Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01548:Tas2r119'

93187

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tas2r119

Ensembl Gene

ENSMUSG00000045267

Gene Name

taste receptor, type 2, member 119

Synonyms

mGR19, T2R19, mt2r19, Tas2r19

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01548

Quality Score

Status

Chromosome

Chromosomal Location

32177289-32178294 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 32177977 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Isoleucine at position 230 (F230I)

Ref Sequence

ENSEMBL: ENSMUSP00000050277 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000057633]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000057633
AA Change: F230I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000050277
Gene: ENSMUSG00000045267
AA Change: F230I

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	293	1.1e-90	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 76 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930402H24Rik	T	C	2: 130,814,259 (GRCm38)	N110D	probably damaging	Het
Acot3	C	T	12: 84,057,089 (GRCm38)	T224I	probably benign	Het
Adamts18	C	T	8: 113,764,299 (GRCm38)	G512E	probably damaging	Het
Atp4b	A	G	8: 13,389,679 (GRCm38)	I181T	probably damaging	Het
Bcl11a	A	G	11: 24,163,346 (GRCm38)	I230V	probably benign	Het
Cenpj	C	A	14: 56,532,319 (GRCm38)	V1138L	probably benign	Het
Cep78	A	G	19: 15,981,200 (GRCm38)		probably benign	Het
Clec2j	T	A	6: 128,655,978 (GRCm38)		noncoding transcript	Het
Col5a3	T	C	9: 20,803,000 (GRCm38)		probably benign	Het
Cpne6	A	T	14: 55,512,726 (GRCm38)	T105S	probably damaging	Het
Csmd1	A	T	8: 16,288,646 (GRCm38)	Y482*	probably null	Het
Ctrl	C	A	8: 105,933,258 (GRCm38)		probably benign	Het
Dhcr24	T	A	4: 106,573,871 (GRCm38)	C252*	probably null	Het
Dnah17	G	A	11: 118,098,612 (GRCm38)	P1261S	probably benign	Het
Dnaic2	T	C	11: 114,752,942 (GRCm38)	L466P	probably damaging	Het
Dync2h1	A	T	9: 7,071,922 (GRCm38)	F3036Y	probably damaging	Het
Eef1akmt2	A	C	7: 132,831,405 (GRCm38)	S191A	probably damaging	Het
Fam205c	T	C	4: 42,868,564 (GRCm38)	E353G	probably benign	Het
Fat4	T	C	3: 38,887,758 (GRCm38)	S267P	probably damaging	Het
Fat4	G	A	3: 39,009,257 (GRCm38)	C4454Y	probably damaging	Het
Frrs1	T	C	3: 116,885,185 (GRCm38)	C219R	probably damaging	Het
Gabra6	T	A	11: 42,317,023 (GRCm38)	Q207L	probably damaging	Het
Gm19668	A	T	10: 77,798,408 (GRCm38)	C242*	probably null	Het
Gm2840	G	A	5: 96,174,277 (GRCm38)		noncoding transcript	Het
Gm6614	A	G	6: 141,992,512 (GRCm38)	I227T	possibly damaging	Het
Gm8765	A	G	13: 50,700,378 (GRCm38)	T91A	probably benign	Het
Gmcl1p1	G	A	X: 3,078,226 (GRCm38)	G423S	probably benign	Het
Golim4	C	T	3: 75,908,125 (GRCm38)		probably null	Het
Gucy1b1	G	T	3: 82,034,862 (GRCm38)	T530K	probably damaging	Het
Hacl1	A	T	14: 31,640,596 (GRCm38)	D31E	possibly damaging	Het
Hectd4	A	G	5: 121,364,660 (GRCm38)	T4276A	possibly damaging	Het
Henmt1	T	C	3: 108,942,779 (GRCm38)	I26T	probably damaging	Het
Hspa1l	G	A	17: 34,978,391 (GRCm38)	A469T	probably damaging	Het
Htra3	T	A	5: 35,664,076 (GRCm38)		probably null	Het
Lrrc28	C	A	7: 67,628,294 (GRCm38)		probably null	Het
Mfhas1	T	C	8: 35,590,459 (GRCm38)	L696P	probably damaging	Het
Mios	A	G	6: 8,234,252 (GRCm38)	K808E	possibly damaging	Het
Mtnr1b	A	G	9: 15,863,200 (GRCm38)	Y188H	probably damaging	Het
Myom1	A	G	17: 71,101,220 (GRCm38)		probably benign	Het
Naca	A	T	10: 128,040,904 (GRCm38)		probably benign	Het
Nckap1l	T	A	15: 103,462,720 (GRCm38)	V213D	probably benign	Het
Ndufa6	C	T	15: 82,354,081 (GRCm38)	V50M	possibly damaging	Het
Olfr1000	A	G	2: 85,608,761 (GRCm38)	W50R	probably benign	Het
Olfr1055	T	A	2: 86,347,733 (GRCm38)	Y11F	possibly damaging	Het
Olfr1260	T	A	2: 89,978,539 (GRCm38)	F254I	possibly damaging	Het
Olfr1465	A	G	19: 13,313,986 (GRCm38)	F100L	possibly damaging	Het
Olfr923	A	G	9: 38,828,350 (GRCm38)	T220A	probably benign	Het
Osbpl1a	T	C	18: 12,763,575 (GRCm38)	Y311C	probably damaging	Het
Parp11	A	C	6: 127,491,599 (GRCm38)	Y204S	probably damaging	Het
Pla2g4a	A	G	1: 149,932,656 (GRCm38)		probably null	Het
Plec	T	C	15: 76,189,258 (GRCm38)	R519G	probably benign	Het
Ppp2r5c	T	A	12: 110,567,827 (GRCm38)	Y375N	probably benign	Het
Prss35	C	A	9: 86,755,274 (GRCm38)	S32R	probably benign	Het
Prss57	C	T	10: 79,785,747 (GRCm38)		probably benign	Het
Ptprc	A	C	1: 138,099,481 (GRCm38)		probably null	Het
Rims1	A	G	1: 22,538,602 (GRCm38)	C188R	probably damaging	Het
Ripk4	G	T	16: 97,751,496 (GRCm38)	Y144*	probably null	Het
Rpgrip1	A	T	14: 52,126,271 (GRCm38)		probably benign	Het
Rps6ka4	A	G	19: 6,832,323 (GRCm38)	V378A	probably benign	Het
Rtf1	A	G	2: 119,712,108 (GRCm38)	K298E	probably benign	Het
Sdk1	T	C	5: 142,085,765 (GRCm38)	F1237L	possibly damaging	Het
Slc40a1	T	C	1: 45,909,492 (GRCm38)	K543E	probably benign	Het
Sorcs3	A	T	19: 48,794,168 (GRCm38)	I1041F	possibly damaging	Het
Taok3	T	C	5: 117,272,197 (GRCm38)	M818T	probably benign	Het
Tbc1d8	T	C	1: 39,381,304 (GRCm38)	D716G	probably damaging	Het
Tfg	A	G	16: 56,701,102 (GRCm38)	S58P	probably damaging	Het
Thnsl1	A	G	2: 21,213,132 (GRCm38)	I45V	probably damaging	Het
Tle1	A	G	4: 72,170,718 (GRCm38)	L96P	probably damaging	Het
Tmem260	A	C	14: 48,480,325 (GRCm38)	S276R	possibly damaging	Het
Utp20	A	G	10: 88,764,781 (GRCm38)	S24P	probably damaging	Het
Vcam1	T	C	3: 116,115,951 (GRCm38)	I576V	probably benign	Het
Vmn1r27	G	T	6: 58,215,553 (GRCm38)	N105K	probably benign	Het
Vmn2r12	A	C	5: 109,093,027 (GRCm38)	Y73*	probably null	Het
Vmn2r86	T	C	10: 130,446,282 (GRCm38)	I822V	probably benign	Het
Wdr6	C	T	9: 108,574,897 (GRCm38)	V596I	possibly damaging	Het
Zfp946	A	T	17: 22,454,662 (GRCm38)	K132N	possibly damaging	Het

