Incidental Mutation 'IGL01621:Secisbp2l'
| ID |
92602 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Secisbp2l
|
| Ensembl Gene |
ENSMUSG00000035093 |
| Gene Name |
SECIS binding protein 2-like |
| Synonyms |
3110001I20Rik |
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.756)
|
| Stock # |
IGL01621
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
2 |
| Chromosomal Location |
125578906-125624790 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 125615131 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Glycine
at position 165
(S165G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000055772
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000053699]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000053699
AA Change: S165G
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000055772
Gene: ENSMUSG00000035093
AA Change: S165G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
441 |
459 |
N/A |
INTRINSIC |
|
low complexity region
|
555 |
568 |
N/A |
INTRINSIC |
|
Pfam:Ribosomal_L7Ae
|
700 |
802 |
7.6e-24 |
PFAM |
|
low complexity region
|
821 |
831 |
N/A |
INTRINSIC |
|
low complexity region
|
970 |
978 |
N/A |
INTRINSIC |
|
low complexity region
|
985 |
996 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 71 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 0610040J01Rik |
C |
T |
5: 64,055,726 (GRCm39) |
T154I |
possibly damaging |
Het |
| 4933434E20Rik |
T |
A |
3: 89,971,809 (GRCm39) |
M56K |
possibly damaging |
Het |
| Abca6 |
A |
G |
11: 110,075,534 (GRCm39) |
L1319S |
probably damaging |
Het |
| Adh4 |
C |
T |
3: 138,134,788 (GRCm39) |
|
probably benign |
Het |
| Aloxe3 |
A |
G |
11: 69,020,839 (GRCm39) |
N188S |
probably benign |
Het |
| Ap1s1 |
G |
A |
5: 137,070,658 (GRCm39) |
R119* |
probably null |
Het |
| Apc2 |
T |
G |
10: 80,142,035 (GRCm39) |
L318R |
probably damaging |
Het |
| Atg101 |
A |
G |
15: 101,184,976 (GRCm39) |
S33G |
possibly damaging |
Het |
| Atp8a2 |
A |
T |
14: 60,253,317 (GRCm39) |
|
probably benign |
Het |
| Bpifb9b |
C |
A |
2: 154,158,871 (GRCm39) |
|
probably null |
Het |
| Braf |
A |
T |
6: 39,623,787 (GRCm39) |
|
probably benign |
Het |
| Cabp5 |
A |
G |
7: 13,135,189 (GRCm39) |
D43G |
probably damaging |
Het |
| Cfap46 |
T |
C |
7: 139,186,523 (GRCm39) |
N2462S |
unknown |
Het |
| Cit |
C |
T |
5: 116,130,662 (GRCm39) |
|
probably benign |
Het |
| Cpa4 |
T |
C |
6: 30,574,415 (GRCm39) |
V68A |
probably damaging |
Het |
| Cyp2j5 |
T |
C |
4: 96,517,791 (GRCm39) |
I474V |
probably benign |
Het |
| Dennd1a |
C |
A |
2: 37,734,821 (GRCm39) |
D49Y |
probably damaging |
Het |
| Dlg5 |
T |
C |
14: 24,198,289 (GRCm39) |
D1525G |
probably damaging |
Het |
| Dnajc18 |
C |
T |
18: 35,813,893 (GRCm39) |
R292H |
probably benign |
Het |
| Dync2h1 |
A |
G |
9: 7,140,897 (GRCm39) |
|
probably null |
Het |
| E2f6 |
A |
G |
12: 16,875,369 (GRCm39) |
D268G |
probably benign |
Het |
| Evi2b |
T |
A |
11: 79,407,126 (GRCm39) |
T150S |
probably damaging |
Het |
| F13b |
A |
G |
1: 139,431,589 (GRCm39) |
D53G |
probably benign |
Het |
| Fbxo38 |
G |
A |
18: 62,655,595 (GRCm39) |
|
probably benign |
Het |
| Flnb |
C |
T |
14: 7,950,470 (GRCm38) |
P2596L |
probably damaging |
Het |
| Fyco1 |
A |
G |
9: 123,656,247 (GRCm39) |
|
probably benign |
Het |
| Gm21759 |
A |
G |
5: 8,229,775 (GRCm39) |
|
probably benign |
Het |
| Gtse1 |
A |
G |
15: 85,759,283 (GRCm39) |
N597S |
probably benign |
Het |
| Hcn3 |
G |
T |
3: 89,055,030 (GRCm39) |
S739Y |
probably damaging |
Het |
| Ighv9-4 |
T |
A |
12: 114,263,612 (GRCm39) |
N107I |
probably damaging |
Het |
| Inava |
C |
A |
1: 136,147,513 (GRCm39) |
A402S |
probably damaging |
Het |
| Iqub |
T |
C |
6: 24,446,211 (GRCm39) |
K738E |
probably benign |
Het |
| Itga6 |
A |
T |
2: 71,656,000 (GRCm39) |
D308V |
probably benign |
Het |
| Klf12 |
T |
C |
14: 100,260,585 (GRCm39) |
Y48C |
probably damaging |
Het |
| Klhdc9 |
A |
G |
1: 171,186,384 (GRCm39) |
*351Q |
probably null |
Het |
| Krt40 |
A |
T |
11: 99,433,694 (GRCm39) |
N97K |
probably damaging |
Het |
| Lrit1 |
A |
C |
14: 36,782,112 (GRCm39) |
T262P |
probably damaging |
Het |
| Mcoln1 |
T |
C |
8: 3,560,910 (GRCm39) |
Y411H |
probably damaging |
Het |
| Mfsd4a |
A |
G |
1: 131,981,881 (GRCm39) |
S149P |
probably benign |
Het |
| Minar2 |
A |
G |
18: 59,195,458 (GRCm39) |
M1V |
probably null |
Het |
| Mipep |
A |
G |
14: 61,033,614 (GRCm39) |
|
probably benign |
Het |
| Mslnl |
A |
G |
17: 25,962,641 (GRCm39) |
|
probably benign |
Het |
| N4bp2 |
A |
T |
5: 65,948,267 (GRCm39) |
