Incidental Mutation 'R1132:Vmn1r22'
ID |
94697 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn1r22
|
Ensembl Gene |
ENSMUSG00000115091 |
Gene Name |
vomeronasal 1 receptor 22 |
Synonyms |
V1rc23 |
MMRRC Submission |
039205-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.095)
|
Stock # |
R1132 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
6 |
Chromosomal Location |
57877067-57877975 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 57877826 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Methionine
at position 50
(I50M)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000154301
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000177435]
[ENSMUST00000227342]
[ENSMUST00000227650]
[ENSMUST00000228076]
[ENSMUST00000228257]
[ENSMUST00000228322]
[ENSMUST00000228905]
|
AlphaFold |
Q8R2D1 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000177435
AA Change: I50M
PolyPhen 2
Score 0.430 (Sensitivity: 0.89; Specificity: 0.90)
|
SMART Domains |
Protein: ENSMUSP00000135207 Gene: ENSMUSG00000114982 AA Change: I50M
Domain | Start | End | E-Value | Type |
Pfam:V1R
|
28 |
293 |
3.9e-57 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000227342
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000227650
AA Change: I50M
PolyPhen 2
Score 0.430 (Sensitivity: 0.89; Specificity: 0.90)
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000228076
AA Change: I50M
PolyPhen 2
Score 0.430 (Sensitivity: 0.89; Specificity: 0.90)
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000228257
AA Change: I50M
PolyPhen 2
Score 0.430 (Sensitivity: 0.89; Specificity: 0.90)
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000228322
AA Change: I50M
PolyPhen 2
Score 0.430 (Sensitivity: 0.89; Specificity: 0.90)
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000228905
|
Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.3%
- 10x: 96.3%
- 20x: 92.7%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 35 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Apba1 |
T |
C |
19: 23,894,917 (GRCm39) |
V451A |
possibly damaging |
Het |
Atxn2l |
CCAGCAGCAGCAGCAGCAGC |
CCAGCAGCAGCAGCAGC |
7: 126,093,420 (GRCm39) |
|
probably benign |
Het |
C3 |
C |
T |
17: 57,514,531 (GRCm39) |
|
probably null |
Het |
Car9 |
G |
T |
4: 43,512,439 (GRCm39) |
|
probably null |
Het |
Cd163 |
G |
T |
6: 124,286,055 (GRCm39) |
G202* |
probably null |
Het |
Cdk8 |
A |
G |
5: 146,236,625 (GRCm39) |
T347A |
probably benign |
Het |
Cep170 |
C |
A |
1: 176,577,603 (GRCm39) |
R1257L |
probably damaging |
Het |
Cib1 |
A |
G |
7: 79,877,778 (GRCm39) |
F168S |
probably damaging |
Het |
Cntnap5c |
G |
A |
17: 58,601,351 (GRCm39) |
G833D |
probably damaging |
Het |
Dhx37 |
A |
T |
5: 125,498,103 (GRCm39) |
I702N |
probably damaging |
Het |
Dnah3 |
T |
C |
7: 119,538,227 (GRCm39) |
K3586R |
possibly damaging |
Het |
Fbxo31 |
ACGGCGCGGCG |
ACGGCGCGGCGCGGCG |
8: 122,279,015 (GRCm39) |
|
probably null |
Het |
Fbxo31 |
CGCGG |
CGCGGAGCGG |
8: 122,279,019 (GRCm39) |
|
probably null |
Het |
Fhod3 |
TGAGGAGGAGGAGGAGGA |
TGAGGAGGAGGAGGA |
18: 25,153,722 (GRCm39) |
|
probably benign |
Het |
Gaa |
T |
C |
11: 119,175,885 (GRCm39) |
S953P |
probably damaging |
Het |
Inpp5j |
T |
C |
11: 3,452,305 (GRCm39) |
E315G |
possibly damaging |
Het |
Itsn2 |
T |
C |
12: 4,708,464 (GRCm39) |
Y840H |
probably damaging |
Het |
Kif1a |
T |
C |
1: 92,983,743 (GRCm39) |
E653G |
probably damaging |
Het |
Loxhd1 |
T |
C |
18: 77,517,639 (GRCm39) |
V1829A |
possibly damaging |
