Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01632:Mup14'

93484

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mup14

Ensembl Gene

ENSMUSG00000073830

Gene Name

major urinary protein 14

Synonyms

Gm13514

Accession Numbers

Essential gene?

Not available question?

Stock #

IGL01632

Quality Score

Status

Chromosome

Chromosomal Location

61256022-61259999 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 61259383 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 56 (F56L)

Ref Sequence

ENSEMBL: ENSMUSP00000074696 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071005] [ENSMUST00000075206] [ENSMUST00000125461]

AlphaFold

A2CEK7

Predicted Effect

probably benign
Transcript: ENSMUST00000071005
AA Change: F56L

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000064072
Gene: ENSMUSG00000073830
AA Change: F56L

Domain	Start	End	E-Value	Type
low complexity region	4	13	N/A	INTRINSIC
Pfam:Lipocalin	34	173	2.8e-34	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000075206
AA Change: F56L

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000074696
Gene: ENSMUSG00000073830
AA Change: F56L

Domain	Start	End	E-Value	Type
low complexity region	4	13	N/A	INTRINSIC
Pfam:Lipocalin	34	173	2.8e-34	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000125461
AA Change: F27L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000115821
Gene: ENSMUSG00000073830
AA Change: F27L

Domain	Start	End	E-Value	Type
Pfam:Lipocalin	5	143	7.5e-33	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000136039

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgra2	G	A	8: 27,608,761 (GRCm39)	A540T	possibly damaging	Het
Alms1	T	A	6: 85,604,928 (GRCm39)	C1724S	probably benign	Het
Anapc10	T	C	8: 80,439,795 (GRCm39)	M1T	probably null	Het
Antxrl	A	G	14: 33,789,904 (GRCm39)	N332S	probably damaging	Het
Cdkl3	A	G	11: 51,895,899 (GRCm39)	R49G	probably damaging	Het
Chodl	A	G	16: 78,741,452 (GRCm39)		probably benign	Het
Clca3a1	G	T	3: 144,733,202 (GRCm39)	A102D	probably damaging	Het
Clip1	T	C	5: 123,755,559 (GRCm39)	E1029G	probably damaging	Het
Cpeb2	T	A	5: 43,394,765 (GRCm39)	I581N	probably benign	Het
Dmxl1	T	C	18: 49,996,092 (GRCm39)	V406A	probably damaging	Het
Dnah17	C	T	11: 117,924,707 (GRCm39)	R3960Q	probably damaging	Het
Fstl5	A	G	3: 76,615,135 (GRCm39)	D732G	probably benign	Het
Fyb2	G	T	4: 104,853,008 (GRCm39)	V499L	probably benign	Het
Gm43191	A	T	3: 116,445,116 (GRCm39)	H39Q	probably damaging	Het
Hspg2	A	G	4: 137,242,084 (GRCm39)	K606R	probably damaging	Het
Klk1b27	C	T	7: 43,706,097 (GRCm39)		probably benign	Het
Mdga2	T	C	12: 66,676,672 (GRCm39)		probably benign	Het
Myh15	A	G	16: 48,881,874 (GRCm39)	K39E	probably benign	Het
Or1j10	A	T	2: 36,267,576 (GRCm39)	N263Y	probably benign	Het
Or5m12	A	G	2: 85,734,714 (GRCm39)	I228T	probably benign	Het
Ppp1r3a	T	A	6: 14,754,810 (GRCm39)	I146F	probably damaging	Het
Ryr2	A	G	13: 11,609,854 (GRCm39)	I759T	probably damaging	Het
Sfmbt1	T	C	14: 30,539,669 (GRCm39)	I819T	probably damaging	Het
Siglec1	A	G	2: 130,925,740 (GRCm39)	V322A	probably benign	Het
Spata3	T	C	1: 85,950,030 (GRCm39)	V87A	possibly damaging	Het
Tacstd2	A	G	6: 67,511,783 (GRCm39)	V303A	possibly damaging	Het
Taok3	T	A	5: 117,403,993 (GRCm39)	F723I	possibly damaging	Het
Tektl1	T	C	10: 78,584,536 (GRCm39)	S329G	probably benign	Het
Vmn1r210	A	T	13: 23,011,366 (GRCm39)	*307R	probably null	Het
Vmn2r70	T	C	7: 85,215,280 (GRCm39)	I85V	probably benign	Het
Zfp384	T	C	6: 125,001,724 (GRCm39)	I123T	probably damaging	Het

Other mutations in Mup14

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R7429:Mup14	UTSW	4	61,259,447 (GRCm39)	missense	probably damaging	1.00
R7430:Mup14	UTSW	4	61,259,447 (GRCm39)	missense	probably damaging	1.00
R7489:Mup14	UTSW	4	61,259,887 (GRCm39)	start codon destroyed	probably null
R8227:Mup14	UTSW	4	61,258,494 (GRCm39)	missense	probably benign	0.06
R9056:Mup14	UTSW	4	61,259,430 (GRCm39)	missense	probably benign
R9088:Mup14	UTSW	4	61,258,496 (GRCm39)	missense	probably damaging	0.99

Posted On

2013-12-09