H299L |
probably damaging |
Het |
| Nbn |
C |
T |
4: 15,965,221 (GRCm39) |
P190S |
probably benign |
Het |
| Nos1 |
T |
A |
5: 118,083,949 (GRCm39) |
I1253N |
probably damaging |
Het |
| Nup210 |
G |
T |
6: 91,007,099 (GRCm39) |
F572L |
probably damaging |
Het |
| Or10k2 |
T |
C |
8: 84,268,247 (GRCm39) |
V158A |
probably benign |
Het |
| Or1e30 |
T |
C |
11: 73,678,103 (GRCm39) |
F113S |
probably damaging |
Het |
| Or2y11 |
T |
C |
11: 49,442,964 (GRCm39) |
L130P |
probably damaging |
Het |
| P4htm |
T |
A |
9: 108,460,935 (GRCm39) |
E106V |
probably damaging |
Het |
| Pcdhb20 |
C |
T |
18: 37,637,860 (GRCm39) |
H129Y |
possibly damaging |
Het |
| Pdcd6ip |
T |
C |
9: 113,514,490 (GRCm39) |
E240G |
probably benign |
Het |
| Pex5l |
T |
C |
3: 33,069,110 (GRCm39) |
|
probably null |
Het |
| Plcd1 |
T |
C |
9: 118,905,246 (GRCm39) |
N181S |
probably damaging |
Het |
| Plekhg6 |
G |
T |
6: 125,349,062 (GRCm39) |
L412M |
probably damaging |
Het |
| Ppp1r13b |
T |
A |
12: 111,801,526 (GRCm39) |
Q386L |
possibly damaging |
Het |
| Pramel25 |
T |
C |
4: 143,520,502 (GRCm39) |
F85L |
probably benign |
Het |
| Prpf40b |
A |
G |
15: 99,207,926 (GRCm39) |
|
probably benign |
Het |
| Rdh11 |
C |
T |
12: 79,233,187 (GRCm39) |
|
probably null |
Het |
| Ripor3 |
A |
T |
2: 167,839,172 (GRCm39) |
S110T |
probably damaging |
Het |
| Sec24d |
G |
A |
3: 123,087,807 (GRCm39) |
|
probably null |
Het |
| Shank1 |
C |
T |
7: 43,991,889 (GRCm39) |
A698V |
unknown |
Het |
| Shank1 |
T |
C |
7: 44,001,023 (GRCm39) |
M914T |
unknown |
Het |
| Slc22a3 |
T |
C |
17: 12,677,379 (GRCm39) |
Q263R |
probably benign |
Het |
| Smc1a |
C |
A |
X: 150,819,125 (GRCm39) |
Q647K |
probably damaging |
Het |
| Sohlh1 |
A |
G |
2: 25,736,873 (GRCm39) |
|
probably benign |
Het |
| Tacc2 |
C |
A |
7: 130,331,498 (GRCm39) |
T484K |
probably damaging |
Het |
| Ubr4 |
G |
T |
4: 139,168,094 (GRCm39) |
E2825* |
probably null |
Het |
| Wbp2nl |
G |
A |
15: 82,192,806 (GRCm39) |
M163I |
probably benign |
Het |
| Zfp69 |
T |
A |
4: 120,788,697 (GRCm39) |
K206M |
probably damaging |
Het |
| Zswim3 |
G |
A |
2: 164,663,440 (GRCm39) |
R640H |
probably damaging |
Het |
|
| Other mutations in Secisbp2l |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00421:Secisbp2l
|
APN |
2 |
125,585,776 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00644:Secisbp2l
|
APN |
2 |
125,585,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01093:Secisbp2l
|
APN |
2 |
125,582,245 (GRCm39) |
missense |
probably benign |
|
|
IGL01955:Secisbp2l
|
APN |
2 |
125,585,732 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02036:Secisbp2l
|
APN |
2 |
125,600,127 (GRCm39) |
missense |
probably benign |
|
|
IGL02045:Secisbp2l
|
APN |
2 |
125,617,498 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02182:Secisbp2l
|
APN |
2 |
125,589,497 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02408:Secisbp2l
|
APN |
2 |
125,582,789 (GRCm39) |
nonsense |
probably null |
|
|
IGL02455:Secisbp2l
|
APN |
2 |
125,615,398 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02953:Secisbp2l
|
APN |
2 |
125,602,194 (GRCm39) |
missense |
probably benign |
0.36 |
|
Rift
|
UTSW |
2 |
125,610,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Seismic
|
UTSW |
2 |
125,587,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0097:Secisbp2l
|
UTSW |
2 |
125,613,376 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0097:Secisbp2l
|
UTSW |
2 |
125,613,376 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1415:Secisbp2l
|
UTSW |
2 |
125,582,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1626:Secisbp2l
|
UTSW |
2 |
125,617,606 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1926:Secisbp2l
|
UTSW |
2 |
125,582,597 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1940:Secisbp2l
|
UTSW |
2 |
125,582,259 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1970:Secisbp2l
|
UTSW |
2 |
125,589,430 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2100:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R2240:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R2252:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R2253:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R2472:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R2474:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R2475:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R2990:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R2993:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R3113:Secisbp2l
|
UTSW |
