Incidental Mutation 'R1061:Wdr25'
ID 94522
Institutional Source Beutler Lab
Gene Symbol Wdr25
Ensembl Gene ENSMUSG00000040877
Gene Name WD repeat domain 25
Synonyms B930090D16Rik
MMRRC Submission 039147-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.932) question?
Stock # R1061 (G1)
Quality Score 225
Status Not validated
Chromosome 12
Chromosomal Location 108860155-108994380 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 108958725 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000129855 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047115] [ENSMUST00000167816] [ENSMUST00000220495]
AlphaFold E9Q349
Predicted Effect probably null
Transcript: ENSMUST00000047115
SMART Domains Protein: ENSMUSP00000035553
Gene: ENSMUSG00000040877

DomainStartEndE-ValueType
low complexity region 120 132 N/A INTRINSIC
low complexity region 180 206 N/A INTRINSIC
WD40 226 268 1.83e-7 SMART
WD40 272 311 6.73e-6 SMART
WD40 312 353 2.58e-1 SMART
Blast:WD40 356 402 7e-11 BLAST
Blast:WD40 407 445 6e-8 BLAST
WD40 451 492 9.6e-2 SMART
WD40 495 535 3e-3 SMART
Predicted Effect probably null
Transcript: ENSMUST00000167816
SMART Domains Protein: ENSMUSP00000129855
Gene: ENSMUSG00000040877

