Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01636:Or8k39'

93004

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or8k39

Ensembl Gene

ENSMUSG00000111711

Gene Name

olfactory receptor family 8 subfamily K member 39

Synonyms

Olfr1089, MOR193-1, GA_x6K02T2Q125-48226321-48225386

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.245) question?

Stock #

IGL01636

Quality Score

Status

Chromosome

Chromosomal Location

86563019-86563954 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 86563945 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Stop codon at position 4 (Q4*)

Ref Sequence

ENSEMBL: ENSMUSP00000149509 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000214317]

AlphaFold

A0A1L1SRK6

Predicted Effect

probably null
Transcript: ENSMUST00000099876
AA Change: Q4*

SMART Domains

Protein: ENSMUSP00000097461
Gene: ENSMUSG00000075173
AA Change: Q4*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	310	4.7e-47	PFAM
Pfam:7tm_1	41	290	2e-20	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000214317
AA Change: Q4*

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam4	T	C	12: 81,466,723 (GRCm39)	T633A	possibly damaging	Het
Adgrd1	G	T	5: 129,219,516 (GRCm39)		probably benign	Het
Bmp7	T	C	2: 172,717,001 (GRCm39)		probably benign	Het
Ccdc54	A	G	16: 50,410,277 (GRCm39)	*330Q	probably null	Het
Chd5	A	T	4: 152,469,110 (GRCm39)	K1812*	probably null	Het
Cnga3	T	A	1: 37,299,874 (GRCm39)	I236N	possibly damaging	Het
Ddost	T	G	4: 138,036,707 (GRCm39)	D135E	possibly damaging	Het
Dicer1	T	C	12: 104,688,500 (GRCm39)	D359G	probably damaging	Het
Dnah17	A	C	11: 117,931,882 (GRCm39)	S3697A	probably benign	Het
Dnttip2	G	A	3: 122,076,123 (GRCm39)	G685D	possibly damaging	Het
Dst	T	G	1: 34,254,650 (GRCm39)	S4552R	probably damaging	Het
Ebf2	G	A	14: 67,476,927 (GRCm39)	E157K	probably damaging	Het
Ehbp1	C	T	11: 22,039,584 (GRCm39)	V839M	probably benign	Het
Ehmt1	G	T	2: 24,729,620 (GRCm39)	T639K	probably damaging	Het
Esyt2	T	C	12: 116,329,550 (GRCm39)		probably null	Het
Etv6	T	C	6: 134,225,350 (GRCm39)	S194P	probably benign	Het
Fam184b	T	C	5: 45,741,637 (GRCm39)	H198R	probably benign	Het
Fam210b	T	C	2: 172,193,460 (GRCm39)	F91S	probably damaging	Het
Fam81a	G	A	9: 70,006,434 (GRCm39)	Q193*	probably null	Het
Fto	A	G	8: 92,135,969 (GRCm39)	D79G	probably damaging	Het
Haspin	C	T	11: 73,028,231 (GRCm39)	R286H	possibly damaging	Het
Hmcn1	C	T	1: 150,455,984 (GRCm39)	C5312Y	probably damaging	Het
Ik	T	A	18: 36,884,254 (GRCm39)	D245E	possibly damaging	Het
Itga1	A	G	13: 115,143,484 (GRCm39)	V349A	possibly damaging	Het
Kdm8	T	C	7: 125,060,377 (GRCm39)	V400A	probably damaging	Het
Larp1b	G	T	3: 40,924,913 (GRCm39)	R177L	probably benign	Het
Lifr	T	G	15: 7,208,499 (GRCm39)		probably benign	Het
Lrrn2	T	C	1: 132,864,959 (GRCm39)	L8P	possibly damaging	Het
Marcksl1	T	A	4: 129,408,587 (GRCm39)	D55E	probably benign	Het
Med12	C	A	X: 100,318,795 (GRCm39)	S74R	probably damaging	Het
Mtarc2	T	C	1: 184,564,838 (GRCm39)	K231E	probably benign	Het
Or52s1	C	A	7: 102,861,384 (GRCm39)	R95S	probably benign	Het
Or6c35	A	T	10: 129,168,752 (GRCm39)	M1L	probably damaging	Het
Or7e170	A	G	9: 19,795,484 (GRCm39)	V39A	probably benign	Het
Orc3	A	C	4: 34,595,096 (GRCm39)	L233R	probably damaging	Het
Pik3cd	A	G	4: 149,738,772 (GRCm39)	M715T	possibly damaging	Het
Prss43	T	A	9: 110,656,505 (GRCm39)	L64Q	possibly damaging	Het
Pyroxd2	C	A	19: 42,726,771 (GRCm39)	G209V	probably benign	Het
Rab3b	A	G	4: 108,797,916 (GRCm39)	D198G	possibly damaging	Het
Rrbp1	A	T	2: 143,789,815 (GRCm39)		probably benign	Het
Smg6	T	C	11: 74,825,929 (GRCm39)		probably null	Het
Ssrp1	T	C	2: 84,871,443 (GRCm39)		probably benign	Het
Strip2	C	A	6: 29,931,192 (GRCm39)	T381K	probably benign	Het
Svep1	A	T	4: 58,116,622 (GRCm39)	L876Q	possibly damaging	Het
Tle4	T	C	19: 14,429,897 (GRCm39)	I625V	probably damaging	Het
Tnfrsf23	T	C	7: 143,233,736 (GRCm39)	T81A	probably damaging	Het
Ttc41	A	G	10: 86,612,542 (GRCm39)	K1272E	probably benign	Het
Usp3	A	G	9: 66,469,834 (GRCm39)		probably null	Het
Vmn1r121	C	T	7: 20,832,282 (GRCm39)	V53M	probably benign	Het
Vmn1r65	A	T	7: 6,011,720 (GRCm39)	S171R	probably benign	Het
Vmn2r4	A	T	3: 64,313,657 (GRCm39)	D441E	probably benign	Het
Vps13d	A	T	4: 144,801,618 (GRCm39)	H2353Q	probably damaging	Het
Vwa8	T	C	14: 79,435,794 (GRCm39)	S1835P	possibly damaging	Het

