Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01637:Arrdc4'

93082

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Arrdc4

Ensembl Gene

ENSMUSG00000042659

Gene Name

arrestin domain containing 4

Synonyms

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.288) question?

Stock #

IGL01637

Quality Score

Status

Chromosome

Chromosomal Location

68736995-68749241 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 68744832 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Stop codon at position 155 (R155*)

Ref Sequence

ENSEMBL: ENSMUSP00000112962 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000048068] [ENSMUST00000118110]

AlphaFold

A0A0B4J1F4

Predicted Effect

probably null
Transcript: ENSMUST00000048068
AA Change: R155*

SMART Domains

Protein: ENSMUSP00000044578
Gene: ENSMUSG00000042659
AA Change: R155*

Domain	Start	End	E-Value	Type
Pfam:Arrestin_N	19	166	6.2e-35	PFAM
Arrestin_C	188	315	8.24e-30	SMART
low complexity region	336	348	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000118110
AA Change: R155*

SMART Domains

Protein: ENSMUSP00000112962
Gene: ENSMUSG00000042659
AA Change: R155*

Domain	Start	End	E-Value	Type
Pfam:Arrestin_N	17	166	6.6e-35	PFAM
Arrestin_C	188	296	6.46e-14	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele show a marked reduction in the amount of extracellular vesicles (EVs) released from mouse gut explants. Mutant mouse embryonic fibroblasts exhibit reduced EV release. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actn4	A	T	7: 28,904,684 (GRCm38)	I384N	probably damaging	Het
Adsl	G	T	15: 80,948,700 (GRCm38)	Q51H	probably null	Het
Apcdd1	A	G	18: 62,937,286 (GRCm38)	E208G	probably damaging	Het
Atp9b	T	C	18: 80,756,455 (GRCm38)	E823G	probably benign	Het
Bmp1	A	G	14: 70,492,461 (GRCm38)	W468R	probably damaging	Het
C6	A	G	15: 4,759,917 (GRCm38)	I281M	possibly damaging	Het
Ccdc88b	T	C	19: 6,846,710 (GRCm38)	T1392A	probably benign	Het
Dhx34	G	T	7: 16,205,473 (GRCm38)	S665Y	probably damaging	Het
Dock1	A	T	7: 135,137,813 (GRCm38)		probably null	Het
Dpp7	T	C	2: 25,354,613 (GRCm38)	N252S	probably benign	Het
Dyrk2	A	G	10: 118,860,507 (GRCm38)	V282A	probably damaging	Het
Edrf1	T	C	7: 133,650,525 (GRCm38)	L401P	probably damaging	Het
Epc1	A	G	18: 6,439,724 (GRCm38)	V150A	probably benign	Het
Fam170a	A	T	18: 50,281,667 (GRCm38)	M127L	possibly damaging	Het
Fam19a3	C	T	3: 104,773,079 (GRCm38)	V75M	probably damaging	Het
Gabrg1	T	A	5: 70,777,205 (GRCm38)	T277S	probably damaging	Het
Galntl5	T	C	5: 25,189,825 (GRCm38)		probably benign	Het
Gbp2b	A	G	3: 142,598,312 (GRCm38)	N56S	probably damaging	Het
Gfm2	T	A	13: 97,150,409 (GRCm38)	V172E	probably damaging	Het
Gm10419	T	C	5: 108,372,358 (GRCm38)		probably benign	Het
Gm7293	A	G	9: 51,623,606 (GRCm38)		noncoding transcript	Het
Gstm3	T	C	3: 107,967,633 (GRCm38)	E101G	probably damaging	Het
Ifnlr1	T	C	4: 135,686,545 (GRCm38)	W2R	possibly damaging	Het
Ighv13-1	A	T	12: 114,267,733 (GRCm38)		probably benign	Het
Ighv7-1	T	A	12: 113,896,503 (GRCm38)	I90F	possibly damaging	Het
Itga2b	A	G	11: 102,455,583 (GRCm38)	L1009P	probably damaging	Het
Kif1a	A	G	1: 93,039,853 (GRCm38)	V1112A	possibly damaging	Het
Kif5a	A	T	10: 127,245,368 (GRCm38)	D232E	possibly damaging	Het
Klb	G	A	5: 65,375,679 (GRCm38)		probably null	Het
Lrriq1	G	A	10: 103,215,628 (GRCm38)	A421V	probably benign	Het
Mdga1	G	A	17: 29,839,871 (GRCm38)	R721C	probably damaging	Het
Mrpl48	G	T	7: 100,550,532 (GRCm38)		probably benign	Het
Myo18b	T	A	5: 112,840,629 (GRCm38)	R1030S	possibly damaging	Het
Nf1	T	A	11: 79,547,120 (GRCm38)	H2101Q	probably damaging	Het
Nlrp3	C	A	11: 59,549,378 (GRCm38)	L594I	probably damaging	Het
Notch2	C	T	3: 98,146,060 (GRCm38)	T2013I	probably damaging	Het
Olfr1018	A	T	2: 85,822,988 (GRCm38)	T6S	probably benign	Het
Olfr131	G	A	17: 38,082,103 (GRCm38)	L292F	possibly damaging	Het
Olfr593	C	A	7: 103,212,177 (GRCm38)	R95S	probably benign	Het
Olfr812	A	G	10: 129,842,610 (GRCm38)	L144P	probably benign	Het
Olfr845	T	C	9: 19,338,964 (GRCm38)	F168S	probably damaging	Het
Panx3	T	C	9: 37,664,056 (GRCm38)	D170G	probably damaging	Het
Pclo	A	G	5: 14,540,034 (GRCm38)	S783G	unknown	Het
Pde3b	T	A	7: 114,526,901 (GRCm38)	L790*	probably null	Het
Pik3r2	T	C	8: 70,772,348 (GRCm38)		probably benign	Het
Rassf4	A	G	6: 116,641,690 (GRCm38)	F211L	probably damaging	Het
Rbl2	C	T	8: 91,106,438 (GRCm38)	P666S	probably benign	Het
Rnf123	A	G	9: 108,058,238 (GRCm38)	F979L	probably damaging	Het
Rock2	T	A	12: 16,965,171 (GRCm38)	D788E	probably benign	Het
Serpina3b	A	G	12: 104,132,957 (GRCm38)	T244A	probably benign	Het
Setd1b	T	C	5: 123,148,513 (GRCm38)	S541P	unknown	Het
Slc12a4	T	C	8: 105,960,707 (GRCm38)	D60G	possibly damaging	Het
Stac2	T	C	11: 98,041,354 (GRCm38)	E241G	probably benign	Het
Tas2r115	A	G	6: 132,737,629 (GRCm38)	Y120H	probably damaging	Het
Tmtc2	A	T	10: 105,370,085 (GRCm38)	F450I	probably benign	Het
Txnl1	A	T	18: 63,674,191 (GRCm38)	I198N	probably damaging	Het
Ubr2	A	T	17: 46,956,654 (GRCm38)	M1049K	probably damaging	Het
Ugt2b5	T	C	5: 87,139,900 (GRCm38)	E136G	probably benign	Het
Unc13b	C	T	4: 43,241,066 (GRCm38)	T3623I	probably damaging	Het
Usp13	T	A	3: 32,919,064 (GRCm38)	S797T	probably benign	Het
Vmn1r173	A	T	7: 23,702,948 (GRCm38)	T203S	probably damaging	Het
Vwf	T	A	6: 125,645,736 (GRCm38)	I1718N	probably damaging	Het
Zfr	A	G	15: 12,159,646 (GRCm38)	H676R	probably benign	Het