Other mutations in Tas2r119

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00577:Tas2r119	APN	15	32,177,453 (GRCm38)	missense	probably damaging	0.97
IGL01522:Tas2r119	APN	15	32,178,193 (GRCm38)	missense	probably benign	0.15
IGL01826:Tas2r119	APN	15	32,177,402 (GRCm38)	missense	probably damaging	1.00
IGL02432:Tas2r119	APN	15	32,177,707 (GRCm38)	missense	probably benign	0.06
IGL02585:Tas2r119	APN	15	32,177,533 (GRCm38)	missense	probably benign	0.04
R2248:Tas2r119	UTSW	15	32,178,151 (GRCm38)	missense	possibly damaging	0.51
R2432:Tas2r119	UTSW	15	32,178,019 (GRCm38)	missense	possibly damaging	0.80
R5098:Tas2r119	UTSW	15	32,178,082 (GRCm38)	missense	probably benign	0.03
R5624:Tas2r119	UTSW	15	32,177,968 (GRCm38)	missense	probably damaging	1.00
R5819:Tas2r119	UTSW	15	32,177,306 (GRCm38)	missense	probably damaging	1.00
R5901:Tas2r119	UTSW	15	32,177,786 (GRCm38)	missense	possibly damaging	0.84
R6363:Tas2r119	UTSW	15	32,177,888 (GRCm38)	missense	possibly damaging	0.91
R6495:Tas2r119	UTSW	15	32,177,530 (GRCm38)	missense	probably benign
R6521:Tas2r119	UTSW	15	32,178,173 (GRCm38)	missense	probably damaging	1.00
R7574:Tas2r119	UTSW	15	32,178,133 (GRCm38)	missense	probably damaging	1.00
R9004:Tas2r119	UTSW	15	32,177,963 (GRCm38)	missense	probably damaging	1.00
R9015:Tas2r119	UTSW	15	32,178,080 (GRCm38)	missense	probably damaging	1.00
R9193:Tas2r119	UTSW	15	32,177,786 (GRCm38)	missense	probably benign	0.02
X0063:Tas2r119	UTSW	15	32,178,155 (GRCm38)	missense	possibly damaging	0.95

Posted On

2013-12-09