Incidental Mutation 'R1052:Or6p1'
ID 94008
Institutional Source Beutler Lab
Gene Symbol Or6p1
Ensembl Gene ENSMUSG00000051509
Gene Name olfactory receptor family 6 subfamily P member 1
Synonyms MOR103-10, Olfr414, GA_x6K02T2P20D-20749615-20748662
MMRRC Submission 039142-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.090) question?
Stock # R1052 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 174257996-174258950 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 174258701 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 236 (K236*)
Ref Sequence ENSEMBL: ENSMUSP00000142051 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053178] [ENSMUST00000192358]
AlphaFold E9Q5P8
Predicted Effect probably null
Transcript: ENSMUST00000053178
AA Change: K236*
SMART Domains Protein: ENSMUSP00000052426
Gene: ENSMUSG00000051509
AA Change: K236*

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.8e-53 PFAM
Pfam:7tm_1 41 290 8.3e-21 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000192358
AA Change: K236*
SMART Domains Protein: ENSMUSP00000142051
Gene: ENSMUSG00000051509
AA Change: K236*

DomainStartEndE-ValueType
Pfam:7tm_1 41 290 2.9e-29 PFAM
Pfam:7tm_4 139 283 1.1e-45 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.3%
  • 20x: 92.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abtb2 A T 2: 103,535,417 (GRCm39) Y528F possibly damaging Het
Acad10 G A 5: 121,787,604 (GRCm39) T115I possibly damaging Het
Adam19 T C 11: 46,018,092 (GRCm39) F385L probably damaging Het
Adgb T C 10: 10,318,357 (GRCm39) N162D probably benign Het
Arhgap20 C A 9: 51,757,570 (GRCm39) P521T probably damaging Het
Arsa A T 15: 89,359,380 (GRCm39) L134Q probably damaging Het
Atp5f1b A G 10: 127,925,921 (GRCm39) Y508C probably damaging Het
AW554918 G A 18: 25,553,067 (GRCm39) M287I probably benign Het
Bmp4 T C 14: 46,621,360 (GRCm39) K395E probably damaging Het
Cacna2d4 A G 6: 119,277,294 (GRCm39) Y669C probably damaging Het
Casq2 T C 3: 102,051,550 (GRCm39) probably null Het
Cdk5rap1 A T 2: 154,202,519 (GRCm39) I237N possibly damaging Het
Cerk G C 15: 86,033,565 (GRCm39) S286C possibly damaging Het
Cir1 A C 2: 73,117,987 (GRCm39) L186R probably damaging Het
Csf3r A T 4: 125,936,781 (GRCm39) probably null Het
Cyp3a41a A T 5: 145,642,621 (GRCm39) I246K possibly damaging Het
Cyp8b1 A G 9: 121,744,348 (GRCm39) F328S possibly damaging Het
Dzank1 A T 2: 144,355,365 (GRCm39) V110D probably benign Het
Gm6729 T A 10: 86,376,799 (GRCm39) noncoding transcript Het
Gnpat T C 8: 125,604,246 (GRCm39) F246L probably benign Het
Gnpat T A 8: 125,605,255 (GRCm39) L248H probably damaging Het
Gstm7 T C 3: 107,834,266 (GRCm39) T163A probably benign Het
Hspa5 A G 2: 34,665,110 (GRCm39) T424A probably damaging Het
Itgb1 T G 8: 129,439,786 (GRCm39) D158E probably damaging Het
Kif21a A G 15: 90,819,853 (GRCm39) V1637A probably benign Het
Kl G T 5: 150,905,985 (GRCm39) V452F probably damaging Het
Krt23 T C 11: 99,369,045 (GRCm39) N416S probably benign Het
Lama4 A T 10: 38,968,241 (GRCm39) H1461L possibly damaging Het
Lamc3 A G 2: 31,818,814 (GRCm39) T1180A probably benign Het
Mboat2 T C 12: 24,996,527 (GRCm39) Y145H probably damaging Het
Mlxipl T A 5: 135,142,564 (GRCm39) I126N probably damaging Het
