Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00648:Cage1'

9352

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cage1

Ensembl Gene

ENSMUSG00000044566

Gene Name

cancer antigen 1

Synonyms

Ctag3, CAGE1, 4933427I01Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.099) question?

Stock #

IGL00648

Quality Score

Status

Chromosome

Chromosomal Location

38190028-38221045 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to T at 38206969 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Stop codon at position 398 (S398*)

Ref Sequence

ENSEMBL: ENSMUSP00000105862 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000074969] [ENSMUST00000089840] [ENSMUST00000110233] [ENSMUST00000131066]

AlphaFold

Q5IR70

Predicted Effect

probably null
Transcript: ENSMUST00000074969
AA Change: S398*

SMART Domains

Protein: ENSMUSP00000074499
Gene: ENSMUSG00000044566
AA Change: S398*

Domain	Start	End	E-Value	Type
Pfam:CAGE1	1	526	5.1e-292	PFAM
low complexity region	664	682	N/A	INTRINSIC
coiled coil region	778	811	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000089840
AA Change: S292*

SMART Domains

Protein: ENSMUSP00000087278
Gene: ENSMUSG00000044566
AA Change: S292*

Domain	Start	End	E-Value	Type
Pfam:CAGE1	1	420	6.8e-230	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000110233
AA Change: S398*

SMART Domains

Protein: ENSMUSP00000105862
Gene: ENSMUSG00000044566
AA Change: S398*

Domain	Start	End	E-Value	Type
Pfam:CAGE1	1	526	2.4e-255	PFAM
low complexity region	664	682	N/A	INTRINSIC
coiled coil region	778	811	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000131066

SMART Domains

Protein: ENSMUSP00000122393
Gene: ENSMUSG00000044566

Domain	Start	End	E-Value	Type
Pfam:CAGE1	1	318	6.5e-167	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 12 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Calr	T	A	8: 85,569,331 (GRCm39)		probably benign	Het
Cmah	A	T	13: 24,644,259 (GRCm39)	K459*	probably null	Het
Edem1	T	A	6: 108,828,168 (GRCm39)		probably null	Het
Elp4	A	T	2: 105,672,711 (GRCm39)		probably benign	Het
Fam3b	C	T	16: 97,279,599 (GRCm39)	G110E	probably damaging	Het
Fmnl3	G	A	15: 99,220,551 (GRCm39)	T577I	probably damaging	Het
Nbea	A	G	3: 55,916,681 (GRCm39)	S860P	probably damaging	Het
Nlrp1a	T	C	11: 70,983,783 (GRCm39)	T1082A	probably benign	Het
Pbrm1	A	T	14: 30,774,240 (GRCm39)	I469F	probably damaging	Het
Ptprq	G	A	10: 107,482,577 (GRCm39)	L999F	probably benign	Het
Taar6	C	T	10: 23,861,406 (GRCm39)	V47M	probably benign	Het
Tom1l2	T	C	11: 60,151,942 (GRCm39)	Y155C	possibly damaging	Het

