Incidental Mutation 'IGL01548:Tas2r119'
ID 93187
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tas2r119
Ensembl Gene ENSMUSG00000045267
Gene Name taste receptor, type 2, member 119
Synonyms mGR19, T2R19, mt2r19, Tas2r19
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01548
Quality Score
Chromosome 15
Chromosomal Location 32177289-32178294 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 32177977 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 230 (F230I)
Ref Sequence ENSEMBL: ENSMUSP00000050277 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057633]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000057633
AA Change: F230I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000050277
Gene: ENSMUSG00000045267
AA Change: F230I

Pfam:TAS2R 1 293 1.1e-90 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930402H24Rik T C 2: 130,814,259 (GRCm38) N110D probably damaging Het
Acot3 C T 12: 84,057,089 (GRCm38) T224I probably benign Het
Adamts18 C T 8: 113,764,299 (GRCm38) G512E probably damaging Het
Atp4b A G 8: 13,389,679 (GRCm38) I181T probably damaging Het
Bcl11a A G 11: 24,163,346 (GRCm38) I230V probably benign Het
Cenpj C A 14: 56,532,319 (GRCm38) V1138L probably benign Het
Cep78 A G 19: 15,981,200 (GRCm38) probably benign Het
Clec2j T A 6: 128,655,978 (GRCm38) noncoding transcript Het
Col5a3 T C 9: 20,803,000 (GRCm38) probably benign Het
Cpne6 A T 14: 55,512,726 (GRCm38) T105S probably damaging Het
Csmd1 A T 8: 16,288,646 (GRCm38) Y482* probably null Het
Ctrl C A 8: 105,933,258 (GRCm38) probably benign Het
Dhcr24 T A 4: 106,573,871 (GRCm38) C252* probably null Het
Dnah17 G A 11: 118,098,612 (GRCm38) P1261S probably benign Het
Dnaic2 T C 11: 114,752,942 (GRCm38) L466P probably damaging Het
Dync2h1 A T 9: 7,071,922 (GRCm38) F3036Y probably damaging Het
Eef1akmt2 A C 7: 132,831,405 (GRCm38) S191A probably damaging Het
Fam205c T C 4: 42,868,564 (GRCm38) E353G probably benign Het
Fat4 T C 3: 38,887,758 (GRCm38) S267P probably damaging Het
Fat4 G A 3: 39,009,257 (GRCm38) C4454Y probably damaging Het
Frrs1 T C 3: 116,885,185 (GRCm38) C219R probably damaging Het
Gabra6 T A 11: 42,317,023 (GRCm38) Q207L probably damaging Het
Gm19668 A T 10: 77,798,408 (GRCm38) C242* probably null Het
Gm2840 G A 5: 96,174,277 (GRCm38) noncoding transcript Het
Gm6614 A G 6: 141,992,512 (GRCm38) I227T possibly damaging Het
Gm8765 A G 13: 50,700,378 (GRCm38) T91A probably benign Het
Gmcl1p1 G A X: 3,078,226 (GRCm38) G423S probably benign Het
Golim4 C T 3: 75,908,125 (GRCm38) probably null Het
Gucy1b1 G T 3: 82,034,862 (GRCm38) T530K probably damaging Het
Hacl1 A T 14: 31,640,596 (GRCm38) D31E possibly damaging Het
Hectd4 A G 5: 121,364,660 (GRCm38) T4276A possibly damaging Het
Henmt1 T C 3: 108,942,779 (GRCm38) I26T probably damaging Het
Hspa1l G A 17: 34,978,391 (GRCm38) A469T probably damaging Het
Htra3 T A 5: 35,664,076 (GRCm38) probably null Het
Lrrc28 C A 7: 67,628,294 (GRCm38) probably null Het
Mfhas1 T C 8: 35,590,459 (GRCm38) L696P probably damaging Het
Mios A G 6: 8,234,252 (GRCm38) K808E possibly damaging Het
Mtnr1b A G 9: 15,863,200 (GRCm38) Y188H probably damaging Het
Myom1 A G 17: 71,101,220 (GRCm38) probably benign Het
Naca A T 10: 128,040,904 (GRCm38) probably benign Het
Nckap1l T A 15: 103,462,720 (GRCm38) V213D probably benign Het
Ndufa6 C T 15: 82,354,081 (GRCm38) V50M possibly damaging Het
Olfr1000 A G 2: 85,608,761 (GRCm38) W50R probably benign Het
Olfr1055 T A 2: 86,347,733 (GRCm38) Y11F possibly damaging Het
