Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01626:Fpr-rs4'

92711

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fpr-rs4

Ensembl Gene

ENSMUSG00000048062

Gene Name

formyl peptide receptor, related sequence 4

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.081) question?

Stock #

IGL01626

Quality Score

Status

Chromosome

Chromosomal Location

18241995-18242966 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 18242493 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Methionine at position 167 (V167M)

Ref Sequence

ENSEMBL: ENSMUSP00000093311 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095651]

AlphaFold

A4FUQ5

Predicted Effect

probably damaging
Transcript: ENSMUST00000095651
AA Change: V167M

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000093311
Gene: ENSMUSG00000048062
AA Change: V167M

Domain	Start	End	E-Value	Type
Pfam:7tm_1	43	297	4.9e-35	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadacl2	A	G	3: 59,926,595 (GRCm39)	D188G	probably damaging	Het
Aoc1	A	G	6: 48,883,465 (GRCm39)	Y447C	probably damaging	Het
Brd1	A	T	15: 88,585,090 (GRCm39)	L915M	probably damaging	Het
Cacna2d3	T	A	14: 28,665,564 (GRCm39)	E152D	possibly damaging	Het
Dnase2b	A	G	3: 146,290,371 (GRCm39)		probably null	Het
Ecpas	G	A	4: 58,832,814 (GRCm39)		probably benign	Het
Fat4	T	C	3: 39,005,181 (GRCm39)	V1860A	probably damaging	Het
Fbxl5	C	A	5: 43,916,047 (GRCm39)	G455V	probably benign	Het
Fut7	C	A	2: 25,315,343 (GRCm39)	Y153*	probably null	Het
Gnptab	A	G	10: 88,273,357 (GRCm39)	T1045A	probably damaging	Het
Gucy1a1	T	A	3: 82,015,926 (GRCm39)	D354V	probably damaging	Het
Gucy2e	A	G	11: 69,123,681 (GRCm39)	V406A	possibly damaging	Het
Herc2	T	C	7: 55,734,890 (GRCm39)	F160S	probably benign	Het
Ice2	T	G	9: 69,314,614 (GRCm39)	V42G	probably benign	Het
L3mbtl4	A	G	17: 68,937,197 (GRCm39)	Y406C	probably damaging	Het
Lepr	C	T	4: 101,590,731 (GRCm39)	T103I	probably benign	Het
Ly75	T	A	2: 60,131,359 (GRCm39)	M1589L	probably benign	Het
Map4k3	A	G	17: 80,913,238 (GRCm39)	V644A	probably damaging	Het
Micall1	A	G	15: 79,014,712 (GRCm39)	D696G	possibly damaging	Het
Muc4	T	C	16: 32,555,220 (GRCm39)	V8A	possibly damaging	Het
Myo1h	A	G	5: 114,453,027 (GRCm39)	D9G	probably damaging	Het
Nop14	T	A	5: 34,806,689 (GRCm39)	K472*	probably null	Het
Npat	T	A	9: 53,467,871 (GRCm39)	D275E	possibly damaging	Het
Nt5c1b	A	G	12: 10,424,798 (GRCm39)	T115A	probably benign	Het
Or2d3c	A	T	7: 106,526,627 (GRCm39)	I13N	probably benign	Het
Or6n1	A	G	1: 173,917,122 (GRCm39)	N172S	probably damaging	Het
Pnpla7	T	A	2: 24,940,905 (GRCm39)	S1086T	possibly damaging	Het
Pold1	C	T	7: 44,182,796 (GRCm39)		probably null	Het
Ppfia1	A	G	7: 144,035,456 (GRCm39)	F1165L	probably benign	Het
Prlr	T	A	15: 10,328,804 (GRCm39)	D426E	probably benign	Het
Ptgs2	G	A	1: 149,979,478 (GRCm39)	R231H	probably damaging	Het
Rorc	A	G	3: 94,296,094 (GRCm39)	D91G	probably damaging	Het
Scaper	C	T	9: 55,819,335 (GRCm39)	V127M	possibly damaging	Het
Sema3g	A	T	14: 30,943,684 (GRCm39)	Y188F	probably damaging	Het
Slc45a3	G	T	1: 131,906,725 (GRCm39)	A400S	possibly damaging	Het
Slc9b2	C	A	3: 135,042,156 (GRCm39)	H478Q	probably benign	Het
Spg11	T	A	2: 121,891,452 (GRCm39)	H1973L	probably damaging	Het
Srgap3	A	G	6: 112,750,609 (GRCm39)	Y359H	probably damaging	Het
Stx16	T	G	2: 173,935,813 (GRCm39)	I248S	probably damaging	Het
Sytl3	A	G	17: 7,002,839 (GRCm39)	R287G	probably damaging	Het
Tiam1	T	C	16: 89,609,856 (GRCm39)	T82A	probably damaging	Het
Trpm1	T	C	7: 63,918,637 (GRCm39)	L659P	probably damaging	Het
Ttc13	G	A	8: 125,400,477 (GRCm39)		probably benign	Het
Unc80	T	C	1: 66,590,213 (GRCm39)		probably null	Het
Vldlr	G	T	19: 27,221,173 (GRCm39)	R613L	probably damaging	Het
Wdr77	C	T	3: 105,867,002 (GRCm39)	R35*	probably null	Het
Zc3h14	T	G	12: 98,745,445 (GRCm39)	I478R	possibly damaging	Het
Zfp366	A	G	13: 99,364,920 (GRCm39)	H27R	probably damaging	Het

