Incidental Mutation 'R1037:Opcml'
ID 93873
Institutional Source Beutler Lab
Gene Symbol Opcml
Ensembl Gene ENSMUSG00000062257
Gene Name opioid binding protein/cell adhesion molecule-like
Synonyms 2900075O15Rik, B930023M13Rik, Obcam, LOC235104
MMRRC Submission 039136-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R1037 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 27702071-28836706 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 28814595 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 290 (D290E)
Ref Sequence ENSEMBL: ENSMUSP00000073493 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073822] [ENSMUST00000115243]
AlphaFold G5E8G3
Predicted Effect probably damaging
Transcript: ENSMUST00000073822
AA Change: D290E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000073493
Gene: ENSMUSG00000062257
AA Change: D290E

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
IG 42 133 2.94e-10 SMART
IGc2 148 209 2.91e-14 SMART
IGc2 235 303 2e-12 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000115243
AA Change: D282E

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000110898
Gene: ENSMUSG00000062257
AA Change: D282E

DomainStartEndE-ValueType
IG 35 126 2.94e-10 SMART
IGc2 141 201 1.36e-14 SMART
IGc2 227 295 2e-12 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215483
Meta Mutation Damage Score 0.5466 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.1%
  • 10x: 94.3%
  • 20x: 85.9%
Validation Efficiency 100% (58/58)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933405L10Rik A G 8: 106,436,144 (GRCm39) S139G probably benign Het
Abca2 T A 2: 25,328,240 (GRCm39) probably benign Het
Abcb1b A T 5: 8,875,657 (GRCm39) N610I probably benign Het
Ahnak T C 19: 8,984,982 (GRCm39) F2089L probably benign Het
Cacnb1 T C 11: 97,895,843 (GRCm39) probably benign Het
Cep57 T C 9: 13,730,275 (GRCm39) I61V possibly damaging Het
Ckap5 T C 2: 91,380,974 (GRCm39) I110T probably benign Het
Clasp2 T C 9: 113,725,702 (GRCm39) probably benign Het
Col11a1 A C 3: 113,987,801 (GRCm39) E265A probably damaging Het
Cst13 A G 2: 148,672,251 (GRCm39) probably benign Het
Cyp24a1 G A 2: 170,333,537 (GRCm39) T272M probably damaging Het
Cyp4a14 A C 4: 115,347,193 (GRCm39) L415R probably damaging Het
Dbnl T C 11: 5,746,807 (GRCm39) F179S probably damaging Het
Eepd1 T C 9: 25,498,079 (GRCm39) L388P possibly damaging Het
Exosc8 G T 3: 54,640,159 (GRCm39) A55E probably damaging Het
Fam72a G A 1: 131,461,557 (GRCm39) V81I probably damaging Het
Fasn C T 11: 120,700,277 (GRCm39) M2182I probably benign Het
Fras1 C T 5: 96,862,322 (GRCm39) P2234S probably damaging Het
Grn C A 11: 102,323,896 (GRCm39) D33E possibly damaging Het
Gsap A G 5: 21,456,163 (GRCm39) probably benign Het
H2bc15 T A 13: 21,938,417 (GRCm39) V42E probably damaging Het
Hook3 T C 8: 26,562,378 (GRCm39) Q229R possibly damaging Het
Itgb6 T C 2: 60,480,412 (GRCm39) E308G probably damaging Het
Kmo C T 1: 175,479,184 (GRCm39) P240L possibly damaging Het
Lrrc4c A G 2: 97,460,330 (GRCm39) M319V probably benign Het
Mia3 T C 1: 183,138,698 (GRCm39) I672M probably benign Het
Mib2 C T 4: 155,743,917 (GRCm39) G42S probably damaging Het
Mlc1 A G 15: 88,849,664 (GRCm39) L223P probably damaging Het
Mmp21 T C 7: 133,276,182 (GRCm39) K554E probably benign Het
Nup160 C T 2: 90,524,246 (GRCm39) T383I probably damaging Het
Or10a3b T A 7: 108,445,191 (GRCm39) T9S probably benign Het
Or4a27 T A 2: 88,559,376 (GRCm39) D189V probably damaging Het
