Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01633:Fam35a'

93613

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fam35a

Ensembl Gene

ENSMUSG00000041471

Gene Name

family with sequence similarity 35, member A

Synonyms

3110001K24Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.099) question?

Stock #

IGL01633

Quality Score

Status

Chromosome

Chromosomal Location

34237033-34310493 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 34249179 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Lysine at position 31 (T31K)

Ref Sequence

ENSEMBL: ENSMUSP00000154214 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000111917] [ENSMUST00000228704]

AlphaFold

Q3UEN2

Predicted Effect

probably damaging
Transcript: ENSMUST00000111917
AA Change: T583K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000107548
Gene: ENSMUSG00000041471
AA Change: T583K

Domain	Start	End	E-Value	Type
low complexity region	66	75	N/A	INTRINSIC
low complexity region	163	177	N/A	INTRINSIC
Pfam:FAM35_C	694	866	4.6e-84	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000228704
AA Change: T31K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca2	T	A	2: 25,444,394	S1868T	possibly damaging	Het
Abca3	G	A	17: 24,397,353	W923*	probably null	Het
Abca8b	A	G	11: 109,936,754	M1476T	probably damaging	Het
Abi3bp	T	C	16: 56,677,800	F729S	probably damaging	Het
Acacb	T	C	5: 114,218,858		probably benign	Het
Aldh3a2	A	G	11: 61,248,905	L467P	probably benign	Het
Appl1	T	C	14: 26,962,838	T85A	probably damaging	Het
Aspm	T	A	1: 139,480,836	I2487N	possibly damaging	Het
Bcl2a1c	G	A	9: 114,330,222	V23I	probably benign	Het
C2cd2	T	A	16: 97,875,123		probably benign	Het
Carmil3	A	T	14: 55,494,227	H170L	possibly damaging	Het
Ccdc141	C	T	2: 77,089,249	V305I	probably benign	Het
Ccdc174	G	A	6: 91,880,362		probably null	Het
Cep126	T	G	9: 8,103,319	Q230P	possibly damaging	Het
Chrm1	T	C	19: 8,678,495	I188T	probably benign	Het
Depdc5	T	C	5: 32,924,200	S569P	probably damaging	Het
Drc1	G	A	5: 30,345,663	E177K	probably damaging	Het
Duox1	A	G	2: 122,333,798	E913G	probably benign	Het
Fbxw9	T	C	8: 85,064,426	S241P	probably damaging	Het
Fez2	C	A	17: 78,404,718		probably benign	Het
Fga	G	T	3: 83,030,299	R161L	possibly damaging	Het
Fn3krp	G	T	11: 121,429,707	G293*	probably null	Het
Gfra1	C	T	19: 58,267,047	E318K	probably benign	Het
Gli3	C	T	13: 15,648,634	P314S	probably damaging	Het
Gm5114	A	T	7: 39,408,066	S710T	probably benign	Het
Gpr141	T	C	13: 19,752,599	D2G	probably benign	Het
Inppl1	G	A	7: 101,833,834	Q63*	probably null	Het
Lrrc73	T	A	17: 46,255,731	V169E	possibly damaging	Het
Lsm11	C	T	11: 45,933,788	R304Q	probably benign	Het
Macf1	T	C	4: 123,502,171	D788G	probably damaging	Het
Nbas	T	A	12: 13,483,897	D1844E	probably damaging	Het
Nt5c	A	G	11: 115,491,335	F73L	probably damaging	Het
Osmr	A	T	15: 6,824,604	I541N	probably damaging	Het
Phrf1	A	G	7: 141,260,500	I1203V	probably benign	Het
Pram1	C	A	17: 33,642,135	P510Q	possibly damaging	Het
Prepl	A	G	17: 85,072,016	Y415H	probably benign	Het
Prss27	A	T	17: 24,045,676	H271L	probably damaging	Het
Ptpn18	A	G	1: 34,471,908	S287G	probably benign	Het
Ptprq	T	C	10: 107,699,723		probably benign	Het
Sars2	A	G	7: 28,747,549	K218E	probably benign	Het
Senp6	G	T	9: 80,092,394	S31I	probably damaging	Het
Skint6	C	A	4: 113,238,049	V138F	probably damaging	Het
Slc4a8	C	A	15: 100,787,247	H168N	probably damaging	Het
Tbx15	T	G	3: 99,313,042	I150S	probably damaging	Het
Tbxas1	A	G	6: 38,982,191	N103D	probably benign	Het
Tmc5	A	G	7: 118,623,586	N170D	probably damaging	Het
Tmem108	A	T	9: 103,484,751	N545K	probably benign	Het
Trub1	A	G	19: 57,453,184	K80E	possibly damaging	Het
Tulp3	A	T	6: 128,325,960	Y299N	probably damaging	Het

