Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01624:Vmn2r10'

92634

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r10

Ensembl Gene

ENSMUSG00000067010

Gene Name

vomeronasal 2, receptor 10

Synonyms

VR16, V2r16

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

IGL01624

Quality Score

Status

Chromosome

Chromosomal Location

109141278-109154337 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 109154112 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Phenylalanine at position 64 (S64F)

Ref Sequence

ENSEMBL: ENSMUSP00000135274 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079163] [ENSMUST00000176594]

AlphaFold

K7N621

Predicted Effect

probably benign
Transcript: ENSMUST00000079163
AA Change: S64F

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000078162
Gene: ENSMUSG00000067010
AA Change: S64F

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	75	464	8.5e-29	PFAM
Pfam:NCD3G	506	560	3.8e-17	PFAM
Pfam:7tm_3	593	828	4e-55	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000176594
AA Change: S64F

PolyPhen 2 Score 0.827 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000135274
Gene: ENSMUSG00000067010
AA Change: S64F

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2210408I21Rik	C	T	13: 77,341,205 (GRCm39)	T18I	probably damaging	Het
Acod1	A	G	14: 103,292,669 (GRCm39)	T398A	probably benign	Het
Adgrl2	A	G	3: 148,542,163 (GRCm39)	V853A	probably damaging	Het
Ankhd1	T	C	18: 36,791,066 (GRCm39)	S2488P	probably damaging	Het
Ankrd28	T	C	14: 31,432,814 (GRCm39)	I578V	probably benign	Het
Atp2c2	A	C	8: 120,484,189 (GRCm39)	R933S	probably benign	Het
Cyp26a1	A	T	19: 37,686,781 (GRCm39)	I78F	possibly damaging	Het
Gck	A	G	11: 5,853,106 (GRCm39)	V338A	possibly damaging	Het
Ints6	A	T	14: 62,934,320 (GRCm39)	M729K	probably benign	Het
Kank2	C	A	9: 21,691,676 (GRCm39)	G500W	probably damaging	Het
Kansl1	G	A	11: 104,315,378 (GRCm39)	T220I	probably benign	Het
Lgi4	T	C	7: 30,767,113 (GRCm39)	L380P	probably damaging	Het
Lhx9	G	T	1: 138,760,521 (GRCm39)	Y276*	probably null	Het
Lipm	T	A	19: 34,098,545 (GRCm39)	Y340N	probably damaging	Het
Mlxip	A	G	5: 123,533,392 (GRCm39)	T134A	probably benign	Het
Nwd2	A	T	5: 63,964,153 (GRCm39)	I1246F	probably damaging	Het
Or14j3	A	T	17: 37,900,816 (GRCm39)	W143R	probably benign	Het
Or6c69c	T	A	10: 129,910,519 (GRCm39)	L80H	probably damaging	Het
Or8h9	A	G	2: 86,789,574 (GRCm39)	V76A	probably benign	Het
Rbm44	T	A	1: 91,084,380 (GRCm39)	N601K	probably damaging	Het
Rgs4	T	A	1: 169,572,047 (GRCm39)	Y84F	probably benign	Het
Scn7a	T	C	2: 66,582,269 (GRCm39)	T131A	probably benign	Het
Slc34a1	A	G	13: 23,998,969 (GRCm39)	I121V	probably benign	Het
Slitrk5	T	A	14: 111,918,526 (GRCm39)	Y717N	probably damaging	Het
Sox6	A	G	7: 115,076,203 (GRCm39)	S770P	probably damaging	Het
Spata31	T	C	13: 65,069,399 (GRCm39)	W516R	probably damaging	Het
Sugt1	A	G	14: 79,834,230 (GRCm39)	N77S	probably benign	Het
Sumf1	C	T	6: 108,130,162 (GRCm39)	D186N	probably damaging	Het
Syde2	T	C	3: 145,712,790 (GRCm39)	L709S	probably damaging	Het
Tcp1	T	A	17: 13,138,812 (GRCm39)	I163K	probably benign	Het
Upf2	A	T	2: 6,038,990 (GRCm39)	E287D	probably benign	Het
Usp17lb	A	G	7: 104,491,720 (GRCm39)		probably benign	Het

