Incidental Mutation 'IGL01634:Vmn2r16'
| ID |
93533 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r16
|
| Ensembl Gene |
ENSMUSG00000092080 |
| Gene Name |
vomeronasal 2, receptor 16 |
| Synonyms |
EG384220 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.154)
|
| Stock # |
IGL01634
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
5 |
| Chromosomal Location |
109478247-109512347 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 109488177 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 350
(M350K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000127838
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000165180]
|
| AlphaFold |
A0A3B2WCY4 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000165180
AA Change: M350K
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000127838
Gene: ENSMUSG00000092080
AA Change: M350K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
76 |
425 |
2.3e-28 |
PFAM |
|
Pfam:NCD3G
|
509 |
563 |
8.2e-19 |
PFAM |
|
Pfam:7tm_3
|
596 |
831 |
3.5e-56 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 64 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700034H15Rik |
A |
T |
1: 191,633,016 (GRCm39) |
|
noncoding transcript |
Het |
| 4933421I07Rik |
C |
T |
7: 42,097,123 (GRCm39) |
D63N |
probably benign |
Het |
| Alg9 |
C |
A |
9: 50,686,677 (GRCm39) |
|
probably null |
Het |
| Anln |
T |
C |
9: 22,271,771 (GRCm39) |
T695A |
probably benign |
Het |
| Aox4 |
G |
T |
1: 58,261,089 (GRCm39) |
D141Y |
possibly damaging |
Het |
| Arhgap21 |
C |
A |
2: 20,919,455 (GRCm39) |
Q84H |
probably benign |
Het |
| Arnt |
G |
A |
3: 95,377,709 (GRCm39) |
|
probably benign |
Het |
| Atp8a2 |
T |
A |
14: 60,235,511 (GRCm39) |
Y677F |
probably benign |
Het |
| Car6 |
C |
T |
4: 150,282,610 (GRCm39) |
V12M |
probably benign |
Het |
| Cd209d |
A |
T |
8: 3,927,974 (GRCm39) |
|
probably null |
Het |
| Ctnna1 |
T |
A |
18: 35,356,501 (GRCm39) |
V390E |
probably damaging |
Het |
| Cypt4 |
T |
A |
9: 24,536,952 (GRCm39) |
N147K |
possibly damaging |
Het |
| Dnah10 |
C |
A |
5: 124,898,405 (GRCm39) |
A3729E |
probably damaging |
Het |
| Dusp8 |
A |
G |
7: 141,638,160 (GRCm39) |
V156A |
probably benign |
Het |
| Ecm1 |
G |
A |
3: 95,642,211 (GRCm39) |
P458L |
probably damaging |
Het |
| Fat3 |
T |
G |
9: 15,909,654 (GRCm39) |
Y2116S |
probably damaging |
Het |
| Fscn3 |
T |
A |
6: 28,430,537 (GRCm39) |
Y236N |
probably damaging |
Het |
| Gaa |
G |
A |
11: 119,164,902 (GRCm39) |
S265N |
possibly damaging |
Het |
| Gas7 |
T |
C |
11: 67,565,057 (GRCm39) |
|
probably benign |
Het |
| Gbp8 |
T |
C |
5: 105,166,438 (GRCm39) |
K297R |
probably damaging |
Het |
| Gm1818 |
G |
A |
12: 48,602,992 (GRCm39) |
|
noncoding transcript |
Het |
| Gm5114 |
G |
T |
7: 39,058,071 (GRCm39) |
T516K |
probably benign |
Het |
| Hectd1 |
A |
G |
12: 51,850,562 (GRCm39) |
S165P |
probably damaging |
Het |
| Hoxb4 |
G |
T |
11: 96,209,726 (GRCm39) |
R44L |
probably damaging |
Het |
| Ivd |
G |
A |
2: 118,706,863 (GRCm39) |
R285H |
probably damaging |
Het |
| Krtap20-2 |
T |
C |
16: 89,002,977 (GRCm39) |
F59S |
unknown |
Het |
| Megf8 |
G |
A |
7: 25,058,206 (GRCm39) |
|
probably benign |
Het |
| Mgat4d |
A |
T |
8: 84,094,745 (GRCm39) |
M261L |
possibly damaging |
Het |
| Mlc1 |
A |
T |
15: 88,858,921 (GRCm39) |
|
probably benign |
Het |
| Mmp20 |
T |
A |
9: 7,635,149 (GRCm39) |
Y43* |
probably null |
Het |
| Morc3 |
G |
A |
16: 93,670,125 (GRCm39) |
V767I |
probably benign |
Het |
| Myo15a |
A |
G |
11: 60,386,298 (GRCm39) |
T1808A |
probably damaging |
Het |
| Notch4 |
T |
C |
17: 34,791,562 (GRCm39) |
F574L |
probably damaging |
Het |
| Npas3 |
G |
A |
12: 53,993,946 (GRCm39) |
V164M |
probably damaging |
Het |
| Nptx1 |
A |
G |
11: 119,435,498 (GRCm39) |
Y273H |
probably damaging |
Het |
| Oaf |
T |
C |
9: 43,135,301 (GRCm39) |
N159S |
probably damaging |
Het |
| Or10a3n |
A |
T |
7: 108,493,292 (GRCm39) |
F107L |
probably benign |
Het |
| Or4c111 |
T |
A |
2: 88,843,788 (GRCm39) |
I207F |
probably damaging |
Het |
| Or5ak24 |
A |
T |
2: 85,260,783 (GRCm39) |
L130H |
probably damaging |
Het |
| Pgm2 |
T |
C |
5: 64,258,317 (GRCm39) |
F101L |
probably benign |
Het |
| Pkd1l3 |
A |
C |
8: 110,394,157 (GRCm39) |
|
probably null |
Het |
| Plcd1 |
C |
T |
9: 118,902,857 (GRCm39) |
