Incidental Mutation 'IGL01595:Mapk15'
ID93376
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mapk15
Ensembl Gene ENSMUSG00000063704
Gene Namemitogen-activated protein kinase 15
Synonyms
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01595
Quality Score
Status
Chromosome15
Chromosomal Location75993769-75999154 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 75995280 bp
ZygosityHeterozygous
Amino Acid Change Proline to Glutamine at position 82 (P82Q)
Ref Sequence ENSEMBL: ENSMUSP00000087098 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089669]
Predicted Effect probably benign
Transcript: ENSMUST00000089669
AA Change: P82Q

PolyPhen 2 Score 0.040 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000087098
Gene: ENSMUSG00000063704
AA Change: P82Q

DomainStartEndE-ValueType
S_TKc 14 305 7.08e-97 SMART
low complexity region 391 404 N/A INTRINSIC
low complexity region 424 434 N/A INTRINSIC
low complexity region 475 505 N/A INTRINSIC
low complexity region 513 525 N/A INTRINSIC
low complexity region 538 548 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160092
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160637
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161961
Predicted Effect probably benign
Transcript: ENSMUST00000230929
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acbd5 A G 2: 23,078,169 M111V probably damaging Het
Adamts14 A T 10: 61,205,473 H819Q probably damaging Het
Adamts7 T A 9: 90,193,306 N1072K probably benign Het
Ahnak T A 19: 9,003,501 Y716* probably null Het
Arfgef3 T C 10: 18,594,912 K1702E possibly damaging Het
BB014433 C A 8: 15,042,499 probably null Het
Bdnf A T 2: 109,723,928 K176* probably null Het
C2cd5 C T 6: 143,018,022 R879H probably damaging Het
Capn11 T A 17: 45,639,434 H327L probably benign Het
Ccdc68 A G 18: 69,956,046 N220S probably benign Het
Cftr T C 6: 18,198,239 probably benign Het
Clca2 G A 3: 145,088,007 L296F probably damaging Het
Cubn A T 2: 13,325,216 L2618Q probably benign Het
Gfi1b A G 2: 28,611,417 probably null Het
Gpr37 G T 6: 25,669,573 T424N probably damaging Het
Kank3 G A 17: 33,819,180 probably null Het
Kcnh5 T C 12: 74,898,327 Q716R probably benign Het
Kntc1 G A 5: 123,803,695 M1817I probably benign Het
Krt79 T G 15: 101,931,771 E330A probably damaging Het
Myh15 A T 16: 49,172,949 D1649V probably damaging Het
Myo1d T C 11: 80,676,110 I326V probably benign Het
Nek9 A T 12: 85,314,420 W504R probably damaging Het
Nlrp4c T A 7: 6,066,112 C337* probably null Het
Nup160 A G 2: 90,729,737 N1269D probably damaging Het
Olfr250 T C 9: 38,368,050 V168A probably benign Het
Olfr594 A G 7: 103,220,351 D211G probably damaging Het
Olfr661 T C 7: 104,688,078 M21T possibly damaging Het
Pde6a A G 18: 61,281,528 M36V probably damaging Het
Perp A G 10: 18,855,659 Q122R probably damaging Het
S100a7a T C 3: 90,657,800 Y101H probably benign Het
Sbk2 C A 7: 4,957,713 V153L possibly damaging Het
Serpinb7 A T 1: 107,428,322 N25I probably damaging Het
Tbx5 A T 5: 119,840,838 D105V probably damaging Het
Trip6 T A 5: 137,313,413 T101S probably benign Het
Ush2a T A 1: 188,654,724 probably null Het
Other mutations in Mapk15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02075:Mapk15 APN 15 75994888 missense probably benign 0.35
IGL02395:Mapk15 APN 15 75998170 missense probably benign
IGL03052:Mapk15 UTSW 15 75993882 missense probably benign 0.01
R0008:Mapk15 UTSW 15 75998254 missense probably benign 0.08
R0109:Mapk15 UTSW 15 75996077 nonsense probably null
R0109:Mapk15 UTSW 15 75996077 nonsense probably null
R1148:Mapk15 UTSW 15 75998155 missense probably benign
R1148:Mapk15 UTSW 15 75998155 missense probably benign
R2406:Mapk15 UTSW 15 75998848 missense possibly damaging 0.75
R4526:Mapk15 UTSW 15 75995255 missense possibly damaging 0.83
R4572:Mapk15 UTSW 15 75998750 splice site probably benign
R4613:Mapk15 UTSW 15 75995910 missense probably damaging 0.98
R5861:Mapk15 UTSW 15 75996359 unclassified probably benign
R6912:Mapk15 UTSW 15 75993898 missense probably damaging 0.99
R7554:Mapk15 UTSW 15 75995896 missense possibly damaging 0.63
R7620:Mapk15 UTSW 15 75998848 missense probably benign 0.00
Z1177:Mapk15 UTSW 15 75998461 nonsense probably null
Posted On2013-12-09