Het |
Myh8 |
C |
T |
11: 67,187,957 (GRCm39) |
Q910* |
probably null |
Het |
Or12d12 |
T |
C |
17: 37,610,423 (GRCm39) |
R297G |
probably benign |
Het |
Or14a257 |
A |
T |
7: 86,138,425 (GRCm39) |
F111L |
probably benign |
Het |
Or14j4 |
G |
T |
17: 37,921,333 (GRCm39) |
T103K |
possibly damaging |
Het |
Or2ag17 |
A |
T |
7: 106,389,758 (GRCm39) |
I150N |
possibly damaging |
Het |
Prdm4 |
A |
G |
10: 85,735,145 (GRCm39) |
S666P |
probably damaging |
Het |
Rad50 |
T |
C |
11: 53,585,788 (GRCm39) |
K331E |
possibly damaging |
Het |
Rbbp6 |
A |
G |
7: 122,599,336 (GRCm39) |
|
probably benign |
Het |
Selenbp1 |
C |
G |
3: 94,844,644 (GRCm39) |
I100M |
probably benign |
Het |
Skint6 |
A |
G |
4: 112,755,296 (GRCm39) |
|
probably null |
Het |
Stac3 |
T |
C |
10: 127,343,128 (GRCm39) |
S208P |
probably benign |
Het |
Tfap2a |
T |
C |
13: 40,874,867 (GRCm39) |
|
probably null |
Het |
Trhde |
T |
C |
10: 114,248,383 (GRCm39) |
K939E |
possibly damaging |
Het |
Vmn1r39 |
C |
T |
6: 66,781,428 (GRCm39) |
V260I |
probably benign |
Het |
Zdhhc25 |
T |
C |
15: 88,484,926 (GRCm39) |
L87P |
probably damaging |
Het |
Zfp202 |
T |
C |
9: 40,122,318 (GRCm39) |
L360P |
probably benign |
Het |
|
Other mutations in Vmn1r22 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
R0089:Vmn1r22
|
UTSW |
6 |
57,877,513 (GRCm39) |
missense |
probably benign |
0.06 |
R0415:Vmn1r22
|
UTSW |
6 |
57,877,317 (GRCm39) |
missense |
probably benign |
0.18 |
R1609:Vmn1r22
|
UTSW |
6 |
57,877,733 (GRCm39) |
nonsense |
probably null |
|
R1666:Vmn1r22
|
UTSW |
6 |
57,877,704 (GRCm39) |
missense |
probably benign |
0.07 |
R1668:Vmn1r22
|
UTSW |
6 |
57,877,704 (GRCm39) |
missense |
probably benign |
0.07 |
R1708:Vmn1r22
|
UTSW |
6 |
57,877,481 (GRCm39) |
missense |
possibly damaging |
0.46 |
R1796:Vmn1r22
|
UTSW |
6 |
57,877,134 (GRCm39) |
missense |
probably damaging |
1.00 |
R2359:Vmn1r22
|
UTSW |
6 |
57,877,974 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
R4600:Vmn1r22
|
UTSW |
6 |
57,877,860 (GRCm39) |
missense |
probably damaging |
1.00 |
R5302:Vmn1r22
|
UTSW |
6 |
57,877,960 (GRCm39) |
missense |
possibly damaging |
0.87 |
R5560:Vmn1r22
|
UTSW |
6 |
57,877,723 (GRCm39) |
missense |
probably damaging |
1.00 |
R6026:Vmn1r22
|
UTSW |
6 |
57,877,390 (GRCm39) |
missense |
probably benign |
0.00 |
R6066:Vmn1r22
|
UTSW |
6 |
57,877,864 (GRCm39) |
missense |
probably benign |
0.01 |
R6343:Vmn1r22
|
UTSW |
6 |
57,877,563 (GRCm39) |
missense |
possibly damaging |
0.65 |
R6639:Vmn1r22
|
UTSW |
6 |
57,877,699 (GRCm39) |
missense |
probably benign |
0.01 |
R7106:Vmn1r22
|
UTSW |
6 |
57,877,296 (GRCm39) |
missense |
probably damaging |
1.00 |
R7683:Vmn1r22
|
UTSW |
6 |
57,877,404 (GRCm39) |
missense |
probably damaging |
1.00 |
R8126:Vmn1r22
|
UTSW |
6 |
57,877,669 (GRCm39) |
missense |
possibly damaging |
0.85 |
R9216:Vmn1r22
|
UTSW |
6 |
57,877,257 (GRCm39) |
missense |
possibly damaging |
0.93 |
R9486:Vmn1r22
|
UTSW |
6 |
57,877,404 (GRCm39) |
missense |
probably damaging |
1.00 |
R9707:Vmn1r22
|
UTSW |
6 |
57,877,890 (GRCm39) |
missense |
probably benign |
0.37 |
R9722:Vmn1r22
|
UTSW |
6 |
57,877,631 (GRCm39) |
missense |
probably benign |
0.04 |
S24628:Vmn1r22
|
UTSW |
6 |
57,877,317 (GRCm39) |
missense |
probably benign |
0.18 |
|
Predicted Primers |
PCR Primer
(F):5'- AACACACCCAGGAGGCATGTGA -3'
(R):5'- GGTATGAGACTCAGGTGAAATGCAGG -3'
Sequencing Primer
(F):5'- TGTGATGCACATAGAGAGTCCTC -3'
(R):5'- CTTGGAGGGTATATAACAATGTAGGC -3'
|
Posted On |
2014-01-05 |