Other mutations in Or8k39

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00332:Or8k39	APN	2	86,563,579 (GRCm39)	missense	possibly damaging	0.90
IGL00944:Or8k39	APN	2	86,563,905 (GRCm39)	missense	possibly damaging	0.80
IGL01478:Or8k39	APN	2	86,563,673 (GRCm39)	nonsense	probably null
IGL01887:Or8k39	APN	2	86,563,030 (GRCm39)	missense	probably benign	0.03
IGL02008:Or8k39	APN	2	86,563,521 (GRCm39)	missense	possibly damaging	0.90
IGL02470:Or8k39	APN	2	86,563,929 (GRCm39)	missense	probably damaging	0.97
IGL02560:Or8k39	APN	2	86,563,578 (GRCm39)	missense	probably damaging	1.00
R1782:Or8k39	UTSW	2	86,563,026 (GRCm39)	missense	probably benign	0.03
R2234:Or8k39	UTSW	2	86,563,921 (GRCm39)	missense	possibly damaging	0.94
R2866:Or8k39	UTSW	2	86,563,773 (GRCm39)	missense	possibly damaging	0.95
R3027:Or8k39	UTSW	2	86,563,930 (GRCm39)	missense	possibly damaging	0.79
R4275:Or8k39	UTSW	2	86,563,936 (GRCm39)	missense	probably damaging	1.00
R4799:Or8k39	UTSW	2	86,563,018 (GRCm39)	splice site	probably null
R5016:Or8k39	UTSW	2	86,563,090 (GRCm39)	missense	probably benign	0.17
R5154:Or8k39	UTSW	2	86,563,121 (GRCm39)	nonsense	probably null
R5355:Or8k39	UTSW	2	86,563,680 (GRCm39)	missense	probably damaging	1.00
R5624:Or8k39	UTSW	2	86,563,149 (GRCm39)	missense	probably benign	0.45
R6265:Or8k39	UTSW	2	86,563,299 (GRCm39)	missense	probably damaging	0.99
R7382:Or8k39	UTSW	2	86,563,129 (GRCm39)	missense	probably benign	0.02
R8009:Or8k39	UTSW	2	86,563,848 (GRCm39)	missense	probably damaging	0.99
R8850:Or8k39	UTSW	2	86,563,302 (GRCm39)	missense	probably damaging	0.99
R9652:Or8k39	UTSW	2	86,563,636 (GRCm39)	missense	probably damaging	1.00
X0028:Or8k39	UTSW	2	86,563,092 (GRCm39)	missense	probably damaging	0.99

Posted On

2013-12-09