Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01551:Ifi202b'

93257

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ifi202b

Ensembl Gene

ENSMUSG00000026535

Gene Name

interferon activated gene 202B

Synonyms

p202

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.049) question?

Stock #

IGL01551

Quality Score

Status

Chromosome

Chromosomal Location

173790134-173810310 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 173798928 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Asparagine at position 373 (K373N)

Ref Sequence

ENSEMBL: ENSMUSP00000000266 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000000266]

AlphaFold

Q9R002

PDB Structure

Structural mimicry for functional antagonism [X-RAY DIFFRACTION]
Molecular basis for abrogation of activation of pro-inflammatory cytokines [X-RAY DIFFRACTION]
Crystal structure of p202 HIN1 [X-RAY DIFFRACTION]
Crystal structure of p202 HIN1 in complex with 20-mer dsDNA [X-RAY DIFFRACTION]
p202 HIN1 in complex with 12-mer dsDNA [X-RAY DIFFRACTION]
Crystal structure of the tetrameric p202 HIN2 [X-RAY DIFFRACTION]
Crystal structure of Ifi202 HINa domain in complex with 20bp dsDNA [X-RAY DIFFRACTION]

Predicted Effect

probably benign
Transcript: ENSMUST00000000266
AA Change: K373N

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000000266
Gene: ENSMUSG00000026535
AA Change: K373N

Domain	Start	End	E-Value	Type
Pfam:HIN	58	223	4.1e-68	PFAM
Pfam:HIN	256	421	1.5e-61	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2610008E11Rik	G	A	10: 78,924,147 (GRCm39)	S103L	possibly damaging	Het
Acvr2a	G	A	2: 48,787,071 (GRCm39)	A389T	probably damaging	Het
Adamts9	A	G	6: 92,784,001 (GRCm39)	S1037P	probably damaging	Het
Adcyap1	A	G	17: 93,511,446 (GRCm39)	Y140C	probably damaging	Het
Ampd3	A	G	7: 110,404,183 (GRCm39)	N569S	probably damaging	Het
Bin1	G	T	18: 32,510,511 (GRCm39)	V18L	probably benign	Het
Ccdc158	A	G	5: 92,814,620 (GRCm39)	Y69H	probably damaging	Het
Ccdc70	A	G	8: 22,463,611 (GRCm39)	R134G	possibly damaging	Het
Cmtm2a	A	G	8: 105,019,286 (GRCm39)	V101A	probably damaging	Het
Edar	T	C	10: 58,441,860 (GRCm39)		probably benign	Het
Gcc2	T	C	10: 58,134,691 (GRCm39)		probably benign	Het
Gm10961	A	G	3: 107,540,281 (GRCm39)		probably benign	Het
Hsd3b3	T	C	3: 98,649,216 (GRCm39)	D369G	probably benign	Het
Khk	C	A	5: 31,082,189 (GRCm39)	H67N	probably benign	Het
Kif7	T	A	7: 79,360,314 (GRCm39)		probably null	Het
Mbd1	C	T	18: 74,402,614 (GRCm39)		probably benign	Het
Mtor	A	G	4: 148,556,494 (GRCm39)	H968R	probably damaging	Het
Nadk	A	G	4: 155,673,157 (GRCm39)		probably benign	Het
Or11g27	A	G	14: 50,771,618 (GRCm39)	T250A	probably benign	Het
Or2f1b	A	G	6: 42,739,046 (GRCm39)	D20G	probably damaging	Het
Or5d40	A	T	2: 88,015,629 (GRCm39)	H136L	probably benign	Het
Otol1	T	C	3: 69,935,057 (GRCm39)	F350L	probably damaging	Het
Pramel22	T	C	4: 143,383,042 (GRCm39)	N59S	probably damaging	Het
Prkcg	G	A	7: 3,352,342 (GRCm39)		probably benign	Het
Rps6kc1	A	T	1: 190,505,837 (GRCm39)	S1042T	possibly damaging	Het
Rtn1	C	T	12: 72,263,709 (GRCm39)	V741I	possibly damaging	Het
Tor2a	T	A	2: 32,650,595 (GRCm39)		probably benign	Het
Vmn1r177	T	C	7: 23,565,688 (GRCm39)	I63V	probably benign	Het
Vmn2r58	T	A	7: 41,514,703 (GRCm39)	I89F	probably damaging	Het
Xirp2	A	G	2: 67,343,849 (GRCm39)	D2030G	probably benign	Het
Zfp326	T	C	5: 106,036,451 (GRCm39)	S121P	probably damaging	Het

Other mutations in Ifi202b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02019:Ifi202b	APN	1	173,802,550 (GRCm39)	missense	possibly damaging	0.95
IGL02466:Ifi202b	APN	1	173,799,875 (GRCm39)	missense	possibly damaging	0.71
IGL02508:Ifi202b	APN	1	173,802,338 (GRCm39)	missense	probably benign	0.18
IGL02567:Ifi202b	APN	1	173,791,370 (GRCm39)	missense	possibly damaging	0.84
IGL02644:Ifi202b	APN	1	173,799,280 (GRCm39)	missense	probably benign	0.00
R0282:Ifi202b	UTSW	1	173,804,926 (GRCm39)	missense	probably benign	0.00
R1178:Ifi202b	UTSW	1	173,799,788 (GRCm39)	missense	probably benign	0.02
R3414:Ifi202b	UTSW	1	173,791,479 (GRCm39)	missense	probably benign	0.19
R5739:Ifi202b	UTSW	1	173,798,918 (GRCm39)	critical splice donor site	probably null
R5944:Ifi202b	UTSW	1	173,791,365 (GRCm39)	missense	probably benign	0.00
R6805:Ifi202b	UTSW	1	173,802,555 (GRCm39)	missense	probably damaging	1.00
R7019:Ifi202b	UTSW	1	173,791,524 (GRCm39)	missense	probably benign	0.00
R7291:Ifi202b	UTSW	1	173,802,381 (GRCm39)	missense	probably benign	0.02
R7555:Ifi202b	UTSW	1	173,799,787 (GRCm39)	missense	probably damaging	0.99
R7825:Ifi202b	UTSW	1	173,802,616 (GRCm39)	missense	probably damaging	1.00
R8151:Ifi202b	UTSW	1	173,804,923 (GRCm39)	missense	probably benign	0.00
R8379:Ifi202b	UTSW	1	173,802,298 (GRCm39)	critical splice donor site	probably null
R8887:Ifi202b	UTSW	1	173,802,480 (GRCm39)	missense	probably damaging	1.00
R9177:Ifi202b	UTSW	1	173,804,949 (GRCm39)	start codon destroyed	probably null	0.01
R9642:Ifi202b	UTSW	1	173,799,850 (GRCm39)	nonsense	probably null

Posted On

2013-12-09