Incidental Mutation 'IGL01642:Or10ak16'
ID 93665
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10ak16
Ensembl Gene ENSMUSG00000073768
Gene Name olfactory receptor family 10 subfamily AK member 16
Synonyms Olfr1330, MOR259-8, GA_x6K02T2QD9B-18644371-18643424
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # IGL01642
Quality Score
Status
Chromosome 4
Chromosomal Location 118750282-118751229 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 118750658 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 126 (Y126C)
Ref Sequence ENSEMBL: ENSMUSP00000101968 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094830] [ENSMUST00000105035] [ENSMUST00000106361]
AlphaFold Q8VEY6
Predicted Effect probably damaging
Transcript: ENSMUST00000094830
AA Change: Y126C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000092425
Gene: ENSMUSG00000073768
AA Change: Y126C

DomainStartEndE-ValueType
Pfam:7tm_4 34 310 1.2e-53 PFAM
Pfam:7TM_GPCR_Srsx 38 308 1.4e-6 PFAM
Pfam:7tm_1 44 293 1.6e-25 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000105035
AA Change: Y126C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000100652
Gene: ENSMUSG00000073768
AA Change: Y126C

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 38 307 6.4e-8 PFAM
Pfam:7tm_1 44 293 2.9e-31 PFAM
Pfam:7tm_4 142 286 6.7e-46 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000106361
AA Change: Y126C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000101968
Gene: ENSMUSG00000073768
AA Change: Y126C

