) S149P probably benign Het
Minar2 A G 18: 59,195,458 (GRCm39) M1V probably null Het
Mipep A G 14: 61,033,614 (GRCm39) probably benign Het
Mslnl A G 17: 25,962,641 (GRCm39) probably benign Het
N4bp2 A T 5: 65,948,267 (GRCm39) H299L probably damaging Het
Nbn C T 4: 15,965,221 (GRCm39) P190S probably benign Het
Nos1 T A 5: 118,083,949 (GRCm39) I1253N probably damaging Het
Nup210 G T 6: 91,007,099 (GRCm39) F572L probably damaging Het
Or10k2 T C 8: 84,268,247 (GRCm39) V158A probably benign Het
Or1e30 T C 11: 73,678,103 (GRCm39) F113S probably damaging Het
Or2y11 T C 11: 49,442,964 (GRCm39) L130P probably damaging Het
P4htm T A 9: 108,460,935 (GRCm39) E106V probably damaging Het
Pcdhb20 C T 18: 37,637,860 (GRCm39) H129Y possibly damaging Het
Pdcd6ip T C 9: 113,514,490 (GRCm39) E240G probably benign Het
Pex5l T C 3: 33,069,110 (GRCm39) probably null Het
Plcd1 T C 9: 118,905,246 (GRCm39) N181S probably damaging Het
Plekhg6 G T 6: 125,349,062 (GRCm39) L412M probably damaging Het
Ppp1r13b T A 12: 111,801,526 (GRCm39) Q386L possibly damaging Het
Pramel25 T C 4: 143,520,502 (GRCm39) F85L probably benign Het
Prpf40b A G 15: 99,207,926 (GRCm39) probably benign Het
Rdh11 C T 12: 79,233,187 (GRCm39) probably null Het
Ripor3 A T 2: 167,839,172 (GRCm39) S110T probably damaging Het
Sec24d G A 3: 123,087,807 (GRCm39) probably null Het
Secisbp2l T C 2: 125,615,131 (GRCm39) S165G probably benign Het
Shank1 C T 7: 43,991,889 (GRCm39) A698V unknown Het
Shank1 T C 7: 44,001,023 (GRCm39) M914T unknown Het
Slc22a3 T C 17: 12,677,379 (GRCm39) Q263R probably benign Het
Smc1a C A X: 150,819,125 (GRCm39) Q647K probably damaging Het
Sohlh1 A G 2: 25,736,873 (GRCm39) probably benign Het
Tacc2 C A 7: 130,331,498 (GRCm39) T484K probably damaging Het
Ubr4 G T 4: 139,168,094 (GRCm39) E2825* probably null Het
Wbp2nl G A 15: 82,192,806 (GRCm39) M163I probably benign Het
Zfp69 T A 4: 120,788,697 (GRCm39) K206M probably damaging Het
Zswim3 G A 2: 164,663,440 (GRCm39) R640H probably damaging Het
Other mutations in Iqub
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01015:Iqub APN 6 24,501,005 (GRCm39) splice site probably benign
IGL01447:Iqub APN 6 24,505,627 (GRCm39) missense probably benign 0.01
IGL01702:Iqub APN 6 24,500,312 (GRCm39) missense probably benign 0.13
IGL01917:Iqub APN 6 24,479,318 (GRCm39) missense probably damaging 0.97
IGL02411:Iqub APN 6 24,449,810 (GRCm39) missense probably damaging 0.98
IGL02580:Iqub APN 6 24,501,398 (GRCm39) missense probably benign 0.06
IGL02704:Iqub APN 6 24,505,909 (GRCm39) splice site probably benign
IGL02901:Iqub APN 6 24,454,194 (GRCm39) missense probably damaging 1.00
D4043:Iqub UTSW 6 24,505,750 (GRCm39) missense possibly damaging 0.81
R0304:Iqub UTSW 6 24,454,290 (GRCm39) missense probably damaging 0.99
R0391:Iqub UTSW 6 24,446,154 (GRCm39) missense probably benign 0.00
R0453:Iqub UTSW 6 24,450,829 (GRCm39) missense probably damaging 1.00
R0464:Iqub UTSW 6 24,479,262 (GRCm39) nonsense probably null
