Incidental Mutation 'IGL01636:Olfr862'
ID92978
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr862
Ensembl Gene ENSMUSG00000063842
Gene Nameolfactory receptor 862
SynonymsGA_x6K02T2PVTD-13624132-13623212, MOR146-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.065) question?
Stock #IGL01636
Quality Score
Status
Chromosome9
Chromosomal Location19882417-19888004 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 19884188 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 39 (V39A)
Ref Sequence ENSEMBL: ENSMUSP00000078603 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073765] [ENSMUST00000079660]
Predicted Effect probably benign
Transcript: ENSMUST00000073765
AA Change: V39A

PolyPhen 2 Score 0.135 (Sensitivity: 0.92; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000073437
Gene: ENSMUSG00000063842
AA Change: V39A

DomainStartEndE-ValueType
low complexity region 6 17 N/A INTRINSIC
Pfam:7tm_4 31 306 3.1e-52 PFAM
Pfam:7TM_GPCR_Srsx 35 282 1.3e-7 PFAM
Pfam:7tm_1 41 290 5.7e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000079660
AA Change: V39A

PolyPhen 2 Score 0.135 (Sensitivity: 0.92; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000078603
Gene: ENSMUSG00000063842
AA Change: V39A

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.3e-51 PFAM
Pfam:7TM_GPCR_Srsx 35 303 8.3e-8 PFAM
Pfam:7tm_1 41 290 4.5e-22 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam4 T C 12: 81,419,949 T633A possibly damaging Het
Adgrd1 G T 5: 129,142,452 probably benign Het
Bmp7 T C 2: 172,875,208 probably benign Het
Ccdc54 A G 16: 50,589,914 *330Q probably null Het
Chd5 A T 4: 152,384,653 K1812* probably null Het
Cnga3 T A 1: 37,260,793 I236N possibly damaging Het
Ddost T G 4: 138,309,396 D135E possibly damaging Het
Dicer1 T C 12: 104,722,241 D359G probably damaging Het
Dnah17 A C 11: 118,041,056 S3697A probably benign Het
Dnttip2 G A 3: 122,282,474 G685D possibly damaging Het
Dst T G 1: 34,215,569 S4552R probably damaging Het
Ebf2 G A 14: 67,239,478 E157K probably damaging Het
Ehbp1 C T 11: 22,089,584 V839M probably benign Het
Ehmt1 G T 2: 24,839,608 T639K probably damaging Het
Esyt2 T C 12: 116,365,930 probably null Het
Etv6 T C 6: 134,248,387 S194P probably benign Het
Fam184b T C 5: 45,584,295 H198R probably benign Het
Fam210b T C 2: 172,351,540 F91S probably damaging Het
Fam81a G A 9: 70,099,152 Q193* probably null Het
Fto A G 8: 91,409,341 D79G probably damaging Het
Haspin C T 11: 73,137,405 R286H possibly damaging Het
Hmcn1 C T 1: 150,580,233 C5312Y probably damaging Het
Ik T A 18: 36,751,201 D245E possibly damaging Het
Itga1 A G 13: 115,006,948 V349A possibly damaging Het
Kdm8 T C 7: 125,461,205 V400A probably damaging Het
Larp1b G T 3: 40,970,478 R177L probably benign Het
Lifr T G 15: 7,179,018 probably benign Het
Lrrn2 T C 1: 132,937,221 L8P possibly damaging Het
Marc2 T C 1: 184,832,641 K231E probably benign Het
Marcksl1 T A 4: 129,514,794 D55E probably benign Het
Med12 C A X: 101,275,189 S74R probably damaging Het
Olfr1089 G A 2: 86,733,601 Q4* probably null Het
Olfr593 C A 7: 103,212,177 R95S probably benign Het
Olfr781 A T 10: 129,332,883 M1L probably damaging Het
Orc3 A C 4: 34,595,096 L233R probably damaging Het
Pik3cd A G 4: 149,654,315 M715T possibly damaging Het
Prss43 T A 9: 110,827,437 L64Q possibly damaging Het
Pyroxd2 C A 19: 42,738,332 G209V probably benign Het
Rab3b A G 4: 108,940,719 D198G possibly damaging Het
Rrbp1 A T 2: 143,947,895 probably benign Het
Smg6 T C 11: 74,935,103 probably null Het
Ssrp1 T C 2: 85,041,099 probably benign Het
Strip2 C A 6: 29,931,193 T381K probably benign Het
Svep1 A T 4: 58,116,622 L876Q possibly damaging Het
Tle4 T C 19: 14,452,533 I625V probably damaging Het
Tnfrsf23 T C 7: 143,679,999 T81A probably damaging Het
Ttc41 A G 10: 86,776,678 K1272E probably benign Het
Usp3 A G 9: 66,562,552 probably null Het
Vmn1r121 C T 7: 21,098,357 V53M probably benign Het
Vmn1r65 A T 7: 6,008,721 S171R probably benign Het
Vmn2r4 A T 3: 64,406,236 D441E probably benign Het
Vps13d A T 4: 145,075,048 H2353Q probably damaging Het
Vwa8 T C 14: 79,198,354 S1835P possibly damaging Het
Other mutations in Olfr862
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01114:Olfr862 APN 9 19883548 nonsense probably null
IGL01765:Olfr862 APN 9 19883951 missense possibly damaging 0.71
IGL01967:Olfr862 APN 9 19883589 missense probably damaging 0.97
IGL03145:Olfr862 APN 9 19883439 missense possibly damaging 0.93
IGL03222:Olfr862 APN 9 19884199 nonsense probably null
R0117:Olfr862 UTSW 9 19884299 missense probably damaging 0.96
R0662:Olfr862 UTSW 9 19883952 missense probably benign 0.32
R2399:Olfr862 UTSW 9 19883924 missense probably damaging 0.98
R4224:Olfr862 UTSW 9 19883600 missense probably benign 0.44
R4572:Olfr862 UTSW 9 19883979 missense probably benign
R5607:Olfr862 UTSW 9 19883976 missense probably benign 0.16
R5741:Olfr862 UTSW 9 19883561 missense possibly damaging 0.92
R5759:Olfr862 UTSW 9 19884188 missense probably benign 0.14
R6237:Olfr862 UTSW 9 19884069 missense probably damaging 1.00
R6434:Olfr862 UTSW 9 19883845 nonsense probably null
R7075:Olfr862 UTSW 9 19884063 missense probably benign 0.16
R7534:Olfr862 UTSW 9 19884176 missense probably benign 0.16
Posted On2013-12-09