Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01637:Olfr845'

93040

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfr845

Ensembl Gene

ENSMUSG00000061614

Gene Name

olfactory receptor 845

Synonyms

Olfr1522-ps1, MOR150-2, MOR150-1P, GA_x6K02T2PVTD-13076685-13077623, MOR150-1P, MOR150-1

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.119) question?

Stock #

IGL01637

Quality Score

Status

Chromosome

Chromosomal Location

19336457-19341718 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 19338964 bp

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 168 (F168S)

Ref Sequence

ENSEMBL: ENSMUSP00000150474 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071259] [ENSMUST00000213344] [ENSMUST00000215572]

Predicted Effect

probably damaging
Transcript: ENSMUST00000071259
AA Change: F168S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000071239
Gene: ENSMUSG00000061614
AA Change: F168S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	1.1e-56	PFAM
Pfam:7tm_1	41	290	2.1e-22	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212246
AA Change: F168S

Predicted Effect

probably damaging
Transcript: ENSMUST00000213344
AA Change: F168S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000215572
AA Change: F168S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actn4	A	T	7: 28,904,684	I384N	probably damaging	Het
Adsl	G	T	15: 80,948,700	Q51H	probably null	Het
Apcdd1	A	G	18: 62,937,286	E208G	probably damaging	Het
Arrdc4	G	A	7: 68,744,832	R155*	probably null	Het
Atp9b	T	C	18: 80,756,455	E823G	probably benign	Het
Bmp1	A	G	14: 70,492,461	W468R	probably damaging	Het
C6	A	G	15: 4,759,917	I281M	possibly damaging	Het
Ccdc88b	T	C	19: 6,846,710	T1392A	probably benign	Het
Dhx34	G	T	7: 16,205,473	S665Y	probably damaging	Het
Dock1	A	T	7: 135,137,813		probably null	Het
Dpp7	T	C	2: 25,354,613	N252S	probably benign	Het
Dyrk2	A	G	10: 118,860,507	V282A	probably damaging	Het
Edrf1	T	C	7: 133,650,525	L401P	probably damaging	Het
Epc1	A	G	18: 6,439,724	V150A	probably benign	Het
Fam170a	A	T	18: 50,281,667	M127L	possibly damaging	Het
Fam19a3	C	T	3: 104,773,079	V75M	probably damaging	Het
Gabrg1	T	A	5: 70,777,205	T277S	probably damaging	Het
Galntl5	T	C	5: 25,189,825		probably benign	Het
Gbp2b	A	G	3: 142,598,312	N56S	probably damaging	Het
Gfm2	T	A	13: 97,150,409	V172E	probably damaging	Het
Gm10419	T	C	5: 108,372,358		probably benign	Het
Gm7293	A	G	9: 51,623,606		noncoding transcript	Het
Gstm3	T	C	3: 107,967,633	E101G	probably damaging	Het
Ifnlr1	T	C	4: 135,686,545	W2R	possibly damaging	Het
Ighv13-1	A	T	12: 114,267,733		probably benign	Het
Ighv7-1	T	A	12: 113,896,503	I90F	possibly damaging	Het
Itga2b	A	G	11: 102,455,583	L1009P	probably damaging	Het
Kif1a	A	G	1: 93,039,853	V1112A	possibly damaging	Het
Kif5a	A	T	10: 127,245,368	D232E	possibly damaging	Het
Klb	G	A	5: 65,375,679		probably null	Het
Lrriq1	G	A	10: 103,215,628	A421V	probably benign	Het
Mdga1	G	A	17: 29,839,871	R721C	probably damaging	Het
Mrpl48	G	T	7: 100,550,532		probably benign	Het
Myo18b	T	A	5: 112,840,629	R1030S	possibly damaging	Het
Nf1	T	A	11: 79,547,120	H2101Q	probably damaging	Het
Nlrp3	C	A	11: 59,549,378	L594I	probably damaging	Het
Notch2	C	T	3: 98,146,060	T2013I	probably damaging	Het
Olfr1018	A	T	2: 85,822,988	T6S	probably benign	Het
Olfr131	G	A	17: 38,082,103	L292F	possibly damaging	Het
Olfr593	C	A	7: 103,212,177	R95S	probably benign	Het
Olfr812	A	G	10: 129,842,610	L144P	probably benign	Het
Panx3	T	C	9: 37,664,056	D170G	probably damaging	Het
Pclo	A	G	5: 14,540,034	S783G	unknown	Het
Pde3b	T	A	7: 114,526,901	L790*	probably null	Het
Pik3r2	T	C	8: 70,772,348		probably benign	Het
Rassf4	A	G	6: 116,641,690	F211L	probably damaging	Het
Rbl2	C	T	8: 91,106,438	P666S	probably benign	Het
Rnf123	A	G	9: 108,058,238	F979L	probably damaging	Het
Rock2	T	A	12: 16,965,171	D788E	probably benign	Het
Serpina3b	A	G	12: 104,132,957	T244A	probably benign	Het
Setd1b	T	C	5: 123,148,513	S541P	unknown	Het
Slc12a4	T	C	8: 105,960,707	D60G	possibly damaging	Het
Stac2	T	C	11: 98,041,354	E241G	probably benign	Het
Tas2r115	A	G	6: 132,737,629	Y120H	probably damaging	Het
Tmtc2	A	T	10: 105,370,085	F450I	probably benign	Het
Txnl1	A	T	18: 63,674,191	I198N	probably damaging	Het
Ubr2	A	T	17: 46,956,654	M1049K	probably damaging	Het
Ugt2b5	T	C	5: 87,139,900	E136G	probably benign	Het
Unc13b	C	T	4: 43,241,066	T3623I	probably damaging	Het
Usp13	T	A	3: 32,919,064	S797T	probably benign	Het
Vmn1r173	A	T	7: 23,702,948	T203S	probably damaging	Het
Vwf	T	A	6: 125,645,736	I1718N	probably damaging	Het
Zfr	A	G	15: 12,159,646	H676R	probably benign	Het

