Incidental Mutation 'IGL01637:Arrdc4'
ID 93082
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Arrdc4
Ensembl Gene ENSMUSG00000042659
Gene Name arrestin domain containing 4
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.288) question?
Stock # IGL01637
Quality Score
Chromosome 7
Chromosomal Location 68736995-68749241 bp(-) (GRCm38)
Type of Mutation nonsense
DNA Base Change (assembly) G to A at 68744832 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 155 (R155*)
Ref Sequence ENSEMBL: ENSMUSP00000112962 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048068] [ENSMUST00000118110]
AlphaFold A0A0B4J1F4
Predicted Effect probably null
Transcript: ENSMUST00000048068
AA Change: R155*
SMART Domains Protein: ENSMUSP00000044578
Gene: ENSMUSG00000042659
AA Change: R155*

Pfam:Arrestin_N 19 166 6.2e-35 PFAM
Arrestin_C 188 315 8.24e-30 SMART
low complexity region 336 348 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000118110
AA Change: R155*
SMART Domains Protein: ENSMUSP00000112962
Gene: ENSMUSG00000042659
AA Change: R155*

Pfam:Arrestin_N 17 166 6.6e-35 PFAM
Arrestin_C 188 296 6.46e-14 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele show a marked reduction in the amount of extracellular vesicles (EVs) released from mouse gut explants. Mutant mouse embryonic fibroblasts exhibit reduced EV release. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actn4 A T 7: 28,904,684 (GRCm38) I384N probably damaging Het
Adsl G T 15: 80,948,700 (GRCm38) Q51H probably null Het
Apcdd1 A G 18: 62,937,286 (GRCm38) E208G probably damaging Het
Atp9b T C 18: 80,756,455 (GRCm38) E823G probably benign Het
Bmp1 A G 14: 70,492,461 (GRCm38) W468R probably damaging Het
C6 A G 15: 4,759,917 (GRCm38) I281M possibly damaging Het
Ccdc88b T C 19: 6,846,710 (GRCm38) T1392A probably benign Het
Dhx34 G T 7: 16,205,473 (GRCm38) S665Y probably damaging Het
Dock1 A T 7: 135,137,813 (GRCm38) probably null Het
Dpp7 T C 2: 25,354,613 (GRCm38) N252S probably benign Het
Dyrk2 A G 10: 118,860,507 (GRCm38) V282A probably damaging Het
Edrf1 T C 7: 133,650,525 (GRCm38) L401P probably damaging Het
Epc1 A G 18: 6,439,724 (GRCm38) V150A probably benign Het
Fam170a A T 18: 50,281,667 (GRCm38) M127L possibly damaging Het
Fam19a3 C T 3: 104,773,079 (GRCm38) V75M probably damaging Het
Gabrg1 T A 5: 70,777,205 (GRCm38) T277S probably damaging Het
Galntl5 T C 5: 25,189,825 (GRCm38) probably benign Het
Gbp2b A G 3: 142,598,312 (GRCm38) N56S probably damaging Het
Gfm2 T A 13: 97,150,409 (GRCm38) V172E probably damaging Het
Gm10419 T C 5: 108,372,358 (GRCm38) probably benign Het
Gm7293 A G 9: 51,623,606 (GRCm38) noncoding transcript Het
Gstm3 T C 3: 107,967,633 (GRCm38) E101G probably damaging Het
Ifnlr1 T C 4: 135,686,545 (GRCm38) W2R possibly damaging Het
Ighv13-1 A T 12: 114,267,733 (GRCm38) probably benign Het
Ighv7-1 T A 12: 113,896,503 (GRCm38) I90F possibly damaging Het
Itga2b A G 11: 102,455,583 (GRCm38) L1009P probably damaging Het
Kif1a A G 1: 93,039,853 (GRCm38) V1112A possibly damaging Het
Kif5a A T 10: 127,245,368 (GRCm38) D232E possibly damaging Het
Klb G A 5: 65,375,679 (GRCm38) probably null Het
Lrriq1 G A 10: 103,215,628 (GRCm38) A421V probably benign Het
Mdga1 G A 17: 29,839,871 (GRCm38) R721C probably damaging Het
