Mutagenetix > Incidental Mutations

Incidental Mutation 'R1054:Fn1'

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94156

Institutional Source

Beutler Lab

Gene Symbol

Fn1

Ensembl Gene

ENSMUSG00000026193

Gene Name

fibronectin 1

Synonyms

Fn-1, Fn

MMRRC Submission

039144-MU

Accession Numbers

Is this an essential gene?

Essential (E-score: 1.000) question?

Stock #

R1054 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

71585520-71653200 bp(-) (GRCm38)

Type of Mutation

makesense

DNA Base Change (assembly)

A to G at 71586214 bp

Zygosity

Heterozygous

Amino Acid Change

Stop codon to Glutamine at position 2272 (*2272Q)

Ref Sequence

ENSEMBL: ENSMUSP00000140816 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055226] [ENSMUST00000186129] [ENSMUST00000187627] [ENSMUST00000187938] [ENSMUST00000188674] [ENSMUST00000188894] [ENSMUST00000189821] [ENSMUST00000190780]

Predicted Effect

probably null
Transcript: ENSMUST00000055226
AA Change: *2478Q

SMART Domains

Protein: ENSMUSP00000054499
Gene: ENSMUSG00000026193
AA Change: *2478Q

Domain	Start	End	E-Value	Type
low complexity region	2	19	N/A	INTRINSIC
FN1	53	93	6.38e-18	SMART
FN1	98	141	6.04e-19	SMART
FN1	142	185	6.94e-19	SMART
FN1	187	231	3.47e-19	SMART
FN1	232	276	6.04e-19	SMART
FN1	308	347	5.91e-13	SMART
FN2	353	401	6.66e-30	SMART
FN2	413	461	5.05e-30	SMART
FN1	470	513	2.59e-18	SMART
FN1	518	560	1.68e-17	SMART
FN1	561	604	5.69e-15	SMART
FN3	609	688	3.79e-2	SMART
FN3	719	798	1.27e-3	SMART
FN3	810	888	7.92e-14	SMART
FN3	906	985	4.28e-10	SMART
FN3	996	1074	2.53e-12	SMART
FN3	1086	1160	1.31e-5	SMART
FN3	1173	1255	1.13e-9	SMART
FN3	1264	1346	4.22e-9	SMART
FN3	1357	1437	9.6e-13	SMART
FN3	1448	1527	1.82e-13	SMART
FN3	1538	1617	6.69e-12	SMART
FN3	1632	1711	2.72e-12	SMART
FN3	1722	1801	8.9e-8	SMART
FN3	1812	1891	1.66e-7	SMART
FN3	1904	1983	4.92e-10	SMART
FN3	1993	2074	3.64e-13	SMART
low complexity region	2148	2165	N/A	INTRINSIC
FN3	2193	2272	2.9e0	SMART
FN1	2296	2340	3.72e-19	SMART
FN1	2341	2383	2.49e-20	SMART
FN1	2385	2425	2.69e-16	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000185408

Predicted Effect

probably null
Transcript: ENSMUST00000186129
AA Change: *2297Q

SMART Domains

Protein: ENSMUSP00000141123
Gene: ENSMUSG00000026193
AA Change: *2297Q

Domain	Start	End	E-Value	Type
low complexity region	2	19	N/A	INTRINSIC
FN1	53	93	6.38e-18	SMART
FN1	98	141	6.04e-19	SMART
FN1	142	185	6.94e-19	SMART
FN1	187	231	3.47e-19	SMART
FN1	232	276	6.04e-19	SMART
FN1	308	347	5.91e-13	SMART
FN2	353	401	6.66e-30	SMART
FN2	413	461	5.05e-30	SMART
FN1	470	513	2.59e-18	SMART
FN1	518	560	1.68e-17	SMART
FN1	561	604	5.69e-15	SMART
FN3	609	688	3.79e-2	SMART
FN3	719	798	1.27e-3	SMART
FN3	810	888	7.92e-14	SMART
FN3	906	985	4.28e-10	SMART
FN3	996	1074	2.53e-12	SMART
FN3	1086	1160	1.31e-5	SMART
FN3	1173	1255	1.13e-9	SMART
FN3	1266	1346	9.6e-13	SMART
FN3	1357	1436	1.82e-13	SMART
FN3	1447	1526	6.69e-12	SMART
FN3	1541	1620	2.72e-12	SMART
FN3	1631	1710	1.66e-7	SMART
FN3	1723	1802	4.92e-10	SMART
FN3	1812	1893	3.64e-13	SMART
low complexity region	1967	1984	N/A	INTRINSIC
FN3	2012	2091	2.9e0	SMART
FN1	2115	2159	3.72e-19	SMART
FN1	2160	2202	2.49e-20	SMART
FN1	2204	2244	2.69e-16	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000186575

