Mutagenetix > Incidental Mutations

Incidental Mutation 'R1061:Olfr1098'

94433

Institutional Source

Beutler Lab

Gene Symbol

Olfr1098

Ensembl Gene

ENSMUSG00000075169

Gene Name

olfactory receptor 1098

Synonyms

MOR206-1, GA_x6K02T2Q125-48410458-48409511

MMRRC Submission

039147-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

R1061 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

86920949-86924545 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 86922782 bp

Zygosity

Heterozygous

Amino Acid Change

Valine to Aspartic acid at position 250 (V250D)

Ref Sequence

ENSEMBL: ENSMUSP00000107200 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099872] [ENSMUST00000111574]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000099872
AA Change: V250D

PolyPhen 2 Score 0.928 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000097457
Gene: ENSMUSG00000075169
AA Change: V250D

Domain	Start	End	E-Value	Type
Pfam:7tm_1	41	290	7e-29	PFAM
Pfam:7tm_4	140	283	3.3e-41	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000111574
AA Change: V250D

PolyPhen 2 Score 0.928 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000107200
Gene: ENSMUSG00000075169
AA Change: V250D

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	1.8e-52	PFAM
Pfam:7tm_1	41	309	8.1e-20	PFAM

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.4%
20x: 93.1%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb11	C	T	2: 69,277,809	A715T	probably benign	Het
Ampd2	A	G	3: 108,075,689	Y641H	probably damaging	Het
Aqp4	A	T	18: 15,398,191	V171E	probably damaging	Het
Arid4a	T	A	12: 71,074,955	S381R	probably damaging	Het
Armc8	T	G	9: 99,537,731	N51H	probably damaging	Het
Asic5	T	A	3: 82,021,001	Y424N	probably damaging	Het
Bcl11a	A	T	11: 24,164,069	K471*	probably null	Het
Birc6	A	G	17: 74,689,312	T4494A	probably damaging	Het
Btbd9	A	G	17: 30,527,435	I139T	probably benign	Het
Ccdc114	T	C	7: 45,941,755	I218T	probably damaging	Het
Ccdc60	C	A	5: 116,172,468	R178S	possibly damaging	Het
Cd163	C	T	6: 124,309,169	A226V	probably benign	Het
Cog1	T	G	11: 113,652,037	S170A	probably benign	Het
Cwc15	T	C	9: 14,507,915	L169P	probably damaging	Het
Cyp3a25	A	T	5: 145,986,833	D333E	probably benign	Het
Ddc	C	T	11: 11,829,132	V331I	probably benign	Het
Dlc1	T	A	8: 36,858,051	T367S	probably benign	Het
Dnah17	T	C	11: 118,052,688	D3183G	possibly damaging	Het
Eif2a	T	A	3: 58,545,065	Y165*	probably null	Het
Eml6	T	C	11: 29,777,267	D1285G	probably damaging	Het
Fam92b	C	A	8: 120,169,704		probably null	Het
Fasn	T	C	11: 120,822,182		probably null	Het
Fbn1	T	C	2: 125,345,963	T1549A	probably benign	Het
Fezf2	T	C	14: 12,342,713	Y384C	probably damaging	Het
Flvcr1	A	T	1: 191,008,173	V550E	probably benign	Het
Gcm2	A	G	13: 41,105,871	W41R	probably damaging	Het
Gli2	A	T	1: 118,854,517	M160K	possibly damaging	Het
Gpr61	C	T	3: 108,150,307	R346H	probably damaging	Het
Hoxa5	A	T	6: 52,204,155	S66T	probably benign	Het
Hsph1	A	T	5: 149,618,418	V781D	possibly damaging	Het
Kdm3b	G	A	18: 34,796,862	V220M	probably damaging	Het
Klhl25	T	A	7: 75,866,520	Y391*	probably null	Het
Mc2r	A	T	18: 68,407,809	Y138N	probably damaging	Het
Mtap	C	A	4: 89,156,584	D106E	probably benign	Het
Nup43	G	T	10: 7,667,671	W37L	probably damaging	Het
Nxpe2	T	A	9: 48,326,363	E197D	probably damaging	Het
Olfr484	T	C	7: 108,124,456	Y269C	probably damaging	Het
Olfr544	T	A	7: 102,484,114	*335C	probably null	Het
Olfr934	C	A	9: 38,982,483	C187F	probably damaging	Het
Pitrm1	A	G	13: 6,555,575	H186R	probably damaging	Het
Pklr	C	T	3: 89,144,881	R467C	probably damaging	Het
Plxna2	A	G	1: 194,644,093	N112D	probably damaging	Het
Ppp1r16a	C	T	15: 76,693,669	Q328*	probably null	Het
Ppp3cb	A	C	14: 20,508,614		probably null	Het
R3hcc1l	C	T	19: 42,583,426	R135*	probably null	Het
Ralyl	A	C	3: 14,115,701	D68A	probably damaging	Het
Rif1	GCCACCA	GCCA	2: 52,110,324		probably benign	Het
S100a1	T	C	3: 90,511,312	N65S	probably damaging	Het
Scn11a	A	T	9: 119,795,663	M531K	probably damaging	Het
Slc5a5	T	A	8: 70,890,221	M232L	probably benign	Het
Tet3	A	T	6: 83,373,323	N1054K	probably damaging	Het
Tg	A	G	15: 66,698,559	N1427D	probably benign	Het
Tns1	A	C	1: 73,917,672	V530G	probably damaging	Het
Trcg1	C	A	9: 57,245,873	Q600K	possibly damaging	Het
Tshz3	A	G	7: 36,768,706	E40G	probably damaging	Het
Usp34	T	C	11: 23,384,420	F1138S	possibly damaging	Het
Vmn2r26	C	T	6: 124,061,644	T726I	probably benign	Het
Vmn2r97	A	T	17: 18,928,178	R112*	probably null	Het
Vwa2	G	T	19: 56,908,994	R577L	probably benign	Het
Vwa3b	A	C	1: 37,157,430	Q46P	probably damaging	Het
Wdr25	T	A	12: 108,992,799		probably null	Het
Wrap53	A	G	11: 69,562,400	L405P	probably damaging	Het
Zfp629	C	A	7: 127,611,989	W216L	probably damaging	Het

