Incidental Mutation 'IGL01626:Olfr429'
ID92707
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr429
Ensembl Gene ENSMUSG00000049528
Gene Nameolfactory receptor 429
SynonymsMOR105-1, GA_x6K02T2P20D-21090094-21089156
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.086) question?
Stock #IGL01626
Quality Score
Status
Chromosome1
Chromosomal Location174084331-174091343 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 174089556 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Serine at position 172 (N172S)
Ref Sequence ENSEMBL: ENSMUSP00000149257 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060693] [ENSMUST00000216346]
Predicted Effect probably damaging
Transcript: ENSMUST00000060693
AA Change: N172S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000051323
Gene: ENSMUSG00000049528
AA Change: N172S

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.2e-65 PFAM
Pfam:7tm_1 41 290 1.3e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000193320
AA Change: N172S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000142323
Gene: ENSMUSG00000049528
AA Change: N172S

DomainStartEndE-ValueType
low complexity region 25 40 N/A INTRINSIC
Pfam:7tm_1 41 290 8.9e-31 PFAM
Pfam:7tm_4 139 283 6.7e-43 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216346
AA Change: N172S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl2 A G 3: 60,019,174 D188G probably damaging Het
AI314180 G A 4: 58,832,814 probably benign Het
Aoc1 A G 6: 48,906,531 Y447C probably damaging Het
Brd1 A T 15: 88,700,887 L915M probably damaging Het
Cacna2d3 T A 14: 28,943,607 E152D possibly damaging Het
Dnase2b A G 3: 146,584,616 probably null Het
Fat4 T C 3: 38,951,032 V1860A probably damaging Het
Fbxl5 C A 5: 43,758,705 G455V probably benign Het
Fpr-rs4 G A 17: 18,022,231 V167M probably damaging Het
Fut7 C A 2: 25,425,331 Y153* probably null Het
Gnptab A G 10: 88,437,495 T1045A probably damaging Het
Gucy1a1 T A 3: 82,108,619 D354V probably damaging Het
Gucy2e A G 11: 69,232,855 V406A possibly damaging Het
Herc2 T C 7: 56,085,142 F160S probably benign Het
Ice2 T G 9: 69,407,332 V42G probably benign Het
L3mbtl4 A G 17: 68,630,202 Y406C probably damaging Het
Lepr C T 4: 101,733,534 T103I probably benign Het
Ly75 T A 2: 60,301,015 M1589L probably benign Het
Map4k3 A G 17: 80,605,809 V644A probably damaging Het
Micall1 A G 15: 79,130,512 D696G possibly damaging Het
Muc4 T C 16: 32,736,402 V8A possibly damaging Het
Myo1h A G 5: 114,314,966 D9G probably damaging Het
Nop14 T A 5: 34,649,345 K472* probably null Het
Npat T A 9: 53,556,571 D275E possibly damaging Het
Nt5c1b A G 12: 10,374,798 T115A probably benign Het
Olfr709-ps1 A T 7: 106,927,420 I13N probably benign Het
Pnpla7 T A 2: 25,050,893 S1086T possibly damaging Het
Pold1 C T 7: 44,533,372 probably null Het
Ppfia1 A G 7: 144,481,719 F1165L probably benign Het
Prlr T A 15: 10,328,718 D426E probably benign Het
Ptgs2 G A 1: 150,103,727 R231H probably damaging Het
Rorc A G 3: 94,388,787 D91G probably damaging Het
Scaper C T 9: 55,912,051 V127M possibly damaging Het
Sema3g A T 14: 31,221,727 Y188F probably damaging Het
Slc45a3 G T 1: 131,978,987 A400S possibly damaging Het
Slc9b2 C A 3: 135,336,395 H478Q probably benign Het
Spg11 T A 2: 122,060,971 H1973L probably damaging Het
Srgap3 A G 6: 112,773,648 Y359H probably damaging Het
Stx16 T G 2: 174,094,020 I248S probably damaging Het
Sytl3 A G 17: 6,735,440 R287G probably damaging Het
Tiam1 T C 16: 89,812,968 T82A probably damaging Het
Trpm1 T C 7: 64,268,889 L659P probably damaging Het
Ttc13 G A 8: 124,673,738 probably benign Het
Unc80 T C 1: 66,551,054 probably null Het
Vldlr G T 19: 27,243,773 R613L probably damaging Het
Wdr77 C T 3: 105,959,686 R35* probably null Het
Zc3h14 T G 12: 98,779,186 I478R possibly damaging Het
Zfp366 A G 13: 99,228,412 H27R probably damaging Het
Other mutations in Olfr429
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01868:Olfr429 APN 1 174089370 missense possibly damaging 0.83
IGL01972:Olfr429 APN 1 174089421 missense probably damaging 0.99
IGL02412:Olfr429 APN 1 174089243 missense probably benign 0.00
IGL02628:Olfr429 APN 1 174089190 missense probably benign
IGL02861:Olfr429 APN 1 174089036 utr 5 prime probably benign
IGL03404:Olfr429 APN 1 174089898 missense probably damaging 1.00
R0267:Olfr429 UTSW 1 174089166 missense probably damaging 1.00
R0357:Olfr429 UTSW 1 174089109 missense possibly damaging 0.71
R1499:Olfr429 UTSW 1 174089247 nonsense probably null
R2051:Olfr429 UTSW 1 174089219 missense possibly damaging 0.95
R4706:Olfr429 UTSW 1 174089702 missense probably damaging 1.00
R4820:Olfr429 UTSW 1 174089176 missense possibly damaging 0.95
R5439:Olfr429 UTSW 1 174089975 missense probably benign 0.01
R5538:Olfr429 UTSW 1 174089978 makesense probably null
R5907:Olfr429 UTSW 1 174089219 missense probably benign 0.08
R6932:Olfr429 UTSW 1 174089750 missense probably damaging 0.96
R7808:Olfr429 UTSW 1 174089851 nonsense probably null
R8040:Olfr429 UTSW 1 174089157 missense possibly damaging 0.68
Posted On2013-12-09