Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00819:Ccl7'

9464

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ccl7

Ensembl Gene

ENSMUSG00000035373

Gene Name

C-C motif chemokine ligand 7

Synonyms

mcp3, Scya7, MCP-3, marc, fic

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.064) question?

Stock #

IGL00819

Quality Score

Status

Chromosome

Chromosomal Location

81936538-81938351 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 81937401 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 45 (N45S)

Ref Sequence

ENSEMBL: ENSMUSP00000021011 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000021011]

AlphaFold

Q03366

Predicted Effect

probably benign
Transcript: ENSMUST00000021011
AA Change: N45S

PolyPhen 2 Score 0.082 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000021011
Gene: ENSMUSG00000035373
AA Change: N45S

Domain	Start	End	E-Value	Type
low complexity region	5	16	N/A	INTRINSIC
SCY	30	88	3.33e-24	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit alterations in blood monocyte counts and in the monocytic response to thioglycollate-induced inflammation. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ankrd35	A	T	3: 96,590,350 (GRCm39)		probably null	Het
Apaf1	G	T	10: 90,833,202 (GRCm39)		probably null	Het
Ash1l	T	A	3: 88,915,043 (GRCm39)	V1891E	possibly damaging	Het
Atm	A	G	9: 53,429,831 (GRCm39)	S402P	probably damaging	Het
Camk2g	C	T	14: 20,787,398 (GRCm39)	G500S	probably damaging	Het
Ccdc150	T	A	1: 54,302,732 (GRCm39)	N117K	probably damaging	Het
Dnah2	A	T	11: 69,364,176 (GRCm39)		probably null	Het
Efcab6	A	G	15: 83,902,843 (GRCm39)	I169T	probably benign	Het
Exo1	T	C	1: 175,723,803 (GRCm39)	V383A	probably benign	Het
Fbxl2	A	G	9: 113,813,047 (GRCm39)		probably benign	Het
Fryl	A	T	5: 73,305,451 (GRCm39)	V106D	possibly damaging	Het
Fsip1	C	A	2: 118,080,393 (GRCm39)	R121L	possibly damaging	Het
Igsf9	T	C	1: 172,324,203 (GRCm39)	S789P	probably benign	Het
Klf7	T	C	1: 64,081,476 (GRCm39)	D284G	possibly damaging	Het
Mbtd1	A	G	11: 93,822,637 (GRCm39)		probably null	Het
Mef2c	A	T	13: 83,773,499 (GRCm39)	D125V	probably damaging	Het
Nectin4	T	C	1: 171,212,254 (GRCm39)	L284S	probably damaging	Het
Numa1	G	T	7: 101,641,917 (GRCm39)	G122W	possibly damaging	Het
Pcbd1	A	C	10: 60,927,919 (GRCm39)	E27A	probably benign	Het
Pclo	A	G	5: 14,908,860 (GRCm39)	N5056S	unknown	Het
Pelp1	G	A	11: 70,285,444 (GRCm39)	P808L	unknown	Het
Ppp1r12a	T	C	10: 108,076,682 (GRCm39)	S304P	probably damaging	Het
Ppp1r7	T	A	1: 93,273,978 (GRCm39)	D51E	probably benign	Het
Rassf6	T	C	5: 90,751,930 (GRCm39)	K308E	probably benign	Het
Rel	A	T	11: 23,693,029 (GRCm39)	F335I	probably benign	Het
Scnn1g	A	G	7: 121,339,660 (GRCm39)	E153G	probably benign	Het
Slc2a5	T	C	4: 150,210,113 (GRCm39)	Y33H	probably damaging	Het
Slit2	G	A	5: 48,146,493 (GRCm39)	E95K	possibly damaging	Het
Tpra1	T	A	6: 88,886,318 (GRCm39)	Y65*	probably null	Het
Trip12	C	T	1: 84,731,993 (GRCm39)	G994S	probably damaging	Het
Trnt1	T	A	6: 106,753,183 (GRCm39)	Y195*	probably null	Het
Ttn	A	G	2: 76,573,394 (GRCm39)	I17506T	probably damaging	Het
Ubr4	C	T	4: 139,203,593 (GRCm39)	T4761I	possibly damaging	Het
Vmn1r204	T	A	13: 22,741,117 (GRCm39)	Y249*	probably null	Het
Zfp212	C	T	6: 47,908,256 (GRCm39)	P412S	probably damaging	Het
Zhx1	A	G	15: 57,918,090 (GRCm39)	V52A	probably benign	Het
Zpbp2	A	T	11: 98,448,418 (GRCm39)	H245L	probably damaging	Het

Other mutations in Ccl7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00540:Ccl7	APN	11	81,937,888 (GRCm39)	missense	probably damaging	1.00
IGL01574:Ccl7	APN	11	81,937,451 (GRCm39)	missense	probably damaging	0.97
IGL03341:Ccl7	APN	11	81,936,661 (GRCm39)	missense	probably benign	0.02
seoraksan	UTSW	11	81,937,412 (GRCm39)	missense	probably damaging	1.00
R0416:Ccl7	UTSW	11	81,936,692 (GRCm39)	splice site	probably benign
R1864:Ccl7	UTSW	11	81,937,378 (GRCm39)	missense	probably benign	0.00
R6161:Ccl7	UTSW	11	81,937,412 (GRCm39)	missense	probably damaging	1.00

Posted On

2012-12-06