DomainStartEndE-ValueType
low complexity region 120 132 N/A INTRINSIC
low complexity region 180 206 N/A INTRINSIC
WD40 226 268 1.83e-7 SMART
WD40 272 311 6.73e-6 SMART
WD40 312 353 2.58e-1 SMART
Blast:WD40 356 402 7e-11 BLAST
Blast:WD40 407 445 6e-8 BLAST
WD40 451 492 9.6e-2 SMART
WD40 495 535 3e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000220495
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220743
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223054
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.4%
  • 20x: 93.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb11 C T 2: 69,108,153 (GRCm39) A715T probably benign Het
Ampd2 A G 3: 107,983,005 (GRCm39) Y641H probably damaging Het
Aqp4 A T 18: 15,531,248 (GRCm39) V171E probably damaging Het
Arid4a T A 12: 71,121,729 (GRCm39) S381R probably damaging Het
Armc8 T G 9: 99,419,784 (GRCm39) N51H probably damaging Het
Asic5 T A 3: 81,928,308 (GRCm39) Y424N probably damaging Het
Bcl11a A T 11: 24,114,069 (GRCm39) K471* probably null Het
Birc6 A G 17: 74,996,307 (GRCm39) T4494A probably damaging Het
Btbd9 A G 17: 30,746,409 (GRCm39) I139T probably benign Het
Ccdc60 C A 5: 116,310,527 (GRCm39) R178S possibly damaging Het
Cd163 C T 6: 124,286,128 (GRCm39) A226V probably benign Het
Cibar2 C A 8: 120,896,443 (GRCm39) probably null Het
Cog1 T G 11: 113,542,863 (GRCm39) S170A probably benign Het
Cwc15 T C 9: 14,419,211 (GRCm39) L169P probably damaging Het
Cyp3a25 A T 5: 145,923,643 (GRCm39) D333E probably benign Het
Ddc C T 11: 11,779,132 (GRCm39) V331I probably benign Het
Dlc1 T A 8: 37,325,205 (GRCm39) T367S probably benign Het
Dnah17 T C 11: 117,943,514 (GRCm39) D3183G possibly damaging Het
Eif2a T A 3: 58,452,486 (GRCm39) Y165* probably null Het
Eml6 T C 11: 29,727,267 (GRCm39) D1285G probably damaging Het
Fasn T C 11: 120,713,008 (GRCm39) probably null Het
Fbn1 T C 2: 125,187,883 (GRCm39) T1549A probably benign Het
Fezf2 T C 14: 12,342,713 (GRCm38) Y384C probably damaging Het
Flvcr1 A T 1: 190,740,370 (GRCm39) V550E probably benign Het
Gcm2 A G 13: 41,259,347 (GRCm39) W41R probably damaging Het
Gli2 A T 1: 118,782,247 (GRCm39) M160K possibly damaging Het
Gpr61 C T 3: 108,057,623 (GRCm39) R346H probably damaging Het
Hoxa5 A T 6: 52,181,135 (GRCm39) S66T probably benign Het
Hsph1 A T 5: 149,541,883 (GRCm39) V781D possibly damaging Het
Kdm3b G A 18: 34,929,915 (GRCm39) V220M probably damaging Het
Klhl25 T A 7: 75,516,268 (GRCm39) Y391* probably null Het
Mc2r A T 18: 68,540,880 (GRCm39) Y138N probably damaging Het
Mtap C A 4: 89,074,821 (GRCm39) D106E probably benign Het
Nup43 G T 10: 7,543,435 (GRCm39) W37L probably damaging Het
Nxpe2 T A 9: 48,237,663 (GRCm39) E197D probably damaging Het
Odad1 T C 7: 45,591,179 (GRCm39) I218T probably damaging Het
Or10d1c C A 9: 38,893,779 (GRCm39) C187F probably damaging Het
Or55b4 T A 7: 102,133,321 (GRCm39) *335C probably null Het
Or5p60 T C 7: 107,723,663 (GRCm39) Y269C probably damaging Het
Or8h8 A T 2: 86,753,126 (GRCm39) V250D possibly damaging Het
Pitrm1 A G 13: 6,605,611 (GRCm39) H186R probably damaging Het
Pklr C T 3: 89,052,188 (GRCm39) R467C probably damaging Het
Plxna2 A G 1: 194,326,401 (GRCm39) N112D probably damaging Het
Ppp1r16a C T 15: 76,577,869 (GRCm39) Q328* probably null Het
Ppp3cb A C 14: 20,558,682 (GRCm39) probably null Het
R3hcc1l C T 19: 42,571,865 (GRCm39) R135* probably null Het
Ralyl A C 3: 14,180,761 (GRCm39) D68A probably damaging Het
Rif1 GCCACCA GCCA 2: 52,000,336 (GRCm39) probably benign Het
S100a1 T C 3: 90,418,619 (GRCm39) N65S probably damaging Het
Scn11a A T 9: 119,624,729 (GRCm39) M531K probably damaging Het
Slc5a5 T A 8: 71,342,865 (GRCm39) M232L probably benign Het
Tet3 A T 6: 83,350,305 (GRCm39) N1054K probably damaging Het
Tg A G 15: 66,570,408 (GRCm39) N1427D probably benign Het
Tns1 A C 1: 73,956,831 (GRCm39) V530G probably damaging Het
Trcg1 C A 9: 57,153,156 (GRCm39) Q600K possibly damaging Het
Tshz3 A G 7: 36,468,131 (GRCm39) E40G probably damaging Het
Usp34 T C 11: 23,334,420 (GRCm39) F1138S possibly damaging Het
Vmn2r26 C T 6: 124,038,603 (GRCm39) T726I probably benign Het
Vmn2r97 A T 17: 19,148,440 (GRCm39) R112* probably null Het
Vwa2 G T 19: 56,897,426 (GRCm39) R577L probably benign Het
Vwa3b A C 1: 37,196,511 (GRCm39) Q46P probably damaging Het
Wrap53 A G 11: 69,453,226 (GRCm39) L405P probably damaging Het
Zfp629 C A 7: 127,211,161 (GRCm39) W216L probably damaging Het
Other mutations in Wdr25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00946:Wdr25 APN 12 108,990,953 (GRCm39) missense possibly damaging 0.89
IGL02479:Wdr25 APN 12 108,864,527 (GRCm39) missense probably benign
IGL02672:Wdr25 APN 12 108,864,007 (GRCm39) nonsense probably null
IGL03329:Wdr25 APN 12 108,864,262 (GRCm39) missense probably benign
R1402:Wdr25 UTSW 12 108,992,465 (GRCm39) missense probably damaging 1.00
R1402:Wdr25 UTSW 12 108,992,465 (GRCm39) missense probably damaging 1.00
R1582:Wdr25 UTSW 12 108,863,980 (GRCm39) missense possibly damaging 0.94
R1764:Wdr25 UTSW 12 108,992,364 (GRCm39) nonsense probably null
R1954:Wdr25 UTSW 12 108,864,467 (GRCm39) missense probably damaging 0.99
R2258:Wdr25 UTSW 12 108,864,100 (GRCm39) missense possibly damaging 0.94
R3770:Wdr25 UTSW 12 108,864,346 (GRCm39) missense probably damaging 0.97
R3803:Wdr25 UTSW 12 108,864,479 (GRCm39) missense probably damaging 1.00
R3948:Wdr25 UTSW 12 108,993,208 (GRCm39) missense probably benign 0.02
R4183:Wdr25 UTSW 12 108,993,257 (GRCm39) missense probably benign 0.00
R5246:Wdr25 UTSW 12 108,993,382 (GRCm39) missense probably benign 0.06
R5290:Wdr25 UTSW 12 108,863,968 (GRCm39) missense probably benign 0.26
R5305:Wdr25 UTSW 12 108,992,366 (GRCm39) missense probably damaging 1.00
R5813:Wdr25 UTSW 12 108,993,347 (GRCm39) missense possibly damaging 0.47
R5942:Wdr25 UTSW 12 108,864,392 (GRCm39) missense probably benign 0.00
R6386:Wdr25 UTSW 12 108,990,991 (GRCm39) missense probably damaging 1.00
R7171:Wdr25 UTSW 12 108,990,922 (GRCm39) missense probably damaging 0.98
R7449:Wdr25 UTSW 12 108,992,367 (GRCm39) missense probably damaging 1.00
R7616:Wdr25 UTSW 12 108,958,819 (GRCm39) missense possibly damaging 0.73
R7617:Wdr25 UTSW 12 108,958,819 (GRCm39) missense possibly damaging 0.73
R7619:Wdr25 UTSW 12 108,958,819 (GRCm39) missense possibly damaging 0.73
R7622:Wdr25 UTSW 12 108,958,819 (GRCm39) missense possibly damaging 0.73
R7623:Wdr25 UTSW 12 108,958,819 (GRCm39) missense possibly damaging 0.73
R7984:Wdr25 UTSW 12 108,976,983 (GRCm39) splice site probably null
R8504:Wdr25 UTSW 12 108,992,393 (GRCm39) nonsense probably null
R9598:Wdr25 UTSW 12 108,864,613 (GRCm39) missense probably benign 0.10
Predicted Primers PCR Primer
(F):5'- AGGATCTAGCCCTGAGTCTTGGTG -3'
(R):5'- TGAAGGCCAAACAGTTCTGCCTC -3'

Sequencing Primer
(F):5'- CTTGGTGGATTTGACAGGAAG -3'
(R):5'- cacacacacacacacacac -3'
Posted On 2014-01-05