Incidental Mutation 'IGL01637:Gstm3'
ID 93028
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gstm3
Ensembl Gene ENSMUSG00000004038
Gene Name glutathione S-transferase, mu 3
Synonyms mGSTM5, Fsc2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.090) question?
Stock # IGL01637
Quality Score
Status
Chromosome 3
Chromosomal Location 107963696-107969283 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 107967633 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 101 (E101G)
Ref Sequence ENSEMBL: ENSMUSP00000004136 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004136]
AlphaFold P19639
Predicted Effect probably damaging
Transcript: ENSMUST00000004136
AA Change: E101G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000004136
Gene: ENSMUSG00000004038
AA Change: E101G

DomainStartEndE-ValueType
Pfam:GST_N 3 82 6.6e-22 PFAM
Pfam:GST_C_3 41 190 7.7e-11 PFAM
Pfam:GST_C 104 191 1.6e-17 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actn4 A T 7: 28,904,684 I384N probably damaging Het
Adsl G T 15: 80,948,700 Q51H probably null Het
Apcdd1 A G 18: 62,937,286 E208G probably damaging Het
Arrdc4 G A 7: 68,744,832 R155* probably null Het
Atp9b T C 18: 80,756,455 E823G probably benign Het
Bmp1 A G 14: 70,492,461 W468R probably damaging Het
C6 A G 15: 4,759,917 I281M possibly damaging Het
Ccdc88b T C 19: 6,846,710 T1392A probably benign Het
Dhx34 G T 7: 16,205,473 S665Y probably damaging Het
Dock1 A T 7: 135,137,813 probably null Het
Dpp7 T C 2: 25,354,613 N252S probably benign Het
Dyrk2 A G 10: 118,860,507 V282A probably damaging Het
Edrf1 T C 7: 133,650,525 L401P probably damaging Het
Epc1 A G 18: 6,439,724 V150A probably benign Het
Fam170a A T 18: 50,281,667 M127L possibly damaging Het
Fam19a3 C T 3: 104,773,079 V75M probably damaging Het
Gabrg1 T A 5: 70,777,205 T277S probably damaging Het
Galntl5 T C 5: 25,189,825 probably benign Het
Gbp2b A G 3: 142,598,312 N56S probably damaging Het
Gfm2 T A 13: 97,150,409 V172E probably damaging Het
Gm10419 T C 5: 108,372,358 probably benign Het
Gm7293 A G 9: 51,623,606 noncoding transcript Het
Ifnlr1 T C 4: 135,686,545 W2R possibly damaging Het
Ighv13-1 A T 12: 114,267,733 probably benign Het
Ighv7-1 T A 12: 113,896,503 I90F possibly damaging Het
Itga2b A G 11: 102,455,583 L1009P probably damaging Het
Kif1a A G 1: 93,039,853 V1112A possibly damaging Het
Kif5a A T 10: 127,245,368 D232E possibly damaging Het
Klb G A 5: 65,375,679 probably null Het
Lrriq1 G A 10: 103,215,628 A421V probably benign Het
Mdga1 G A 17: 29,839,871 R721C probably damaging Het
Mrpl48 G T 7: 100,550,532 probably benign Het
Myo18b T A 5: 112,840,629 R1030S possibly damaging Het
Nf1 T A 11: 79,547,120 H2101Q probably damaging Het
Nlrp3 C A 11: 59,549,378 L594I probably damaging Het
Notch2 C T 3: 98,146,060 T2013I probably damaging Het
Olfr1018 A T 2: 85,822,988 T6S probably benign Het
Olfr131 G A 17: 38,082,103 L292F possibly damaging Het
Olfr593 C A 7: 103,212,177 R95S probably benign Het
Olfr812 A G 10: 129,842,610 L144P probably benign Het
Olfr845 T C 9: 19,338,964 F168S probably damaging Het
Panx3 T C 9: 37,664,056 D170G probably damaging Het
Pclo A G 5: 14,540,034 S783G unknown Het
Pde3b T A 7: 114,526,901 L790* probably null Het
Pik3r2 T C 8: 70,772,348 probably benign Het
Rassf4 A G 6: 116,641,690 F211L probably damaging Het
Rbl2 C T 8: 91,106,438 P666S probably benign Het
Rnf123 A G 9: 108,058,238 F979L probably damaging Het
Rock2 T A 12: 16,965,171 D788E probably benign Het
Serpina3b A G 12: 104,132,957 T244A probably benign Het
Setd1b T C 5: 123,148,513 S541P unknown Het
Slc12a4 T C 8: 105,960,707 D60G possibly damaging Het
Stac2 T C 11: 98,041,354 E241G probably benign Het
Tas2r115 A G 6: 132,737,629 Y120H probably damaging Het
Tmtc2 A T 10: 105,370,085 F450I probably benign Het
Txnl1 A T 18: 63,674,191 I198N probably damaging Het
Ubr2 A T 17: 46,956,654 M1049K probably damaging Het
Ugt2b5 T C 5: 87,139,900 E136G probably benign Het
Unc13b C T 4: 43,241,066 T3623I probably damaging Het
Usp13 T A 3: 32,919,064 S797T probably benign Het
Vmn1r173 A T 7: 23,702,948 T203S probably damaging Het
Vwf T A 6: 125,645,736 I1718N probably damaging Het
Zfr A G 15: 12,159,646 H676R probably benign Het
Other mutations in Gstm3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01585:Gstm3 APN 3 107966158 missense probably benign 0.42
IGL01937:Gstm3 APN 3 107967657 missense probably damaging 0.98
IGL01945:Gstm3 APN 3 107967657 missense probably damaging 0.98
IGL02307:Gstm3 APN 3 107967613 missense probably damaging 0.98
IGL02820:Gstm3 APN 3 107968758 splice site probably benign
IGL03038:Gstm3 APN 3 107966169 missense possibly damaging 0.75
IGL03108:Gstm3 APN 3 107967764 critical splice donor site probably null
IGL03271:Gstm3 APN 3 107966197 missense possibly damaging 0.47
IGL03097:Gstm3 UTSW 3 107968801 missense probably benign
R0009:Gstm3 UTSW 3 107967840 missense probably damaging 1.00
R0883:Gstm3 UTSW 3 107966270 splice site probably benign
R1623:Gstm3 UTSW 3 107967835 missense possibly damaging 0.80
R2108:Gstm3 UTSW 3 107966134 missense probably damaging 0.99
R3005:Gstm3 UTSW 3 107967607 missense probably benign 0.03
R3802:Gstm3 UTSW 3 107964235 missense probably benign 0.03
R3803:Gstm3 UTSW 3 107964235 missense probably benign 0.03
R3804:Gstm3 UTSW 3 107964235 missense probably benign 0.03
R4604:Gstm3 UTSW 3 107968197 missense possibly damaging 0.73
R4837:Gstm3 UTSW 3 107964215 missense probably benign
R6593:Gstm3 UTSW 3 107968195 missense probably benign 0.01
R6963:Gstm3 UTSW 3 107967624 missense probably benign 0.01
R7790:Gstm3 UTSW 3 107969239 start gained probably benign
R9245:Gstm3 UTSW 3 107967640 missense probably benign 0.01
Posted On 2013-12-09