Predicted Effect

probably benign
Transcript: ENSMUST00000187627

SMART Domains

Protein: ENSMUSP00000140955
Gene: ENSMUSG00000026193

Domain	Start	End	E-Value	Type
Pfam:fn3	1	49	1.1e-6	PFAM
FN3	58	139	1.7e-15	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000187938
AA Change: *2362Q

SMART Domains

Protein: ENSMUSP00000140975
Gene: ENSMUSG00000026193
AA Change: *2362Q

Domain	Start	End	E-Value	Type
low complexity region	2	19	N/A	INTRINSIC
FN1	53	93	6.38e-18	SMART
FN1	98	141	6.04e-19	SMART
FN1	142	185	6.94e-19	SMART
FN1	187	231	3.47e-19	SMART
FN1	232	276	6.04e-19	SMART
FN1	308	347	5.91e-13	SMART
FN2	353	401	6.66e-30	SMART
FN2	413	461	5.05e-30	SMART
FN1	470	513	2.59e-18	SMART
FN1	518	560	1.68e-17	SMART
FN1	561	604	5.69e-15	SMART
FN3	609	688	3.79e-2	SMART
FN3	719	798	1.27e-3	SMART
FN3	810	888	7.92e-14	SMART
FN3	906	985	4.28e-10	SMART
FN3	996	1074	2.53e-12	SMART
FN3	1086	1160	1.31e-5	SMART
FN3	1173	1255	1.13e-9	SMART
FN3	1266	1346	9.6e-13	SMART
FN3	1357	1436	1.82e-13	SMART
FN3	1447	1526	6.69e-12	SMART
FN3	1541	1620	2.72e-12	SMART
FN3	1631	1710	8.9e-8	SMART
FN3	1721	1800	1.66e-7	SMART
FN3	1813	1892	4.92e-10	SMART
FN3	1902	1983	3.64e-13	SMART
low complexity region	2032	2049	N/A	INTRINSIC
FN3	2077	2156	2.9e0	SMART
FN1	2180	2224	3.72e-19	SMART
FN1	2225	2267	2.49e-20	SMART
FN1	2269	2309	2.69e-16	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000188674
AA Change: *2267Q

SMART Domains

Protein: ENSMUSP00000140907
Gene: ENSMUSG00000026193
AA Change: *2267Q

Domain	Start	End	E-Value	Type
low complexity region	2	19	N/A	INTRINSIC
FN1	53	93	6.38e-18	SMART
FN1	98	141	6.04e-19	SMART
FN1	142	185	6.94e-19	SMART
FN1	187	231	3.47e-19	SMART
FN1	232	276	6.04e-19	SMART
FN1	308	347	5.91e-13	SMART
FN2	353	401	6.66e-30	SMART
FN2	413	461	5.05e-30	SMART
FN1	470	513	2.59e-18	SMART
FN1	518	560	1.68e-17	SMART
FN1	561	604	5.69e-15	SMART
FN3	609	688	3.79e-2	SMART
FN3	719	798	1.27e-3	SMART
FN3	810	888	7.92e-14	SMART
FN3	906	985	4.28e-10	SMART
FN3	996	1074	2.53e-12	SMART
FN3	1086	1160	1.31e-5	SMART
FN3	1173	1255	1.13e-9	SMART
FN3	1266	1346	9.6e-13	SMART
FN3	1357	1436	1.82e-13	SMART
FN3	1447	1526	6.69e-12	SMART
FN3	1541	1620	2.72e-12	SMART
FN3	1631	1710	8.9e-8	SMART
FN3	1721	1800	1.66e-7	SMART
FN3	1813	1892	4.92e-10	SMART
FN3	1902	1981	6.79e-13	SMART
FN3	1983	2061	1.01e1	SMART
FN1	2085	2129	3.72e-19	SMART
FN1	2130	2172	2.49e-20	SMART
FN1	2174	2214	2.69e-16	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000188894
AA Change: *2387Q

