Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01626:Aadacl2'

92783

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Aadacl2

Ensembl Gene

ENSMUSG00000091376

Gene Name

arylacetamide deacetylase like 2

Synonyms

EG639634

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.066) question?

Stock #

IGL01626

Quality Score

Status

Chromosome

Chromosomal Location

60006743-60025420 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 60019174 bp

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 188 (D188G)

Ref Sequence

ENSEMBL: ENSMUSP00000129444 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169794]

Predicted Effect

probably damaging
Transcript: ENSMUST00000169794
AA Change: D188G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000129444
Gene: ENSMUSG00000091376
AA Change: D188G

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:COesterase	91	219	2.7e-7	PFAM
Pfam:Abhydrolase_3	107	272	8.2e-38	PFAM
Pfam:Abhydrolase_3	270	375	3.2e-13	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000195422

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
AI314180	G	A	4: 58,832,814		probably benign	Het
Aoc1	A	G	6: 48,906,531	Y447C	probably damaging	Het
Brd1	A	T	15: 88,700,887	L915M	probably damaging	Het
Cacna2d3	T	A	14: 28,943,607	E152D	possibly damaging	Het
Dnase2b	A	G	3: 146,584,616		probably null	Het
Fat4	T	C	3: 38,951,032	V1860A	probably damaging	Het
Fbxl5	C	A	5: 43,758,705	G455V	probably benign	Het
Fpr-rs4	G	A	17: 18,022,231	V167M	probably damaging	Het
Fut7	C	A	2: 25,425,331	Y153*	probably null	Het
Gnptab	A	G	10: 88,437,495	T1045A	probably damaging	Het
Gucy1a1	T	A	3: 82,108,619	D354V	probably damaging	Het
Gucy2e	A	G	11: 69,232,855	V406A	possibly damaging	Het
Herc2	T	C	7: 56,085,142	F160S	probably benign	Het
Ice2	T	G	9: 69,407,332	V42G	probably benign	Het
L3mbtl4	A	G	17: 68,630,202	Y406C	probably damaging	Het
Lepr	C	T	4: 101,733,534	T103I	probably benign	Het
Ly75	T	A	2: 60,301,015	M1589L	probably benign	Het
Map4k3	A	G	17: 80,605,809	V644A	probably damaging	Het
Micall1	A	G	15: 79,130,512	D696G	possibly damaging	Het
Muc4	T	C	16: 32,736,402	V8A	possibly damaging	Het
Myo1h	A	G	5: 114,314,966	D9G	probably damaging	Het
Nop14	T	A	5: 34,649,345	K472*	probably null	Het
Npat	T	A	9: 53,556,571	D275E	possibly damaging	Het
Nt5c1b	A	G	12: 10,374,798	T115A	probably benign	Het
Olfr429	A	G	1: 174,089,556	N172S	probably damaging	Het
Olfr709-ps1	A	T	7: 106,927,420	I13N	probably benign	Het
Pnpla7	T	A	2: 25,050,893	S1086T	possibly damaging	Het
Pold1	C	T	7: 44,533,372		probably null	Het
Ppfia1	A	G	7: 144,481,719	F1165L	probably benign	Het
Prlr	T	A	15: 10,328,718	D426E	probably benign	Het
Ptgs2	G	A	1: 150,103,727	R231H	probably damaging	Het
Rorc	A	G	3: 94,388,787	D91G	probably damaging	Het
Scaper	C	T	9: 55,912,051	V127M	possibly damaging	Het
Sema3g	A	T	14: 31,221,727	Y188F	probably damaging	Het
Slc45a3	G	T	1: 131,978,987	A400S	possibly damaging	Het
Slc9b2	C	A	3: 135,336,395	H478Q	probably benign	Het
Spg11	T	A	2: 122,060,971	H1973L	probably damaging	Het
Srgap3	A	G	6: 112,773,648	Y359H	probably damaging	Het
Stx16	T	G	2: 174,094,020	I248S	probably damaging	Het
Sytl3	A	G	17: 6,735,440	R287G	probably damaging	Het
Tiam1	T	C	16: 89,812,968	T82A	probably damaging	Het
Trpm1	T	C	7: 64,268,889	L659P	probably damaging	Het
Ttc13	G	A	8: 124,673,738		probably benign	Het
Unc80	T	C	1: 66,551,054		probably null	Het
Vldlr	G	T	19: 27,243,773	R613L	probably damaging	Het
Wdr77	C	T	3: 105,959,686	R35*	probably null	Het
Zc3h14	T	G	12: 98,779,186	I478R	possibly damaging	Het
Zfp366	A	G	13: 99,228,412	H27R	probably damaging	Het

Other mutations in Aadacl2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01543:Aadacl2	APN	3	60024676	missense	probably benign
IGL01777:Aadacl2	APN	3	60024784	missense	possibly damaging	0.61
IGL02189:Aadacl2	APN	3	60025188	missense	probably damaging	0.99
IGL03238:Aadacl2	APN	3	60024918	missense	probably benign	0.31
R0369:Aadacl2	UTSW	3	60024722	nonsense	probably null
R0540:Aadacl2	UTSW	3	60019206	missense	possibly damaging	0.50
R1440:Aadacl2	UTSW	3	60024892	missense	probably damaging	0.99
R1589:Aadacl2	UTSW	3	60010576	missense	probably benign	0.00
R1778:Aadacl2	UTSW	3	60017450	splice site	probably null
R1781:Aadacl2	UTSW	3	60024696	missense	probably damaging	1.00
R1812:Aadacl2	UTSW	3	60025077	missense	probably damaging	1.00
R2411:Aadacl2	UTSW	3	60017423	missense	possibly damaging	0.94
R4622:Aadacl2	UTSW	3	60007053	missense	probably damaging	1.00
R4698:Aadacl2	UTSW	3	60025039	missense	probably benign	0.00
R5326:Aadacl2	UTSW	3	60025063	missense	probably damaging	1.00
R5542:Aadacl2	UTSW	3	60025063	missense	probably damaging	1.00
R6314:Aadacl2	UTSW	3	60017403	missense	probably damaging	1.00
R6469:Aadacl2	UTSW	3	60024789	missense	probably benign	0.24
R6953:Aadacl2	UTSW	3	60024760	missense	possibly damaging	0.78
R7082:Aadacl2	UTSW	3	60024885	missense	probably damaging	1.00
R7206:Aadacl2	UTSW	3	60025241	missense	probably benign	0.17
R8000:Aadacl2	UTSW	3	60017375	missense	possibly damaging	0.60

Posted On

2013-12-09