Other mutations in Fpr-rs4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00539:Fpr-rs4	APN	17	18,242,188 (GRCm39)	missense	probably damaging	1.00
IGL01064:Fpr-rs4	APN	17	18,242,779 (GRCm39)	missense	probably damaging	1.00
IGL02544:Fpr-rs4	APN	17	18,242,473 (GRCm39)	missense	probably benign
IGL02837:Fpr-rs4	UTSW	17	18,242,513 (GRCm39)	missense	probably benign	0.00
R0179:Fpr-rs4	UTSW	17	18,242,289 (GRCm39)	nonsense	probably null
R0383:Fpr-rs4	UTSW	17	18,242,359 (GRCm39)	missense	probably damaging	1.00
R0686:Fpr-rs4	UTSW	17	18,242,613 (GRCm39)	missense	probably benign	0.05
R1551:Fpr-rs4	UTSW	17	18,242,589 (GRCm39)	missense	possibly damaging	0.89
R1956:Fpr-rs4	UTSW	17	18,242,518 (GRCm39)	missense	probably damaging	0.97
R2040:Fpr-rs4	UTSW	17	18,242,596 (GRCm39)	frame shift	probably null
R2041:Fpr-rs4	UTSW	17	18,242,596 (GRCm39)	frame shift	probably null
R2043:Fpr-rs4	UTSW	17	18,242,596 (GRCm39)	frame shift	probably null
R2045:Fpr-rs4	UTSW	17	18,242,596 (GRCm39)	frame shift	probably null
R2048:Fpr-rs4	UTSW	17	18,242,596 (GRCm39)	frame shift	probably null
R2092:Fpr-rs4	UTSW	17	18,242,596 (GRCm39)	frame shift	probably null
R2093:Fpr-rs4	UTSW	17	18,242,596 (GRCm39)	frame shift	probably null
R2136:Fpr-rs4	UTSW	17	18,242,596 (GRCm39)	frame shift	probably null
R3624:Fpr-rs4	UTSW	17	18,242,596 (GRCm39)	frame shift	probably null
R4684:Fpr-rs4	UTSW	17	18,242,446 (GRCm39)	missense	probably damaging	1.00
R6076:Fpr-rs4	UTSW	17	18,242,317 (GRCm39)	missense	probably damaging	1.00
R6247:Fpr-rs4	UTSW	17	18,242,748 (GRCm39)	missense	probably benign	0.00
R6639:Fpr-rs4	UTSW	17	18,242,394 (GRCm39)	nonsense	probably null
R6757:Fpr-rs4	UTSW	17	18,242,394 (GRCm39)	nonsense	probably null
R8703:Fpr-rs4	UTSW	17	18,242,332 (GRCm39)	missense	probably damaging	0.99
R9007:Fpr-rs4	UTSW	17	18,242,416 (GRCm39)	missense	probably damaging	1.00
R9318:Fpr-rs4	UTSW	17	18,242,217 (GRCm39)	missense	probably benign
R9357:Fpr-rs4	UTSW	17	18,242,211 (GRCm39)	missense	probably damaging	0.97
R9435:Fpr-rs4	UTSW	17	18,242,391 (GRCm39)	missense	probably benign	0.00
Z1088:Fpr-rs4	UTSW	17	18,242,956 (GRCm39)	missense	probably benign	0.16
Z1088:Fpr-rs4	UTSW	17	18,242,181 (GRCm39)	missense	possibly damaging	0.85

Posted On

2013-12-09