SMART Domains

Protein: ENSMUSP00000140471
Gene: ENSMUSG00000026193
AA Change: *2387Q

Domain	Start	End	E-Value	Type
low complexity region	2	19	N/A	INTRINSIC
FN1	53	93	6.38e-18	SMART
FN1	98	141	6.04e-19	SMART
FN1	142	185	6.94e-19	SMART
FN1	187	231	3.47e-19	SMART
FN1	232	276	6.04e-19	SMART
FN1	308	347	5.91e-13	SMART
FN2	353	401	6.66e-30	SMART
FN2	413	461	5.05e-30	SMART
FN1	470	513	2.59e-18	SMART
FN1	518	560	1.68e-17	SMART
FN1	561	604	5.69e-15	SMART
FN3	609	688	3.79e-2	SMART
FN3	719	798	1.27e-3	SMART
FN3	810	888	7.92e-14	SMART
FN3	906	985	4.28e-10	SMART
FN3	996	1074	2.53e-12	SMART
FN3	1086	1160	1.31e-5	SMART
FN3	1173	1255	1.13e-9	SMART
FN3	1266	1346	9.6e-13	SMART
FN3	1357	1436	1.82e-13	SMART
FN3	1447	1526	6.69e-12	SMART
FN3	1541	1620	2.72e-12	SMART
FN3	1631	1710	8.9e-8	SMART
FN3	1721	1800	1.66e-7	SMART
FN3	1813	1892	4.92e-10	SMART
FN3	1902	1983	3.64e-13	SMART
low complexity region	2057	2074	N/A	INTRINSIC
FN3	2102	2181	2.9e0	SMART
FN1	2205	2249	3.72e-19	SMART
FN1	2250	2292	2.49e-20	SMART
FN1	2294	2334	2.69e-16	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000189821
AA Change: *2177Q

SMART Domains

Protein: ENSMUSP00000139702
Gene: ENSMUSG00000026193
AA Change: *2177Q

Domain	Start	End	E-Value	Type
low complexity region	2	19	N/A	INTRINSIC
FN1	53	93	6.38e-18	SMART
FN1	98	141	6.04e-19	SMART
FN1	142	185	6.94e-19	SMART
FN1	187	231	3.47e-19	SMART
FN1	232	276	6.04e-19	SMART
FN1	308	347	5.91e-13	SMART
FN2	353	401	6.66e-30	SMART
FN2	413	461	5.05e-30	SMART
FN1	470	513	2.59e-18	SMART
FN1	518	560	1.68e-17	SMART
FN1	561	604	5.69e-15	SMART
FN3	609	688	3.79e-2	SMART
FN3	719	798	1.27e-3	SMART
FN3	810	888	7.92e-14	SMART
FN3	906	985	4.28e-10	SMART
FN3	996	1074	2.53e-12	SMART
FN3	1086	1160	1.31e-5	SMART
FN3	1173	1255	1.13e-9	SMART
FN3	1266	1346	9.6e-13	SMART
FN3	1357	1436	1.82e-13	SMART
FN3	1447	1526	6.69e-12	SMART
FN3	1541	1620	2.72e-12	SMART
FN3	1631	1710	1.66e-7	SMART
FN3	1723	1802	4.92e-10	SMART
FN3	1812	1891	6.79e-13	SMART
FN3	1893	1971	1.01e1	SMART
FN1	1995	2039	3.72e-19	SMART
FN1	2040	2082	2.49e-20	SMART
FN1	2084	2124	2.69e-16	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000190780
AA Change: *2272Q