2 |
125,592,206 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3696:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R3749:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R3750:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R3800:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R3810:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R3812:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R3815:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R3816:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R3817:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R3880:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4077:Secisbp2l
|
UTSW |
2 |
125,593,785 (GRCm39) |
splice site |
probably benign |
|
|
R4096:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4097:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4164:Secisbp2l
|
UTSW |
2 |
125,593,803 (GRCm39) |
intron |
probably benign |
|
|
R4332:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4418:Secisbp2l
|
UTSW |
2 |
125,594,835 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4598:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4600:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4602:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4603:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4678:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4679:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4684:Secisbp2l
|
UTSW |
2 |
125,587,862 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4741:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4749:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4934:Secisbp2l
|
UTSW |
2 |
125,582,409 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5245:Secisbp2l
|
UTSW |
2 |
125,589,511 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5521:Secisbp2l
|
UTSW |
2 |
125,594,897 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5547:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R5630:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R5631:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R5632:Secisbp2l
|
UTSW |
2 |
125,582,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R6039:Secisbp2l
|
UTSW |
2 |
125,615,136 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6039:Secisbp2l
|
UTSW |
2 |
125,615,136 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6378:Secisbp2l
|
UTSW |
2 |
125,610,245 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R6616:Secisbp2l
|
UTSW |
2 |
125,610,146 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6938:Secisbp2l
|
UTSW |
2 |
125,592,272 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7287:Secisbp2l
|
UTSW |
2 |
125,582,289 (GRCm39) |
missense |
probably benign |
|
|
R7373:Secisbp2l
|
UTSW |
2 |
125,599,191 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7403:Secisbp2l
|
UTSW |
2 |
125,602,199 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R7484:Secisbp2l
|
UTSW |
2 |
125,613,452 (GRCm39) |
nonsense |
probably null |
|
|
R7504:Secisbp2l
|
UTSW |
2 |
125,600,091 (GRCm39) |
missense |
probably benign |
0.30 |
|
R7762:Secisbp2l
|
UTSW |
2 |
125,610,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7769:Secisbp2l
|
UTSW |
2 |
125,613,465 (GRCm39) |
critical splice acceptor site |
probably benign |
|
|
R8018:Secisbp2l
|
UTSW |
2 |
125,587,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8487:Secisbp2l
|
UTSW |
2 |
125,617,502 (GRCm39) |
nonsense |
probably null |
|
|
R8784:Secisbp2l
|
UTSW |
2 |
125,602,263 (GRCm39) |
nonsense |
probably null |
|
|
R8810:Secisbp2l
|
UTSW |
2 |
125,617,596 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8872:Secisbp2l
|
UTSW |
2 |
125,594,892 (GRCm39) |
missense |
probably benign |
|
|
R9111:Secisbp2l
|
UTSW |
2 |
125,602,206 (GRCm39) |
missense |
probably benign |
|
|
R9154:Secisbp2l
|
UTSW |
2 |
125,617,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9155:Secisbp2l
|
UTSW |
2 |
125,617,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9589:Secisbp2l
|
UTSW |
2 |
125,589,430 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9589:Secisbp2l
|
UTSW |
2 |
125,589,425 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9592:Secisbp2l
|
UTSW |
2 |
125,582,561 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9602:Secisbp2l
|
UTSW |
2 |
125,609,356 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9620:Secisbp2l
|
UTSW |
2 |
125,589,394 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Posted On |
2013-12-09 |
Incidental Mutation