Other mutations in Vmn2r10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00816:Vmn2r10	APN	5	109,150,451 (GRCm39)	missense	possibly damaging	0.75
IGL01618:Vmn2r10	APN	5	109,150,345 (GRCm39)	missense	probably damaging	1.00
IGL01941:Vmn2r10	APN	5	109,143,820 (GRCm39)	missense	probably damaging	1.00
IGL01959:Vmn2r10	APN	5	109,145,571 (GRCm39)	missense	probably benign	0.00
IGL01973:Vmn2r10	APN	5	109,143,543 (GRCm39)	missense	probably damaging	1.00
IGL01985:Vmn2r10	APN	5	109,154,125 (GRCm39)	missense	probably benign	0.21
IGL02451:Vmn2r10	APN	5	109,143,788 (GRCm39)	nonsense	probably null
IGL02503:Vmn2r10	APN	5	109,151,341 (GRCm39)	missense	probably damaging	1.00
IGL03275:Vmn2r10	APN	5	109,151,243 (GRCm39)	missense	probably benign	0.00
R0035:Vmn2r10	UTSW	5	109,145,467 (GRCm39)	splice site	probably benign
R0395:Vmn2r10	UTSW	5	109,149,859 (GRCm39)	missense	probably damaging	1.00
R0454:Vmn2r10	UTSW	5	109,151,327 (GRCm39)	missense	probably benign	0.25
R0648:Vmn2r10	UTSW	5	109,143,782 (GRCm39)	missense	probably benign	0.00
R1251:Vmn2r10	UTSW	5	109,143,890 (GRCm39)	missense	probably benign	0.01
R1580:Vmn2r10	UTSW	5	109,154,117 (GRCm39)	missense	possibly damaging	0.82
R1845:Vmn2r10	UTSW	5	109,149,861 (GRCm39)	nonsense	probably null
R1986:Vmn2r10	UTSW	5	109,154,120 (GRCm39)	nonsense	probably null
R2137:Vmn2r10	UTSW	5	109,151,410 (GRCm39)	missense	possibly damaging	0.87
R2495:Vmn2r10	UTSW	5	109,143,961 (GRCm39)	missense	probably damaging	1.00
R3932:Vmn2r10	UTSW	5	109,150,088 (GRCm39)	missense	possibly damaging	0.47
R3933:Vmn2r10	UTSW	5	109,150,088 (GRCm39)	missense	possibly damaging	0.47
R4899:Vmn2r10	UTSW	5	109,151,324 (GRCm39)	missense	probably damaging	1.00
R4992:Vmn2r10	UTSW	5	109,145,592 (GRCm39)	missense	possibly damaging	0.89
R5124:Vmn2r10	UTSW	5	109,154,286 (GRCm39)	missense	probably benign	0.01
R5145:Vmn2r10	UTSW	5	109,143,761 (GRCm39)	missense	possibly damaging	0.64
R5156:Vmn2r10	UTSW	5	109,143,466 (GRCm39)	missense	probably benign	0.11
R5265:Vmn2r10	UTSW	5	109,143,586 (GRCm39)	missense	probably damaging	1.00
R5311:Vmn2r10	UTSW	5	109,154,121 (GRCm39)	missense	probably damaging	1.00
R5321:Vmn2r10	UTSW	5	109,143,505 (GRCm39)	missense	probably damaging	1.00
R5666:Vmn2r10	UTSW	5	109,146,910 (GRCm39)	nonsense	probably null
R5670:Vmn2r10	UTSW	5	109,146,910 (GRCm39)	nonsense	probably null
R5872:Vmn2r10	UTSW	5	109,151,377 (GRCm39)	missense	possibly damaging	0.84
R6004:Vmn2r10	UTSW	5	109,146,944 (GRCm39)	missense	probably benign	0.30
R6108:Vmn2r10	UTSW	5	109,143,667 (GRCm39)	missense	probably damaging	1.00
R6332:Vmn2r10	UTSW	5	109,151,328 (GRCm39)	missense	probably damaging	1.00
R6599:Vmn2r10	UTSW	5	109,143,944 (GRCm39)	missense	probably benign	0.09
R6651:Vmn2r10	UTSW	5	109,143,488 (GRCm39)	missense	probably null	0.22
R6891:Vmn2r10	UTSW	5	109,149,845 (GRCm39)	missense	probably damaging	1.00
R7023:Vmn2r10	UTSW	5	109,149,894 (GRCm39)	missense	probably damaging	0.96
R7146:Vmn2r10	UTSW	5	109,151,200 (GRCm39)	missense	probably damaging	1.00
R7941:Vmn2r10	UTSW	5	109,144,306 (GRCm39)	missense	probably damaging	1.00
R8058:Vmn2r10	UTSW	5	109,149,955 (GRCm39)	missense	probably benign	0.00
R8478:Vmn2r10	UTSW	5	109,143,636 (GRCm39)	missense	probably damaging	1.00
R8526:Vmn2r10	UTSW	5	109,145,572 (GRCm39)	missense	possibly damaging	0.51
R8698:Vmn2r10	UTSW	5	109,151,390 (GRCm39)	missense	probably benign	0.00
R8796:Vmn2r10	UTSW	5	109,143,917 (GRCm39)	missense	possibly damaging	0.74
R8854:Vmn2r10	UTSW	5	109,144,126 (GRCm39)	missense	probably benign	0.20
R8871:Vmn2r10	UTSW	5	109,146,899 (GRCm39)	missense	possibly damaging	0.67
R8893:Vmn2r10	UTSW	5	109,143,677 (GRCm39)	missense	probably benign	0.09
R8907:Vmn2r10	UTSW	5	109,149,791 (GRCm39)	missense	probably benign
R8957:Vmn2r10	UTSW	5	109,149,780 (GRCm39)	missense	possibly damaging	0.60
R8976:Vmn2r10	UTSW	5	109,145,479 (GRCm39)	missense	probably damaging	1.00
R9155:Vmn2r10	UTSW	5	109,144,212 (GRCm39)	missense	probably benign	0.10
R9308:Vmn2r10	UTSW	5	109,145,476 (GRCm39)	nonsense	probably null
R9800:Vmn2r10	UTSW	5	109,150,404 (GRCm39)	missense	probably damaging	0.99
Z1088:Vmn2r10	UTSW	5	109,143,979 (GRCm39)	missense	probably damaging	1.00
Z1176:Vmn2r10	UTSW	5	109,149,854 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-12-09