Incidental Mutation 'IGL01640:Olfr945'
ID93093
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr945
Ensembl Gene ENSMUSG00000063380
Gene Nameolfactory receptor 945
SynonymsMOR171-20, GA_x6K02T2PVTD-32955932-32954982
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.056) question?
Stock #IGL01640
Quality Score
Status
Chromosome9
Chromosomal Location39256869-39276818 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 39258263 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Isoleucine at position 136 (M136I)
Ref Sequence ENSEMBL: ENSMUSP00000151086 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076903] [ENSMUST00000216698]
Predicted Effect probably benign
Transcript: ENSMUST00000076903
AA Change: M139I

PolyPhen 2 Score 0.238 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000076169
Gene: ENSMUSG00000063380
AA Change: M139I

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 1.2e-50 PFAM
Pfam:7tm_1 44 293 2.3e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216698
AA Change: M136I

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700003H04Rik T C 3: 124,579,938 T3A probably damaging Het
4933402N03Rik A T 7: 131,139,119 S123T possibly damaging Het
Adamts17 A T 7: 67,029,680 T559S probably damaging Het
Adh4 C T 3: 138,429,027 probably benign Het
Arel1 G A 12: 84,920,701 T783M probably damaging Het
B3gntl1 C T 11: 121,673,020 E5K probably benign Het
Faf1 T A 4: 109,840,403 F309I probably damaging Het
Fhod3 T G 18: 25,115,793 M1343R probably benign Het
Fnbp1 A G 2: 31,105,291 F44L probably damaging Het
Gm3633 A T 14: 42,638,367 Y206* probably null Het
Gprc6a A C 10: 51,627,084 F228V probably damaging Het
Il31ra T C 13: 112,531,758 I453V possibly damaging Het
Kif2a A G 13: 106,974,552 I529T probably damaging Het
Lrrc19 C T 4: 94,638,508 V271I probably damaging Het
Ncaph2 A G 15: 89,363,838 probably null Het
Nek5 A G 8: 22,120,840 I49T probably benign Het
Nhlrc3 A T 3: 53,453,537 probably benign Het
Olfr616 A G 7: 103,565,021 V86A probably damaging Het
Olfr659 A T 7: 104,671,664 S321C probably damaging Het
Pcnx2 T C 8: 125,801,558 T1308A probably benign Het
Pla2g6 T C 15: 79,304,313 N448S probably benign Het
Pole T A 5: 110,298,266 L571Q probably null Het
Rufy1 A G 11: 50,390,378 probably benign Het
Sftpd C A 14: 41,172,635 A276S probably benign Het
Slc35f4 A C 14: 49,318,768 V176G probably damaging Het
Snrpb T C 2: 130,175,331 D89G probably benign Het
Stab2 A T 10: 86,954,171 V577D probably benign Het
Synrg A C 11: 83,981,508 S152R probably damaging Het
Tcrg-V7 T C 13: 19,178,090 probably benign Het
Trpm1 A G 7: 64,226,897 E682G probably damaging Het
Unc80 T C 1: 66,679,585 I2989T probably benign Het
Vmn1r116 A G 7: 20,872,448 T65A probably benign Het
Zfp469 G A 8: 122,271,270 probably benign Het
Other mutations in Olfr945
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01773:Olfr945 APN 9 39258534 missense probably damaging 0.96
IGL02869:Olfr945 APN 9 39258224 nonsense probably null
IGL03245:Olfr945 APN 9 39257998 missense probably damaging 0.99
K3955:Olfr945 UTSW 9 39258630 missense probably damaging 1.00
R1710:Olfr945 UTSW 9 39258571 missense probably benign 0.07
R1746:Olfr945 UTSW 9 39258202 missense probably damaging 1.00
R1820:Olfr945 UTSW 9 39258399 missense possibly damaging 0.74
R3410:Olfr945 UTSW 9 39258601 missense possibly damaging 0.75
R4091:Olfr945 UTSW 9 39258034 missense possibly damaging 0.76
R4625:Olfr945 UTSW 9 39258318 missense probably damaging 1.00
R6475:Olfr945 UTSW 9 39258082 missense probably benign 0.00
R7114:Olfr945 UTSW 9 39258601 missense possibly damaging 0.75
R7500:Olfr945 UTSW 9 39258466 missense probably benign 0.03
R7545:Olfr945 UTSW 9 39258688 critical splice acceptor site probably null
R7850:Olfr945 UTSW 9 39258222 missense possibly damaging 0.94
R8263:Olfr945 UTSW 9 39258603 missense probably damaging 1.00
R8477:Olfr945 UTSW 9 39257803 missense probably damaging 1.00
Z1088:Olfr945 UTSW 9 39257871 missense probably benign 0.06
Posted On2013-12-09