R527H |
probably damaging |
Het |
| Rexo2 |
C |
T |
9: 48,380,215 (GRCm39) |
E206K |
probably damaging |
Het |
| Ropn1 |
C |
A |
16: 34,487,148 (GRCm39) |
T28N |
possibly damaging |
Het |
| Ropn1 |
A |
T |
16: 34,487,141 (GRCm39) |
I26F |
probably damaging |
Het |
| Rpgrip1l |
C |
A |
8: 91,979,171 (GRCm39) |
S998I |
probably benign |
Het |
| Rpgrip1l |
T |
A |
8: 91,979,172 (GRCm39) |
S998C |
probably benign |
Het |
| Scap |
T |
C |
9: 110,207,857 (GRCm39) |
|
probably null |
Het |
| Sec23b |
T |
C |
2: 144,401,150 (GRCm39) |
Y4H |
probably damaging |
Het |
| Sfrp4 |
C |
A |
13: 19,807,800 (GRCm39) |
D66E |
possibly damaging |
Het |
| Slc25a36 |
T |
C |
9: 96,962,534 (GRCm39) |
T13A |
probably benign |
Het |
| Synpr |
A |
T |
14: 13,608,576 (GRCm38) |
I119F |
possibly damaging |
Het |
| Tamm41 |
A |
C |
6: 114,993,059 (GRCm39) |
H109Q |
probably benign |
Het |
| Tet1 |
A |
T |
10: 62,714,367 (GRCm39) |
I476K |
possibly damaging |
Het |
| Tg |
A |
T |
15: 66,601,415 (GRCm39) |
I142F |
probably benign |
Het |
| Thada |
A |
T |
17: 84,700,786 (GRCm39) |
|
probably null |
Het |
| Triobp |
T |
C |
15: 78,877,568 (GRCm39) |
L1654P |
probably damaging |
Het |
| Trpm7 |
A |
G |
2: 126,668,738 (GRCm39) |
V726A |
probably damaging |
Het |
| Txndc15 |
T |
G |
13: 55,869,438 (GRCm39) |
V197G |
probably damaging |
Het |
| Ubr3 |
A |
T |
2: 69,803,916 (GRCm39) |
T1169S |
probably benign |
Het |
| Uhmk1 |
C |
T |
1: 170,034,682 (GRCm39) |
|
probably null |
Het |
| Vmn2r77 |
G |
A |
7: 86,460,857 (GRCm39) |
V728I |
probably benign |
Het |
| Wipf1 |
G |
A |
2: 73,278,225 (GRCm39) |
P7S |
unknown |
Het |
| Zswim3 |
A |
G |
2: 164,661,922 (GRCm39) |
D134G |
probably damaging |
Het |
|
| Other mutations in Vmn2r16 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01116:Vmn2r16
|
APN |
5 |
109,488,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01374:Vmn2r16
|
APN |
5 |
109,478,283 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01391:Vmn2r16
|
APN |
5 |
109,511,627 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL01419:Vmn2r16
|
APN |
5 |
109,510,267 (GRCm39) |
splice site |
probably benign |
|
|
IGL01845:Vmn2r16
|
APN |
5 |
109,511,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01875:Vmn2r16
|
APN |
5 |
109,478,277 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01910:Vmn2r16
|
APN |
5 |
109,487,951 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02217:Vmn2r16
|
APN |
5 |
109,487,676 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02327:Vmn2r16
|
APN |
5 |
109,487,987 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02491:Vmn2r16
|
APN |
5 |
109,487,703 (GRCm39) |
nonsense |
probably null |
|
|
IGL02531:Vmn2r16
|
APN |
5 |
109,488,134 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02680:Vmn2r16
|
APN |
5 |
109,487,948 (GRCm39) |
missense |
probably benign |
0.44 |
|
IGL02884:Vmn2r16
|
APN |
5 |
109,508,757 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03084:Vmn2r16
|
APN |
5 |
109,478,292 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03096:Vmn2r16
|
APN |
5 |
109,487,751 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03355:Vmn2r16
|
APN |
5 |
109,511,580 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R0280:Vmn2r16
|
UTSW |
5 |
109,488,005 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0594:Vmn2r16
|
UTSW |
5 |
109,511,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1016:Vmn2r16
|
UTSW |
5 |
109,487,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1109:Vmn2r16
|
UTSW |
5 |
109,487,652 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1248:Vmn2r16
|
UTSW |
5 |
109,508,643 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1626:Vmn2r16
|
UTSW |
5 |
109,511,443 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1909:Vmn2r16
|
UTSW |
5 |
109,511,853 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1929:Vmn2r16
|
UTSW |
5 |
109,487,124 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1982:Vmn2r16
|
UTSW |
5 |
109,511,890 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3038:Vmn2r16
|
UTSW |
5 |
109,487,199 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3437:Vmn2r16
|
UTSW |
5 |
109,478,362 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3734:Vmn2r16
|
UTSW |
5 |
109,478,280 (GRCm39) |
