Incidental Mutation 'IGL01640:Il31ra'
ID 93113
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Il31ra
Ensembl Gene ENSMUSG00000050377
Gene Name interleukin 31 receptor A
Synonyms GLM-R, GPL
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01640
Quality Score
Status
Chromosome 13
Chromosomal Location 112649439-112717266 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 112668292 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 453 (I453V)
Ref Sequence ENSEMBL: ENSMUSP00000152979 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051756] [ENSMUST00000223752] [ENSMUST00000223819] [ENSMUST00000224510] [ENSMUST00000224576]
AlphaFold Q8K5B1
Predicted Effect probably benign
Transcript: ENSMUST00000051756
AA Change: I426V

PolyPhen 2 Score 0.075 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000058045
Gene: ENSMUSG00000050377
AA Change: I426V

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
FN3 115 198 7.75e0 SMART
Blast:FN3 216 297 1e-40 BLAST
FN3 325 394 1.15e1 SMART
FN3 408 490 7.18e-3 SMART
low complexity region 508 522 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223577
Predicted Effect probably benign
Transcript: ENSMUST00000223752
Predicted Effect possibly damaging
Transcript: ENSMUST00000223819
AA Change: I453V

PolyPhen 2 Score 0.580 (Sensitivity: 0.88; Specificity: 0.91)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224070
Predicted Effect probably benign
Transcript: ENSMUST00000224510
AA Change: I345V