SMART Domains

Protein: ENSMUSP00000140816
Gene: ENSMUSG00000026193
AA Change: *2272Q

Domain	Start	End	E-Value	Type
low complexity region	2	19	N/A	INTRINSIC
FN1	53	93	6.38e-18	SMART
FN1	98	141	6.04e-19	SMART
FN1	142	185	6.94e-19	SMART
FN1	187	231	3.47e-19	SMART
FN1	232	276	6.04e-19	SMART
FN1	308	347	5.91e-13	SMART
FN2	353	401	6.66e-30	SMART
FN2	413	461	5.05e-30	SMART
FN1	470	513	2.59e-18	SMART
FN1	518	560	1.68e-17	SMART
FN1	561	604	5.69e-15	SMART
FN3	609	688	3.79e-2	SMART
FN3	719	798	1.27e-3	SMART
FN3	810	888	7.92e-14	SMART
FN3	906	985	4.28e-10	SMART
FN3	996	1074	2.53e-12	SMART
FN3	1086	1160	1.31e-5	SMART
FN3	1173	1255	1.13e-9	SMART
FN3	1266	1346	9.6e-13	SMART
FN3	1357	1436	1.82e-13	SMART
FN3	1447	1526	6.69e-12	SMART
FN3	1541	1620	2.72e-12	SMART
FN3	1631	1710	1.66e-7	SMART
FN3	1723	1802	4.92e-10	SMART
FN3	1812	1893	3.64e-13	SMART
low complexity region	1942	1959	N/A	INTRINSIC
FN3	1987	2066	2.9e0	SMART
FN1	2090	2134	3.72e-19	SMART
FN1	2135	2177	2.49e-20	SMART
FN1	2179	2219	2.69e-16	SMART

Coding Region Coverage

1x: 99.2%
3x: 98.4%
10x: 96.7%
20x: 93.9%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]
PHENOTYPE: Mutants are defective in mesodermal function. Null mutants are embryonic lethal with major patterning and organizational defects. Conditional mutants live and show increased neuronal apoptosis and susceptibility to induced cerebral ischemia. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arhgap39	T	C	15: 76,751,559	T159A	probably benign	Het
Arhgef38	T	C	3: 133,116,465	Y763C	probably damaging	Het
Arv1	T	A	8: 124,731,872	F245Y	probably benign	Het
Ccdc175	A	G	12: 72,178,544	I113T	possibly damaging	Het
Cdc42bpb	A	T	12: 111,313,353	M932K	probably benign	Het
Cdh15	T	C	8: 122,864,337	F442L	possibly damaging	Het
Col28a1	C	T	6: 8,175,534	D105N	probably damaging	Het
Cpne4	A	G	9: 105,022,401	T428A	probably benign	Het
Cramp1l	T	A	17: 24,983,177	I444F	probably damaging	Het
Dhx32	T	A	7: 133,725,272	K360M	probably damaging	Het
Dna2	T	A	10: 62,963,823	C669S	possibly damaging	Het
Dusp8	ACTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGC	ACTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGC	7: 142,082,067		probably benign	Het
Eif3f	G	A	7: 108,937,817		probably null	Het
Elmod1	T	C	9: 53,912,774	D310G	probably benign	Het
Fam105a	T	C	15: 27,664,549	R79G	probably damaging	Het
Gm12800	A	G	4: 101,909,164	E15G	probably benign	Het
Gm8765	T	C	13: 50,702,396	V690A	probably benign	Het
Gnat1	A	G	9: 107,677,439	S76P	probably damaging	Het
Gtf2f2	T	C	14: 75,995,445	T94A	probably benign	Het
Hacd4	A	T	4: 88,423,027	W152R	probably damaging	Het
Kcnh8	A	G	17: 52,803,484	Y241C	probably damaging	Het
Lepr	T	C	4: 101,782,596	I753T	probably damaging	Het
Med12l	C	T	3: 59,248,651	H1162Y	probably damaging	Het
Med25	C	T	7: 44,880,380	A485T	probably benign	Het
Mup5	A	T	4: 61,832,634	S145R	probably benign	Het
Myo1g	A	G	11: 6,518,987	V105A	probably damaging	Het
Npc2	A	G	12: 84,760,718		probably null	Het
Olfr414	A	G	1: 174,430,853	T142A	probably benign	Het
Olfr648	A	G	7: 104,180,291	I39T	probably benign	Het
Pdzd2	A	G	15: 12,371,639	S2557P	probably damaging	Het
Pop1	T	C	15: 34,509,809	V353A	probably benign	Het
Pou3f2	A	G	4: 22,487,536	V199A	possibly damaging	Het
Ptprm	A	T	17: 67,042,318	N43K	probably damaging	Het
Qrsl1	C	T	10: 43,882,081	D339N	probably damaging	Het
Rpl13-ps3	C	A	14: 58,893,945		noncoding transcript	Het
Sdk2	C	T	11: 113,838,646		silent	Het
Sdr16c6	A	G	4: 4,069,908	V144A	probably damaging	Het
Spata31d1b	C	A	13: 59,717,518	H827N	probably damaging	Het
Taf4b	T	A	18: 14,821,473	H535Q	probably benign	Het
Timmdc1	A	G	16: 38,522,428	V36A	probably benign	Het
Tmem74b	C	T	2: 151,706,419	A22V	probably benign	Het
Txnrd3	T	A	6: 89,650,561	Y65*	probably null	Het
Vmn1r200	T	A	13: 22,395,454	S133R	probably damaging	Het
Vwf	G	A	6: 125,590,227	C311Y	probably damaging	Het
Wipf2	G	A	11: 98,896,315	R390H	possibly damaging	Het
Zfp282	T	A	6: 47,904,599	S407T	probably benign	Het

