Incidental Mutation 'IGL01629:Zfp563'
ID92866
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp563
Ensembl Gene ENSMUSG00000067424
Gene Namezinc finger protein 563
Synonymszinc finger protein, Zfp413
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.074) question?
Stock #IGL01629
Quality Score
Status
Chromosome17
Chromosomal Location33089310-33106203 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 33104626 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Histidine at position 105 (R105H)
Gene Model predicted gene model for transcript(s): [ENSMUST00000131722] [ENSMUST00000140829]
Predicted Effect probably benign
Transcript: ENSMUST00000131722
AA Change: R65H

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000118809
Gene: ENSMUSG00000067424
AA Change: R65H

DomainStartEndE-ValueType
KRAB 4 61 5.45e-16 SMART
ZnF_C2H2 141 163 2.63e2 SMART
ZnF_C2H2 169 191 9.08e-4 SMART
ZnF_C2H2 197 219 9.88e-5 SMART
ZnF_C2H2 225 247 3.16e-3 SMART
ZnF_C2H2 253 275 5.81e-2 SMART
ZnF_C2H2 281 303 2.4e-3 SMART
ZnF_C2H2 309 331 1.82e-3 SMART
ZnF_C2H2 337 359 1.72e-4 SMART
ZnF_C2H2 365 387 4.54e-4 SMART
ZnF_C2H2 393 415 7.78e-3 SMART
ZnF_C2H2 421 443 3.63e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000140829
AA Change: R65H

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000121678
Gene: ENSMUSG00000067424
AA Change: R65H

DomainStartEndE-ValueType
KRAB 4 61 5.45e-16 SMART
ZnF_C2H2 141 163 2.63e2 SMART
ZnF_C2H2 169 191 9.08e-4 SMART
Pfam:zf-C2H2_4 197 209 9.4e-2 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000153072
AA Change: R105H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000119142
Gene: ENSMUSG00000067424
AA Change: R105H

DomainStartEndE-ValueType
low complexity region 30 41 N/A INTRINSIC
KRAB 45 102 5.45e-16 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A430078G23Rik T A 8: 3,381,942 C168S possibly damaging Het
Adgra2 G A 8: 27,118,733 A540T possibly damaging Het
Adm2 T A 15: 89,323,402 probably null Het
Alox12 G A 11: 70,242,834 P555S probably damaging Het
Alpk2 A G 18: 65,300,042 S1798P probably damaging Het
Amfr T A 8: 93,987,508 probably null Het
Atxn7l3 A T 11: 102,292,494 probably benign Het
Ccdc191 A G 16: 43,959,300 K707E possibly damaging Het
Cdc5l G T 17: 45,413,190 D391E probably benign Het
Cmtm2b T C 8: 104,329,788 S110P possibly damaging Het
Cyp2j8 T C 4: 96,499,603 D207G probably damaging Het
Ddhd2 A G 8: 25,735,828 F501L possibly damaging Het
Dnah1 C T 14: 31,292,320 V1823M probably damaging Het
Gjb4 T C 4: 127,351,626 D174G possibly damaging Het
Gm10471 C T 5: 26,085,702 S157N probably damaging Het
Gm45213 A G 7: 66,062,214 D58G probably damaging Het
Hes1 C T 16: 30,066,158 probably benign Het
Krt33b T A 11: 100,029,560 Q89L probably benign Het
Llcfc1 C A 6: 41,684,525 S3Y possibly damaging Het
Ltf A G 9: 111,035,806 N569S probably damaging Het
Mknk1 T A 4: 115,875,534 W320R probably damaging Het
Mrgprx3-ps T A 7: 47,309,605 K213* probably null Het
Mslnl T G 17: 25,744,775 V388G possibly damaging Het
Nfkb1 T C 3: 135,601,467 I566V probably benign Het
Npy1r G A 8: 66,704,221 V98I probably benign Het
Phf1 G T 17: 26,934,273 A22S probably benign Het
Pih1d3 T A 1: 31,222,933 probably null Het
Plcg1 T G 2: 160,758,010 F897V possibly damaging Het
Ric1 A T 19: 29,603,981 E1367D probably benign Het
Slc24a3 T C 2: 145,640,210 probably benign Het
Sorl1 A G 9: 42,057,269 probably null Het
Spink5 T C 18: 43,996,610 probably benign Het
Syne2 A G 12: 76,004,603 I4036V possibly damaging Het
Taok1 A T 11: 77,538,204 M890K possibly damaging Het
Tenm2 A T 11: 36,864,884 Y96N probably damaging Het
Ttll10 T A 4: 156,046,894 T233S probably benign Het
Vps39 G T 2: 120,323,598 L628M probably benign Het
Other mutations in Zfp563
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01981:Zfp563 APN 17 33105409 missense probably benign 0.16
IGL02407:Zfp563 APN 17 33104821 missense probably benign 0.00
IGL02662:Zfp563 APN 17 33102279 missense probably damaging 1.00
IGL03220:Zfp563 APN 17 33104687 missense probably benign 0.44
R0241:Zfp563 UTSW 17 33104685 missense possibly damaging 0.61
R0241:Zfp563 UTSW 17 33104685 missense possibly damaging 0.61
R0537:Zfp563 UTSW 17 33104685 missense possibly damaging 0.61
R0552:Zfp563 UTSW 17 33104685 missense possibly damaging 0.61
R1544:Zfp563 UTSW 17 33105213 missense probably benign 0.01
R3763:Zfp563 UTSW 17 33104928 nonsense probably null
R3979:Zfp563 UTSW 17 33105727 missense probably benign 0.03
R4938:Zfp563 UTSW 17 33105709 missense probably damaging 1.00
R5280:Zfp563 UTSW 17 33104838 missense probably damaging 0.99
R5383:Zfp563 UTSW 17 33104707 missense probably benign
R5485:Zfp563 UTSW 17 33089566 unclassified probably benign
R5524:Zfp563 UTSW 17 33102541 critical splice acceptor site probably null
R5567:Zfp563 UTSW 17 33089457 unclassified probably benign
R5736:Zfp563 UTSW 17 33104986 missense possibly damaging 0.91
R5758:Zfp563 UTSW 17 33104920 missense probably damaging 1.00
R6034:Zfp563 UTSW 17 33104961 missense probably damaging 0.96
R6034:Zfp563 UTSW 17 33104961 missense probably damaging 0.96
R6532:Zfp563 UTSW 17 33105698 missense probably benign 0.21
RF007:Zfp563 UTSW 17 33105025 missense probably benign
X0023:Zfp563 UTSW 17 33105721 missense probably damaging 1.00
Posted On2013-12-09