PolyPhen 2 Score 0.061 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect probably benign
Transcript: ENSMUST00000224576
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
PHENOTYPE: Homozygous null mice display no apparent abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700003H04Rik T C 3: 124,373,587 (GRCm39) T3A probably damaging Het
4933402N03Rik A T 7: 130,740,848 (GRCm39) S123T possibly damaging Het
Adamts17 A T 7: 66,679,428 (GRCm39) T559S probably damaging Het
Adh4 C T 3: 138,134,788 (GRCm39) probably benign Het
Arel1 G A 12: 84,967,475 (GRCm39) T783M probably damaging Het
B3gntl1 C T 11: 121,563,846 (GRCm39) E5K probably benign Het
Faf1 T A 4: 109,697,600 (GRCm39) F309I probably damaging Het
Fhod3 T G 18: 25,248,850 (GRCm39) M1343R probably benign Het
Fnbp1 A G 2: 30,995,303 (GRCm39) F44L probably damaging Het
Gm3633 A T 14: 42,460,324 (GRCm39) Y206* probably null Het
Gprc6a A C 10: 51,503,180 (GRCm39) F228V probably damaging Het
Kif2a A G 13: 107,111,060 (GRCm39) I529T probably damaging Het
Lrrc19 C T 4: 94,526,745 (GRCm39) V271I probably damaging Het
Ncaph2 A G 15: 89,248,041 (GRCm39) probably null Het
Nek5 A G 8: 22,610,856 (GRCm39) I49T probably benign Het
Nhlrc3 A T 3: 53,360,958 (GRCm39) probably benign Het
Or51ac3 A G 7: 103,214,228 (GRCm39) V86A probably damaging Het
Or52n20 A T 7: 104,320,871 (GRCm39) S321C probably damaging Het
Or8g28 C A 9: 39,169,559 (GRCm39) M136I probably damaging Het
Pcnx2 T C 8: 126,528,297 (GRCm39) T1308A probably benign Het
Pla2g6 T C 15: 79,188,513 (GRCm39) N448S probably benign Het
Pole T A 5: 110,446,132 (GRCm39) L571Q probably null Het
Rufy1 A G 11: 50,281,205 (GRCm39) probably benign Het
Sftpd C A 14: 40,894,592 (GRCm39) A276S probably benign Het
Slc35f4 A C 14: 49,556,225 (GRCm39) V176G probably damaging Het
Snrpb T C 2: 130,017,251 (GRCm39) D89G probably benign Het
Stab2 A T 10: 86,790,035 (GRCm39) V577D probably benign Het
Synrg A C 11: 83,872,334 (GRCm39) S152R probably damaging Het
Trgv7 T C 13: 19,362,260 (GRCm39) probably benign Het
Trpm1 A G 7: 63,876,645 (GRCm39) E682G probably damaging Het
Unc80 T C 1: 66,718,744 (GRCm39) I2989T probably benign Het
Vmn1r116 A G 7: 20,606,373 (GRCm39) T65A probably benign Het
Zfp469 G A 8: 122,998,009 (GRCm39) probably benign Het
Other mutations in Il31ra
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00095:Il31ra APN 13 112,684,012 (GRCm39) missense possibly damaging 0.94
IGL00639:Il31ra APN 13 112,686,093 (GRCm39) nonsense probably null
IGL02009:Il31ra APN 13 112,670,401 (GRCm39) missense probably damaging 0.98
IGL02431:Il31ra APN 13 112,666,830 (GRCm39) missense probably damaging 1.00
IGL02675:Il31ra APN 13 112,660,886 (GRCm39) missense probably benign 0.00
IGL02718:Il31ra APN 13 112,666,903 (GRCm39) nonsense probably null
IGL03388:Il31ra APN 13 112,682,746 (GRCm39) missense probably damaging 1.00
IGL03408:Il31ra APN 13 112,662,422 (GRCm39) missense probably benign 0.21
R0482:Il31ra UTSW 13 112,664,015 (GRCm39) missense possibly damaging 0.89
R0639:Il31ra UTSW 13 112,662,377 (GRCm39) missense possibly damaging 0.95
R0905:Il31ra UTSW 13 112,668,207 (GRCm39) missense probably damaging 1.00
R0948:Il31ra UTSW 13 112,666,912 (GRCm39) missense possibly damaging 0.81
R1420:Il31ra UTSW 13 112,668,286 (GRCm39) missense probably damaging 1.00
R1538:Il31ra UTSW 13 112,684,000 (GRCm39) missense possibly damaging 0.91
R1776:Il31ra UTSW 13 112,677,773 (GRCm39) missense probably damaging 0.97
R1931:Il31ra UTSW 13 112,677,756 (GRCm39) missense probably damaging 1.00
R2006:Il31ra UTSW 13 112,666,890 (GRCm39) missense probably damaging 1.00
R2134:Il31ra UTSW 13 112,680,422 (GRCm39) missense possibly damaging 0.94
R3103:Il31ra UTSW 13 112,666,885 (GRCm39) missense probably damaging 1.00
R4089:Il31ra UTSW 13 112,688,453 (GRCm39) nonsense probably null
R4742:Il31ra UTSW 13 112,660,501 (GRCm39) nonsense probably null
R4787:Il31ra UTSW 13 112,664,079 (GRCm39) missense possibly damaging 0.82
R5154:Il31ra UTSW 13 112,660,531 (GRCm39) missense possibly damaging 0.87
R5193:Il31ra UTSW 13 112,660,864 (GRCm39) missense probably benign 0.34
R5402:Il31ra UTSW 13 112,660,669 (GRCm39) missense probably benign 0.01
R5743:Il31ra UTSW 13 112,664,021 (GRCm39) missense possibly damaging 0.89
R5917:Il31ra UTSW 13 112,682,846 (GRCm39) missense probably benign
R6126:Il31ra UTSW 13 112,666,908 (GRCm39) missense probably damaging 1.00
R6414:Il31ra UTSW 13 112,660,441 (GRCm39) missense possibly damaging 0.90
R6580:Il31ra UTSW 13 112,688,476 (GRCm39) missense possibly damaging 0.90
R6727:Il31ra UTSW 13 112,683,902 (GRCm39) missense probably damaging 1.00
R6783:Il31ra UTSW 13 112,688,522 (GRCm39) critical splice acceptor site probably null
R6912:Il31ra UTSW 13 112,685,998 (GRCm39) missense probably damaging 0.99
R6925:Il31ra UTSW 13 112,664,063 (GRCm39) missense possibly damaging 0.56
R7187:Il31ra UTSW 13 112,682,845 (GRCm39) missense probably benign 0.04
R7210:Il31ra UTSW 13 112,686,034 (GRCm39) missense possibly damaging 0.95
R7236:Il31ra UTSW 13 112,660,439 (GRCm39) makesense probably null
R7323:Il31ra UTSW 13 112,688,497 (GRCm39) missense probably damaging 1.00
R7618:Il31ra UTSW 13 112,688,514 (GRCm39) missense possibly damaging 0.66
R7783:Il31ra UTSW 13 112,677,785 (GRCm39) missense probably benign
R8353:Il31ra UTSW 13 112,660,717 (GRCm39) missense probably damaging 1.00
R8453:Il31ra UTSW 13 112,660,717 (GRCm39) missense probably damaging 1.00
R8679:Il31ra UTSW 13 112,662,372 (GRCm39) missense possibly damaging 0.81
R8890:Il31ra UTSW 13 112,660,861 (GRCm39) missense possibly damaging 0.95
R9032:Il31ra UTSW 13 112,660,628 (GRCm39) missense
R9077:Il31ra UTSW 13 112,670,361 (GRCm39) missense probably benign 0.00
R9085:Il31ra UTSW 13 112,660,628 (GRCm39) missense
R9147:Il31ra UTSW 13 112,670,276 (GRCm39) missense probably benign 0.01
R9148:Il31ra UTSW 13 112,670,276 (GRCm39) missense probably benign 0.01
R9158:Il31ra UTSW 13 112,670,394 (GRCm39) nonsense probably null
R9178:Il31ra UTSW 13 112,677,780 (GRCm39) missense probably damaging 1.00
R9250:Il31ra UTSW 13 112,669,508 (GRCm39) missense probably damaging 1.00
R9260:Il31ra UTSW 13 112,668,202 (GRCm39) missense probably damaging 0.98
R9312:Il31ra UTSW 13 112,686,023 (GRCm39) missense probably benign 0.01
R9381:Il31ra UTSW 13 112,668,253 (GRCm39) missense possibly damaging 0.81
Posted On 2013-12-09