Incidental Mutation 'IGL01571:Olfr763'
ID 93306
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr763
Ensembl Gene ENSMUSG00000063374
Gene Name olfactory receptor 763
Synonyms GA_x6K02T2PULF-10696986-10697915, MOR269-2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.072) question?
Stock # IGL01571
Quality Score
Status
Chromosome 10
Chromosomal Location 129010791-129013313 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 129011827 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 181 (I181F)
Ref Sequence ENSEMBL: ENSMUSP00000076671 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077460]
AlphaFold Q8VGC1
Predicted Effect probably damaging
Transcript: ENSMUST00000077460
AA Change: I181F

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000076671
Gene: ENSMUSG00000063374
AA Change: I181F

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 3.9e-46 PFAM
Pfam:7TM_GPCR_Srsx 35 305 3.3e-10 PFAM
Pfam:7tm_1 41 290 6.9e-15 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AB124611 T A 9: 21,539,081 probably benign Het
Cep164 T C 9: 45,794,338 Q127R possibly damaging Het
Ces1f T A 8: 93,258,368 M444L probably benign Het
Chd5 T A 4: 152,384,115 probably benign Het
Cpd T A 11: 76,782,296 Y1341F probably damaging Het
Cryz T C 3: 154,621,743 I268T probably damaging Het
Csnk2a1 G A 2: 152,275,406 R278H probably damaging Het
Cyp4a12b A G 4: 115,438,157 I487V probably benign Het
Dnajb5 T C 4: 42,956,516 probably benign Het
Dxo A T 17: 34,839,040 H214L probably damaging Het
Etfb T C 7: 43,452,959 probably null Het
G6pc2 G A 2: 69,222,967 V122I probably damaging Het
Gm5431 A T 11: 48,894,713 D278E probably benign Het
Gstt2 C T 10: 75,834,171 probably benign Het
Hnf4g A C 3: 3,651,266 probably benign Het
Ifi44 T C 3: 151,745,537 D259G probably damaging Het
Klk1 T C 7: 44,228,596 V92A probably damaging Het
Lypla1 T C 1: 4,844,988 I222T probably benign Het
Nbeal2 T C 9: 110,632,758 N1510D possibly damaging Het
Ndufaf7 A G 17: 78,943,852 R229G probably damaging Het
Nphp4 G A 4: 152,556,382 V1069M probably benign Het
Nsd2 A G 5: 33,864,687 H528R probably benign Het
Olfr1298 C A 2: 111,645,380 V206L probably benign Het
Olfr1355 A G 10: 78,879,837 I222V possibly damaging Het
Pigh A C 12: 79,085,860 probably benign Het
Prr14l A T 5: 32,828,806 M1115K probably benign Het
Psg21 T C 7: 18,654,825 D114G probably damaging Het
Psmg2 G A 18: 67,653,223 V218I probably benign Het
Pygb T C 2: 150,830,473 S831P probably benign Het
Ryr2 T A 13: 11,721,761 D2260V probably damaging Het
Sgo2a T C 1: 58,017,974 S1106P probably damaging Het
Slc5a5 G A 8: 70,891,332 probably benign Het
Tekt4 A G 17: 25,476,384 D397G probably benign Het
Trrap T A 5: 144,833,287 probably benign Het
Upf2 T C 2: 6,018,939 probably benign Het
Usp17lb A T 7: 104,840,381 N445K possibly damaging Het
Vmn2r111 A G 17: 22,571,392 V211A probably damaging Het
Vmn2r23 A G 6: 123,704,407 I91M probably damaging Het
Vps13b C T 15: 35,877,489 probably benign Het
Zc3hc1 G A 6: 30,390,863 T47I probably benign Het
Other mutations in Olfr763
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01448:Olfr763 APN 10 129011860 missense probably damaging 1.00
R0189:Olfr763 UTSW 10 129011322 missense possibly damaging 0.88
R2079:Olfr763 UTSW 10 129012029 missense probably damaging 1.00
R5074:Olfr763 UTSW 10 129011344 missense possibly damaging 0.55
R5363:Olfr763 UTSW 10 129011914 missense probably damaging 1.00
R5905:Olfr763 UTSW 10 129011287 start codon destroyed probably benign 0.01
R7943:Olfr763 UTSW 10 129012065 missense possibly damaging 0.88
R8195:Olfr763 UTSW 10 129011575 missense probably damaging 1.00
R8240:Olfr763 UTSW 10 129011897 missense possibly damaging 0.53
R8936:Olfr763 UTSW 10 129011933 missense probably benign 0.01
Z1177:Olfr763 UTSW 10 129011171 start gained probably benign
Posted On 2013-12-09