DomainStartEndE-ValueType
Pfam:7tm_4 33 309 6.1e-56 PFAM
Pfam:7tm_1 43 292 3.9e-25 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215186
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216386
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aanat A G 11: 116,486,514 (GRCm39) T18A possibly damaging Het
Abat A T 16: 8,418,783 (GRCm39) I126F possibly damaging Het
Adcy6 G A 15: 98,492,390 (GRCm39) A958V possibly damaging Het
Ago2 T C 15: 72,995,239 (GRCm39) I447V probably benign Het
Arid1a A G 4: 133,409,155 (GRCm39) V1784A unknown Het
Atp1b1 A G 1: 164,285,330 (GRCm39) F33L probably benign Het
Bpnt1 G A 1: 185,086,238 (GRCm39) V198I probably benign Het
Cemip2 T A 19: 21,801,265 (GRCm39) I794N probably damaging Het
Cfap251 T C 5: 123,426,761 (GRCm39) V383A possibly damaging Het
Cgas G A 9: 78,344,680 (GRCm39) P247L probably damaging Het
Clip3 G A 7: 29,998,287 (GRCm39) M244I probably benign Het
Clip3 A T 7: 29,996,494 (GRCm39) probably benign Het
Cyp2a22 A T 7: 26,638,184 (GRCm39) N107K possibly damaging Het
Cyp2c23 A T 19: 43,993,995 (GRCm39) L457Q probably damaging Het
Dbr1 A G 9: 99,458,031 (GRCm39) Y17C probably damaging Het
Drc7 G A 8: 95,785,767 (GRCm39) V208I probably benign Het
Dst T A 1: 34,228,470 (GRCm39) L2021Q probably damaging Het
E2f4 C A 8: 106,027,968 (GRCm39) P299T probably damaging Het
Eef1b2 T C 1: 63,216,990 (GRCm39) L53P probably damaging Het
Enpp3 T C 10: 24,674,167 (GRCm39) T378A probably damaging Het
Eps15 A G 4: 109,223,670 (GRCm39) N302S probably benign Het
Esrrg G A 1: 187,943,112 (GRCm39) V362M probably benign Het
Gcc2 T A 10: 58,116,434 (GRCm39) N1014K probably benign Het
Gm3099 T A 14: 15,346,476 (GRCm39) M114K possibly damaging Het
Gnptab C T 10: 88,271,994 (GRCm39) T928I possibly damaging Het
Gpd2 A T 2: 57,158,083 (GRCm39) R31* probably null Het
Impdh1 T C 6: 29,207,165 (GRCm39) T60A possibly damaging Het
Kcnab3 A G 11: 69,221,256 (GRCm39) E191G probably benign Het
Kcnh5 A G 12: 75,011,943 (GRCm39) S659P probably damaging Het
Kl T C 5: 150,904,334 (GRCm39) I362T possibly damaging Het
Kpna4 A G 3: 68,993,117 (GRCm39) V414A probably damaging Het
Magi1 G A 6: 93,663,605 (GRCm39) P1111S possibly damaging Het
Myo18a A G 11: 77,755,558 (GRCm39) D1965G probably benign Het
Nadsyn1 G A 7: 143,351,615 (GRCm39) P673S probably damaging Het
Naip2 A G 13: 100,297,445 (GRCm39) S864P probably damaging Het
Or2d2b A T 7: 106,706,029 (GRCm39) I13N possibly damaging Het
Or2f1 G T 6: 42,721,486 (GRCm39) V172L probably benign Het
Paics T A 5: 77,109,357 (GRCm39) probably benign Het
Papss1 G T 3: 131,288,996 (GRCm39) probably benign Het
Pax3 A G 1: 78,173,300 (GRCm39) probably null Het
Pgbd5 T G 8: 125,110,941 (GRCm39) Q159P probably benign Het
Pkd1 A G 17: 24,800,266 (GRCm39) Y3009C probably damaging Het
Pla2g4d T C 2: 120,111,117 (GRCm39) T161A probably damaging Het
Podxl2 T A 6: 88,820,529 (GRCm39) Y521F probably damaging Het
Pramel34 A G 5: 93,784,154 (GRCm39) Y437H possibly damaging Het
Prmt2 C T 10: 76,058,327 (GRCm39) G161S probably damaging Het
Rft1 C T 14: 30,398,825 (GRCm39) T265I probably damaging Het
Rims2 T A 15: 39,321,192 (GRCm39) L736M probably damaging Het
Slf1 C T 13: 77,198,034 (GRCm39) A747T probably benign Het
Snx2 A G 18: 53,349,519 (GRCm39) K427E probably damaging Het
Tmem131l A T 3: 83,845,357 (GRCm39) D424E possibly damaging Het
Tnxb A G 17: 34,937,488 (GRCm39) T3826A probably damaging Het
Tpp2 T C 1: 43,993,813 (GRCm39) Y233H probably damaging Het
Ubl4b C A 3: 107,462,147 (GRCm39) E38* probably null Het
Usp5 A T 6: 124,797,416 (GRCm39) I486N probably damaging Het
Vmn1r193 A C 13: 22,403,794 (GRCm39) L66R probably damaging Het
Vps13b T C 15: 35,792,218 (GRCm39) I2162T probably benign Het
Wipf2 T C 11: 98,781,650 (GRCm39) V63A probably benign Het
Zfp735 G T 11: 73,601,305 (GRCm39) C83F possibly damaging Het
Zfyve26 T C 12: 79,308,348 (GRCm39) probably null Het
Other mutations in Or10ak16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01385:Or10ak16 APN 4 118,750,748 (GRCm39) missense probably benign 0.00
R0402:Or10ak16 UTSW 4 118,750,426 (GRCm39) missense possibly damaging 0.95
R0418:Or10ak16 UTSW 4 118,750,448 (GRCm39) missense possibly damaging 0.51
R0646:Or10ak16 UTSW 4 118,750,687 (GRCm39) missense probably damaging 0.96
R1075:Or10ak16 UTSW 4 118,750,402 (GRCm39) missense probably damaging 1.00
R1743:Or10ak16 UTSW 4 118,750,723 (GRCm39) missense probably benign
R1950:Or10ak16 UTSW 4 118,750,537 (GRCm39) missense probably benign 0.22
R2265:Or10ak16 UTSW 4 118,751,071 (GRCm39) missense probably damaging 1.00
R2268:Or10ak16 UTSW 4 118,751,071 (GRCm39) missense probably damaging 1.00
R2269:Or10ak16 UTSW 4 118,751,071 (GRCm39) missense probably damaging 1.00
R4648:Or10ak16 UTSW 4 118,751,147 (GRCm39) missense possibly damaging 0.84
R5635:Or10ak16 UTSW 4 118,750,832 (GRCm39) missense probably benign 0.31
R6881:Or10ak16 UTSW 4 118,750,304 (GRCm39) missense probably damaging 1.00
R7351:Or10ak16 UTSW 4 118,751,033 (GRCm39) missense probably benign 0.05
R7412:Or10ak16 UTSW 4 118,750,327 (GRCm39) missense possibly damaging 0.83
R8402:Or10ak16 UTSW 4 118,750,716 (GRCm39) missense probably benign 0.01
R9355:Or10ak16 UTSW 4 118,750,784 (GRCm39) missense probably benign 0.00
Posted On 2013-12-09