Or5ac19 C T 16: 59,089,307 (GRCm39) C241Y probably damaging Het
Or5d38 A G 2: 87,954,573 (GRCm39) I252T probably damaging Het
Or5k14 T C 16: 58,693,333 (GRCm39) Y60C probably damaging Het
Palm3 C A 8: 84,755,901 (GRCm39) T471K probably benign Het
Prl2c5 T A 13: 13,360,492 (GRCm39) L50* probably null Het
Pzp T C 6: 128,496,389 (GRCm39) N281S probably benign Het
Qser1 T C 2: 104,590,900 (GRCm39) Y1722C probably damaging Het
Ryr3 A G 2: 112,699,453 (GRCm39) V879A probably benign Het
Sbno1 A G 5: 124,531,975 (GRCm39) S736P possibly damaging Het
Septin5 G A 16: 18,441,844 (GRCm39) probably benign Het
Slc17a6 A G 7: 51,298,996 (GRCm39) probably benign Het
Spag17 A T 3: 100,010,433 (GRCm39) T1976S probably benign Het
Swt1 A T 1: 151,246,320 (GRCm39) probably benign Het
Tenm4 T C 7: 96,446,688 (GRCm39) W853R probably damaging Het
Thbs1 A T 2: 117,953,532 (GRCm39) Q983L probably damaging Het
Tmem191 A G 16: 17,094,347 (GRCm39) probably benign Het
Tmprss11g A T 5: 86,638,606 (GRCm39) V294D probably damaging Het
Tor1aip2 A G 1: 155,941,082 (GRCm39) S463G probably benign Het
Trim36 A G 18: 46,329,385 (GRCm39) probably benign Het
Ttc1 A G 11: 43,621,326 (GRCm39) V285A possibly damaging Het
Uckl1 C T 2: 181,214,278 (GRCm39) R303H possibly damaging Het
Vwa8 C A 14: 79,324,094 (GRCm39) C1132* probably null Het
Other mutations in Opcml
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00864:Opcml APN 9 28,812,887 (GRCm39) missense probably damaging 1.00
IGL00864:Opcml APN 9 28,812,886 (GRCm39) missense probably damaging 1.00
IGL00956:Opcml APN 9 28,586,624 (GRCm39) missense possibly damaging 0.86
IGL02391:Opcml APN 9 28,586,560 (GRCm39) missense probably damaging 0.96
IGL03210:Opcml APN 9 28,812,833 (GRCm39) missense probably damaging 0.99
R0373:Opcml UTSW 9 28,724,694 (GRCm39) missense possibly damaging 0.48
R1564:Opcml UTSW 9 28,814,612 (GRCm39) missense probably damaging 1.00
R2094:Opcml UTSW 9 28,812,886 (GRCm39) missense probably damaging 1.00
R2268:Opcml UTSW 9 28,814,651 (GRCm39) missense possibly damaging 0.91
R2426:Opcml UTSW 9 28,814,663 (GRCm39) critical splice donor site probably null
R2938:Opcml UTSW 9 27,702,682 (GRCm39) start codon destroyed probably null 0.00
R3746:Opcml UTSW 9 28,812,826 (GRCm39) missense possibly damaging 0.54
R4058:Opcml UTSW 9 28,812,884 (GRCm39) missense probably damaging 1.00
R4173:Opcml UTSW 9 28,814,654 (GRCm39) missense probably benign
R4882:Opcml UTSW 9 28,812,886 (GRCm39) missense probably damaging 1.00
R5335:Opcml UTSW 9 28,586,621 (GRCm39) missense possibly damaging 0.88
R7058:Opcml UTSW 9 28,586,507 (GRCm39) nonsense probably null
R7559:Opcml UTSW 9 28,814,620 (GRCm39) missense probably benign
R8050:Opcml UTSW 9 28,724,640 (GRCm39) missense probably damaging 0.97
R8250:Opcml UTSW 9 28,586,566 (GRCm39) missense probably damaging 1.00
R8350:Opcml UTSW 9 28,813,463 (GRCm39) missense probably benign 0.00
R8772:Opcml UTSW 9 27,702,707 (GRCm39) missense probably benign 0.04
R8879:Opcml UTSW 9 28,813,447 (GRCm39) missense probably damaging 1.00
R9355:Opcml UTSW 9 28,814,650 (GRCm39) missense probably benign 0.00
R9364:Opcml UTSW 9 28,814,624 (GRCm39) missense probably damaging 1.00
R9385:Opcml UTSW 9 28,586,459 (GRCm39) missense possibly damaging 0.62
Z1177:Opcml UTSW 9 28,315,673 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TGCATCCTTTGAGTGCCTGCTG -3'
(R):5'- ACCTTGGACACATGACTGCATGG -3'

Sequencing Primer
(F):5'- GAGTGCCTGCTGCTTCTC -3'
(R):5'- GGGTTGAGCAATATGGATGGAAAC -3'
Posted On 2014-01-05