Other mutations in Cage1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01736:Cage1	APN	13	38,206,789 (GRCm39)	missense	possibly damaging	0.93
IGL02149:Cage1	APN	13	38,206,505 (GRCm39)	missense	probably damaging	1.00
IGL02267:Cage1	APN	13	38,207,233 (GRCm39)	missense	probably damaging	1.00
IGL03030:Cage1	APN	13	38,212,123 (GRCm39)	missense	probably benign
IGL03216:Cage1	APN	13	38,190,153 (GRCm39)	splice site	probably benign
R0487:Cage1	UTSW	13	38,209,334 (GRCm39)	missense	probably benign	0.00
R0606:Cage1	UTSW	13	38,200,470 (GRCm39)	splice site	probably benign
R1015:Cage1	UTSW	13	38,200,451 (GRCm39)	missense	possibly damaging	0.96
R1170:Cage1	UTSW	13	38,206,856 (GRCm39)	missense	probably damaging	1.00
R1400:Cage1	UTSW	13	38,216,400 (GRCm39)	missense	possibly damaging	0.86
R1721:Cage1	UTSW	13	38,207,309 (GRCm39)	nonsense	probably null
R2057:Cage1	UTSW	13	38,207,356 (GRCm39)	missense	probably benign	0.04
R2058:Cage1	UTSW	13	38,207,356 (GRCm39)	missense	probably benign	0.04
R2059:Cage1	UTSW	13	38,207,356 (GRCm39)	missense	probably benign	0.04
R2197:Cage1	UTSW	13	38,207,029 (GRCm39)	missense	probably damaging	1.00
R3757:Cage1	UTSW	13	38,209,705 (GRCm39)	missense	possibly damaging	0.71
R3758:Cage1	UTSW	13	38,209,705 (GRCm39)	missense	possibly damaging	0.71
R4041:Cage1	UTSW	13	38,203,153 (GRCm39)	missense	possibly damaging	0.96
R4370:Cage1	UTSW	13	38,209,626 (GRCm39)	missense	probably damaging	1.00
R4401:Cage1	UTSW	13	38,207,078 (GRCm39)	missense	probably damaging	1.00
R4402:Cage1	UTSW	13	38,207,078 (GRCm39)	missense	probably damaging	1.00
R4403:Cage1	UTSW	13	38,207,078 (GRCm39)	missense	probably damaging	1.00
R4490:Cage1	UTSW	13	38,207,393 (GRCm39)	missense	possibly damaging	0.86
R4621:Cage1	UTSW	13	38,209,477 (GRCm39)	missense	possibly damaging	0.85
R4921:Cage1	UTSW	13	38,203,184 (GRCm39)	missense	probably benign	0.33
R4950:Cage1	UTSW	13	38,207,302 (GRCm39)	missense	possibly damaging	0.55
R4953:Cage1	UTSW	13	38,207,406 (GRCm39)	missense	possibly damaging	0.51
R5023:Cage1	UTSW	13	38,195,387 (GRCm39)	nonsense	probably null
R5808:Cage1	UTSW	13	38,206,301 (GRCm39)	unclassified	probably benign
R5845:Cage1	UTSW	13	38,199,682 (GRCm39)	missense	probably damaging	0.96
R6278:Cage1	UTSW	13	38,200,395 (GRCm39)	missense	possibly damaging	0.53
R6503:Cage1	UTSW	13	38,209,425 (GRCm39)	missense	possibly damaging	0.73
R6882:Cage1	UTSW	13	38,206,534 (GRCm39)	missense	probably damaging	1.00
R7146:Cage1	UTSW	13	38,207,025 (GRCm39)	missense	probably benign	0.03
R7192:Cage1	UTSW	13	38,203,220 (GRCm39)	missense	probably benign
R7529:Cage1	UTSW	13	38,209,731 (GRCm39)	missense	possibly damaging	0.71
R7580:Cage1	UTSW	13	38,206,700 (GRCm39)	missense	possibly damaging	0.90
R7646:Cage1	UTSW	13	38,206,823 (GRCm39)	missense	probably damaging	1.00
R7837:Cage1	UTSW	13	38,206,381 (GRCm39)	missense	not run
R8355:Cage1	UTSW	13	38,203,225 (GRCm39)	missense	probably damaging	0.99
R8435:Cage1	UTSW	13	38,203,161 (GRCm39)	missense	possibly damaging	0.73
R8466:Cage1	UTSW	13	38,206,987 (GRCm39)	missense	probably damaging	1.00
R9047:Cage1	UTSW	13	38,201,338 (GRCm39)	missense	possibly damaging	0.85
R9086:Cage1	UTSW	13	38,206,898 (GRCm39)	missense	probably damaging	1.00
R9146:Cage1	UTSW	13	38,207,005 (GRCm39)	missense	probably benign	0.16
R9442:Cage1	UTSW	13	38,196,447 (GRCm39)	missense	possibly damaging	0.72
R9587:Cage1	UTSW	13	38,207,233 (GRCm39)	missense	probably damaging	1.00
R9608:Cage1	UTSW	13	38,195,371 (GRCm39)	missense	possibly damaging	0.73
R9612:Cage1	UTSW	13	38,216,351 (GRCm39)	missense	probably damaging	0.99
R9630:Cage1	UTSW	13	38,206,855 (GRCm39)	missense	probably damaging	1.00
R9690:Cage1	UTSW	13	38,203,141 (GRCm39)	critical splice donor site	probably null
R9736:Cage1	UTSW	13	38,207,393 (GRCm39)	missense	probably damaging	0.99

Posted On

2012-12-06