Other mutations in Fam35a

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00157:Fam35a	APN	14	34268625	missense	probably benign	0.02
IGL00962:Fam35a	APN	14	34249251	missense	probably damaging	1.00
IGL01288:Fam35a	APN	14	34259643	missense	probably benign	0.00
IGL01302:Fam35a	APN	14	34259727	missense	probably benign	0.03
IGL01312:Fam35a	APN	14	34268193	missense	possibly damaging	0.56
IGL01444:Fam35a	APN	14	34237557	missense	probably damaging	1.00
IGL02251:Fam35a	APN	14	34268278	missense	probably benign	0.10
IGL02927:Fam35a	APN	14	34267701	missense	probably damaging	1.00
IGL03183:Fam35a	APN	14	34245186	missense	probably benign	0.02
IGL03226:Fam35a	APN	14	34268371	missense	probably benign	0.08
R0111:Fam35a	UTSW	14	34267729	missense	probably damaging	0.98
R1170:Fam35a	UTSW	14	34268491	missense	possibly damaging	0.92
R1348:Fam35a	UTSW	14	34268923	missense	probably damaging	1.00
R1467:Fam35a	UTSW	14	34268662	missense	possibly damaging	0.92
R1467:Fam35a	UTSW	14	34268662	missense	possibly damaging	0.92
R1538:Fam35a	UTSW	14	34268876	missense	probably damaging	1.00
R1602:Fam35a	UTSW	14	34267650	missense	probably damaging	1.00
R1650:Fam35a	UTSW	14	34259617	intron	probably benign
R1777:Fam35a	UTSW	14	34268173	missense	probably benign	0.07
R1843:Fam35a	UTSW	14	34267803	missense	probably benign	0.01
R2425:Fam35a	UTSW	14	34268689	missense	probably damaging	0.96
R3837:Fam35a	UTSW	14	34249185	missense	probably damaging	0.99
R3838:Fam35a	UTSW	14	34245368	missense	probably benign	0.01
R3904:Fam35a	UTSW	14	34259709	missense	probably damaging	1.00
R3964:Fam35a	UTSW	14	34259687	missense	probably damaging	1.00
R4322:Fam35a	UTSW	14	34259675	missense	probably damaging	0.99
R4708:Fam35a	UTSW	14	34267833	missense	probably benign	0.17
R4771:Fam35a	UTSW	14	34268706	missense	probably damaging	1.00
R4838:Fam35a	UTSW	14	34268625	missense	probably benign	0.02
R5448:Fam35a	UTSW	14	34268370	missense	probably benign	0.32
R5874:Fam35a	UTSW	14	34245258	missense	probably benign	0.08
R6332:Fam35a	UTSW	14	34268172	missense	probably benign	0.07
R6333:Fam35a	UTSW	14	34267608	missense	probably damaging	1.00
R6476:Fam35a	UTSW	14	34268014	missense	probably benign	0.27
R6576:Fam35a	UTSW	14	34268242	missense	probably damaging	1.00
R7172:Fam35a	UTSW	14	34237568	missense	probably damaging	1.00
R7574:Fam35a	UTSW	14	34237466	missense	probably damaging	1.00
R7725:Fam35a	UTSW	14	34268704	missense	possibly damaging	0.86
R7755:Fam35a	UTSW	14	34248890	missense	probably damaging	0.99
R7840:Fam35a	UTSW	14	34237566	missense	probably damaging	1.00
R7881:Fam35a	UTSW	14	34267767	missense	possibly damaging	0.63
R7947:Fam35a	UTSW	14	34268479	missense	probably benign	0.27
R8192:Fam35a	UTSW	14	34245216	missense	probably benign	0.04
R8443:Fam35a	UTSW	14	34267985	missense	probably benign	0.00
R8492:Fam35a	UTSW	14	34245232	missense	probably damaging	0.99
R9323:Fam35a	UTSW	14	34259639	missense	probably damaging	0.98
R9524:Fam35a	UTSW	14	34249288	nonsense	probably null
X0009:Fam35a	UTSW	14	34245186	missense	probably benign	0.02
Z1177:Fam35a	UTSW	14	34241471	missense	probably benign	0.31
Z1177:Fam35a	UTSW	14	34268598	missense	probably damaging	1.00

Posted On

2013-12-09