Incidental Mutation 'IGL01640:Olfr659'
ID93095
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr659
Ensembl Gene ENSMUSG00000073922
Gene Nameolfactory receptor 659
SynonymsGA_x6K02T2PBJ9-7298889-7299857, MOR34-4
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.105) question?
Stock #IGL01640
Quality Score
Status
Chromosome7
Chromosomal Location104666753-104674948 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 104671664 bp
ZygosityHeterozygous
Amino Acid Change Serine to Cysteine at position 321 (S321C)
Ref Sequence ENSEMBL: ENSMUSP00000149939 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098170] [ENSMUST00000214986]
Predicted Effect probably damaging
Transcript: ENSMUST00000098170
AA Change: S321C

PolyPhen 2 Score 0.959 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000095772
Gene: ENSMUSG00000073922
AA Change: S321C

DomainStartEndE-ValueType
Pfam:7tm_4 33 314 5.2e-99 PFAM
Pfam:7TM_GPCR_Srsx 37 256 7.2e-9 PFAM
Pfam:7tm_1 43 296 4.7e-16 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214986
AA Change: S321C

PolyPhen 2 Score 0.959 (Sensitivity: 0.78; Specificity: 0.95)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700003H04Rik T C 3: 124,579,938 T3A probably damaging Het
4933402N03Rik A T 7: 131,139,119 S123T possibly damaging Het
Adamts17 A T 7: 67,029,680 T559S probably damaging Het
Adh4 C T 3: 138,429,027 probably benign Het
Arel1 G A 12: 84,920,701 T783M probably damaging Het
B3gntl1 C T 11: 121,673,020 E5K probably benign Het
Faf1 T A 4: 109,840,403 F309I probably damaging Het
Fhod3 T G 18: 25,115,793 M1343R probably benign Het
Fnbp1 A G 2: 31,105,291 F44L probably damaging Het
Gm3633 A T 14: 42,638,367 Y206* probably null Het
Gprc6a A C 10: 51,627,084 F228V probably damaging Het
Il31ra T C 13: 112,531,758 I453V possibly damaging Het
Kif2a A G 13: 106,974,552 I529T probably damaging Het
Lrrc19 C T 4: 94,638,508 V271I probably damaging Het
Ncaph2 A G 15: 89,363,838 probably null Het
Nek5 A G 8: 22,120,840 I49T probably benign Het
Nhlrc3 A T 3: 53,453,537 probably benign Het
Olfr616 A G 7: 103,565,021 V86A probably damaging Het
Olfr945 C A 9: 39,258,263 M136I probably damaging Het
Pcnx2 T C 8: 125,801,558 T1308A probably benign Het
Pla2g6 T C 15: 79,304,313 N448S probably benign Het
Pole T A 5: 110,298,266 L571Q probably null Het
Rufy1 A G 11: 50,390,378 probably benign Het
Sftpd C A 14: 41,172,635 A276S probably benign Het
Slc35f4 A C 14: 49,318,768 V176G probably damaging Het
Snrpb T C 2: 130,175,331 D89G probably benign Het
Stab2 A T 10: 86,954,171 V577D probably benign Het
Synrg A C 11: 83,981,508 S152R probably damaging Het
Tcrg-V7 T C 13: 19,178,090 probably benign Het
Trpm1 A G 7: 64,226,897 E682G probably damaging Het
Unc80 T C 1: 66,679,585 I2989T probably benign Het
Vmn1r116 A G 7: 20,872,448 T65A probably benign Het
Zfp469 G A 8: 122,271,270 probably benign Het
Other mutations in Olfr659
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01443:Olfr659 APN 7 104671071 missense probably damaging 1.00
IGL01774:Olfr659 APN 7 104670942 missense probably benign 0.01
IGL01912:Olfr659 APN 7 104671233 missense possibly damaging 0.91
IGL02338:Olfr659 APN 7 104671681 utr 3 prime probably benign
IGL02611:Olfr659 APN 7 104671407 missense possibly damaging 0.91
IGL02707:Olfr659 APN 7 104670929 missense probably damaging 0.97
R1139:Olfr659 UTSW 7 104670891 missense probably damaging 1.00
R1283:Olfr659 UTSW 7 104670943 missense possibly damaging 0.94
R1867:Olfr659 UTSW 7 104671317 missense possibly damaging 0.89
R2004:Olfr659 UTSW 7 104671601 missense possibly damaging 0.88
R2265:Olfr659 UTSW 7 104670860 missense probably benign 0.00
R4057:Olfr659 UTSW 7 104671269 missense probably damaging 1.00
R4519:Olfr659 UTSW 7 104670839 missense probably damaging 1.00
R4735:Olfr659 UTSW 7 104670993 missense probably benign
R4745:Olfr659 UTSW 7 104671504 missense probably damaging 1.00
R4816:Olfr659 UTSW 7 104670735 missense probably benign 0.04
R5274:Olfr659 UTSW 7 104671526 missense probably damaging 0.99
R6299:Olfr659 UTSW 7 104670868 missense probably benign 0.08
R6312:Olfr659 UTSW 7 104671589 missense probably damaging 1.00
R6770:Olfr659 UTSW 7 104671518 missense probably damaging 1.00
R7293:Olfr659 UTSW 7 104670718 missense probably damaging 1.00
R8119:Olfr659 UTSW 7 104670854 missense probably damaging 1.00
R8425:Olfr659 UTSW 7 104671295 missense probably damaging 1.00
R8493:Olfr659 UTSW 7 104670815 missense probably benign 0.13
R8694:Olfr659 UTSW 7 104671089 missense probably damaging 1.00
RF004:Olfr659 UTSW 7 104671041 missense probably damaging 0.98
Posted On2013-12-09