R0465:Iqub UTSW 6 24,503,783 (GRCm39) missense probably damaging 1.00
R0479:Iqub UTSW 6 24,505,809 (GRCm39) missense probably benign 0.28
R0606:Iqub UTSW 6 24,501,260 (GRCm39) splice site probably benign
R1146:Iqub UTSW 6 24,505,627 (GRCm39) missense possibly damaging 0.89
R1146:Iqub UTSW 6 24,505,627 (GRCm39) missense possibly damaging 0.89
R1238:Iqub UTSW 6 24,505,884 (GRCm39) missense probably benign 0.03
R1452:Iqub UTSW 6 24,491,558 (GRCm39) missense probably benign 0.13
R1927:Iqub UTSW 6 24,491,670 (GRCm39) missense probably benign 0.11
R3195:Iqub UTSW 6 24,462,036 (GRCm39) splice site probably benign
R4438:Iqub UTSW 6 24,505,867 (GRCm39) missense probably benign 0.01
R4577:Iqub UTSW 6 24,501,290 (GRCm39) missense probably damaging 0.99
R4671:Iqub UTSW 6 24,479,183 (GRCm39) missense probably benign 0.00
R4860:Iqub UTSW 6 24,450,841 (GRCm39) missense probably damaging 0.99
R4860:Iqub UTSW 6 24,450,841 (GRCm39) missense probably damaging 0.99
R4906:Iqub UTSW 6 24,501,368 (GRCm39) missense probably damaging 0.99
R5605:Iqub UTSW 6 24,505,620 (GRCm39) missense probably benign
R5772:Iqub UTSW 6 24,454,250 (GRCm39) missense possibly damaging 0.64
R5801:Iqub UTSW 6 24,449,768 (GRCm39) missense probably benign 0.11
R5853:Iqub UTSW 6 24,491,601 (GRCm39) missense probably benign 0.00
R6423:Iqub UTSW 6 24,491,528 (GRCm39) missense probably damaging 0.98
R6475:Iqub UTSW 6 24,449,744 (GRCm39) missense probably damaging 1.00
R6476:Iqub UTSW 6 24,449,744 (GRCm39) missense probably damaging 1.00
R6477:Iqub UTSW 6 24,449,744 (GRCm39) missense probably damaging 1.00
R6701:Iqub UTSW 6 24,449,744 (GRCm39) missense probably damaging 1.00
R6702:Iqub UTSW 6 24,449,744 (GRCm39) missense probably damaging 1.00
R6703:Iqub UTSW 6 24,449,744 (GRCm39) missense probably damaging 1.00
R6860:Iqub UTSW 6 24,505,737 (GRCm39) missense possibly damaging 0.81
R7331:Iqub UTSW 6 24,500,393 (GRCm39) missense possibly damaging 0.73
R7530:Iqub UTSW 6 24,450,622 (GRCm39) missense probably benign 0.00
R7997:Iqub UTSW 6 24,501,413 (GRCm39) missense possibly damaging 0.86
R8050:Iqub UTSW 6 24,503,784 (GRCm39) missense possibly damaging 0.95
R8141:Iqub UTSW 6 24,491,608 (GRCm39) missense probably benign 0.00
R8153:Iqub UTSW 6 24,450,789 (GRCm39) nonsense probably null
R8163:Iqub UTSW 6 24,449,714 (GRCm39) missense probably benign 0.01
R8702:Iqub UTSW 6 24,461,914 (GRCm39) missense probably damaging 1.00
R8824:Iqub UTSW 6 24,479,307 (GRCm39) nonsense probably null
R8899:Iqub UTSW 6 24,505,768 (GRCm39) missense probably benign 0.00
R9075:Iqub UTSW 6 24,446,124 (GRCm39) missense probably damaging 1.00
R9186:Iqub UTSW 6 24,450,766 (GRCm39) missense possibly damaging 0.92
R9240:Iqub UTSW 6 24,505,622 (GRCm39) missense probably benign
R9256:Iqub UTSW 6 24,446,198 (GRCm39) missense possibly damaging 0.92
X0025:Iqub UTSW 6 24,500,383 (GRCm39) missense probably damaging 0.96
Z1088:Iqub UTSW 6 24,500,242 (GRCm39) splice site probably null
Posted On 2013-12-09