Incidental Mutation 'R1132:Selenbp1'
ID 94675
Institutional Source Beutler Lab
Gene Symbol Selenbp1
Ensembl Gene ENSMUSG00000068874
Gene Name selenium binding protein 1
Synonyms Lp56, Lpsb
MMRRC Submission 039205-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1132 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 94840394-94852069 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to G at 94844644 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Methionine at position 100 (I100M)
Ref Sequence ENSEMBL: ENSMUSP00000118563 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090839] [ENSMUST00000134202] [ENSMUST00000140757]
AlphaFold P17563
Predicted Effect probably benign
Transcript: ENSMUST00000090839
AA Change: I100M

PolyPhen 2 Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000088349
Gene: ENSMUSG00000068874
AA Change: I100M

DomainStartEndE-ValueType
Pfam:SBP56 6 472 3.2e-225 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000134202
AA Change: I100M

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000120159
Gene: ENSMUSG00000068874
AA Change: I100M

DomainStartEndE-ValueType
Pfam:SBP56 6 123 4.7e-56 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139949
Predicted Effect probably benign
Transcript: ENSMUST00000140757
AA Change: I100M

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000118563
Gene: ENSMUSG00000068874
AA Change: I100M

DomainStartEndE-ValueType
Pfam:SBP56 6 123 4.7e-56 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145551
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.3%
  • 10x: 96.3%
  • 20x: 92.7%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit sex-specific changes in organ weights. Mice homozygous for a different allele lack methanethiol oxidase activity and exhibit an increase in dimethylsulfide and dimethyl-sulfone serum levels. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apba1 T C 19: 23,894,917 (GRCm39) V451A possibly damaging Het
Atxn2l CCAGCAGCAGCAGCAGCAGC CCAGCAGCAGCAGCAGC 7: 126,093,420 (GRCm39) probably benign Het
C3 C T 17: 57,514,531 (GRCm39) probably null Het
Car9 G T 4: 43,512,439 (GRCm39) probably null Het
Cd163 G T 6: 124,286,055 (GRCm39) G202* probably null Het
Cdk8 A G 5: 146,236,625 (GRCm39) T347A probably benign Het
Cep170 C A 1: 176,577,603 (GRCm39) R1257L probably damaging Het
Cib1 A G 7: 79,877,778 (GRCm39) F168S probably damaging Het
Cntnap5c G A 17: 58,601,351 (GRCm39) G833D probably damaging Het
Dhx37 A T 5: 125,498,103 (GRCm39) I702N probably damaging Het
Dnah3 T C 7: 119,538,227 (GRCm39) K3586R possibly damaging Het
Fbxo31 ACGGCGCGGCG ACGGCGCGGCGCGGCG 8: 122,279,015 (GRCm39) probably null Het
Fbxo31 CGCGG CGCGGAGCGG 8: 122,279,019 (GRCm39) probably null Het
Fhod3 TGAGGAGGAGGAGGAGGA TGAGGAGGAGGAGGA 18: 25,153,722 (GRCm39) probably benign Het
Gaa T C 11: 119,175,885 (GRCm39) S953P probably damaging Het
Inpp5j T C 11: 3,452,305 (GRCm39) E315G possibly damaging Het
Itsn2 T C 12: 4,708,464 (GRCm39) Y840H probably damaging Het
Kif1a T C 1: 92,983,743 (GRCm39) E653G probably damaging Het
Loxhd1 T C 18: 77,517,639 (GRCm39) V1829A possibly damaging Het
