Incidental Mutation 'R1036:Dcaf13'
ID 93820
Institutional Source Beutler Lab
Gene Symbol Dcaf13
Ensembl Gene ENSMUSG00000022300
Gene Name DDB1 and CUL4 associated factor 13
Synonyms Wdsof1, LOC223499
MMRRC Submission 039135-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.955) question?
Stock # R1036 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 38976300-39010251 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 39007113 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 349 (I349N)
Ref Sequence ENSEMBL: ENSMUSP00000022909 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022909]
AlphaFold Q6PAC3
Predicted Effect probably damaging
Transcript: ENSMUST00000022909
AA Change: I349N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000022909
Gene: ENSMUSG00000022300
AA Change: I349N

DomainStartEndE-ValueType
WD40 55 95 5.77e-5 SMART
WD40 98 137 4.38e-5 SMART
WD40 185 225 5.97e-1 SMART
Blast:WD40 228 267 1e-18 BLAST
WD40 271 310 2.69e-5 SMART
WD40 312 353 2.96e-2 SMART
Pfam:Sof1 354 440 7.2e-38 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000122613
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226224
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227219
Meta Mutation Damage Score 0.9423 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.9%
  • 10x: 94.7%
  • 20x: 86.2%
Validation Efficiency 100% (40/40)
Allele List at MGI

All alleles(9) : Targeted, other(2) Gene trapped(7)

Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aasdh G A 5: 77,024,130 (GRCm39) T174M probably damaging Het
Abca12 A G 1: 71,302,569 (GRCm39) probably null Het
Abcg1 C A 17: 31,330,243 (GRCm39) Q515K probably damaging Het
Acaa1b A T 9: 118,979,884 (GRCm39) probably benign Het
Adamts3 T C 5: 89,843,952 (GRCm39) probably benign Het
Aoah A C 13: 21,024,339 (GRCm39) probably benign Het
Arhgap10 G A 8: 78,037,398 (GRCm39) P610L probably damaging Het
Casq2 G T 3: 102,049,531 (GRCm39) A295S probably damaging Het
Col6a4 A G 9: 105,945,397 (GRCm39) Y906H probably damaging Het
Ecd A G 14: 20,383,386 (GRCm39) probably benign Het
Enpep C A 3: 129,077,758 (GRCm39) V620L probably damaging Het
Fbln7 A G 2: 128,735,815 (GRCm39) S268G possibly damaging Het
Fcho1 C T 8: 72,165,204 (GRCm39) A418T probably benign Het
Gatd1 T A 7: 140,989,045 (GRCm39) T205S probably damaging Het
Gbe1 T A 16: 70,325,775 (GRCm39) V604E probably damaging Het
Ghsr T A 3: 27,428,869 (GRCm39) I298N probably damaging Het
Glis1 T C 4: 107,489,461 (GRCm39) Y683H probably benign Het
Gpr162 T A 6: 124,837,823 (GRCm39) I276F probably damaging Het
Hps6 A G 19: 45,992,680 (GRCm39) T206A probably benign Het
Kcnk10 T C 12: 98,462,445 (GRCm39) probably benign Het
Krt90 A G 15: 101,471,151 (GRCm39) V37A probably benign Het
Lmbr1 T C 5: 29,463,745 (GRCm39) K160E probably damaging Het
Nif3l1 A G 1: 58,487,032 (GRCm39) T73A probably damaging Het
Nup107 A T 10: 117,593,199 (GRCm39) D826E probably damaging Het
Nup210l C T 3: 90,100,247 (GRCm39) probably benign Het
Omd A G 13: 49,743,447 (GRCm39) R166G probably damaging Het
Plekha4 T C 7: 45,199,400 (GRCm39) probably benign Het
Ptgdr A G 14: 45,096,572 (GRCm39) S47P probably damaging Het
Sec24c A G 14: 20,742,965 (GRCm39) I940V probably benign Het
Shkbp1 A G 7: 27,044,721 (GRCm39) S457P possibly damaging Het
Skint1 T C 4: 111,876,493 (GRCm39) V138A possibly damaging Het
Slc38a9 A G 13: 112,838,193 (GRCm39) probably benign Het
Spata31e5 A G 1: 28,816,883 (GRCm39) L383P probably benign Het
Srsf7 A T 17: 80,513,266 (GRCm39) probably benign Het
Stau1 T C 2: 166,793,235 (GRCm39) K300R probably damaging Het
Stox1 A T 10: 62,503,674 (GRCm39) I127K probably damaging Het
Sympk G A 7: 18,782,378 (GRCm39) R832Q probably damaging Het
Usp3 A G 9: 66,437,513 (GRCm39) probably benign Het
Other mutations in Dcaf13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00787:Dcaf13 APN 15 39,007,027 (GRCm39) nonsense probably null
IGL01081:Dcaf13 APN 15 38,982,201 (GRCm39) missense probably damaging 1.00
IGL01766:Dcaf13 APN 15 38,982,145 (GRCm39) missense probably benign 0.00
IGL02174:Dcaf13 APN 15 39,001,544 (GRCm39) missense probably damaging 1.00
IGL02262:Dcaf13 APN 15 38,982,102 (GRCm39) splice site probably benign
IGL02740:Dcaf13 APN 15 39,008,495 (GRCm39) nonsense probably null
IGL03092:Dcaf13 APN 15 38,991,371 (GRCm39) splice site probably benign
IGL03374:Dcaf13 APN 15 39,008,543 (GRCm39) nonsense probably null
R0590:Dcaf13 UTSW 15 39,008,480 (GRCm39) splice site probably benign
R0594:Dcaf13 UTSW 15 38,986,663 (GRCm39) missense probably benign 0.00
R0711:Dcaf13 UTSW 15 39,001,484 (GRCm39) missense probably damaging 1.00
R1770:Dcaf13 UTSW 15 38,993,633 (GRCm39) missense probably damaging 1.00
R1826:Dcaf13 UTSW 15 38,982,294 (GRCm39) missense probably damaging 1.00
R1933:Dcaf13 UTSW 15 39,001,483 (GRCm39) missense probably damaging 0.99
R2508:Dcaf13 UTSW 15 39,008,547 (GRCm39) missense probably benign
R4113:Dcaf13 UTSW 15 38,993,615 (GRCm39) missense probably damaging 0.98
R4595:Dcaf13 UTSW 15 38,982,288 (GRCm39) missense probably damaging 1.00
R4649:Dcaf13 UTSW 15 39,001,637 (GRCm39) missense possibly damaging 0.54
R5431:Dcaf13 UTSW 15 38,986,619 (GRCm39) missense probably benign 0.16
R5454:Dcaf13 UTSW 15 38,987,759 (GRCm39) missense probably benign
R5834:Dcaf13 UTSW 15 39,007,037 (GRCm39) nonsense probably null
R5929:Dcaf13 UTSW 15 39,007,048 (GRCm39) missense possibly damaging 0.89
R5944:Dcaf13 UTSW 15 39,010,072 (GRCm39) missense probably benign
R6319:Dcaf13 UTSW 15 39,007,067 (GRCm39) missense probably benign 0.00
R6394:Dcaf13 UTSW 15 39,007,132 (GRCm39) missense probably benign 0.04
R6664:Dcaf13 UTSW 15 38,982,283 (GRCm39) missense probably damaging 1.00
R6884:Dcaf13 UTSW 15 38,986,635 (GRCm39) missense probably damaging 1.00
R7419:Dcaf13 UTSW 15 38,993,615 (GRCm39) missense probably damaging 0.98
R8750:Dcaf13 UTSW 15 38,982,836 (GRCm39) missense probably damaging 1.00
R8944:Dcaf13 UTSW 15 39,001,612 (GRCm39) missense possibly damaging 0.79
R9294:Dcaf13 UTSW 15 38,993,687 (GRCm39) missense possibly damaging 0.92
R9300:Dcaf13 UTSW 15 39,010,102 (GRCm39) missense probably damaging 1.00
R9663:Dcaf13 UTSW 15 38,982,178 (GRCm39) missense possibly damaging 0.88
R9696:Dcaf13 UTSW 15 39,001,496 (GRCm39) missense possibly damaging 0.80
R9778:Dcaf13 UTSW 15 39,008,586 (GRCm39) missense probably damaging 0.99
Z1088:Dcaf13 UTSW 15 39,008,642 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGGAGAAGCCAACTTTTGTGGAGTTT -3'
(R):5'- CCTTCCATCACAATGGTGTTACCCTGA -3'

Sequencing Primer
(F):5'- CTCCAGACACAAAAGTGGTTTTTC -3'
(R):5'- CACAATGGTGTTACCCTGATTAAG -3'
Posted On 2014-01-05