Incidental Mutation 'IGL01625:Wdr26'
ID 92733
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Wdr26
Ensembl Gene ENSMUSG00000038733
Gene Name WD repeat domain 26
Synonyms Gid7, 1600024A01Rik
Accession Numbers
Essential gene? Probably essential (E-score: 0.915) question?
Stock # IGL01625
Quality Score
Status
Chromosome 1
Chromosomal Location 181000793-181039566 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 181019381 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 332 (T332I)
Ref Sequence ENSEMBL: ENSMUSP00000124186 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000162819] [ENSMUST00000162963]
AlphaFold Q8C6G8
Predicted Effect probably benign
Transcript: ENSMUST00000036329
SMART Domains Protein: ENSMUSP00000045177
Gene: ENSMUSG00000038733

DomainStartEndE-ValueType
low complexity region 1 16 N/A INTRINSIC
low complexity region 43 70 N/A INTRINSIC
low complexity region 71 83 N/A INTRINSIC
LisH 100 132 9.73e-1 SMART
Blast:CTLH 133 183 6e-28 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159625
Predicted Effect possibly damaging
Transcript: ENSMUST00000162819
AA Change: T348I

PolyPhen 2 Score 0.855 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000124592
Gene: ENSMUSG00000038733
AA Change: T348I

DomainStartEndE-ValueType
low complexity region 5 19 N/A INTRINSIC
low complexity region 46 73 N/A INTRINSIC
low complexity region 74 86 N/A INTRINSIC
LisH 103 135 9.73e-1 SMART
CTLH 136 211 2.41e-5 SMART
low complexity region 276 287 N/A INTRINSIC
WD40 324 363 4.76e-6 SMART
WD40 370 411 1.35e-5 SMART
WD40 414 454 2.12e-3 SMART
WD40 537 579 2.77e-1 SMART
WD40 582 622 3.83e-10 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000162963
AA Change: T332I

PolyPhen 2 Score 0.855 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000124186
Gene: ENSMUSG00000038733
AA Change: T332I