Myo16 T A 8: 10,620,181 (GRCm39) N1577K possibly damaging Het
Nlrp4f A G 13: 65,332,897 (GRCm39) V87A possibly damaging Het
Or5al5 A G 2: 85,961,915 (GRCm39) F31L probably benign Het
Pask A T 1: 93,258,549 (GRCm39) D266E probably benign Het
Pcdhb17 A G 18: 37,619,899 (GRCm39) Y563C probably damaging Het
Pdlim3 T A 8: 46,349,837 (GRCm39) I49N probably damaging Het
Pla2g4c T A 7: 13,077,334 (GRCm39) V292E possibly damaging Het
Pramel23 T C 4: 143,423,477 (GRCm39) I437M possibly damaging Het
Prrt4 G T 6: 29,169,813 (GRCm39) Q880K possibly damaging Het
Pygb A G 2: 150,628,858 (GRCm39) D24G probably benign Het
R3hcc1l T A 19: 42,552,093 (GRCm39) D363E probably damaging Het
Rif1 A C 2: 52,001,574 (GRCm39) Q1676P probably benign Het
Ryr1 C A 7: 28,795,683 (GRCm39) R1069L probably damaging Het
Sdk2 C T 11: 113,729,472 (GRCm39) silent Het
Slc2a13 A G 15: 91,296,363 (GRCm39) V317A probably damaging Het
Slc35b4 A T 6: 34,138,619 (GRCm39) F197I probably damaging Het
Tchhl1 G A 3: 93,377,520 (GRCm39) V75I probably benign Het
Ubr4 T C 4: 139,182,771 (GRCm39) S3521P possibly damaging Het
Zbtb14 C A 17: 69,695,497 (GRCm39) F398L probably damaging Het
Zfp335 GTCCTCCTCCTCCTCCTC GTCCTCCTCCTCCTC 2: 164,749,388 (GRCm39) probably benign Het
Zfp874a T G 13: 67,590,539 (GRCm39) I382L possibly damaging Het
Other mutations in Or6p1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01018:Or6p1 APN 1 174,258,908 (GRCm39) missense probably benign 0.00
IGL01560:Or6p1 APN 1 174,258,467 (GRCm39) missense probably benign 0.17
IGL01795:Or6p1 APN 1 174,258,215 (GRCm39) missense possibly damaging 0.83
IGL03286:Or6p1 APN 1 174,258,743 (GRCm39) missense probably benign 0.01
PIT4131001:Or6p1 UTSW 1 174,258,390 (GRCm39) missense probably damaging 1.00
R0219:Or6p1 UTSW 1 174,258,032 (GRCm39) missense probably benign 0.00
R0492:Or6p1 UTSW 1 174,258,129 (GRCm39) missense possibly damaging 0.95
R1054:Or6p1 UTSW 1 174,258,419 (GRCm39) missense probably benign 0.36
R1473:Or6p1 UTSW 1 174,258,209 (GRCm39) missense probably damaging 0.97
R1675:Or6p1 UTSW 1 174,258,663 (GRCm39) missense probably benign
R1774:Or6p1 UTSW 1 174,258,905 (GRCm39) missense probably benign 0.00
R1861:Or6p1 UTSW 1 174,258,657 (GRCm39) missense probably damaging 1.00
R1959:Or6p1 UTSW 1 174,258,471 (GRCm39) missense probably damaging 1.00
R1978:Or6p1 UTSW 1 174,258,657 (GRCm39) missense probably damaging 1.00
R4043:Or6p1 UTSW 1 174,258,657 (GRCm39) missense probably damaging 1.00
R5020:Or6p1 UTSW 1 174,258,237 (GRCm39) missense probably damaging 0.98
R5354:Or6p1 UTSW 1 174,258,252 (GRCm39) missense probably damaging 0.98
R5873:Or6p1 UTSW 1 174,258,348 (GRCm39) missense possibly damaging 0.84
R6053:Or6p1 UTSW 1 174,258,135 (GRCm39) nonsense probably null
R8300:Or6p1 UTSW 1 174,258,100 (GRCm39) nonsense probably null
R9105:Or6p1 UTSW 1 174,258,861 (GRCm39) missense probably damaging 1.00
R9716:Or6p1 UTSW 1 174,258,641 (GRCm39) missense probably benign 0.21
Z1176:Or6p1 UTSW 1 174,258,157 (GRCm39) missense probably benign 0.39
Predicted Primers PCR Primer
(F):5'- ACTGCTCAACCTCACTTGTTCAGAC -3'
(R):5'- GCTGGGATCTGCCACACATCAATC -3'

Sequencing Primer
(F):5'- TTGTTCAGACAAGGAACAGGC -3'
(R):5'- AGTACCGTCTTTCTGAAGGCATC -3'
Posted On 2014-01-05