Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01571:Gstt2'

93313

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gstt2

Ensembl Gene

ENSMUSG00000033318

Gene Name

glutathione S-transferase, theta 2

Synonyms

Yrs, mGSTT2

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01571

Quality Score

Status

Chromosome

Chromosomal Location

75667676-75673253 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

C to T at 75670005 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000151239 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000038257] [ENSMUST00000218500] [ENSMUST00000220195] [ENSMUST00000220440]

AlphaFold

Q61133

Predicted Effect

probably benign
Transcript: ENSMUST00000038257

SMART Domains

Protein: ENSMUSP00000046324
Gene: ENSMUSG00000033318

Domain	Start	End	E-Value	Type
Pfam:GST_N	1	76	4.6e-12	PFAM
Pfam:GST_N_3	5	84	1.4e-11	PFAM
Pfam:GST_N_2	11	77	3.5e-10	PFAM
Pfam:GST_C	73	199	1.5e-10	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000218034

Predicted Effect

probably benign
Transcript: ENSMUST00000218500

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000218646

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000218745

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000219343

Predicted Effect

probably benign
Transcript: ENSMUST00000220195

Predicted Effect

probably benign
Transcript: ENSMUST00000220440

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a disruption in this gene display a normal phenotype. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
AB124611	T	A	9: 21,450,377 (GRCm39)		probably benign	Het
Cep164	T	C	9: 45,705,636 (GRCm39)	Q127R	possibly damaging	Het
Ces1f	T	A	8: 93,984,996 (GRCm39)	M444L	probably benign	Het
Chd5	T	A	4: 152,468,572 (GRCm39)		probably benign	Het
Cpd	T	A	11: 76,673,122 (GRCm39)	Y1341F	probably damaging	Het
Cryz	T	C	3: 154,327,380 (GRCm39)	I268T	probably damaging	Het
Csnk2a1	G	A	2: 152,117,326 (GRCm39)	R278H	probably damaging	Het
Cyp4a12b	A	G	4: 115,295,354 (GRCm39)	I487V	probably benign	Het
Dnajb5	T	C	4: 42,956,516 (GRCm39)		probably benign	Het
Dxo	A	T	17: 35,058,016 (GRCm39)	H214L	probably damaging	Het
Etfb	T	C	7: 43,102,383 (GRCm39)		probably null	Het
G6pc2	G	A	2: 69,053,311 (GRCm39)	V122I	probably damaging	Het
Gm5431	A	T	11: 48,785,540 (GRCm39)	D278E	probably benign	Het
Hnf4g	A	C	3: 3,716,326 (GRCm39)		probably benign	Het
Ifi44	T	C	3: 151,451,174 (GRCm39)	D259G	probably damaging	Het
Klk1	T	C	7: 43,878,020 (GRCm39)	V92A	probably damaging	Het
Lypla1	T	C	1: 4,915,211 (GRCm39)	I222T	probably benign	Het
Nbeal2	T	C	9: 110,461,826 (GRCm39)	N1510D	possibly damaging	Het
Ndufaf7	A	G	17: 79,251,281 (GRCm39)	R229G	probably damaging	Het
Nphp4	G	A	4: 152,640,839 (GRCm39)	V1069M	probably benign	Het
Nsd2	A	G	5: 34,022,031 (GRCm39)	H528R	probably benign	Het
Or10p21	A	T	10: 128,847,696 (GRCm39)	I181F	probably damaging	Het
Or4k48	C	A	2: 111,475,725 (GRCm39)	V206L	probably benign	Het
Or7a39	A	G	10: 78,715,671 (GRCm39)	I222V	possibly damaging	Het
Pigh	A	C	12: 79,132,634 (GRCm39)		probably benign	Het
Prr14l	A	T	5: 32,986,150 (GRCm39)	M1115K	probably benign	Het
Psg21	T	C	7: 18,388,750 (GRCm39)	D114G	probably damaging	Het
Psmg2	G	A	18: 67,786,293 (GRCm39)	V218I	probably benign	Het
Pygb	T	C	2: 150,672,393 (GRCm39)	S831P	probably benign	Het
Ryr2	T	A	13: 11,736,647 (GRCm39)	D2260V	probably damaging	Het
Sgo2a	T	C	1: 58,057,133 (GRCm39)	S1106P	probably damaging	Het
Slc5a5	G	A	8: 71,343,976 (GRCm39)		probably benign	Het
Tekt4	A	G	17: 25,695,358 (GRCm39)	D397G	probably benign	Het
Trrap	T	A	5: 144,770,097 (GRCm39)		probably benign	Het
Upf2	T	C	2: 6,023,750 (GRCm39)		probably benign	Het
Usp17lb	A	T	7: 104,489,588 (GRCm39)	N445K	possibly damaging	Het
Vmn2r111	A	G	17: 22,790,373 (GRCm39)	V211A	probably damaging	Het
Vmn2r23	A	G	6: 123,681,366 (GRCm39)	I91M	probably damaging	Het
Vps13b	C	T	15: 35,877,635 (GRCm39)		probably benign	Het
Zc3hc1	G	A	6: 30,390,862 (GRCm39)	T47I	probably benign	Het

Other mutations in Gstt2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01710:Gstt2	APN	10	75,669,579 (GRCm39)	splice site	probably benign
IGL02642:Gstt2	APN	10	75,668,652 (GRCm39)	missense	probably benign	0.17
IGL03375:Gstt2	APN	10	75,668,655 (GRCm39)	splice site	probably null
R0389:Gstt2	UTSW	10	75,668,266 (GRCm39)	missense	probably damaging	1.00
R1751:Gstt2	UTSW	10	75,670,098 (GRCm39)	missense	probably damaging	1.00
R1767:Gstt2	UTSW	10	75,670,098 (GRCm39)	missense	probably damaging	1.00
R1971:Gstt2	UTSW	10	75,668,499 (GRCm39)	missense	probably benign	0.10
R2367:Gstt2	UTSW	10	75,668,524 (GRCm39)	missense	probably benign	0.44
R5027:Gstt2	UTSW	10	75,667,726 (GRCm39)	missense	probably damaging	0.99
R7457:Gstt2	UTSW	10	75,668,354 (GRCm39)	missense	probably damaging	1.00
R7579:Gstt2	UTSW	10	75,670,019 (GRCm39)	missense	probably benign	0.00
R7910:Gstt2	UTSW	10	75,667,736 (GRCm39)	missense	probably benign	0.25
R7912:Gstt2	UTSW	10	75,668,418 (GRCm39)	missense	probably benign	0.27
R8282:Gstt2	UTSW	10	75,668,291 (GRCm39)	missense	probably benign	0.00
R8348:Gstt2	UTSW	10	75,668,526 (GRCm39)	missense	probably damaging	0.98
R8448:Gstt2	UTSW	10	75,668,526 (GRCm39)	missense	probably damaging	0.98
R8488:Gstt2	UTSW	10	75,667,823 (GRCm39)	missense	possibly damaging	0.69
R9259:Gstt2	UTSW	10	75,669,511 (GRCm39)	missense	possibly damaging	0.77
R9261:Gstt2	UTSW	10	75,669,511 (GRCm39)	missense	possibly damaging	0.77

Posted On

2013-12-09