DomainStartEndE-ValueType
low complexity region 5 19 N/A INTRINSIC
low complexity region 46 73 N/A INTRINSIC
low complexity region 74 86 N/A INTRINSIC
LisH 103 135 9.73e-1 SMART
CTLH 136 195 4.97e-7 SMART
low complexity region 260 271 N/A INTRINSIC
WD40 308 347 4.76e-6 SMART
WD40 354 395 1.35e-5 SMART
WD40 398 438 2.12e-3 SMART
WD40 521 563 2.77e-1 SMART
WD40 566 606 3.83e-10 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700018F24Rik T A 5: 144,979,957 (GRCm39) H37Q possibly damaging Het
Akr1c19 T A 13: 4,283,816 (GRCm39) I16N probably damaging Het
Arpc1b T C 5: 145,058,555 (GRCm39) probably null Het
Bzw1 A G 1: 58,440,599 (GRCm39) T191A probably benign Het
Cacna1h G A 17: 25,604,686 (GRCm39) T1209I possibly damaging Het
Cacna1h T C 17: 25,602,459 (GRCm39) D1523G probably damaging Het
Cdc20b T C 13: 113,196,319 (GRCm39) L148P possibly damaging Het
Cubn A G 2: 13,311,085 (GRCm39) F3147L possibly damaging Het
Dagla A G 19: 10,228,566 (GRCm39) probably benign Het
Dnah9 T C 11: 65,935,471 (GRCm39) N1983D probably damaging Het
Fbxw10 G A 11: 62,750,853 (GRCm39) D479N probably damaging Het
Fer A T 17: 64,344,621 (GRCm39) Q630L probably damaging Het
Gbp5 A G 3: 142,208,789 (GRCm39) N111D probably damaging Het
Gm8127 T G 14: 43,148,520 (GRCm39) probably benign Het
Heatr1 T A 13: 12,428,409 (GRCm39) N814K probably damaging Het
Iba57 G A 11: 59,049,775 (GRCm39) R191W probably damaging Het
Itgae C A 11: 73,010,263 (GRCm39) F584L probably benign Het
Kdm5b A G 1: 134,545,706 (GRCm39) K956E possibly damaging Het
Muc4 C T 16: 32,575,918 (GRCm39) probably benign Het
Mybpc2 T C 7: 44,166,337 (GRCm39) K218E possibly damaging Het
Pcdh10 T C 3: 45,333,832 (GRCm39) S49P probably damaging Het
Prss3b A C 6: 41,009,882 (GRCm39) S151A probably benign Het
Rai14 T C 15: 10,572,460 (GRCm39) D889G probably benign Het
Rbpjl A G 2: 164,249,705 (GRCm39) K102R possibly damaging Het
Retreg2 A G 1: 75,121,359 (GRCm39) probably benign Het
Rfc4 A T 16: 22,934,573 (GRCm39) L149Q probably damaging Het
Rft1 T A 14: 30,398,853 (GRCm39) D274E possibly damaging Het
Rlf A T 4: 121,045,457 (GRCm39) S143R possibly damaging Het
Rptn T A 3: 93,305,201 (GRCm39) S845T probably benign Het
Slamf8 C A 1: 172,410,049 (GRCm39) D267Y probably damaging Het
Smoc2 C T 17: 14,545,876 (GRCm39) S55L probably damaging Het
Sptan1 C T 2: 29,916,126 (GRCm39) A2038V probably damaging Het
Stx17 C A 4: 48,181,526 (GRCm39) P210T probably damaging Het
Tbc1d5 A G 17: 51,224,601 (GRCm39) Y317H probably benign Het
Tenm4 C A 7: 96,534,565 (GRCm39) T1737N probably damaging Het
Tesk2 T C 4: 116,628,998 (GRCm39) F116L possibly damaging Het
Tln2 T C 9: 67,277,905 (GRCm39) S370G probably damaging Het
Tm6sf2 G T 8: 70,528,733 (GRCm39) G162C probably null Het
Togaram2 A C 17: 72,021,693 (GRCm39) E718D probably benign Het
Ttn A C 2: 76,578,327 (GRCm39) F15862V probably damaging Het
Uba6 T A 5: 86,268,388 (GRCm39) R916* probably null Het
Umodl1 A G 17: 31,215,229 (GRCm39) M1018V probably benign Het
Xdh A T 17: 74,223,781 (GRCm39) probably null Het
Other mutations in Wdr26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01941:Wdr26 APN 1 181,038,635 (GRCm39) splice site probably benign
IGL02612:Wdr26 APN 1 181,005,361 (GRCm39) utr 3 prime probably benign
IGL02660:Wdr26 APN 1 181,026,463 (GRCm39) missense probably damaging 1.00
IGL02685:Wdr26 APN 1 181,011,345 (GRCm39) missense possibly damaging 0.64
IGL02884:Wdr26 APN 1 181,010,349 (GRCm39) missense probably damaging 1.00
R0396:Wdr26 UTSW 1 181,008,216 (GRCm39) intron probably benign
R0453:Wdr26 UTSW 1 181,010,444 (GRCm39) nonsense probably null
R0530:Wdr26 UTSW 1 181,013,635 (GRCm39) splice site probably null
R0729:Wdr26 UTSW 1 181,013,470 (GRCm39) splice site probably null
R1170:Wdr26 UTSW 1 181,008,859 (GRCm39) splice site probably benign
R1466:Wdr26 UTSW 1 181,013,499 (GRCm39) splice site probably benign
R1830:Wdr26 UTSW 1 181,019,340 (GRCm39) missense probably damaging 1.00
R2883:Wdr26 UTSW 1 181,038,685 (GRCm39) missense probably damaging 0.99
R4090:Wdr26 UTSW 1 181,030,679 (GRCm39) missense probably damaging 1.00
R4097:Wdr26 UTSW 1 181,010,352 (GRCm39) missense probably benign 0.00
R4953:Wdr26 UTSW 1 181,025,216 (GRCm39) missense probably damaging 1.00
R5223:Wdr26 UTSW 1 181,015,251 (GRCm39) missense probably benign 0.07
R5834:Wdr26 UTSW 1 181,030,712 (GRCm39) missense probably damaging 1.00
R5884:Wdr26 UTSW 1 181,015,106 (GRCm39) intron probably benign
R6174:Wdr26 UTSW 1 181,019,433 (GRCm39) missense probably damaging 1.00
R6334:Wdr26 UTSW 1 181,030,771 (GRCm39)
R7161:Wdr26 UTSW 1 181,030,695 (GRCm39) missense probably damaging 1.00
R7255:Wdr26 UTSW 1 181,008,889 (GRCm39) missense probably benign 0.24
R7406:Wdr26 UTSW 1 181,015,240 (GRCm39) missense probably damaging 1.00
R7804:Wdr26 UTSW 1 181,010,387 (GRCm39) missense probably damaging 1.00
R7815:Wdr26 UTSW 1 181,036,638 (GRCm39) missense probably benign 0.28
R8717:Wdr26 UTSW 1 181,011,913 (GRCm39) missense possibly damaging 0.92
R9072:Wdr26 UTSW 1 181,010,351 (GRCm39) missense probably damaging 0.99
R9358:Wdr26 UTSW 1 181,019,423 (GRCm39) missense probably damaging 0.98
R9520:Wdr26 UTSW 1 181,036,587 (GRCm39) missense probably benign 0.06
R9523:Wdr26 UTSW 1 181,013,620 (GRCm39) missense probably benign 0.38
R9719:Wdr26 UTSW 1 181,015,224 (GRCm39) missense possibly damaging 0.89
R9793:Wdr26 UTSW 1 181,036,812 (GRCm39) missense probably damaging 0.98
R9795:Wdr26 UTSW 1 181,036,812 (GRCm39) missense probably damaging 0.98
Posted On 2013-12-09