missense |
probably benign |
0.11 |
|
R3820:Vmn2r16
|
UTSW |
5 |
109,510,143 (GRCm39) |
missense |
probably benign |
0.36 |
|
R3873:Vmn2r16
|
UTSW |
5 |
109,488,177 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4165:Vmn2r16
|
UTSW |
5 |
109,478,427 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4373:Vmn2r16
|
UTSW |
5 |
109,511,667 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4575:Vmn2r16
|
UTSW |
5 |
109,511,665 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4576:Vmn2r16
|
UTSW |
5 |
109,511,665 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4578:Vmn2r16
|
UTSW |
5 |
109,511,665 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4637:Vmn2r16
|
UTSW |
5 |
109,478,280 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4696:Vmn2r16
|
UTSW |
5 |
109,487,168 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5026:Vmn2r16
|
UTSW |
5 |
109,508,722 (GRCm39) |
nonsense |
probably null |
|
|
R5180:Vmn2r16
|
UTSW |
5 |
109,478,391 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5433:Vmn2r16
|
UTSW |
5 |
109,511,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5955:Vmn2r16
|
UTSW |
5 |
109,511,613 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R5958:Vmn2r16
|
UTSW |
5 |
109,510,153 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6353:Vmn2r16
|
UTSW |
5 |
109,488,119 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6389:Vmn2r16
|
UTSW |
5 |
109,478,344 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6819:Vmn2r16
|
UTSW |
5 |
109,488,412 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6994:Vmn2r16
|
UTSW |
5 |
109,487,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7061:Vmn2r16
|
UTSW |
5 |
109,511,620 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7063:Vmn2r16
|
UTSW |
5 |
109,511,650 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7220:Vmn2r16
|
UTSW |
5 |
109,508,772 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7268:Vmn2r16
|
UTSW |
5 |
109,488,331 (GRCm39) |
nonsense |
probably null |
|
|
R7420:Vmn2r16
|
UTSW |
5 |
109,511,736 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7591:Vmn2r16
|
UTSW |
5 |
109,510,223 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7644:Vmn2r16
|
UTSW |
5 |
109,487,837 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7939:Vmn2r16
|
UTSW |
5 |
109,487,705 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R7977:Vmn2r16
|
UTSW |
5 |
109,488,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7987:Vmn2r16
|
UTSW |
5 |
109,488,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8023:Vmn2r16
|
UTSW |
5 |
109,488,272 (GRCm39) |
nonsense |
probably null |
|
|
R8427:Vmn2r16
|
UTSW |
5 |
109,488,138 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8436:Vmn2r16
|
UTSW |
5 |
109,511,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8475:Vmn2r16
|
UTSW |
5 |
109,487,073 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8554:Vmn2r16
|
UTSW |
5 |
109,511,997 (GRCm39) |
missense |
probably benign |
0.13 |
|
R8771:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8774:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8774-TAIL:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8775:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8775-TAIL:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8777:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8777-TAIL:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8825:Vmn2r16
|
UTSW |
5 |
109,487,019 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8865:Vmn2r16
|
UTSW |
5 |
109,487,910 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8900:Vmn2r16
|
UTSW |
5 |
109,511,619 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9365:Vmn2r16
|
UTSW |
5 |
109,488,064 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9683:Vmn2r16
|
UTSW |
5 |
109,511,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0027:Vmn2r16
|
UTSW |
5 |
109,487,175 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r16
|
UTSW |
5 |
109,511,779 (GRCm39) |
frame shift |
probably null |
|
|
Z1088:Vmn2r16
|
UTSW |
5 |
109,488,381 (GRCm39) |
missense |
probably benign |
0.03 |
|
Z1177:Vmn2r16
|
UTSW |
5 |
109,487,864 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
| Posted On |
2013-12-09 |
Incidental Mutation