Myh8 C T 11: 67,187,957 (GRCm39) Q910* probably null Het
Or12d12 T C 17: 37,610,423 (GRCm39) R297G probably benign Het
Or14a257 A T 7: 86,138,425 (GRCm39) F111L probably benign Het
Or14j4 G T 17: 37,921,333 (GRCm39) T103K possibly damaging Het
Or2ag17 A T 7: 106,389,758 (GRCm39) I150N possibly damaging Het
Prdm4 A G 10: 85,735,145 (GRCm39) S666P probably damaging Het
Rad50 T C 11: 53,585,788 (GRCm39) K331E possibly damaging Het
Rbbp6 A G 7: 122,599,336 (GRCm39) probably benign Het
Skint6 A G 4: 112,755,296 (GRCm39) probably null Het
Stac3 T C 10: 127,343,128 (GRCm39) S208P probably benign Het
Tfap2a T C 13: 40,874,867 (GRCm39) probably null Het
Trhde T C 10: 114,248,383 (GRCm39) K939E possibly damaging Het
Vmn1r22 T C 6: 57,877,826 (GRCm39) I50M probably benign Het
Vmn1r39 C T 6: 66,781,428 (GRCm39) V260I probably benign Het
Zdhhc25 T C 15: 88,484,926 (GRCm39) L87P probably damaging Het
Zfp202 T C 9: 40,122,318 (GRCm39) L360P probably benign Het
Other mutations in Selenbp1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01970:Selenbp1 APN 3 94,844,313 (GRCm39) missense probably benign 0.24
IGL03281:Selenbp1 APN 3 94,844,621 (GRCm39) nonsense probably null
PIT4131001:Selenbp1 UTSW 3 94,844,607 (GRCm39) missense probably damaging 0.99
R0415:Selenbp1 UTSW 3 94,844,224 (GRCm39) missense possibly damaging 0.61
R1421:Selenbp1 UTSW 3 94,851,183 (GRCm39) missense probably benign
R1522:Selenbp1 UTSW 3 94,844,669 (GRCm39) missense probably damaging 1.00
R1676:Selenbp1 UTSW 3 94,851,854 (GRCm39) missense probably damaging 1.00
R1701:Selenbp1 UTSW 3 94,844,701 (GRCm39) missense probably damaging 1.00
R2152:Selenbp1 UTSW 3 94,851,441 (GRCm39) missense probably damaging 1.00
R3033:Selenbp1 UTSW 3 94,845,351 (GRCm39) missense probably benign 0.22
R4363:Selenbp1 UTSW 3 94,850,060 (GRCm39) splice site probably null
R4631:Selenbp1 UTSW 3 94,851,879 (GRCm39) makesense probably null
R4798:Selenbp1 UTSW 3 94,851,211 (GRCm39) missense probably benign 0.27
R4935:Selenbp1 UTSW 3 94,845,269 (GRCm39) missense probably benign 0.10
R5464:Selenbp1 UTSW 3 94,851,727 (GRCm39) missense probably benign
R6253:Selenbp1 UTSW 3 94,851,157 (GRCm39) missense possibly damaging 0.95
R6314:Selenbp1 UTSW 3 94,844,576 (GRCm39) missense probably damaging 1.00
R7199:Selenbp1 UTSW 3 94,851,745 (GRCm39) missense possibly damaging 0.79
R7330:Selenbp1 UTSW 3 94,847,021 (GRCm39) missense probably benign
R7637:Selenbp1 UTSW 3 94,844,659 (GRCm39) nonsense probably null
R7658:Selenbp1 UTSW 3 94,851,413 (GRCm39) missense probably benign 0.03
R8739:Selenbp1 UTSW 3 94,844,601 (GRCm39) missense probably damaging 0.99
R8803:Selenbp1 UTSW 3 94,851,821 (GRCm39) missense possibly damaging 0.88
R8987:Selenbp1 UTSW 3 94,847,425 (GRCm39) missense probably benign 0.10
R9145:Selenbp1 UTSW 3 94,851,414 (GRCm39) missense probably benign 0.38
R9209:Selenbp1 UTSW 3 94,847,079 (GRCm39) missense probably benign 0.08
R9747:Selenbp1 UTSW 3 94,844,648 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GCTGAACTGAAACCCTGTCTATGCC -3'
(R):5'- CAGCCCATGCTTGAAACTTGCTTG -3'

Sequencing Primer
(F):5'- CCCTGTCTATGCCTAGTCAAAAATG -3'
(R):5'- AGTTCAGGAGCCCTCTGAAG -3'
Posted On 2014-01-05