Other mutations in Fn1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00236:Fn1	APN	1	71652873	missense	probably benign	0.28
IGL00402:Fn1	APN	1	71641163	missense	probably damaging	1.00
IGL00946:Fn1	APN	1	71645540	splice site	probably benign
IGL01311:Fn1	APN	1	71628140	missense	probably damaging	1.00
IGL01338:Fn1	APN	1	71626210	missense	probably damaging	0.98
IGL01353:Fn1	APN	1	71586939	missense	probably damaging	1.00
IGL01674:Fn1	APN	1	71606741	missense	probably damaging	1.00
IGL01701:Fn1	APN	1	71629853	splice site	probably benign
IGL01734:Fn1	APN	1	71619485	missense	probably damaging	1.00
IGL01788:Fn1	APN	1	71613837	missense	probably damaging	1.00
IGL02186:Fn1	APN	1	71638534	missense	probably damaging	1.00
IGL02398:Fn1	APN	1	71618670	splice site	probably null
IGL02425:Fn1	APN	1	71641143	splice site	probably benign
IGL02516:Fn1	APN	1	71637323	missense	possibly damaging	0.78
IGL02593:Fn1	APN	1	71602432	missense	probably benign
IGL02651:Fn1	APN	1	71597676	missense	possibly damaging	0.65
IGL02681:Fn1	APN	1	71619482	missense	probably damaging	1.00
IGL02890:Fn1	APN	1	71598372	critical splice donor site	probably null
IGL02929:Fn1	APN	1	71595662	critical splice donor site	probably null
IGL03036:Fn1	APN	1	71629773	missense	probably damaging	1.00
IGL03088:Fn1	APN	1	71614038	splice site	probably null
IGL03142:Fn1	APN	1	71637296	missense	probably damaging	1.00
IGL03172:Fn1	APN	1	71641262	missense	probably damaging	0.99
IGL03184:Fn1	APN	1	71609497	missense	probably benign	0.02
IGL03212:Fn1	APN	1	71641325	nonsense	probably null
IGL03246:Fn1	APN	1	71624296	missense	possibly damaging	0.89
IGL03367:Fn1	APN	1	71597553	missense	probably benign	0.27
PIT4514001:Fn1	UTSW	1	71628456	missense	probably benign	0.01
R0008:Fn1	UTSW	1	71595720	missense	probably damaging	0.98
R0112:Fn1	UTSW	1	71609653	missense	probably damaging	1.00
R0138:Fn1	UTSW	1	71624110	missense	possibly damaging	0.82
R0383:Fn1	UTSW	1	71597685	missense	probably damaging	0.99
R0386:Fn1	UTSW	1	71595786	missense	probably damaging	1.00
R0648:Fn1	UTSW	1	71597585	missense	possibly damaging	0.79
R0684:Fn1	UTSW	1	71595809	splice site	probably null
R1183:Fn1	UTSW	1	71586245	missense	probably damaging	0.98
R1405:Fn1	UTSW	1	71642078	missense	probably damaging	1.00
R1405:Fn1	UTSW	1	71642078	missense	probably damaging	1.00
R1414:Fn1	UTSW	1	71601303	splice site	probably benign
R1677:Fn1	UTSW	1	71597655	missense	probably benign	0.00