Other mutations in Olfr1098

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01318:Olfr1098	APN	2	86922949	missense	probably benign
IGL02547:Olfr1098	APN	2	86923028	missense	probably damaging	1.00
IGL02881:Olfr1098	APN	2	86922713	missense	possibly damaging	0.94
IGL03073:Olfr1098	APN	2	86923353	missense	probably damaging	1.00
R0117:Olfr1098	UTSW	2	86922870	missense	probably damaging	1.00
R0808:Olfr1098	UTSW	2	86923451	missense	probably damaging	1.00
R1471:Olfr1098	UTSW	2	86922578	splice site	probably null
R1571:Olfr1098	UTSW	2	86923445	missense	probably benign	0.01
R1680:Olfr1098	UTSW	2	86923161	missense	probably benign	0.10
R2341:Olfr1098	UTSW	2	86922638	missense	possibly damaging	0.63
R2368:Olfr1098	UTSW	2	86923107	missense	probably benign
R3158:Olfr1098	UTSW	2	86922606	missense	probably benign
R3425:Olfr1098	UTSW	2	86922606	missense	probably benign
R3499:Olfr1098	UTSW	2	86923029	missense	possibly damaging	0.94
R4156:Olfr1098	UTSW	2	86922878	missense	probably damaging	1.00
R4526:Olfr1098	UTSW	2	86922995	missense	possibly damaging	0.90
R5743:Olfr1098	UTSW	2	86923205	missense	probably benign	0.01
R5942:Olfr1098	UTSW	2	86923406	missense	probably damaging	1.00
R6372:Olfr1098	UTSW	2	86923155	missense	probably damaging	1.00
R6409:Olfr1098	UTSW	2	86923171	nonsense	probably null
R6517:Olfr1098	UTSW	2	86923097	missense	probably benign	0.05
R6661:Olfr1098	UTSW	2	86923148	missense	probably benign	0.02
R7075:Olfr1098	UTSW	2	86922646	missense	possibly damaging	0.88
R7166:Olfr1098	UTSW	2	86922748	missense	probably damaging	0.97
R8058:Olfr1098	UTSW	2	86922807	missense	probably benign	0.32
R8234:Olfr1098	UTSW	2	86922969	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TTTTGTGCCAAGAGCAAAGCTGAAG -3'
(R):5'- GCACACTGGATTTCTGCAACTCCAC -3'

Sequencing Primer
(F):5'- ATTTTAGTTTCTGGATGCACTCTC -3'
(R):5'- AGTGATACCTATAATGCAGAAGCC -3'

Posted On

2014-01-05