Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01585:Lilra6'

93321

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lilra6

Ensembl Gene

ENSMUSG00000030427

Gene Name

leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6

Synonyms

Pira3, 7M1

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.079) question?

Stock #

IGL01585

Quality Score

Status

Chromosome

Chromosomal Location

3908280-3915503 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 3914499 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 166 (T166A)

Ref Sequence

ENSEMBL: ENSMUSP00000088188 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000038176] [ENSMUST00000090689] [ENSMUST00000206077]

AlphaFold

A0A0B4J1F3

Predicted Effect

probably benign
Transcript: ENSMUST00000038176
AA Change: T166A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000042636
Gene: ENSMUSG00000030427
AA Change: T166A

Domain	Start	End	E-Value	Type
low complexity region	8	17	N/A	INTRINSIC
IG_like	40	105	3.11e0	SMART
IG	129	315	4.53e-2	SMART
IG_like	237	302	1.54e-1	SMART
IG_like	328	415	1.79e1	SMART
IG_like	429	517	2.66e1	SMART
IG	529	618	8.59e-3	SMART
low complexity region	637	646	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000090689
AA Change: T166A

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000088188
Gene: ENSMUSG00000030427
AA Change: T166A

Domain	Start	End	E-Value	Type
low complexity region	8	17	N/A	INTRINSIC
IG_like	34	118	7.25e0	SMART
IG_like	129	220	1.62e2	SMART
IG_like	290	377	1.79e1	SMART
IG_like	391	479	2.66e1	SMART
IG	491	580	8.59e-3	SMART
low complexity region	599	608	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000131255

Predicted Effect

probably benign
Transcript: ENSMUST00000206077

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206851

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5430419D17Rik	T	G	7: 131,244,758	V637G	probably damaging	Het
Abca12	T	C	1: 71,319,886	D587G	probably benign	Het
Adcy1	T	A	11: 7,167,143	N1003K	probably damaging	Het
Alpk1	T	C	3: 127,679,813	D847G	probably benign	Het
Atp5a1	T	C	18: 77,781,058	V417A	possibly damaging	Het
Avp	A	C	2: 130,580,709	S159A	probably benign	Het
Brca2	C	A	5: 150,539,516	A915D	possibly damaging	Het
Cdc42bpg	G	A	19: 6,320,432	R1185H	possibly damaging	Het
Clrn2	A	G	5: 45,460,158	I124V	probably benign	Het
Cntn4	A	T	6: 106,618,328	K469*	probably null	Het
Cxcl1	T	A	5: 90,891,724	N70K	probably damaging	Het
Dbf4	A	G	5: 8,408,492		probably null	Het
Fbn1	A	T	2: 125,360,110	V1281E	probably damaging	Het
Fgfr3	A	T	5: 33,733,961	Q523L	probably damaging	Het
Golga5	A	G	12: 102,479,695	K403R	probably benign	Het
Gpr22	A	G	12: 31,709,337	I262T	probably benign	Het
Gstm3	G	T	3: 107,966,158	Q166K	probably benign	Het
Ilf2	T	A	3: 90,484,542	N183K	probably damaging	Het
Ip6k2	T	A	9: 108,796,313	L40Q	probably damaging	Het
Itga8	A	T	2: 12,160,312		probably benign	Het
Lbr	T	A	1: 181,825,643	R70*	probably null	Het
Map3k4	T	C	17: 12,248,959	K1063E	probably damaging	Het
Msi1	T	C	5: 115,430,890		probably null	Het
Pam	A	G	1: 97,864,472	V408A	probably damaging	Het
Plxna1	A	G	6: 89,329,556		probably null	Het
Ppp1r36	A	T	12: 76,439,117		probably null	Het
Prrt4	A	G	6: 29,177,690	S27P	probably benign	Het
Psmg1	G	A	16: 95,988,021	T112I	possibly damaging	Het
Rfx7	T	G	9: 72,617,061	I511S	probably benign	Het
Ros1	G	A	10: 52,155,102	T481M	probably damaging	Het
Scfd1	A	G	12: 51,415,553	D397G	probably damaging	Het
Sel1l3	A	G	5: 53,154,236	Y636H	probably damaging	Het
Sgms1	T	G	19: 32,142,845	R220S	probably damaging	Het
Slc37a3	A	T	6: 39,337,262	I472N	probably damaging	Het
Syne2	A	G	12: 75,949,060		probably null	Het
Tert	T	C	13: 73,634,344	V579A	probably benign	Het
Ush2a	A	T	1: 188,430,727	H1002L	probably damaging	Het