R1773:Fn1	UTSW	1	71637383	missense	probably damaging	1.00
R1830:Fn1	UTSW	1	71624259	missense	probably damaging	1.00
R1987:Fn1	UTSW	1	71651625	missense	probably damaging	1.00
R1989:Fn1	UTSW	1	71651625	missense	probably damaging	1.00
R2068:Fn1	UTSW	1	71600439	missense	probably damaging	1.00
R2113:Fn1	UTSW	1	71626164	missense	probably damaging	1.00
R2145:Fn1	UTSW	1	71606004	missense	probably damaging	1.00
R2246:Fn1	UTSW	1	71628535	missense	probably benign	0.10
R2273:Fn1	UTSW	1	71613943	missense	probably null	1.00
R2274:Fn1	UTSW	1	71613943	missense	probably null	1.00
R2275:Fn1	UTSW	1	71613943	missense	probably null	1.00
R2303:Fn1	UTSW	1	71614036	critical splice acceptor site	probably null
R2379:Fn1	UTSW	1	71649284	nonsense	probably null
R2382:Fn1	UTSW	1	71648119	missense	probably damaging	1.00
R2567:Fn1	UTSW	1	71597736	nonsense	probably null
R2864:Fn1	UTSW	1	71602419	missense	probably damaging	0.99
R3154:Fn1	UTSW	1	71593083	missense	probably damaging	1.00
R3837:Fn1	UTSW	1	71653155	splice site	probably null
R3844:Fn1	UTSW	1	71609574	missense	possibly damaging	0.61
R3886:Fn1	UTSW	1	71640306	missense	probably damaging	1.00
R3887:Fn1	UTSW	1	71640306	missense	probably damaging	1.00
R3888:Fn1	UTSW	1	71640306	missense	probably damaging	1.00
R3889:Fn1	UTSW	1	71640306	missense	probably damaging	1.00
R3905:Fn1	UTSW	1	71607913	missense	probably damaging	1.00
R3906:Fn1	UTSW	1	71607913	missense	probably damaging	1.00
R3907:Fn1	UTSW	1	71607913	missense	probably damaging	1.00
R3909:Fn1	UTSW	1	71607913	missense	probably damaging	1.00
R4611:Fn1	UTSW	1	71624178	nonsense	probably null
R4724:Fn1	UTSW	1	71648148	critical splice acceptor site	probably null
R4732:Fn1	UTSW	1	71602512	splice site	probably null
R4733:Fn1	UTSW	1	71602512	splice site	probably null
R4756:Fn1	UTSW	1	71590808	missense	probably damaging	1.00
R4809:Fn1	UTSW	1	71652800	intron	probably benign
R4839:Fn1	UTSW	1	71642083	missense	probably damaging	1.00
R4915:Fn1	UTSW	1	71595809	splice site	probably null
R4917:Fn1	UTSW	1	71595809	splice site	probably null
R4918:Fn1	UTSW	1	71595809	splice site	probably null
R5002:Fn1	UTSW	1	71629728	missense	possibly damaging	0.48
R5015:Fn1	UTSW	1	71626177	missense	probably damaging	0.98
R5022:Fn1	UTSW	1	71624179	missense	probably damaging	1.00
R5109:Fn1	UTSW	1	71649235	missense	probably damaging	1.00
R5267:Fn1	UTSW	1	71629704	missense	probably damaging	1.00