Olfr1260 T A 2: 89,978,539 (GRCm38) F254I possibly damaging Het
Olfr1465 A G 19: 13,313,986 (GRCm38) F100L possibly damaging Het
Olfr923 A G 9: 38,828,350 (GRCm38) T220A probably benign Het
Osbpl1a T C 18: 12,763,575 (GRCm38) Y311C probably damaging Het
Parp11 A C 6: 127,491,599 (GRCm38) Y204S probably damaging Het
Pla2g4a A G 1: 149,932,656 (GRCm38) probably null Het
Plec T C 15: 76,189,258 (GRCm38) R519G probably benign Het
Ppp2r5c T A 12: 110,567,827 (GRCm38) Y375N probably benign Het
Prss35 C A 9: 86,755,274 (GRCm38) S32R probably benign Het
Prss57 C T 10: 79,785,747 (GRCm38) probably benign Het
Ptprc A C 1: 138,099,481 (GRCm38) probably null Het
Rims1 A G 1: 22,538,602 (GRCm38) C188R probably damaging Het
Ripk4 G T 16: 97,751,496 (GRCm38) Y144* probably null Het
Rpgrip1 A T 14: 52,126,271 (GRCm38) probably benign Het
Rps6ka4 A G 19: 6,832,323 (GRCm38) V378A probably benign Het
Rtf1 A G 2: 119,712,108 (GRCm38) K298E probably benign Het
Sdk1 T C 5: 142,085,765 (GRCm38) F1237L possibly damaging Het
Slc40a1 T C 1: 45,909,492 (GRCm38) K543E probably benign Het
Sorcs3 A T 19: 48,794,168 (GRCm38) I1041F possibly damaging Het
Taok3 T C 5: 117,272,197 (GRCm38) M818T probably benign Het
Tbc1d8 T C 1: 39,381,304 (GRCm38) D716G probably damaging Het
Tfg A G 16: 56,701,102 (GRCm38) S58P probably damaging Het
Thnsl1 A G 2: 21,213,132 (GRCm38) I45V probably damaging Het
Tle1 A G 4: 72,170,718 (GRCm38) L96P probably damaging Het
Tmem260 A C 14: 48,480,325 (GRCm38) S276R possibly damaging Het
Utp20 A G 10: 88,764,781 (GRCm38) S24P probably damaging Het
Vcam1 T C 3: 116,115,951 (GRCm38) I576V probably benign Het
Vmn1r27 G T 6: 58,215,553 (GRCm38) N105K probably benign Het
Vmn2r12 A C 5: 109,093,027 (GRCm38) Y73* probably null Het
Vmn2r86 T C 10: 130,446,282 (GRCm38) I822V probably benign Het
Wdr6 C T 9: 108,574,897 (GRCm38) V596I possibly damaging Het
Zfp946 A T 17: 22,454,662 (GRCm38) K132N possibly damaging Het
Other mutations in Tas2r119
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00577:Tas2r119 APN 15 32,177,453 (GRCm38) missense probably damaging 0.97
IGL01522:Tas2r119 APN 15 32,178,193 (GRCm38) missense probably benign 0.15
IGL01826:Tas2r119 APN 15 32,177,402 (GRCm38) missense probably damaging 1.00
IGL02432:Tas2r119 APN 15 32,177,707 (GRCm38) missense probably benign 0.06
IGL02585:Tas2r119 APN 15 32,177,533 (GRCm38) missense probably benign 0.04
R2248:Tas2r119 UTSW 15 32,178,151 (GRCm38) missense possibly damaging 0.51
R2432:Tas2r119 UTSW 15 32,178,019 (GRCm38) missense possibly damaging 0.80
R5098:Tas2r119 UTSW 15 32,178,082 (GRCm38) missense probably benign 0.03
R5624:Tas2r119 UTSW 15 32,177,968 (GRCm38) missense probably damaging 1.00
R5819:Tas2r119 UTSW 15 32,177,306 (GRCm38) missense probably damaging 1.00
R5901:Tas2r119 UTSW 15 32,177,786 (GRCm38) missense possibly damaging 0.84
R6363:Tas2r119 UTSW 15 32,177,888 (GRCm38) missense possibly damaging 0.91
R6495:Tas2r119 UTSW 15 32,177,530 (GRCm38) missense probably benign
R6521:Tas2r119 UTSW 15 32,178,173 (GRCm38) missense probably damaging 1.00
R7574:Tas2r119 UTSW 15 32,178,133 (GRCm38) missense probably damaging 1.00
R9004:Tas2r119 UTSW 15 32,177,963 (GRCm38) missense probably damaging 1.00
R9015:Tas2r119 UTSW 15 32,178,080 (GRCm38) missense probably damaging 1.00
R9193:Tas2r119 UTSW 15 32,177,786 (GRCm38) missense probably benign 0.02
X0063:Tas2r119 UTSW 15 32,178,155 (GRCm38) missense possibly damaging 0.95
Posted On 2013-12-09