Other mutations in Lilra6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00508:Lilra6	APN	7	3911554	missense	probably benign	0.04
IGL00569:Lilra6	APN	7	3914589	missense	probably damaging	0.99
IGL00899:Lilra6	APN	7	3913057	missense	probably damaging	1.00
IGL00955:Lilra6	APN	7	3911404	splice site	probably benign
IGL02195:Lilra6	APN	7	3914550	missense	probably benign	0.00
IGL02586:Lilra6	APN	7	3908820	missense	probably benign	0.36
IGL02719:Lilra6	APN	7	3912992	missense	possibly damaging	0.96
IGL03166:Lilra6	APN	7	3912627	missense	possibly damaging	0.69
IGL03329:Lilra6	APN	7	3914648	splice site	probably benign
R0233:Lilra6	UTSW	7	3914936	missense	possibly damaging	0.69
R0233:Lilra6	UTSW	7	3914936	missense	possibly damaging	0.69
R0423:Lilra6	UTSW	7	3914775	splice site	probably benign
R0483:Lilra6	UTSW	7	3913139	missense	probably benign	0.02
R0511:Lilra6	UTSW	7	3912785	missense	possibly damaging	0.77
R1472:Lilra6	UTSW	7	3912719	missense	probably damaging	1.00
R1560:Lilra6	UTSW	7	3911408	critical splice donor site	probably null
R1584:Lilra6	UTSW	7	3912662	missense	probably damaging	1.00
R1781:Lilra6	UTSW	7	3915067	missense	probably benign	0.28
R2411:Lilra6	UTSW	7	3911454	missense	probably damaging	1.00
R2420:Lilra6	UTSW	7	3914858	missense	probably damaging	1.00
R4021:Lilra6	UTSW	7	3911418	missense	probably benign	0.20
R4074:Lilra6	UTSW	7	3914890	missense	probably benign	0.23
R4284:Lilra6	UTSW	7	3908804	missense	possibly damaging	0.76
R4508:Lilra6	UTSW	7	3912029	nonsense	probably null
R4894:Lilra6	UTSW	7	3912531	missense	probably benign	0.01
R4977:Lilra6	UTSW	7	3914383	missense	probably benign	0.01
R5048:Lilra6	UTSW	7	3915441	critical splice donor site	probably null
R5164:Lilra6	UTSW	7	3914881	missense	probably damaging	1.00
R5185:Lilra6	UTSW	7	3914636	missense	probably benign	0.00
R5527:Lilra6	UTSW	7	3914587	start gained	probably benign
R6281:Lilra6	UTSW	7	3911973	missense	probably damaging	1.00
R6480:Lilra6	UTSW	7	3912933	missense	probably damaging	1.00
R6512:Lilra6	UTSW	7	3914388	missense	probably benign	0.06
R6565:Lilra6	UTSW	7	3915020	missense	probably benign
R7017:Lilra6	UTSW	7	3908708	missense	possibly damaging	0.93
R7095:Lilra6	UTSW	7	3913197	missense	probably damaging	1.00
R7747:Lilra6	UTSW	7	3912996	missense	probably benign	0.16
R8056:Lilra6	UTSW	7	3912552	missense	probably damaging	1.00
R8280:Lilra6	UTSW	7	3913047	missense	probably benign	0.01
R9197:Lilra6	UTSW	7	3912717	missense	possibly damaging	0.94
R9354:Lilra6	UTSW	7	3911629	missense	probably damaging	1.00
R9379:Lilra6	UTSW	7	3913167	missense	probably damaging	1.00
R9406:Lilra6	UTSW	7	3914854	missense	probably benign
R9462:Lilra6	UTSW	7	3911995	missense	probably damaging	0.97
Z1176:Lilra6	UTSW	7	3915074	critical splice acceptor site	probably null
Z1177:Lilra6	UTSW	7	3912581	missense	possibly damaging	0.48

Posted On

2013-12-09