R5323:Fn1	UTSW	1	71597432	missense	probably benign	0.09
R5333:Fn1	UTSW	1	71624180	missense	probably damaging	1.00
R5631:Fn1	UTSW	1	71590196	missense	probably damaging	1.00
R5644:Fn1	UTSW	1	71627250	missense	probably damaging	1.00
R5754:Fn1	UTSW	1	71600322	missense	probably damaging	1.00
R5807:Fn1	UTSW	1	71648059	missense	probably damaging	1.00
R6053:Fn1	UTSW	1	71599290	missense	probably damaging	1.00
R6133:Fn1	UTSW	1	71597727	missense	probably damaging	1.00
R6186:Fn1	UTSW	1	71637290	missense	probably damaging	1.00
R6270:Fn1	UTSW	1	71637275	missense	probably damaging	1.00
R6332:Fn1	UTSW	1	71628071	missense	probably benign	0.01
R6431:Fn1	UTSW	1	71647844	splice site	probably null
R6571:Fn1	UTSW	1	71626190	missense	probably damaging	1.00
R6596:Fn1	UTSW	1	71609482	missense	probably damaging	1.00
R6862:Fn1	UTSW	1	71613907	missense	probably benign	0.43
R6898:Fn1	UTSW	1	71600413	missense	probably damaging	1.00
R6984:Fn1	UTSW	1	71626079	missense	probably damaging	1.00
R7107:Fn1	UTSW	1	71627249	missense	probably damaging	1.00
R7121:Fn1	UTSW	1	71600538	intron	probably benign
R7127:Fn1	UTSW	1	71597544	missense	probably benign	0.16
R7194:Fn1	UTSW	1	71602323	missense	probably damaging	1.00
R7274:Fn1	UTSW	1	71628113	missense	probably benign
R7285:Fn1	UTSW	1	71637339	missense	probably damaging	1.00
R7426:Fn1	UTSW	1	71649225	missense	probably damaging	1.00
R7453:Fn1	UTSW	1	71590880	missense	probably damaging	1.00
R7508:Fn1	UTSW	1	71597516	missense	probably benign	0.01
R7724:Fn1	UTSW	1	71603735	missense	probably benign	0.02
R7848:Fn1	UTSW	1	71650601	missense	probably damaging	1.00
R7992:Fn1	UTSW	1	71599666	missense	probably benign	0.34
R8036:Fn1	UTSW	1	71590151	nonsense	probably null
R8077:Fn1	UTSW	1	71612602	missense	probably damaging	1.00
R8175:Fn1	UTSW	1	71599665	missense	probably damaging	1.00
R8177:Fn1	UTSW	1	71609587	missense	probably benign
R8212:Fn1	UTSW	1	71642905	missense	probably benign	0.01
R8322:Fn1	UTSW	1	71628459	missense	probably benign	0.04
X0023:Fn1	UTSW	1	71598373	critical splice donor site	probably null
Z1088:Fn1	UTSW	1	71649292	missense	probably damaging	1.00
Z1176:Fn1	UTSW	1	71597411	missense	probably benign	0.10

Predicted Primers

PCR Primer
(F):5'- GTTTCCCTATTGATCCCAGACCAAACC -3'
(R):5'- TGTGACACAAATCTCCACTCAACCCT -3'

Sequencing Primer
(F):5'- TGACCAACTGTCACCATTGAGG -3'
(R):5'- TCCACTCAACCCTCCCCG -3'

Posted On

2014-01-05