Other mutations in Olfr845

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01546:Olfr845	APN	9	19338772	missense	possibly damaging	0.56
IGL01767:Olfr845	APN	9	19339302	missense	possibly damaging	0.54
IGL01945:Olfr845	APN	9	19339332	missense	probably damaging	0.98
IGL02202:Olfr845	APN	9	19339249	missense	probably benign	0.06
IGL02877:Olfr845	APN	9	19339201	missense	possibly damaging	0.86
R0466:Olfr845	UTSW	9	19339179	missense	probably damaging	1.00
R1521:Olfr845	UTSW	9	19338652	missense	probably benign	0.35
R1650:Olfr845	UTSW	9	19338647	missense	possibly damaging	0.49
R1766:Olfr845	UTSW	9	19338858	missense	probably benign	0.06
R2060:Olfr845	UTSW	9	19339056	missense	probably benign	0.01
R2082:Olfr845	UTSW	9	19339278	missense	probably benign	0.36
R2257:Olfr845	UTSW	9	19338493	missense	probably benign	0.01
R2892:Olfr845	UTSW	9	19338738	missense	probably benign	0.04
R3156:Olfr845	UTSW	9	19339424	splice site	probably null
R3943:Olfr845	UTSW	9	19339075	missense	probably benign	0.05
R4116:Olfr845	UTSW	9	19338644	missense	probably benign	0.39
R4518:Olfr845	UTSW	9	19339260	missense	possibly damaging	0.86
R4814:Olfr845	UTSW	9	19339180	missense	probably damaging	1.00
R5339:Olfr845	UTSW	9	19339159	missense	possibly damaging	0.78
R6647:Olfr845	UTSW	9	19338629	missense	possibly damaging	0.50
R7493:Olfr845	UTSW	9	19338813	missense	probably damaging	0.98
R7522:Olfr845	UTSW	9	19338998	nonsense	probably null
R7584:Olfr845	UTSW	9	19339273	missense	possibly damaging	0.94

Posted On

2013-12-09