Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01571:Ifi44'

93299

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ifi44

Ensembl Gene

ENSMUSG00000028037

Gene Name

interferon-induced protein 44

Synonyms

A430056A10Rik, p44, MTAP44

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01571

Quality Score

Status

Chromosome

Chromosomal Location

151730922-151749960 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 151745537 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 259 (D259G)

Ref Sequence

ENSEMBL: ENSMUSP00000029671 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000029671]

AlphaFold

Q8BV66

Predicted Effect

probably damaging
Transcript: ENSMUST00000029671
AA Change: D259G

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000029671
Gene: ENSMUSG00000028037
AA Change: D259G

Domain	Start	End	E-Value	Type
Pfam:TLD	26	147	2.8e-7	PFAM
low complexity region	193	208	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000127733

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000133888

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000149919

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
AB124611	T	A	9: 21,539,081		probably benign	Het
Cep164	T	C	9: 45,794,338	Q127R	possibly damaging	Het
Ces1f	T	A	8: 93,258,368	M444L	probably benign	Het
Chd5	T	A	4: 152,384,115		probably benign	Het
Cpd	T	A	11: 76,782,296	Y1341F	probably damaging	Het
Cryz	T	C	3: 154,621,743	I268T	probably damaging	Het
Csnk2a1	G	A	2: 152,275,406	R278H	probably damaging	Het
Cyp4a12b	A	G	4: 115,438,157	I487V	probably benign	Het
Dnajb5	T	C	4: 42,956,516		probably benign	Het
Dxo	A	T	17: 34,839,040	H214L	probably damaging	Het
Etfb	T	C	7: 43,452,959		probably null	Het
G6pc2	G	A	2: 69,222,967	V122I	probably damaging	Het
Gm5431	A	T	11: 48,894,713	D278E	probably benign	Het
Gstt2	C	T	10: 75,834,171		probably benign	Het
Hnf4g	A	C	3: 3,651,266		probably benign	Het
Klk1	T	C	7: 44,228,596	V92A	probably damaging	Het
Lypla1	T	C	1: 4,844,988	I222T	probably benign	Het
Nbeal2	T	C	9: 110,632,758	N1510D	possibly damaging	Het
Ndufaf7	A	G	17: 78,943,852	R229G	probably damaging	Het
Nphp4	G	A	4: 152,556,382	V1069M	probably benign	Het
Nsd2	A	G	5: 33,864,687	H528R	probably benign	Het
Olfr1298	C	A	2: 111,645,380	V206L	probably benign	Het
Olfr1355	A	G	10: 78,879,837	I222V	possibly damaging	Het
Olfr763	A	T	10: 129,011,827	I181F	probably damaging	Het
Pigh	A	C	12: 79,085,860		probably benign	Het
Prr14l	A	T	5: 32,828,806	M1115K	probably benign	Het
Psg21	T	C	7: 18,654,825	D114G	probably damaging	Het
Psmg2	G	A	18: 67,653,223	V218I	probably benign	Het
Pygb	T	C	2: 150,830,473	S831P	probably benign	Het
Ryr2	T	A	13: 11,721,761	D2260V	probably damaging	Het
Sgo2a	T	C	1: 58,017,974	S1106P	probably damaging	Het
Slc5a5	G	A	8: 70,891,332		probably benign	Het
Tekt4	A	G	17: 25,476,384	D397G	probably benign	Het
Trrap	T	A	5: 144,833,287		probably benign	Het
Upf2	T	C	2: 6,018,939		probably benign	Het
Usp17lb	A	T	7: 104,840,381	N445K	possibly damaging	Het
Vmn2r111	A	G	17: 22,571,392	V211A	probably damaging	Het
Vmn2r23	A	G	6: 123,704,407	I91M	probably damaging	Het
Vps13b	C	T	15: 35,877,489		probably benign	Het
Zc3hc1	G	A	6: 30,390,863	T47I	probably benign	Het

Other mutations in Ifi44

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00858:Ifi44	APN	3	151749580	missense	probably benign	0.03
IGL01477:Ifi44	APN	3	151745998	splice site	probably benign
IGL02165:Ifi44	APN	3	151749430	missense	probably damaging	1.00
IGL02238:Ifi44	APN	3	151732382	makesense	probably null
IGL02609:Ifi44	APN	3	151732497	missense	probably damaging	1.00
IGL02650:Ifi44	APN	3	151745855	missense	probably damaging	1.00
IGL02726:Ifi44	APN	3	151749596	start gained	probably benign
IGL02977:Ifi44	APN	3	151739379	missense	probably benign	0.00
R0201:Ifi44	UTSW	3	151745636	missense	probably damaging	1.00
R0454:Ifi44	UTSW	3	151745497	missense	possibly damaging	0.78
R0763:Ifi44	UTSW	3	151749498	missense	probably damaging	1.00
R1640:Ifi44	UTSW	3	151732534	missense	probably benign	0.00
R1747:Ifi44	UTSW	3	151749285	missense	probably benign	0.00
R2278:Ifi44	UTSW	3	151732388	missense	probably benign
R3816:Ifi44	UTSW	3	151749257	missense	possibly damaging	0.92
R4075:Ifi44	UTSW	3	151745976	missense	probably benign	0.00
R4084:Ifi44	UTSW	3	151745489	critical splice donor site	probably null
R4782:Ifi44	UTSW	3	151745592	missense	probably damaging	0.99
R5071:Ifi44	UTSW	3	151749632	start gained	probably benign
R5074:Ifi44	UTSW	3	151749632	start gained	probably benign
R6030:Ifi44	UTSW	3	151749558	missense	probably benign	0.00
R6030:Ifi44	UTSW	3	151749558	missense	probably benign	0.00
R6128:Ifi44	UTSW	3	151749186	missense	probably benign	0.00
R6192:Ifi44	UTSW	3	151745639	critical splice acceptor site	probably null
R6434:Ifi44	UTSW	3	151749189	missense	probably benign	0.02
R6536:Ifi44	UTSW	3	151732489	missense	probably benign	0.03
R6902:Ifi44	UTSW	3	151745899	missense	possibly damaging	0.92
R6946:Ifi44	UTSW	3	151745899	missense	possibly damaging	0.92
R7346:Ifi44	UTSW	3	151732457	missense	probably benign
R7608:Ifi44	UTSW	3	151732408	missense	probably damaging	0.97
R7704:Ifi44	UTSW	3	151732424	missense	probably benign	0.44
R7971:Ifi44	UTSW	3	151749220	missense	possibly damaging	0.89
R8255:Ifi44	UTSW	3	151745982	missense	probably benign	0.00
R8428:Ifi44	UTSW	3	151739341	nonsense	probably null
R8940:Ifi44	UTSW	3	151749309	missense	probably benign	0.00
R9087:Ifi44	UTSW	3	151745880	missense	probably damaging	1.00
R9259:Ifi44	UTSW	3	151749238	missense	possibly damaging	0.75
R9436:Ifi44	UTSW	3	151749249	missense	probably benign	0.00
Z1176:Ifi44	UTSW	3	151732453	missense	probably damaging	1.00
Z1177:Ifi44	UTSW	3	151749438	missense	probably damaging	1.00

Posted On

2013-12-09