Mrpl48 G T 7: 100,550,532 (GRCm38) probably benign Het
Myo18b T A 5: 112,840,629 (GRCm38) R1030S possibly damaging Het
Nf1 T A 11: 79,547,120 (GRCm38) H2101Q probably damaging Het
Nlrp3 C A 11: 59,549,378 (GRCm38) L594I probably damaging Het
Notch2 C T 3: 98,146,060 (GRCm38) T2013I probably damaging Het
Olfr1018 A T 2: 85,822,988 (GRCm38) T6S probably benign Het
Olfr131 G A 17: 38,082,103 (GRCm38) L292F possibly damaging Het
Olfr593 C A 7: 103,212,177 (GRCm38) R95S probably benign Het
Olfr812 A G 10: 129,842,610 (GRCm38) L144P probably benign Het
Olfr845 T C 9: 19,338,964 (GRCm38) F168S probably damaging Het
Panx3 T C 9: 37,664,056 (GRCm38) D170G probably damaging Het
Pclo A G 5: 14,540,034 (GRCm38) S783G unknown Het
Pde3b T A 7: 114,526,901 (GRCm38) L790* probably null Het
Pik3r2 T C 8: 70,772,348 (GRCm38) probably benign Het
Rassf4 A G 6: 116,641,690 (GRCm38) F211L probably damaging Het
Rbl2 C T 8: 91,106,438 (GRCm38) P666S probably benign Het
Rnf123 A G 9: 108,058,238 (GRCm38) F979L probably damaging Het
Rock2 T A 12: 16,965,171 (GRCm38) D788E probably benign Het
Serpina3b A G 12: 104,132,957 (GRCm38) T244A probably benign Het
Setd1b T C 5: 123,148,513 (GRCm38) S541P unknown Het
Slc12a4 T C 8: 105,960,707 (GRCm38) D60G possibly damaging Het
Stac2 T C 11: 98,041,354 (GRCm38) E241G probably benign Het
Tas2r115 A G 6: 132,737,629 (GRCm38) Y120H probably damaging Het
Tmtc2 A T 10: 105,370,085 (GRCm38) F450I probably benign Het
Txnl1 A T 18: 63,674,191 (GRCm38) I198N probably damaging Het
Ubr2 A T 17: 46,956,654 (GRCm38) M1049K probably damaging Het
Ugt2b5 T C 5: 87,139,900 (GRCm38) E136G probably benign Het
Unc13b C T 4: 43,241,066 (GRCm38) T3623I probably damaging Het
Usp13 T A 3: 32,919,064 (GRCm38) S797T probably benign Het
Vmn1r173 A T 7: 23,702,948 (GRCm38) T203S probably damaging Het
Vwf T A 6: 125,645,736 (GRCm38) I1718N probably damaging Het
Zfr A G 15: 12,159,646 (GRCm38) H676R probably benign Het
Other mutations in Arrdc4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02164:Arrdc4 APN 7 68,739,537 (GRCm38) unclassified probably benign
IGL03009:Arrdc4 APN 7 68,739,493 (GRCm38) missense probably damaging 1.00
R0454:Arrdc4 UTSW 7 68,741,871 (GRCm38) missense probably damaging 1.00
R1146:Arrdc4 UTSW 7 68,740,008 (GRCm38) missense probably damaging 0.99
R1146:Arrdc4 UTSW 7 68,740,008 (GRCm38) missense probably damaging 0.99
R1588:Arrdc4 UTSW 7 68,741,736 (GRCm38) missense possibly damaging 0.95
R1764:Arrdc4 UTSW 7 68,741,874 (GRCm38) missense probably damaging 1.00
R1956:Arrdc4 UTSW 7 68,741,799 (GRCm38) missense probably benign 0.16
R4717:Arrdc4 UTSW 7 68,741,658 (GRCm38) missense probably damaging 0.98
R6321:Arrdc4 UTSW 7 68,749,045 (GRCm38) missense probably benign 0.21
R6784:Arrdc4 UTSW 7 68,748,846 (GRCm38) missense probably benign 0.00
R7329:Arrdc4 UTSW 7 68,741,027 (GRCm38) missense probably damaging 1.00
R7689:Arrdc4 UTSW 7 68,741,875 (GRCm38) missense probably damaging 1.00
R7909:Arrdc4 UTSW 7 68,745,176 (GRCm38) missense probably benign 0.30
R7911:Arrdc4 UTSW 7 68,745,176 (GRCm38) missense probably benign 0.30
R7970:Arrdc4 UTSW 7 68,741,072 (GRCm38) missense probably damaging 1.00
R9356:Arrdc4 UTSW 7 68,744,879 (GRCm38) missense possibly damaging 0.55
R9623:Arrdc4 UTSW 7 68,740,993 (GRCm38) missense
Posted On 2013-12-09