Other mutations in Arrdc4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02164:Arrdc4	APN	7	68,739,537 (GRCm38)	unclassified	probably benign
IGL03009:Arrdc4	APN	7	68,739,493 (GRCm38)	missense	probably damaging	1.00
R0454:Arrdc4	UTSW	7	68,741,871 (GRCm38)	missense	probably damaging	1.00
R1146:Arrdc4	UTSW	7	68,740,008 (GRCm38)	missense	probably damaging	0.99
R1146:Arrdc4	UTSW	7	68,740,008 (GRCm38)	missense	probably damaging	0.99
R1588:Arrdc4	UTSW	7	68,741,736 (GRCm38)	missense	possibly damaging	0.95
R1764:Arrdc4	UTSW	7	68,741,874 (GRCm38)	missense	probably damaging	1.00
R1956:Arrdc4	UTSW	7	68,741,799 (GRCm38)	missense	probably benign	0.16
R4717:Arrdc4	UTSW	7	68,741,658 (GRCm38)	missense	probably damaging	0.98
R6321:Arrdc4	UTSW	7	68,749,045 (GRCm38)	missense	probably benign	0.21
R6784:Arrdc4	UTSW	7	68,748,846 (GRCm38)	missense	probably benign	0.00
R7329:Arrdc4	UTSW	7	68,741,027 (GRCm38)	missense	probably damaging	1.00
R7689:Arrdc4	UTSW	7	68,741,875 (GRCm38)	missense	probably damaging	1.00
R7909:Arrdc4	UTSW	7	68,745,176 (GRCm38)	missense	probably benign	0.30
R7911:Arrdc4	UTSW	7	68,745,176 (GRCm38)	missense	probably benign	0.30
R7970:Arrdc4	UTSW	7	68,741,072 (GRCm38)	missense	probably damaging	1.00
R9356:Arrdc4	UTSW	7	68,744,879 (GRCm38)	missense	possibly damaging	0.55
R9623:Arrdc4	UTSW	7	68,740,993 (GRCm38)	missense

Posted On

2013-12-09